Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine.
Duchardt-Ferner E, Juen MA, Bourgeois B, Madl T, Kreutz C, Ohlenschläger O, Wöhnert J.*
Nucleic Acids Res. 2019, in press. 

Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing.
Plangger R, Juen M, Hoernes T, Nußbaumer F, Kremser J, Strebitzer E, Klingler D, Erharter K, Tollinger M, Erlacher M, Kreutz C.*
Nucleic Acids Res. 2019 Oct 29. pii: gkz965. doi: 10.1093/nar/gkz965. link

Direct evidence for (G)O6···H2-N4(C)+ hydrogen bonding in transient G(syn)-C+ and G(syn)-m5C+ Hoogsteen base pairs in duplex DNA from cytosine amino nitrogen off-resonance R relaxation dispersion measurements.
Rangadurai A, Kremser J, Shi H, Kreutz C*, Al-Hashimi HM.*
J Magn Reson. 2019 Sep 5;308:106589. doi: 10.1016/j.jmr.2019.106589. link

Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site.
Chu CC, Plangger R, Kreutz C, Al-Hashimi HM.
Nucleic Acids Res. 2019 Jun 14. pii: gkz498. doi: 10.1093/nar/gkz498. link

The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B12 Cofactors for Catalysis.
Kieninger C, Deery E, Lawrence AD, Podewitz M, Wurst K, Nemoto-Smith E, Widner FJ, Baker JA, Jockusch S, Kreutz CR, Liedl KR, Gruber K, Warren MJ, Kräutler B.
Angew Chem Int Ed Engl. 2019 May 22. doi: 10.1002/anie.201904713. link
Access to 3-Deazaguanosine Building Blocks for RNA Solid-Phase Synthesis Involving Hartwig-Buchwald C-N Cross-Coupling.
Mairhofer E, Flemmich L, Kreutz C, Micura R.
Org Lett. 2019 Jun 7;21(11):3900-3903. doi: 10.1021/acs.orglett.9b00855 link
NMR resonance assignments for the GTP-binding RNA aptamer 9-12 in complex with GTP.
Wolter AC, Pianu A, Kremser J, Strebitzer E, Schnieders R, Fürtig B, Kreutz C, Duchardt-Ferner E, Wöhnert J.
Biomol NMR Assign. 2019 Apr 27. doi: 10.1007/s12104-019-09892-z. link
Eukaryotic Translation Elongation is Modulated by Single Natural Nucleotide Derivatives in the Coding Sequences of mRNAs.
Hoernes TP, Heimdörfer D, Köstner D, Faserl K, Nußbaumer F, Plangger R, Kreutz C, Lindner H, Erlacher MD.
Genes (Basel). 2019 Jan 25;10(2). pii: E84. doi: 10.3390/genes10020084. link
The structure of the SAM/SAH-binding riboswitch.
Weickhmann AK, Keller H, Wurm JP, Strebitzer E, Juen MA, Kremser J, Weinberg Z, Kreutz C, Duchardt-Ferner E, Wöhnert J.*
Nucleic Acids Res
. (2019); 47(5): 2654-2665. doi: 10.1093/nar/gky1283. link


Synthetic and structural studies on pentafluorobenzylated imidazole systems.
Lampl M, Schlapp-Hackl I, Wurst H, Gelbrich T, Kopacka H, Mueller T, Kreutz C, Naier B, Partl G*, Kahlenberg V, Amer H, Bacher M, Rosenau T, Huppertz H, Schottenberger H.
Journal of Fluorine Chemistry (2018);218: 51-62.

Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions.
Hoernes TP, Faserl K, Juen MA, Kremser J, Gasser C, Fuchs E, Shi X, Siewert A, Lindner H, Kreutz C, Micura R, Joseph S, Höbartner C, Westhof E, Hüttenhofer A, Erlacher MD*.
Nat Commun. (2018); doi: 10.1038/s41467-018-07321-8. link

The 5-oxyacetic acid modification destabilizes double helical stem structures and favors anionic Watson-Crick like cmo5U-G base pairs.
Strebitzer E#, Rangadurai A#, Plangger R, Kremser J, Juen MA, Tollinger M, Al-Hashimi H*, Kreutz C*
Chemistry (2018); 24:18903-18906. link
# These authors contributed equally.

Chlorophyll Breakdown in a Fern - Discovery of Carbon-Skeleton Rearranged Phyllobilin Isomers.
Erhart T, Vergeiner S, Kreutz C, Kräutler B*, Müller T.*
Angew Chem Int Ed Engl. (2018); 57(45): 14937-14941.

NMR resonance assignments for the SAM/SAH-binding riboswitch RNA bound to S-adenosylhomocysteine.
Weickhmann AK, Keller H, Duchardt-Ferner E, Strebitzer E, Juen MA, Kremser J, Wurm JP, Kreutz C, Wöhnert J.*
Biomol NMR Assign. (2018); 12(2): 329-334. link

A potentially abundant junctional RNA motif stabilized by m6A and Mg2+.
Liu B, Merriman DK, Choi SH, Schumacher MA, Plangger R, Kreutz C, Horner SM, Meyer KD, Al-Hashimi HM.*
Nat Commun. (2018); 9(1): 2761. link

Studying sparsely populated conformational states in RNA combining chemical synthesis and solution NMR spectroscopy.
Strebitzer E, Nußbaumer F, Kremser J, Tollinger M, Kreutz C.*
Methods (2018); 148: 39-47. link

Isotope labeling for studying RNA by solid-state NMR spectroscopy.
Marchanka A, Kreutz C, Carlomagno T.*
J. Biomol. NMR (2018); 71: 151-164. link

Residue and site-specific labeling of CCR5 RNA pseudoknot reveals internal motions that correlate with microRNA binding.
Chen B, Longhini AP, Nußbaumer F, Kreutz C, Dinman J*, Dayie TK.*
Chemistry - A European Journal (2018); 24(21):5462-5468. link

Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release.
Hoernes TP, Clementi N, Juen MA, Shi X, Faserl K, Willi J, Gasser C, Kreutz C, Simpson J, Linder H, Huettenhofer A, Erlacher MD.*
Proc Natl Acad Sci U S A. (2018) ; 115(3): E382-E389. link


Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD / Dcr-2 complex in RNA interference.
Tants JN, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich CH, Juen MA, Hartlmüller C, Böttcher R, Kunzelmann S, Lange O, Kreutz C, Förstemann K, Sattler M.*
Nucl. Acids Res. (2017); 45(21): 12536-12550. link

Chemical synthesis and NMR spectroscopy of long stable isotope labelled RNA.
Kremser J, Strebitzer E, Plangger R, Juen MA, Nußbaumer F, Glasner H, Breuker K, Kreutz C.*
ChemComm (2017); 53: 12938-12941. link

Synthesis and incorporation of 13C-labeled DNA building blocks to probe structural dynamics of DNA by NMR.
Nußbaumer F, Juen MA, Gasser C, Kremser J, Mueller T, Tollinger M, Kreutz C.*
Nucl. Acids Res. (2017); 45(15): 9178-9192. link

Phenylbenzenesulfonates and -sulfonamides as 17β-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis.
Vuorinen A, Engeli RT, Leugger S, Kreutz C, Schuster D, Odermatt A*, Matuszczak B.*
Bioorg. Med. Chem. Lett. (2017);27(13):2982-2985. link

RNA binding and chaperone activity of E. coli cold-shock protein CspA.
Rennella E, Sara T, Juen M, Wunderlich C, Imbert L, Solyom Z, Favier A, Ayala I, Weinhaeupl K, Schanda P, Konrat R, Kreutz C, Brutscher B.* 
Nucl. Acids Res. (2017);45(7):4255-4268. link

The synthesis of 15N7-Hoogsteen face-labeled adenosine amidite for solid phase RNA synthesis.
Neuner S, Kreutz C*, Micura R.*
Monatsh. Chem. (2017);148(1):149-155. link

A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer.
Wolter AC, Weickhmann AK, Nasiri AH, Hantke K, Ohlenschläger O, Wunderlich CH, Kreutz C, Duchardt-Ferner E, Wöhnert J.*
Angew. Chem. Int. Ed. Engl. (2017);56(1):401-404. link


Measurement of ligand-target residence times by 1H relaxation dispersion NMR spectroscopy.
Moschen T, Grutsch S, Juen, MA, Wunderlich CH, Kreutz C*, Tollinger M*.
J. Med. Chem. (2016);59(23):10788-10793. link

NMR resonance assignments for the tetramethylrhodamine binding RNA aptamer 3 in complex with the ligand 5-carboxy-tetramethylrhodamine.
Duchardt-Ferner E*, Juen M, Kreutz C, Wöhnert J.
Biomol. NMR Assign. (2016);11(1):29-34. link

Excited states of nucleic acids probed by proton relaxation dispersion NMR spectroscopy.
Juen MA, Wunderlich CH, Nußbaumer F, Tollinger M, Kontaxis G, Konrat R, Hansen DF*,
Kreutz C.*
Angew. Chem. Int. Ed. Engl. (2016);55(39):12008-12012. link

m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs.
Zhou H, Kimsey IJ, Nikolova EN, Sathyamoorthy B, Grazioli G, McSally J, Bai T, Wunderlich CH, Kreutz C, Andricioaei I*, Al-Hashimi HM.*
Nat. Struct. Mol. Biol. (2016);23:803-810. link

Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.
Ren A, Vusurovic N, Gebetsberger J, Gao P, Juen M, Kreutz C, Micura R*, Patel DJ.*
Nat. Chem. Biol. (2016);12:702-708. link

Chlorophyll Catabolites in Fall Leaves of the Wych Elm Tree Present a Novel Glycosylation Motif.
Scherl M, Müller T, Kreutz C, Huber RG, Zass E*, Liedl KR,* Kräutler B.*
Chemistry Eur. J. (2016);22(28):9498-9503. link

Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations.
Longhini AP, LeBlanc RM, Becette O, Salguero C, Wunderlich CH, Johnson BA, D’Souza VM, Kreutz C, Dayie TK.*
Nucl. Acids Res. (2016);44(6):e52. link


Stable Isotope-Labeled RNA Phosphoramidites to Facilitate Dynamics by NMR.
Wunderlich CH, Juen MA, LeBlanc RM, Longhini AP, Dayie TK, Kreutz C.*
Methods Enzymol. 2015;565:461-494. link

A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.
Košutić M, Neuner S, Ren A, Flür S, Wunderlich C, Mairhofer E, Vušurović N, Seikowski J, Breuker K, Höbartner C, Patel DJ*, Kreutz C*, Micura R.*
Angew. Chem. Int. Ed. Engl. (2015);127(50):15343-15348. link

NMR resonance assignments for the class II GTP binding RNA aptamer in complex with GTP.
Wolter AC, Duchardt-Ferner E, Nasiri AH, Hantke K, Wunderlich CH, Kreutz C, Wöhnert J.*
Biomol. NMR Assign. (2015);10(1):101-105. link

Hydroxymethylated Dioxobilins in Senescent Arabidopsis thaliana Leaves: Sign of a Puzzling Biosynthetic Intermezzo of Chlorophyll Breakdown.
Süssenbacher I, Kreutz C, Christ B, Hörtensteiner S, Kräutler B.*
Chem. Eur. J. (2015), 21. link

The "speedy" synthesis of atom-specific 15N imino/amido-labeled RNA.
Neuner S, Santner T, Kreutz C, Micura R.*
Chem. Eur. J. (2015), 21(33):11634-11643. link

Expanding the Scope of 2'-SCF3 Modified RNA.
Jud L, Košutić M, Schwarz V, Hartl M, Kreutz C, Bister K, Micura R.*
Chem. Eur. J. (2015);21(29):10400-7. link

Role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis.
Koch M, Flür S, Kreutz C, Ennifar E, Micura R*, Polacek N.*
Proc. Natl. Acad. Sci. USA (2015);112(20):E2561-8. link

Intermolecular 'cross-torque': the N4-cytosine propargyl residue is rotated to the 'CH'-edge as a result of Watson-Crick interaction.
Domingo O, Hellmuth I, Jäschke A, Kreutz C, Helm M.*
Nucl. Acids Res. (2015); 43(11):5275-5283. link

Ligand-Detected Relaxation Dispersion NMR Spectroscopy: Dynamics of preQ1–RNA Binding.
Moschen T, Wunderlich C, Spitzer R, Levic J, Micura R, Tollinger M*, Kreutz C.*
Angew. Chem. Int. Ed. (2015); 54(2):560-563. link

2014 & before

book contributions

NMR of Large Molecules
Wunderlich C, Grutsch S, Tollinger M, Kreutz C, (2014), in ‘Handbook of Chemical and Biological Plant Analytical Methods’, edited by Kurt Hostettmann, Shilin Chen, Andrew Marston and Hermann Stuppner. Chichester, UK: John Wiley & Sons, Ltd, pp 361-378.

Investigations on fluorine-labeled ribonucleic acids by 19F-NMR spectroscopy.
Kreutz C, Micura R.
Modified Nucleotides in Biochemistry, Biotechnology and Medicine (Editor: P. Herdewijn), Wiley-VCH, (2008), 3-22.

Nach oben scrollen