Innsbruck Doctoral College Ageing and Regeneration

Publications 2022

Herzog C., Marín F., Jones A., Evans I., Reisel D., Redl E., Schreiberhuber L., Paytubi S., Pelegrina B., Carmona A., Peremiquel-Trillas P., Frias-Gomez J., Pineda M., Brunet J., Ponce J., Matias-Guiu X., de Sanjosé S., Alemany L., Olaitan A., Wong M., Jurkovic D., Crosbie E.J., Rosenthal A.N., Bjørge L., Zikan M., Dostalek L., Cibula D., Sundström K., Dillner J., Costas L., Widschwendter M. A simple cervico-vaginal epigenetic test for screening and rapid triage of women with suspected endometrial cancer – validation in several cohort and case/control sets. J Clin Oncol. 2022; online ahead of print Aug 24. doi: 10.1200/JCO.22.00266

Holzknecht M., Guerrero-Navarro L., Petit M., Albertini E., Damisch E., Simonini A., Schmitt F., Parson W., Fiegl H., Weiss A., Jansen-Duerr P. The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro. FEBS Lett. 2022; Aug 2 doi: 10.1002/1873-3468.14462. 

Martic I., Jansen-Dürr P., Cavinato M. Effects of air pollution on cellular senescence and skin aging. Cells 2022;11(14):2220. doi:10.3390/cells11142220.

Gerna D., Clara D., Allwardt D., Mitter B., Roach T. Tailored Media Are Key to Unlocking the Diversity of Endophytic Bacteria in Distinct Compartments of Germinating Seeds. Microbiol Spectr. 2022 Jul 18:e0017222. doi: 10.1128/spectrum.00172-22. 

Mandl M., Viertler H.P., Hatzmann F.M., Brucker C., Großmann S., Waldegger P., Rauchenwald T., Mattesich M., Zwierzina M., Pierer G., Zwerschke W. An organoid model derived from human adipose stem/progenitor cells to study adipose tissue physiology. Adipocyte. 2022;11(1):164-174. doi: 10.1080/21623945.2022.2044601

Tisch M., Carmen De Mingo Alemany M., Suarez-Cubero M., Fauth C., Defrancesco M., Zschocke J., Günther K., Edenhofer F. Generation of the human induced pluripotent stem cell line (IBKMOLi002-A) from PBMCs of a patient carrying the heterozygous L271H mutation of the voltage-gated calcium channel subunit Cav1.3-encoding CACNA1D gene. Stem Cell Res. 2022;61:102784. doi: 10.1016/j.scr.2022.102784.

Andric A., Wagner E., Heberle A., Holzknecht M., Weiss A.K.H. Extraction and purification of FAHD1 protein from swine kidney and mouse liver. J Vis Exp. 2022 Feb 18;(180). doi: 10.3791/63333.

Gerna D, Ballesteros D, Arc E, Stöggl W, Seal CE, Marami-Zonouz N, Na CS, Kranner I, Roach T. Does oxygen affect ageing mechanisms of Pinus densiflora seeds? A matter of cytoplasmic physical state. J Exp Bot. 2022 Jan 27:erac024. doi: 10.1093/jxb/erac024. Epub ahead of print. PMID: 35084458.

Publications 2021

Albertos P, Tatematsu K, Mateos I, Sánchez-Vicente I, Fernández-Arbaizar A, Nakabayashi K, Nambara E, Godoy M, Franco JM, Solano R, Gerna D, Roach T, Stöggl W, Kranner I, Perea-Resa C, Salinas J, Lorenzo O. Redox feedback regulation of ANAC089 signaling alters seed germination and stress response. Cell Rep. 2021 Jun 15;35(11):109263. doi: 10.1016/j.celrep.2021.109263. PMID: 34133931; PMCID: PMC8220255.

Cavinato M, Madreiter-Sokolowski CT, Büttner S, Schosserer M, Zwerschke W, Wedel S, Grillari J, Graier WF, Jansen-Dürr P. Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic
control. FEBS J. 2021 Jun;288(12):3834-3854. doi: 10.1111/febs.15631. Epub 2020 Dec 8. PMID: 33200494; PMCID: PMC7611050.

Fellner L, Gabassi E, Haybaeck J, Edenhofer F. Autophagy inα-Synucleinopathies-An Overstrained System. Cells. 2021 Nov 12;10(11):3143. doi:10.3390/cells10113143. PMID: 34831366; PMCID: PMC8618716.

Ghorbel A., Wedel S., Kallel I., Cavinato M., Sakavitsi M.E., Fakhfakh J., Halabalaki M., Jansen-Dürr P., Allouche N. Extraction yield optimization of Oleaster (Olea europaea var. sylvestris) fruits using response surface methodology, LC/MS profiling and evaluation of its effects on antioxidant activity and autophagy in HFF cells. J. Food Meas. Charact. 2021;15:4946-4959. doi:10.1007/s11694-021-01058-7.  

Salti A., Etemad S., Cubero M.S., Albertini E., Kovacs-Szalka B., Holzknecht M., Cappuccio E., Cavinato M., Edenhofer F., Jansen-Dürr P. High glycolytic activity enhances stem cell reprogramming of Fahd1-KO mouse embryonic fibroblasts. Cells 2021;10(8):2040. doi: 10.3390/cells10082040. 

Gerna D, Arc E, Holzknecht M, Roach T, Jansen-Dürr P, Weiss AKH, Kranner I. AtFAHD1a: A New Player Influencing Seed Longevity and Dormancy in Arabidopsis? Int J Mol Sci. 2021 Mar 15;22(6):2997. doi: 10.3390/ijms22062997. PMID: 33804275; PMCID: PMC8001395.

Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yanng L, Karbacher l, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A Goldstein LSB, Galasko D, Gage FH. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell. 2021 Sep 2;28(9):1533-1548.e6. doi: 10.1016/j.stem.2021.04.004. Epub 2021 Apr 27.

Temocin O, Regele D, Sathianathan M, Überbacher C, Hartl M, Edenhofer F, Meyer D. Generation of an hiPSC-1 knock-in line expressing TY1-tagged MNX1-protein together with mScarlet. Stem Cell Res. 2021 Oct;56:102522. doi: 10.1016/j.scr.2021.102522. Epub 2021 Sep 2. PMID: 34509159

Narzt MS, Pils V, Kremslehner C, Nagelreiter IM, Schosserer M, Bessonova E, Bayer A, Reifschneider R, Terlecki-Zaniewicz L, Waidhofer-Söllner P, Mildner M, Tschachler E, Cavinato M, Wedel S, Jansen-Dürr P, Nanic L, Rubelj I, El-
Ghalbzouri A, Zoratto S, Marchetti-Deschmann M, Grillari J, Gruber F, Lämmermann I. Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory
Phenotype (SASP) Factors. J Invest Dermatol. 2021 Apr;141(4S):993-1006.e15. doi: 10.1016/j.jid.2020.11.020. Epub 2020 Dec 15. PMID: 33333126.

Publications 2020

Cavinato M., Wedel S., Jansen-Dürr P. Aging of Cells In Vitro. In: Rattan, S.I.S. (Ed.), Encyclopedia of Biomedical Gerontology. Elsevier 2020, vol. 1, Academic Press, pp. 138–148. ISBN: 9780128160756

Gerna D, Roach T, Mitter B, Stöggl W, Kranner I. Hydrogen Peroxide Metabolism in Interkingdom Interaction Between Bacteria and Wheat Seeds and Seedlings. Mol Plant Microbe Interact. 2020 Feb;33(2):336-348. doi: 10.1094/MPMI-09-19-0248-R. Epub 2019 Dec 18. PMID: 31631769.

Hagen M, Derudder E. Inflammation and the Alteration of B-Cell Physiology in Aging. Gerontology. 2020;66(2):105-113. doi: 10.1159/000501963. Epub 2019 Sep 25. PMID: 31553969

Martic I, Wedel S, Jansen-Dürr P, Cavinato M. A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes. Mech Ageing Dev.2020 Sep;190:111322. doi: 10.1016/j.mad.2020.111322. Epub 2020 Jul 29. PMID:32735894; PMCID: PMC7116475.

Wedel S, Martic I, Hrapovic N, Fabre S, Madreiter-Sokolowski CT, Haller T,Pierer G, Ploner C, Jansen-Dürr P, Cavinato M. tBHP treatment as a model forcellular senescence and pollution-induced skin aging. Mech Ageing Dev. 2020
Sep;190:111318. doi: 10.1016/j.mad.2020.111318. Epub 2020 Jul 22. PMID: 32710895; PMCID: PMC7610711.

Weiss A.K.H., Naschberger A., Cappuccio E., Metzger C., Mottes L., Holzknecht M., von Velsen J., Bowler M.W., Rupp B., Jansen-Dürr P. Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse. Biosci Rep. 2020 Mar 27;40(3). pii: BSR20194431. doi: 10.1042/BSR20194431

Weiss A.K.H., Albertini E., Holzknecht M., Cappuccio E., Dorigatti I., Krahbichler A., Damisch E., Gstach H., Jansen-Dürr P. Regulation of cellular senescence by eukaryotic members of the FAH superfamily - a role in calcium homeostasis? Mech Ageing Dev. 2020 Jun 20:111284. doi: 10.1016/j.mad.2020.111284

Publications 2019

Etemad S., Petit M., Weiss A.K.H., Schrattenholz A., Baraldo G., Jansen-Dürr P. Oxaloacetate decarboxylase FAHD1 - a new regulator of mitochondrial function and senescence. Mech Ageing Dev 2019;177:22-29. doi: 10.1016/j.mad.2018.07.007.

Böhnke L., Traxler L., Herdy J.R., Mertens J. Human neurons to model aging: A dish best served old. Drug Discovery Today: Disease Models (2019)
Hartl M., Glasauer S., Gufler S., Raffeiner A., Puglisi K., Breuker K., Bister K., Hobmayer B. Differential regulation of myc homologs by Wnt/β-catenin signaling in the early metazoan Hydra. FEBS J. 2019;286(12): 2295-2310. doi: 10.1111/febs.14812

Baraldo G., Etemad S., Weiss A.K.H., Jansen-Dürr P., Mack H.I.D. Modulation of serotonin signaling by the putative oxaloacetate decarboxylase FAHD-1 in Caenorhabditis elegans. PLoS One. 2019 Aug 14;14(8):e0220434. doi: 10.1371/journal.pone.0220434. eCollection 2019.

Rocamora-Reverte L, Tuzlak S, von Raffay L, Tisch M, Fiegl H, Drach M,Reichardt HM, Villunger A, Tischner D, Wiegers GJ. Glucocorticoid Receptor-Deficient Foxp3+ Regulatory T Cells Fail to Control ExperimentalInflammatory Bowel Disease. Front Immunol. 2019 Mar 18;10:472. doi:10.3389/fimmu.2019.00472. PMID: 30936873; PMCID: PMC6431616.

Zeng F., Wunderer J., Salvenmoser W., Hess M.W., Ladurner P., Rothbächer U. Papillae revisited and the nature of the adhesive secreting collocytes. Dev Biol. 2019;448(2):183-198. doi: 10.1016/j.ydbio. 2018.11.012.

Weiss AKH, Holzknecht M, Cappuccio E, Dorigatti I, Kreidl K, Naschberger A,Rupp B, Gstach H, Jansen-Dürr P. Expression, Purification, Crystallization, andEnzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins. J Vis
Exp. 2019 Jun 20;(148):10.3791/59729. doi: 10.3791/59729. PMID: 31282888; PMCID:PMC7115867.

Meryk A., Pangrazzi L., Hagen M., Hatzmann F., Jenewein B., Jakic B., Hermann-Kleiter N., Baier G., Jylhävä J., Hurme M., Trieb K., Grubeck-Loebenstein B. Fcµ receptor as a costimulatory molecule for T cells. Cell Rep 2019;26(10):2681-2691.e5. doi: 10.1016/j.celrep.2019.02.024

Erharter A., Rizzi S., Mertens J., Edenhofer F.; Take the shortcut - direct conversion of somatic cells into induced neural stem cells and their biomedical applications; FEBS Lett 2019 Dec;593(23):3353-3369; doi: 10.1002/1873-3468.13656. Epub 2019 Dec 1.PMID: 31663609; PMCID: PMC6916337; DOI: 1002/1873-3468.13656

Publications 2018

Gerna D., Roach T., Arc E., Stöggl W., Limonta M., Vaccino P., Kranner I. Redox poise and metabolite changes in bread wheat seeds are advanced by priming with hot steam. Biochem J. 2018;475(23):3725-3743. doi: 10.1042/BCJ20180632.

Gufler S., Artes B., Bielen H., Krainer I., Eder M-K., Falschlunger J., Bollmann A., Ostermann T., Hartl M., Bister K., Technau U., Hobmayer B. β-Catenin acts in a position-independent regeneration response in the simple eumetazoan Hydra. Dev. Biol. 2018;433(2):310-323. doi: 10.1016/j.ydbio.2017.09.005.

Wedel S., Manola M., Cavinato M., Trougakos I.P., Jansen-Dürr P. Targeting protein quality control mechanisms by natural products to promote healthy ageing. Molecules 2018; 23(5). pii. E1219. doi: 10.3390/molecules23051219.

Revoltella S., Baraldo G., Waltenberger B., Schwaiger S., Kofler P., Moesslacher J., Huber-Seidel A., Pagitz K., Kohl R., Jansen-Duerr P., Stuppner H. Identification of the NADPH Oxidase 4 Inhibiting Principle of Lycopus europaeus. Molecules 2018;23(3). pii: E653. doi: 10.3390/molecules23030653.

Weiss A.K.H., Naschberger A., Loeffler J.R., Gstach H., Bowler M.W., Holzknecht M., Cappuccio E., Pittl A., Etemad S., Dunzendorfer-Matt T., Scheffzek K., Liedl K.R., Jansen-Dürr P. Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1. Biochem J 2018;475 (22):3561-3576. doi: 10.1042/BCJ20180750.

Publications 2017

Petit M., Koziel R., Etemad S., Pircher H., Jansen-Dürr P. Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells. Exp Gerontol. 2017;92:7-12. doi: 10.1016/j.exger.2017.03.004.

Gerna D., Roach T., Stöggl W., Wagner J., Vaccino P., Limonta M., Kranner I. Changes in low-molecular-weight thiol-disulphide redox couples are part of bread wheat seed germination and early seedling growth. Free Radic Res. 2017;51(6):568-581. doi:10.1080/10715762.2017.1338344

Bu H., Wedel S., Cavinato M., Jansen-Dürr P. MicroRNA regulation of oxidative stress-induced cellular senescence. Oxid Med Cell Longev, vol. 2017;2017:2398696.doi:10.1155/2017/2398696.

Publications 2016

Kari W., Zeng F., Zitzelsberger L., Will J., Rothbächer U. Embryo microinjection and electroporation in the Chordate Ciona intestinalis. J Vis Exp. 2016 Oct 16;(116). doi: 10.3791/54313.


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