Birgit WALTENBERGER, Mag. pharm. Dr. Assistant Professor
Contact: Institute of Pharmacy/Pharmacognosy University of Innsbruck Center for Chemistry and Biomedicine Innrain 80 - 82/IV Room: L.04.062 6020 Innsbruck / Austria
In silico and bioactivity guided discovery of novel anti-inflammatory agents October 2011, Institute of Pharmacy/Pharmacognosy, University of Innsbruck
Diploma-thesis
Transport of sennoside A, sennoside B, sennidine A and sennidine B across Caco-2 cell monolayers December 2006, Institute of Pharmacy/Pharmacognosy, University of Innsbruck
Publications (*corresponding authorship, 1shared first or last authorship)
Vu T.H., Delalande O., Lalli C., Reider S., Ferron S., Boustie J., Waltenberger B.*,1, Lohezic-Le Devehat F.*,1 Inhibitory effects of secondary metabolites from the lichen Stereocaulon evolutum on protein tyrosine phosphatase 1B. Planta Medica 2021, 87(9), 701-708. Doi: 10.1055/a-1334-4480.
Tran T.V.A., Alilou M., Zhigang R., Pace S., Schwaiger S., Kretzer C., Temml V., Giesel C., Jordan P.M., Bilancia R., Weinigel C., Rummler S., Waltenberger B., Hung T., Rossi A., Stuppner H., Werz O., Koeberle A. From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution. Acta Pharmaceutica Sinica B 2021, 11(6), 1629-1647. Doi: 10.1016/j.apsb.2021.04.011.
Engels N.S., Gierlikowska B., Waltenberger B.*, Chang F.R., Kiss A.K., Stuppner H. A new diterpene and anti-inflammatory sesquiterpene lactones from Sigesbeckia orientalis. Planta Medica 2020, 86(15), 1108-1117. Doi: 10.1055/a-1232-6869.
Kaserer T., Steinacher T., Kainhofer R., Erli F., Sturm S., Waltenberger B.*, Schuster D.*, Spetea M.* Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Scientific Reports 2020, 10(1), 13804. Doi: 10.1038/s41598-020-70493-1.
Rapa S.F., Waltenberger B., Di Paola R., Adesso S., Siracusa R., Peritore A.F., D´Amico R., Autore G., Cuzzocrea S., Stuppner H., Marzocco S. (2020): Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo. The FASEB Journal 2020, 34(1), 1576-1590. Doi: 10.1096/fj.201902040R.
Mayr F., Moeller G., Garscha U., Fischer J., Castano P.R., Inderbinen S.G., Temml V., Waltenberger B., Schwaiger S., Hartmann R.W., Gege C., Martens S., Odermatt A., Pandey A.V., Werz O., Adamski J., Stuppner H., Schuster D. Finding new molecular targets of familiar natural products using in silico target prediction. International Journal of Molecular Sciences 2020, 21(19), 7102. Doi: 10.3390/ijms21197102.
Engels N.S., Waltenberger B.*, Schwaiger S., Huynh L., Tran H., Stuppner H. Melodamide A from Melodorum fruticosum - Quantification using HPLC and one-step-isolation by centrifugal partition chromatography. Journal of Separation Science 2019, 42(20), 3165 - 3172. Doi: 10.1002/jssc.201900392.
Revoltella S., Rainer B., Waltenberger B., Pagitz K., Schwaiger S., Stuppner H. HPTLC autography based screening and isolation of mushroom tyrosinase inhibitors of European plant species. Chemistry and Biodiversity 2019, 16(3), e1800541. Doi: 10.1002/cbdv.201800541.
Gerstmeier J., Seegers J., Witt F., Waltenberger B., Temml V., Rollinger J.M., Stuppner H., Koeberle A., Schuster D., Werz O. Ginkgolic acid is a multi-target inhibitor of key enzymes in pro-inflammatory lipid mediator biosynthesis. Frontiers in Pharmacology 2019, 10, 797. Doi: 10.3389/fphar.2019.00797.
Mayr F., Sturm S., Ganzera M., Waltenberger B., Martens S., Schwaiger S., Schuster D., Stuppner H. Mushroom tyrosinase-based enzyme inhibition assays are not suitable for bioactivity-guided fractionation of extracts. Jounal of Natural Products 2019, 82(1), 136-147. Doi: 10.1021/acs.jnatprod.8b00847.
Michalak B., Piwowarski J.P., Granica S., Waltenberger B., Atanasov A.G., Khan S.Y., Breuss J.M., Uhrin P., Zyznska-Granica B., Stojakowska A., Stuppner H., Kiss A.K. Eupatoriopicrin inhibits pro-inflammatory functions of neutrophils via suppression of IL-8 and TNF-alpha production and p38 and ERK 1/2 MAP kinases. Journal of Natural Products 2019, 82(2), 375-385. Doi: 10.1021/acs.jnatprod.8b00939.
Rainer B., Revoltella S., Mayr F., Moesslacher J., Scalfari V., Kohl R., Waltenberger B., Pagitz K., Siewert B., Schwaiger S., Stuppner H. From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. European Journal of Medicinal Chemistry 2019, 184, 111738. Doi: 10.1016/j.ejmech.2019.111738.
Waltenberger B.*, Halabalaki M., Schwaiger S., Adamopoulos N., Allouche N., Fiebich B.L., Hermans N., Jansen-Dürr P., Kesternich V., Pieters L., Schönbichler S., Skaltsounis A.-L., Tran H., Trougakos I.P., Viljoen A., Wolfender J.-L., Wolfrum C., Xynos N., Stuppner H. Novel natural products for healthy ageing from the Mediterranean diet and food plants of other global sources—The MediHealth project. Molecules 2018, 23(5), 1097. Doi: 10.3390/molecules23051097.
Engels N., Waltenberger B.*, Michalak B., Huynh L., Tran H., Kiss A.K., Stuppner H. Inhibition of pro‐inflammatory functions of human neutrophils by constituents of Melodorum fruticosum leaves. Chemistry and Biodiversity 2018, 15(11), e1800269. Doi: 10.1002/cbdv.201800269.
Revoltella S., Baraldo G., Waltenberger B.*, Schwaiger S.*, Kofler P., Moesslacher J., Huber-Seidel A., Pagitz K., Kohl R., Jansen-Dürr P., Stuppner H. Identification of the NADPH oxidase 4 inhibiting principle of Lycopus europaeus. Molecules 2018, 23(3), 653. Doi: 10.3390/molecules23030653.
Liu R.1, Heiss E.H.1, Waltenberger B.1, Blazevic T., Schachner D., Jiang B., Krystof V., Liu W., Schwaiger S., Pena-Rodriguez L.M., Breuss J.M., Stuppner H., Dirsch V., Ananasov A.G. Constituents of Mediterranean spices counteracting vascular smooth muscle cell proliferation: Identification and characterization of rosmarinic acid methyl ester as a novel inhibitor. Molecular Nutrition and Food Research 2018, 62(7), e1700860. Doi: 10.1002/mnfr.201700860.
Becker K.1, Schwaiger S.1, Waltenberger B.1, Fuchs D., Pezzei C.K., Schennach H., Stuppner H., Gostner J.M. Immunomodulatory effects of diterpene quinone derivatives from the roots of Horminum pyrenaicum in human PBMC. Oxidative Medicine and Cellular Longevity 2018, 2018, 2980295. Doi: 10.1155/2018/2980295.
Piwowarski J., Waltenberger B., Stuppner H., Kiss A.K., Granica S. The analysis of phenolic compounds from the aerial parts of Eupatorium cannabinum L. subsp. cannabinum. Biochemical Systematics and Ecology 2018, 79, 37-43. Doi: 10.1016/j.bse.2018.05.001.
Wang D.D., Uhrin P., Mocan A., Waltenberger B., Breuss J.M., Tewari D., Mihaly-Bison J., Huminiecki L., Starzynski R.R., Tzvetkov N.T., Horbanczuk J., Atanasov A.G. Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: Molecular targets and pathways. Biotechnology Advances 2018, 36(6), 1586 - 1607. Doi: 10.1016/j.biotechadv.2018.04.006.
Uhrin P., Wang D.D., Mocan A., Waltenberger B., Breuss J.M., Tewari D., Mihaly-Bison J., Huminiecki L., Starzynski R.R., Tzvetkov N.T., Horbanczuk J., Atanasov A.G. Vascular smooth muscle cell proliferation as a therapeutic target. Part 2: Natural products inhibiting proliferation. Biotechnology Advances 2018, 36(6), 1608 - 1621. Doi: 10.1016/j.biotechadv.2018.04.002.
Pein H., Ville A., Pace S., Temml V., Garscha U., Raasch M., Alsabil K., Viault G., Dinh C.-P., Guilet D., Troisi F., Neukirch K., König S., Bilancia R., Waltenberger B., Stuppner H., Wallert M., Lorkowski S., Weinigel C., Rummler S., Birringer M., Roviezzo F., Sautebin L., Helesbeux J.J., Seraphin D., Mosig A.S., Schuster D., Rossi A., Richomme P., Werz O., Koeberle A. Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications 2018, 9(1), 3834. Doi: 10.1038/s41467-018-06158-5.
Cavinato M., Waltenberger B., Baraldo G., Grade C.V.C., Stuppner H., Jansen-Dürr P. Plant extracts and natural compounds used against UVB-induced photoaging. Biogerontology 2017, 18(4), 499 - 516. Doi: 10.1007/s10522-017-9715-7.
Escalante-Erosa F., Ruiz-Vargas J.A., Gomez-Guzman A., Waltenberger B., Stuppner H., Pena-Rodriguez L.M. Antioxidant metabolites from the stems of Bakeridesia gaumeri. Natural Product Communications2017, 12(9), 1473-1474. Doi: 10.1177/1934578X1701200923.
Hochleitner J., Akram M., Ueberall M., Davis R.A., Waltenberger B., Stuppner H., Sturm S., Ueberall F., Gostner J.M., Schuster D. A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature. Scientific Reports 2017, 7, 8071. Doi: 10.1038/s41598-017-08404-0.
Khan S.Y., Awad E.M., Oszwald A., Mayr M., Yin X., Waltenberger B., Stuppner H., Lipovac M., Uhrin P., Breuss J.M. Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin. Scientific Reports 2017, 7, 39501. Doi: 10.1038/srep39501.
Temml V., Garscha U., Romp E., Schubert G., Gerstmeier J., Kutil Z., Matuszczak B., Waltenberger B., Stuppner H., Werz O., Schuster D. Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Scientific Reports 2017, 7, 42751. Doi: 10.1038/srep42751.
Vuorinen A., Engeli R.T., Leugger S., Bachmann F., Akram M., Atanasov A.G., Waltenberger B., Temml V., Stuppner H., Krenn L., Ateba S.B., Njamen D., Davis R.A., Odermatt A., Schuster D. Potential antiosteoporotic natural product lead compounds that inhibit 17β-hydroxysteroid dehydrogenase type 2. Journal of Natural Products 2017, 80(4), 965 - 974. Doi: 10.1021/acs.jnatprod.6b00950.
Perczel A., Atanasov A.G., Sklenář V., Nováček J., Papoušková V., Kadeřávek P., Žídek L., Kozłowski H., Wątły J., Hecel A., Kołkowska P., Koča J., Svobodová-Vařeková R., Pravda L., Sehnal D., Horský V., Geidl S., Enriz R.D., Matějka P., Jeništová A., Dendisová M., Kokaislová A., Weissig V., Olsen M., Coffey A., Ajuebor J., Keary R., Sanz-Gaitero M., van Raaij M.J., McAuliffe O., Waltenberger B., Mocan A., Šmejkal K., Heiss E.H., Diederich M., Musioł R., Košmrlj J., Polański J., Jampílek J. The eighth central European conference "Chemistry towards Biology": snapshot. Molecules 2016, 21(10), 1381. Doi: 10.3390/molecules21101381.
Waltenberger B., Garscha U., Temml V., Liers J., Werz O., Schuster D., Stuppner H. Discovery of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore-based virtual screening. Journal of Chemical Information and Modeling 2016, 56(4), 747-62. Doi: 10.1021/acs.jcim.5b00592.
Waltenberger B.1, Mocan A.1, Šmejkal K., Heiss E.H., Atanasov A.G. Natural products to counteract the epidemic of cardiovascular and metabolic disorders. Molecules 2016, 21(6), 807. Doi: 10.3390/molecules21060807.
Waltenberger B., Atanasov A.G., Heiss E.H., Bernhard D., Rollinger J.M., Breuss J.M., Schuster D., Bauer R., Kopp B., Franz C., Bochkov V., Mihovilovic M.D., Dirsch V.M., Stuppner H. Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project. Monatshefte für Chemie/Chemical Monthly 2016, 147(3), 479-491. Doi: 10.1007/s00706-015-1653-y.
Heiss E.H., Liu R., Waltenberger B., Khan S., Schachner D., Kollmann P., Zimmermann K., Cabaravdic M., Uhrin P., Stuppner H., Breuss J.M., Atanasov A.G., Dirsch V.M. Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation. Scientific Reports 2016, 6, 20771. Doi: 10.1038/srep20771.
Alsabil K., Suor-Cherer S., Koeberle A., Viault G., Lavaud A., Temml V., Waltenberger B., Schuster D., Litaudon M., Lorkowski S., de Vaumas R., Helesbeux J.J., Guilet D., Stuppner H., Werz O., Seraphin D., Richomme P. Semisynthetic and natural garcinoic acid isoforms as new mPGES-1 inhibitors. Planta Medica 2016, 82 (11/12), 1110-1116. Doi: 10.1055/s-0042-108739.
Waltenberger B.1, Liu R.1, Atanasov A.G., Schwaiger S., Heiss E.H., Dirsch V.M., Stuppner H. Nonprenylated xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as novel inhibitors of vascular smooth muscle cell proliferation. Molecules 2015, 20(11), 20381-20390. Doi: 10.3390/molecules201119703.
Atanasov A.G.1, Waltenberger B.1, Pferschy-Wenzig E.-M.1, Linder T., Wawrosch C., Uhrin P., Temml V., Wang L., Schwaiger S., Heiss E.H., Rollinger J.M., Schuster D., Breuss J.M., Bochkov V., Mihovilovic M.D., Kopp B., Bauer R., Dirsch V.M., Stuppner H. Discovery and resupply of pharmacologically active plant-derived natural products: A review.Biotechnology Advances 2015, 33(8), 1582-1614. Doi: 10.1016/j.biotechadv.2015.08.001.
Winekenstädde D., Angelis A., Waltenberger B., Schwaiger S., Tchoumtchoua J., König S., Werz O., Aligiannis N., Skaltsounis A.-L., Stuppner H. Phytochemical profile of the aerial parts of Sedum sediforme and anti-inflammatory activity of Myricitrin. Natural Product Communications2015, 10(1), 83-88.
Wang L.1, Waltenberger B.1, Pferschy-Wenzig E.M., Blunder M., Liu X., Malainer C., Blazevic T., Schwaiger S., Rollinger J.M., Heiss E.H., Schuster D., Kopp B., Bauer R., Stuppner H., Dirsch V.M., Atanasov A.G. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochemical Pharmacology2014, 92(1), 73-89. Doi: 10.1016/j.bcp.2014.07.018, Audio-slide-presentation: http://goo.gl/xDPMgq.
Picker P., Vogl S., McKinnon R., Mihaly-Bison J., Binder M., Atanasov A.G., Fakhrudin N., Grzywacz A.M., Heiss E.H., Zehl M., Saukel J., Wawrosch C., Schinkovitz A., Waltenberger B., Bauer R., Rollinger J.M., Stuppner H., Dirsch V.M., Bochkov V.N., Reznicek G., Kopp B. Plant extracts in cell-based anti-inflammatory assays – Pitfalls and considerations related to removal of activity masking bulk components. Phytochemistry Letters 2014, 10, xli–xlvii. Doi: 10.1016/j.phytol.2014.04.001.
Fakhrudin N.1, Waltenberger B.1, Cabaravdic M.1, Atanasov A.G., Malainer C., Schachner D., Heiss E.H., Liu R., Noha S.M., Grzywacz A.M., Mihaly-Bison J., Awad E.M., Schuster D., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Identification of plumericin as a potent new scaffold inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. British Journal of Pharmacology2014, 171(7), 1676-1686. Doi: 10.1111/bph.12558.
Bauer J., Waltenberger B., Noha S.M., Schuster D., Rollinger J.M., Boustie J., Stuppner H., Werz O. Discovery of depsides and depsidones from lichen as novel, potent inhibitors of microsomal prostaglandin E2 synthase-1 using pharmacophore models. ChemMedChem2012, 7(12), 2077-2081. Doi: 10.1002/cmdc.201200345.
Waltenberger B., Rollinger J.M., Griesser U.J., Stuppner H., Gelbrich T. Plumeridoid C from the Amazonian traditional medicinal plant Himatanthus sucuuba. Acta Crystallographic Section C, Crystal Structure Communications 2011, 67/10, 409-412. Doi: 10.1107/S0108270111035761.
Waltenberger B., Wiechmann K., Bauer J., Markt P., Noha S.M., Wolber G., Rollinger J.M., Werz O., Schuster D., Stuppner H. Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1). Journal of Medicinal Chemistry2011, 54(9), 3163-3174. Doi: 10.1021/jm101309g.
Waltenberger B., Schuster D., Paramapojn S., Gritsanapan W., Wolber G., Rollinger J.M., Stuppner H. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine. Phytomedicine2011, 18(2-3), 119-133. Doi: 10.1016/j.phymed.2010.08.002.
Schuster D., Waltenberger B., Kirchmair J., Distinto S., Markt P., Stuppner H., Rollinger J.M., Wolber G. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part I: Model generation, validation and applicability in ethnopharmacology. Molecular Informatics2010, 29(1-2), 75-86. Doi: 10.1002/minf.200900071.
Waltenberger B., Avula B., Ganzera M., Khan I.A., Stuppner H., Khan S.I. Transport of sennosides and sennidines from Cassia angustifolia and Cassia senna across Caco-2 monolayers - an in vitro model for intestinal absorption. Phytomedicine2008, 15(5), 373-377. Doi: 10.1016/j.phymed.2007.03.008.
Patents
Schuster D., Temml V., Kutil Z., Matuszczak B., Werz O., Garscha U., Waltenberger B., Stuppner H. N,N' -diarylurea, N,N'-diarylthiourea and N,N'-diarylguanidino compounds for use in treatment and prevention of inflammatory disease. European Patent Office, EP 3315495 A1 20180502 (2018).
Richomme P., Helesbeux J.-J., Guilet D., Seraphin D., Stuppner H., Waltenberger B., Schuster D., Temml V., Koeberle A., Werz O. Tocotrienol derivatives, pharmaceutical composition and method of use in 5-lipoxygenase related diseases. World Intellectual Property Organization, WO/2017/032881 (2017).
Conferences and presentations (presenting authors underlined)
Waltenberger B., Engels N.S., Temml V., Huynh L., Tran H., Werz O., Koeberle A. Chalcones from Melodorum fruticosum inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). Poster presentation at the “71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, July 4, 2023, Dublin, Ireland.
Temml V., Kafka M., Huber-Cantonati P., Mähr T., Schwitzer F., Mayr F., Möller G., Adamski J., Waltenberger B., Stuppner H., Pachmayr J, Eder I.E., Schuster, D. Many roads to bioactivity: Polypharmacological effects of benzylated dihydrochalcone MF-15 and resulting anti-cancer activities. Oral presentation at the “13th Austrian Association of Molecular Life Sciences and Biotechnology (ÖGMBT) Annual Meeting”, October 14, 2021, online.
Tran V.A., Alilou M., Zhigang R., Pace S., Schwaiger S., Kretzer C., Temml V., Jordan P., Rosella B., Waltenberger B., Tran H., Rossi A., Stuppner H., Werz O., Koeberle A. (2021): Switching from inflammation to resolution: what can we learn from medical plants? Oral presentation at the “69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 6, 2021, Bonn, Germany, online.
Temml V., Huber-Cantonati P., Mähr T., Schwitzer F., Kretzer C., Köberle A., Mayr F., Engels N., Waltenberger B., Stuppner H., Werz O., Pachmayr J., Schuster D. (2021): Benzylated dihydrochalcone MF-15 as a potent multitarget inhibitor of cancer cell growth. Poster presentation at the “69th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 5-8, 2021, Bonn, Germany, online.
Waltenberger B., Adamopoulos N., Allouche N., Fiebich B., Halabalaki M., Jansen-Dürr P., Kesternich V., Pieters L., Schönbichler S., Skaltsounis A.-L., Tran H., Trougakos I.P., Viljoen A., Wolfender J.-L., Wolfrum C., Xynos N., Stuppner H. MediHealth – an interdisciplinary and international research and innovation staff exchange project to identify novel natural products for healthy ageing. Poster presentation at the “67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 4, 2019, Innsbruck, Austria.
Mayr F., Sturm S., Ganzera M., Waltenberger B., Martens S., Schwaiger S., Schuster D., Stuppner H. Bioactivity-Guided fractionation of extracts using mushroom tyrosinase – friend or foe? Poster presentation at the “67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 4, 2019, Innsbruck, Austria.
Temml V., Pein H., Pace S., Garscha U., Waltenberger B., Roviezzo F., Helesbeux J.J., Sèrazphin D., Rossi A., Lorkowski S., Richomme P., Werz O., Köberle A., Schuster D., Stuppner H. Computational investigation of multi-target effects in the arachidonic acid cascade on the example of potent natural 5-LO inhibitor garcinoic acid. Poster presentation at the “67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 4, 2019, Innsbruck, Austria.
Engels N., Waltenberger B., Michalak B., Chang F.-R., Kiss A.K., Stuppner H. Sesquiterpene lactones from Siegesbeckia orientalis inhibit pro-in flammatory functions of human neutrophils. Oral presentation at the “67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 2, 2019, Innsbruck, Austria.
Marzocco S., Rapa S.F., Waltenberger B., Di Paola R., Autore G., Cuzzocrea S., Stuppner H. Protective effect of plumericin in inflammatory bowel disease: regulation of inflammatory and oxidative stress response in vitro and in vivo. Oral presentation at the “67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 2, 2019, Innsbruck, Austria.
Mayr F., Temml V., Möller G., Garscha U., Schwaiger S., Waltenberger B., Martens, Adamskic J., Werz O., Stuppner H., Schuster D. Establishing dihydrochalcones as new lead structures using a combined in-silico target prediction workflow. Oral presentation at the “26th Scientific Congress of the Austrian Pharmaceutical Society (ÖPhG)“, April 26, 2019, Graz, Austria.
Pace S., König S., Czapka A., Bilancia R., Troisi F., Rizza R., Parisi O., Opfermann M., Waltenberger B., Gerstmeier J., Rossi A., Stuppner H., Borrelli F., Werz O. The neolignan kadsurenin F from Piper kadsura controls inflammation and ameliorates murine colitis. Oral presentation at “PHYTO Valley - Second Austrian Summit on Natural Products”, January 15, 2019, Seefeld, Austria.
Mayr F., Sturm S., Ganzera M., Waltenberger B., Martens S., Schwaiger S., Schuster D., Stuppner H. A critical assessment of mushroom tyrosinase-based enzyme inhibition assays: Are they suitable for bioactivity-guided fractionation of extracts? Oral presentation at “PHYTO Valley - Second Austrian Summit on Natural Products”, January 14, 2019, Seefeld, Austria.
Mayr F., Möller G., Martens S., Inderbinen S., Schwaiger S., Waltenberger B., Stuppner H., Odermatt A., Adamski J., Schuster D. From apple leaves to steroid dehydrogenase inhibitors as potential anticancer lead structures – a virtual screening success story. Poster presentation at the “17th International Congress on Hormonal Steroids and Hormones & Cancer (ICHSHC 2018)”, November 27, 2018, Stellenbosch, South Africa.
Mayr F., Möller G., Martens S., Schwaiger S., Waltenberger B., Adamski J., Stuppner H., Schuster D. Drug repositioning of ten dihydrochalcones from Malus leaves using a combined in-silico method. Poster presentation at the “Paracelsus Science Get Together 2018”, June 29, 2018, Salzburg, Austria.
Temml V., Pein H., Pace S., Garscha U., Waltenberger B., Stuppner H., Roviezzo F., Helesbeux J.-J., Seraphin D., Rossi A., Richomme P., Werz O., Koeberle A., Schuster D. Computational analysis of the interaction between vitamin E derivatives and 5-lipoxygenase. Poster presentation at the “Paracelsus Science Get Together 2018”, June 29, 2018, Salzburg, Austria.
Mayr F., Schuster D., Schwaiger S., Waltenberger B., Stuppner H. Novel insights into the specificity of mushroom-tyrosinase towards ubiquitous polyphenols found in plant extracts. Poster presentation at “PHYTO Valley - First Austrian Summit on Natural Products”, January 16, 2018, Seefeld, Austria and the „Life Science PhD Meeting Innsbruck 2018“, April 5, 2018, Innsbruck, Austria.
Koeberle A., Pein H., Pace S., Temml V., Garscha U., Waltenberger B., Stuppner H., Helesbeux J.-J., Seaphin D., Mosig A., Schuster D., Rossi A. ω-Oxidized tocotrienols from Garcinia species are potent and selective, allosteric inhibitors of 5-lipoxygenase and provide novel insights into human vitamin E physiology. Oral presentation at “PHYTO Valley - First Austrian Summit on Natural Products”, January 16, 2018, Seefeld, Austria.
Waltenberger B., Adamopoulos N., Allouche N., Fiebich B., Halabalaki M., Heinke R., Jansen-Dürr P., Kesternich V., Pieters L., Queiroz E.F., Schönbichler S., Schwaiger S., Skaltsounis A.-L., Tran H., Trougakos I.P., Viljoen A., Wolfender J.-L., Wolfrum C., Xynos N., Stuppner H. Novel natural products for healthy ageing from Mediterranean diet and food plants of other global sources - the MediHealth project. Poster presentation at “PHYTO Valley - First Austrian Summit on Natural Products”, January 15, 2018, Seefeld, Austria.
Schuster D., Mayr F., Waltenberger B., Stuppner H. Semi-automatic, computational target prediction for dihydrochalcones using publicly available profiling tools. Oral presentation at “PHYTO Valley - First Austrian Summit on Natural Products”, January 15, 2018, Seefeld, Austria.
Revoltella S., Baraldo G., Waltenberger B., Schwaiger S., Kofler P., Mösslacher J., Kohl R., Huber-Seidel A., Jansen-Dürr P., Stuppner H. Identification of the NADPH oxidase 4 inhibiting principal of Lycopus europaeus. Poster presentation at “PHYTO Valley - First Austrian Summit on Natural Products”, January 15, 2018, Seefeld, Austria.
Temml V., Koeberle A., Garscha U., Helesbeux J.-J., Waltenberger B., Seraphin D., Richomme P., Stuppner H., Werz O., Schuster D. Computational binding mode prediction of natural and synthetic tocotrienols as inhibitors of 5-lipoxygenase. Poster presentation at “PHYTO Valley - First Austrian Summit on Natural Products”, January 15, 2018, Seefeld, Austria.
Michalak B., Granica S., Piwowarski J., Waltenberger B., Stuppner H., Kiss A. Searching for extracts with a potential anti-inflammatory activity conducted using in vitro models. Poster presentation at the “65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 5, 2017, Basel, Switzerland.
Mncwangi N., Waltenberger B., Baraldo G.; Jansen-Dürr P.; Viljoen A, Stuppner H. Sclerocarya birrea cortex ethanolic extract – chemical characterisation and NOX4 inhibition (anti-ageing property). Poster presentation at the “65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 4, 2017, Basel, Switzerland.
Revoltella S., Waltenberger B., Baraldo G., Mösslacher J., Pagitz K., Kohl R., Jansen-Dürr P., Stuppner H.: Alnus viridis: a potential source of constituents with anti-ageing effects. Poster presentation at the “65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 4, 2017, Basel, Switzerland.
Pompermaier L., Schwaiger S., Lautenschläger T., Mandombe J.L., Waltenberger B., Stuppner H. New PTP1B inhibiting ellagitannins from the rhizome of Thonningia sanguinea. Poster presentation at the “65th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 4, 2017, Basel, Switzerland.
Schuster D., Temml V., Köberle A., Helesbeux J.-J.; Waltenberger B., Stuppner H., Richomme P., Werz O. Inhibition of 5-lipoxygenase – new aspects of an old target. Oral presentation at the “5th AFERP International Conference: Pharmacognosy from Here and There”, July 19, 2017, Angers, France.
Mncwangi N., Waltenberger B., Baraldo G.; Jansen-Dürr P.; Viljoen A. Sclerocarya birrea cortex ethanol extract – chemical characterisation and NOX4 inhibition (anti-ageing property). Oral presentation at the „20th Indigenous Plant Use Forum (IPUF)“, July 11, 2017, Pretoria, South Africa.
Temml V., Garscha U., Romp E., Schubert G., Gerstmeier J., Kutil Z., Matuszczak B., Waltenberger B., Stuppner H., Werz O., Schuster D. Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Oral presentation at „Pharma 2030 – Current and Future Challenges“, April 21, 2017, Innsbruck, Austria.
Waltenberger B., Hubert J., Baraldo G., Gamper N., Engels N., Jansen-Dürr P., Renault J.-H., Stuppner H. Dereplication of constituents of a Rhinanthus glacialis extract with NADPH Oxidase 4 (NOX4) inhibitory activity. Poster presentation at „Pharma 2030 – Current and Future Challenges“, April 20, 2017, Innsbruck, Austria.
Temml V., Garscha U., Romp E., Schubert G., Gerstmeier J., Kutil Z., Matuszczak B., Waltenberger B., Stuppner H., Werz O., Schuster D. Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Poster presentation at the „Life Science PhD Meeting Innsbruck 2017“, April 19, 2017, Innsbruck, Austria.
Baraldo G., Revoltella S., Cavinato Nascimento M.A., Waltenberger B., Pagitz K., Stuppner H., Jansen-Dürr P. Alpine plants contain phytochemicals that interact with intracellular pathways to delay aging. Poster presentation at the Joint Winter School "Novel targets in ageing research" of the Doktoratskolleg Ageing and Regeneration (DK AGE_REG) and the EU-RISE-Project “MediHealth”, March 10, 2017, Innsbruck, Austria and the „Life Science PhD Meeting Innsbruck 2017“, April 19, 2017, Innsbruck, Austria.
Baraldo G., Revoltella S., Cavinato Nascimento M.A., Waltenberger B., Stuppner H., Mösslacher J., Kohl R., Jenewein B., Pagitz K., Jansen-Dürr P. Phytochemicals from alpine plants interacting with intracellular pathways to delay skin aging. Poster presentation at the „ÖGDV Science Days“, January 13, 2017, Fuschl am See, Austria.
Engels N., Waltenberger B., Michalak B., Huynh L., Tran H., Kiss A., Stuppner H. Inhibition of interleukin-8 release in human neutrophils by Melodorum fruticosum. Poster presentation at the “9th Joint Natural Products Conference 2016”, July 26, 2016, Kopenhagen, Denmark.
Revoltella S., Waltenberger B., Baraldo G., Kohl C., Konrad P., Kohl R., Jansen-Dürr P., Stuppner, H. Alpine plants with anti-ageing effects. Poster presentation at the “9th Joint Natural Products Conference 2016”, July 26, 2016, Kopenhagen, Denmark.
Sturm S., Gallmetzer K., Friedl A., Waltenberger B., Temml V., Stuppner H. Laricifomes officinalis – a rich source of pharmacologically active triterpenes. Poster presentation at the“9th Joint Natural Products Conference 2016”, July 26, 2016, Kopenhagen, Denmark.
Waltenberger B., Hubert J., Baraldo G., Gamper N., Engels N., Jansen-Dürr P., Renault J.-H., Stuppner H. Identification of constituents of the Alpine plant Rhinanthus glacialis by 13C nuclear magnetic resonance pattern recognition. Poster presentation at the “9th Joint Natural Products Conference 2016”, July 25, 2016, Kopenhagen, Denmark.
Vuorinen A., Engeli R.T., Leugger S., Bachmann F., Akram M., Atanasov A.G., Waltenberger B., Temml V., Stuppner H., Krenn L., Ateba S.B., Njamen D., Davis R., Odermatt A., Schuster D. Natural products as a rich source for potential anti-osteoporotic lead agents inhibiting 17β-hydroxysteroid dehydrogenase type 2. Poster presentation at the “Swiss Society of Pharmacology and Toxicology (SSPT) Spring Meeting 2016: Innovative Therapeutic Modalities: Opportunities and Challenges", April 21, 2016, Bern, Switzerland.
Waltenberger B., Garscha U., Temml V., Liers J., Werz O., Schuster D., Stuppner H. Pharmacophore modeling and virtual screening for the discovery of potent soluble epoxide hydrolase (sEH) inhibitors. Oral presentation at the “6th CMBI Meeting”, March 3, 2016, Gnadenwald, Austria.
Revoltella S., Waltenberger B., Baraldo G., Kohl C., Kohl R., Jansen-Dürr P., Stuppner H. Alpine plants in cosmetics. Poster presentation at the “6th CMBI Meeting”, March 3, 2016, Gnadenwald, Austria.
Waltenberger B., Liu R., Atanasov A.G., Schwaiger S., Heiss E.H., Dirsch V.M., Stuppner H. Xanthones from the bitter plants Gentiana lutea, Centaurium erythraea, and Frasera caroliniensis (Gentianaceae) inhibit vascular smooth muscle cell (VSMC) proliferation. Oral presentation at the “63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, August 25, 2015, Budapest, Hungary.
Koeberle A., Waltenberger B., Temml V., Schuster D., Sautebin L., Stuppner H., Richomme P., Werz, O. Vitamin E metabolites as potent inhibitors of 5-lipoxygenase. Oral presentation at the “81st Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology e. V. (DGPT)”, March 11, 2015, Kiel, Germany.
Skaltsounis A.L., Mikros E., Stuppner H., Rollinger J.M., Wolfender J.L., Cuendet M. Integrated technologies for the discovery and development of cosmeceutical agents from plant biodiversity – NATPROTEC project. Poster presented by Waltenberger B. within the “48. Wissenschaftlichen Fortbildungswoche der Apothekerkammer“, February 24, 2015, Schladming, Austria.
Waltenberger B., Liers J., Temml V., Garscha U., Werz O., Schuster D., Stuppner H. Pharmacophore modeling and virtual screening for soluble epoxide hydrolase (sEH) inhibitors. Poster presentation at the “International Symposium Natural Products & Drug Discovery – Future Perspectives”, November 13, 2014, Vienna, Austria.
Winekenstädde D., Angelis A., Waltenberger B., Schwaiger S., Tchoumtchoua J., König S., Werz O., Aligiannis N., Skaltsounis A.L., Stuppner H. Sedum sediforme: Phytochemical composition and the 5-lipoxygenase (5-LO) inhibitor myricitrin. Poster presentation at the “International Symposium Natural Products & Drug Discovery – Future Perspectives”, November 13, 2014, Vienna, Austria.
Khan S.Y., Awad E.M., Oszwald A., Waltenberger B., Stuppner H., Breuss J.M. The NF-κB inhibitor plumericin inhibits senescence associated SA Beta-gal activity, ICAM-1 expression and ROS production and promotes nitric oxide bioavailability in stress-induced endothelial cells. Poster presentation at the “International Symposium Natural Products & Drug Discovery – Future Perspectives”, November 13, 2014, Vienna, Austria.
Temml V., Kutil Z., Romp E., Garscha U., Waltenberger B., Stuppner H., Werz O., Schuster D. Search for new dual inhibitors of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase with pharmacophore modeling. Poster presentation at the “20th EuroQSAR: Understanding Chemical-Biological Interactions”, September 1, 2014, St. Petersburg, Russia.
Atanasov A.G., Fakhrudin N., Waltenberger B., Cabaravdic M., Malainer C., Schachner D., Heiss E.H., Liu R., Noha S.M., Grzywacz A.M., Mihaly-Bison J., Awad E.M., Schuster D., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Discovery of bioactive natural products to combat inflammation. Oral presentation at the “Trends in Natural Products Research 2014 Young Scientists Meeting”, June 25, 2014, Olomouc, Czech Republic.
Waltenberger B., Liers J., Temml V., Garscha U., Werz O., Schuster D., Stuppner H. Identification of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore modeling and virtual screening. Oral presentation at the “23rd Scientific Meeting of the Austrian Pharmaceutical Society (ÖPhG)”, April 24, 2014, Graz, Austria.
Waltenberger B., Liers J., Temml V., Garscha U., Werz O., Schuster D., Stuppner H. Pharmacophore-based discovery of novel inhibitors of the innovative therapeutic target soluble epoxide hydrolase (sEH). Oral presentation at the “28th Molecular Modelling Workshop”, March 18, 2014, Erlangen, Germany.
Waltenberger B., Stuppner H. Drugs from Nature Targeting Inflammation - Entzündungshemmende Arzneistoffe aus der Natur. Poster presentation within the „47. Wissenschaftliche Fortbildungswoche für ApothekerInnen – Medikationsmanagement bei chronischen Erkrankungen“, February 24, 2014, Schladming, Austria.
Atanasov A.G., Liu X., Waltenberger B., Wang L., Malainer C., Schwaiger S., Rollinger J.M., Heiss E.H., Schuster D., Bauer R., Stuppner H., Dirsch V.M. Natural product-inspired discovery of novel activators of peroxisome proliferator-activated receptor-gamma. Oral presentation at the “Metabolism 2014 Meeting: Alterations of metabolic pathways as therapeutic targets”, January 30, 2014, Esch-sur-Alzette, Luxembourg.
Fakhrudin N., Waltenberger B., Cabaravdic M., Atanasov A.G., Malainer C., Schachner D., Heiss E.H., Liu R., Noha S.M., Grzywacz A.M., Mihaly-Bison J., Awad E.M., Schuster D., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Identification of plumericin as a potent new scaffold inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. Oral presentation at the „2nd Vascular Biology Meeting”, January 24, 2014, Vienna, Austria.
Fakhrudin N., Waltenberger B., Cabaravdic M., Atanasov A.G., Heiss E.H., Grzywacz A.M., Mihaly-Bison J., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V. Discovery of plumericin as a novel potent NF-κB inhibitor from Himatanthus sucuuba. Poster presentation at the “61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 2, 2013, Münster, Germany.
Oettl S.K., Gerstmeier J., Wiechmann K., Bauer J., Atanasov A.G., Malainer C., Heiss E.H., Waltenberger B., Remias D., Boustie J., Dirsch V.M., Stuppner H., Werz O., Rollinger J.M. Anti-inflammatory depsides from Cetrelia monachorum potently targeting mPGES-1, 5-LO and NF-κB. Oral and poster presentation at the “61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 1 and 4, 2013, Münster, Germany.
Oettl S.K., Gerstmeier J., Wiechmann K., Bauer J., Atanasov A.G., Malainer C., Heiss E.H., Waltenberger B., Remias D., Boustie J., Dirsch V.M., Stuppner H., Werz O., Rollinger J.M. In vitro screening of Alpine lichen species for anti-inflammatory lead structures. Oral presentation at the “Young Scientists Meeting of PSE and ÖPhG: Trends in natural products research”, July 24, 2013, Obergurgl, Austria.
Rollinger J.M., Waltenberger B., Fakhrudin N., Cabaravdic M., Grzywac A.M., Noha S., Atanasov A.G., Heiss E.H., Schuster D., Breuss J.M., Bochkov V., Stuppner H., Dirsch V.M. New findings on the medicinal plant Himatanthus sucuuba. Oral presentation at the “III International Symposium on Medicinal and Nutraceutical Plants”, October 16, 2012, Aracaju, Brazil.
Waltenberger B.In silico and bioactivity guided discovery of natural products with anti-inflammatory activity. Oral presentation within the course “Neue Forschungsergebnisse in der Pharmazie”, October 15, 2012, Innsbruck, Austria.
Waltenberger B., Fakhrudin N., Cabaravdic M., Atanasov A.G., Heiss E.H., Breuss J.M., Rollinger J.M., Bochkov V., Dirsch V.M., Stuppner H. New studies on the Amazonian traditional medicinal plant Himatanthus sucuuba - an ethnopharmacological approach. Oral presentation at the “4th Life Science Meeting Innsbruck Universities”, September 27, 2012, Igls, Austria.
Fakhrudin N., Waltenberger B., Cabaravdic M., Atanasov A.G., Heiss E.H., Noha S., Grzywac A.M., Mihaly-Bison J., Schuster D., Breuss J.M.,Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Plumericin is a novel potent NF-κB inhibitor from the Amazonian plant Himatanthus sucuuba. Oral presentation at the “13th International Congress of the Society for Ethnopharmacology”, September 3, 2012, Graz, Austria.
Waltenberger B., Fakhrudin N., Cabaravdic M., Atanasov A.G., Heiss E.H., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Identification of plumericin from Himatanthus sucuuba as a novel potent inhibitor of the NF‐κB pathway directly targeting IKK‐β. Oral presentation at the “2012 International Congress on Natural Products Research”, July 30, 2012, New York City, USA.
Atanasov A.G., Fakhrudin N., Waltenberger B., Cabaravdic M., Heiss E.H., Noha S., Grzywac A.M., Mihaly-Bison J., Schuster D., Breuss J.M.,Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Plumericin isolated from Himatanthus sucuuba is a novel potent NF‐κB inhibitor directly targeting IKK‐β. Poster presentation at the „3rd EMBO Conference Series on Cellular Signaling & Molecular Medicine”, May 28, 2012, Dubrovnik, Croatia.
Waltenberger B., Mihály-Bison J., Gelbrich T., Griesser U.J., Bochkov V.N., Binder B.R., Rollinger J.M., Stuppner H. Phytochemical investigation of Himatanthus sucuuba bark leading to the identification of novel and anti-inflammatory compounds. Poster presentation at the “59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, September 6, 2011, Anatalya, Türkei, und the “3rd Life Science Meeting Innsbruck Universities”, September 23, 2011, Igls, Austria.
Waltenberger B., Wiechmann K., Bauer J., Markt P., Noha S.M., Wolber G., Rollinger J.M., Werz O., Schuster D., Stuppner H. Microsomal prostaglandin E2 synthase-1 (mPGES-1): Pharmacophore modeling and virtual screening leading to novel acidic inhibitors. Poster presentation at the “Joint Meeting of the Austrian and German Pharmaceutical Societies”, September 22, 2011, Innsbruck, Austria.
Waltenberger B.Himatanthus sucuuba - a rainforest tree used in traditional Amazonian medicine: Discovery of novel anti-inflammatory natural products. Oral presentation within the course “Neue Forschungsergebnisse in der Pharmazie”, June 27, 2011, Innsbruck, Austria.
Waltenberger B., Wiechmann K., Schuster D., Wolber G., Rollinger J.M., Werz O., Stuppner H. Insilico discovery of novel acidic microsomal prostaglandin E2 synthase-1 inhibitors. Poster presentation at the “2nd Life Science Meeting Innsbruck Universities”, September 24, 2010, Igls, Austria and oral presentation at the “6th Meeting of Doctoral Students from Innsbruck's Medical Universities and of the Life Science Disciplines of the LFU Innsbruck”, November 24, 2010, Innsbruck, Austria.
Waltenberger B., Schuster D., Paramapojn S., Gritsanapan W., Wolber G., Rollinger J.M., Stuppner H. In silico strategy for the identification of cyclooxygenase inhibitors from the Thai medicinal mixture Prasaplai. Oral and poster presentation at the “58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)”, August 29 and 31, 2010, Berlin, Germany.
Waltenberger B., Schuster D., Paramapojn S., Gritsanapan W., Wolber G., Rollinger J.M., Stuppner H. Identification of cyclooxygenase inhibitors from Prasaplai, a Thai traditional medicine, via virtual parallel screening. Poster presentation at the “Life Science Meeting Innsbruck Universities”, September 18, 2009, Igls, Austria and the “International Symposium Drugs from Nature Targeting Inflammation”, April 9, 2010, Innsbruck, Austria.
