Birgit WaltenbergerBirgit WALTENBERGER, Mag. pharm. Dr.
Assistant Professor

Contact:
Institute of Pharmacy/Pharmacognosy
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/IV
Room: L.04.062
6020 Innsbruck / Austria

Phone: +43 512 507 - 58420 | Fax: +43 512 507 - 58499
Email: birgit.waltenberger@uibk.ac.at

Research
Publications
Teaching
Publication List

Publications  |  Conferences and presentations

 

PhD-thesis

In silico and bioactivity guided discovery of novel anti-inflammatory agents
October 2011, Institute of Pharmacy/Pharmacognosy, University of Innsbruck

 

Diploma-thesis

Transport of sennoside A, sennoside B, sennidine A and sennidine B across Caco-2 cell monolayers
December 2006, Institute of Pharmacy/Pharmacognosy, University of Innsbruck

 

Publications (first authors underlined)

Waltenberger B., Garscha U., Temml V., Liers J., Werz O., Schuster D., Stuppner H. Discovery of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore-based virtual screening. Journal of Chemical Information and Modeling 2016, 56(4), 747-62. Doi: 10.1021/acs.jcim.5b00592.

Waltenberger B., Mocan A., Šmejkal K., Heiss E.H., Atanasov A.G. Natural products to counteract the epidemic of cardiovascular and metabolic disorders. Molecules 2016, 21(6), 807. Doi:  10.3390/molecules21060807.

Waltenberger B., Atanasov A.G., Heiss E.H., Bernhard D., Rollinger J.M., Breuss J.M., Schuster D., Bauer R., Kopp B., Franz C., Bochkov V., Mihovilovic M.D., Dirsch V.M., Stuppner H. Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project. Monatshefte für Chemie/Chemical Monthly 2016, 147(3), 479-491. Doi: 10.1007/s00706-015-1653-y.

Heiss E.H., Liu R., Waltenberger B., Khan S., Schachner D., Kollmann P., Zimmermann K., Cabaravdic M., Uhrin P., Stuppner H., Breuss J.M., Atanasov A.G., Dirsch V.M. Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation. Scientific Reports 2016, 6, 20771. Doi: 10.1038/srep20771.

Alsabil K., Suor-Cherer S., Koeberle A., Viault G., Lavaud A., Temml V., Waltenberger B., Schuster D., Litaudon M., Lorkowski S., de Vaumas R., Helesbeux J.J., Guilet D., Stuppner H., Werz O., Seraphin D., Richomme P. Semisynthetic and natural garcinoic acid isoforms as new mPGES-1 inhibitors. Planta Medica 2016, 82 (11/12), 1110-1116. Doi: 10.1055/s-0042-108739.

Waltenberger B., Liu R., Atanasov A.G., Schwaiger S., Heiss E.H., Dirsch V.M., Stuppner H. Nonprenylated xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as novel inhibitors of vascular smooth muscle cell proliferation. Molecules 2015, 20(11), 20381-20390. Doi: 10.3390/molecules201119703.

Atanasov A.G., Waltenberger B., Pferschy-Wenzig E.-M., Linder T., Wawrosch C., Uhrin P., Temml V., Wang L., Schwaiger S., Heiss E.H., Rollinger J.M., Schuster D., Breuss J.M., Bochkov V., Mihovilovic M.D., Kopp B., Bauer R., Dirsch V.M., Stuppner H. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology Advances 2015, 33(8), 1582-1614. Doi: 10.1016/j.biotechadv.2015.08.001.

Winekenstädde D., Angelis A., Waltenberger B., Schwaiger S., Tchoumtchoua J., König S., Werz O., Aligiannis N., Skaltsounis A.-L., Stuppner H. Phytochemical profile of the aerial parts of Sedum sediforme and anti-inflammatory activity of Myricitrin. Natural Product Communications 2015, 10(1), 83-88.

Wang L., Waltenberger B., Pferschy-Wenzig E.M., Blunder M., Liu X., Malainer C., Blazevic T., Schwaiger S., Rollinger J.M., Heiss E.H., Schuster D., Kopp B., Bauer R., Stuppner H., Dirsch V.M., Atanasov A.G. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochemical Pharmacology 2014, 92(1), 73-89. Doi:10.1016/j.bcp.2014.07.018, Audio-slide-presentation: http://goo.gl/xDPMgq.

Picker P., Vogl S., McKinnon R., Mihaly-Bison J., Binder M., Atanasov A.G., Fakhrudin N., Grzywacz A.M., Heiss E.H., Zehl M., Saukel J., Wawrosch C., Schinkovitz A., Waltenberger B., Bauer R., Rollinger J.M., Stuppner H., Dirsch V.M., Bochkov V.N., Reznicek G., Kopp B. Plant extracts in cell-based anti-inflammatory assays – Pitfalls and considerations related to removal of activity masking bulk components. Phytochemistry Letters 2014, 10, xli–xlvii. Doi: 10.1016/j.phytol.2014.04.001.

Fakhrudin N., Waltenberger B., Cabaravdic M., Atanasov A.G., Malainer C., Schachner D., Heiss E.H., Liu R., Noha S.M., Grzywacz A.M., Mihaly-Bison J., Awad E.M., Schuster D., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Identification of plumericin as a potent new scaffold inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. British Journal of Pharmacology 2014, 171(7), 1676-1686. Doi: 10.1111/bph.12558.

Oettl S.K., Gerstmeier J., Khan S.Y., Wiechmann K., Bauer J., Atanasov A.G., Malainer C., Awad E.M., Uhrin P., Heiss E.H., Waltenberger B., Remias D., Breuss J.M., Boustie J., Dirsch V.M., Stuppner H., Werz O., Rollinger J.M. Imbricaric acid and perlatolic acid: Multi-targeting anti-inflammatory depsides from Cetrelia monachorum. PlosOne 2013, 8(10), e76929. Doi: 10.1371/journal.pone.0076929.

Bauer J., Waltenberger B., Noha S.M., Schuster D., Rollinger J.M., Boustie J., Stuppner H., Werz O. Discovery of depsides and depsidones from lichen as novel, potent inhibitors of microsomal prostaglandin E2 synthase-1 using pharmacophore models. ChemMedChem 2012, 7(12), 2077-2081. Doi: 10.1002/cmdc.201200345.

Waltenberger B., Rollinger J.M., Griesser U.J., Stuppner H., Gelbrich T. Plumeridoid C from the Amazonian traditional medicinal plant Himatanthus sucuuba. Acta Crystallographic Section C, Crystal Structure Communications 2011, 67/10, 409-412. Doi: 10.1107/S0108270111035761.

Waltenberger B., Wiechmann K., Bauer J., Markt P., Noha S.M., Wolber G., Rollinger J.M., Werz O., Schuster D., Stuppner H. Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1). Journal of Medicinal Chemistry 2011, 54(9), 3163-3174. Doi: 10.1021/jm101309g.

Waltenberger B., Schuster D., Paramapojn S., Gritsanapan W., Wolber G., Rollinger J.M., Stuppner H. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine. Phytomedicine 2011, 18(2-3), 119-133. Doi: 10.1016/j.phymed.2010.08.002.

Schuster D., Waltenberger B., Kirchmair J., Distinto S., Markt P., Stuppner H., Rollinger J.M., Wolber G. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part I: Model generation, validation and applicability in ethnopharmacology. Molecular Informatics 2010, 29(1-2), 75-86. Doi: 10.1002/minf.200900071.

Waltenberger B., Avula B., Ganzera M., Khan I.A., Stuppner H., Khan S.I. Transport of sennosides and sennidines from Cassia angustifolia and Cassia senna across Caco-2 monolayers - an in vitro model for intestinal absorption. Phytomedicine 2008, 15(5), 373-377. Doi: 10.1016/j.phymed.2007.03.008.

top

Conferences and presentations

Oral presentations (presenting authors underlined)

Waltenberger B., Garscha U., Temml V., Liers J., Werz O., Schuster D., Stuppner H. Pharmacophore modeling and virtual screening for the discovery of potent soluble epoxide hydrolase (sEH) inhibitors. “6th CMBI Meeting”, March 3-4, 2016, Gnadenwald, Austria.

Waltenberger B., Liu R., Atanasov A.G., Schwaiger S., Heiss E.H., Dirsch V.M., Stuppner H. Xanthones from the bitter plants Gentiana lutea, Centaurium erythraea, and Frasera caroliniensis (Gentianaceae) inhibit vascular smooth muscle cell (VSMC) proliferation. “63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research”, August 23-27, 2015, Budapest, Hungary.

Koeberle A., Waltenberger B., Temml V., Schuster D., Sautebin L., Stuppner H., Richomme P., Werz, O. Vitamin E metabolites as potent inhibitors of 5-lipoxygenase. “81st Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology e. V. (DGPT)”, March 10-12, 2015, Kiel, Germany.

Atanasov A.G., Fakhrudin N., Waltenberger B., Cabaravdic M., Malainer C., Schachner D., Heiss E.H., Liu R., Noha S.M., Grzywacz A.M., Mihaly-Bison J., Awad E.M., Schuster D., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Discovery of bioactive natural products to combat inflammation. “Trends in Natural Products Research 2014 Young Scientists Meeting”, June 23-25, 2014, Olomouc, Czech Republic.

Waltenberger B., Liers J., Temml V., Garscha U., Werz O., Schuster D., Stuppner H. Identification of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore modeling and virtual screening. “23rd Scientific Meeting of the Austrian Pharmaceutical Society (ÖPhG)”, April 23-25, 2014, Graz, Austria.

Waltenberger B., Liers J., Temml V., Garscha U., Werz O., Schuster D., Stuppner H. Pharmacophore-based discovery of novel inhibitors of the innovative therapeutic target soluble epoxide hydrolase (sEH). “28th Molecular Modelling Workshop”, March 17-19, 2014, Erlangen, Germany.

Atanasov A.G., Liu X., Waltenberger B., Wang L., Malainer C., Schwaiger S., Rollinger J.M., Heiss E.H., Schuster D., Bauer R., Stuppner H., Dirsch V.M. Natural product-inspired discovery of novel activators of peroxisome proliferator-activated receptor-gamma. “Metabolism 2014” Meeting “Alterations of metabolic pathways as therapeutic targets”, January 29-31, 2014, Esch sur Alzette, Luxembourg.

Fakhrudin N., Waltenberger B., Cabaravdic M., Atanasov A.G., Malainer C., Schachner D., Heiss E.H., Liu R., Noha S.M., Grzywacz A.M., Mihaly-Bison J., Awad E.M., Schuster D., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Identification of plumericin as a potent new scaffold inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. „2nd Vascular Biology Meeting”, January 24, 2014, Vienna, Austria.

Oettl S.K., Gerstmeier J., Wiechmann K., Bauer J., Atanasov A.G., Malainer C., Heiss E.H., Waltenberger B., Remias D., Boustie J., Dirsch V.M., Stuppner H., Werz O., Rollinger J.M. Anti-inflammatory depsides from Cetrelia monachorum potently targeting mPGES-1, 5-LO and NF-κB. “61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research”, September 1-5, 2013, Münster, Germany.

Oettl S.K., Gerstmeier J., Wiechmann K., Bauer J., Atanasov A.G., Malainer C., Heiss E.H., Waltenberger B., Remias D., Boustie J., Dirsch V.M., Stuppner H., Werz O., Rollinger J.M. In vitro screening of Alpine lichen species for anti-inflammatory lead structures. Young Scientists Meeting von PSE und ÖPhG “Trends in natural products research”, July 21-25, 2013, Obergurgl, Austria.

Waltenberger B. In silico and bioactivity guided discovery of natural products with anti-inflammatory activity. “Neue Forschungsergebnisse in der Pharmazie (Pharmakognosie, Pharmazeutische Technologie)”, October 15, 2012, Innsbruck, Austria.

Rollinger J.M., Waltenberger B., Fakhrudin N., Cabaravdic M., Grzywac A.M., Noha S., Atanasov A.G., Heiss E.H., Schuster D., Breuss J.M., Bochkov V., Stuppner H., Dirsch V.M. New findings on the medicinal plant Himatanthus sucuuba. “III International Symposium on Medicinal and Nutraceutical Plants”, October 14-19, 2012, Aracaju, Brazil.

Waltenberger B., Fakhrudin N., Cabaravdic M., Atanasov A.G., Heiss E.H., Breuss J.M., Rollinger J.M., Bochkov V., Dirsch V.M., Stuppner H. New studies on the Amazonian traditional medicinal plant Himatanthus sucuuba - an ethnopharmacological approach. “4th Life Science Meeting Innsbruck Universities”, September 27-28, 2012, Igls, Austria.

Fakhrudin N., Waltenberger B., Cabaravdic M., Atanasov A.G., Heiss E.H., Noha S., Grzywac A.M., Mihaly-Bison J., Schuster D., Breuss J.M.,Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Plumericin is a novel potent NF-κB inhibitor from the Amazonian plant Himatanthus sucuuba. “13th International Congress of the Society for Ethnopharmacology”, September 2-6, 2012, Graz, Austria.

Waltenberger B., Fakhrudin N., Cabaravdic M., Atanasov A.G., Heiss E.H., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Identification of plumericin from Himatanthus sucuuba as a novel potent inhibitor of the NF‐κB pathway directly targeting IKK‐β. “2012 International Congress on Natural Products Research”, July 28 – August 1, 2012, New York City, USA.

Waltenberger B. Himatanthus sucuuba - a rainforest tree used in traditional Amazonian medicine: Discovery of novel anti-inflammatory natural products. “Neue Forschungsergebnisse in der Pharmazie (Pharmakognosie, Pharmazeutische Technologie)”, June 27, 2011, Innsbruck, Austria.

Waltenberger B., Schuster D., Paramapojn S., Gritsanapan W., Wolber G., Rollinger J.M., Stuppner H. In silico strategy for the identification of cyclooxygenase inhibitors from the Thai medicinal mixture Prasaplai. “58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research”, August 29 - September 2, 2010, Berlin, Germany.

 

Poster presentations (presenting authors underlined)

Waltenberger B., Hubert J., Baraldo G., Gamper N., Engels N., Jansen-Dürr P., Renault J.-H., Stuppner H. Identification of constituents of the Alpine plant Rhinanthus glacialis by 13C nuclear magnetic resonance pattern recognition. “9th Joint Natural Products Conference 2016”, July 24-27, 2016, Copenhagen, Denmark.

Revoltella S., Waltenberger B., Baraldo G., Kohl C., Konrad P., Kohl R., Jansen-Dürr P., Stuppner, H. Alpine plants with anti-ageing effects. “9th Joint Natural Products Conference 2016”, July 24-27, 2016, Copenhagen, Denmark.

Engels N., Waltenberger B.­, Michalak B., Huynh L., Tran H., Kiss A., Stuppner H. Inhibition of interleukin-8 release in human neutrophils by Melodorum fruticosum. “9th Joint Natural Products Conference 2016”, July 24-27, 2016, Copenhagen, Denmark.

Sturm S., Gallmetzer K., Friedl A., Waltenberger B., Temml V., Stuppner H. Laricifomes officinalis – a rich source of pharmacologically active triterpenes. “9th Joint Natural Products Conference 2016”, July 24-27, 2016, Copenhagen, Denmark.

Vuorinen A., Engeli R.T., Leugger S., Bachmann F., Akram M., Atanasov A.G., Waltenberger B., Temml V., Stuppner H., Krenn L., Ateba S.B., Njamen D., Davis R., Odermatt A., Schuster D. Natural products as a rich source for potential anti-osteoporotic lead agents inhibiting 17β-hydroxysteroid dehydrogenase type 2. “Swiss Society of Pharmacology and Toxicology (SSPT) Spring Meeting 2016: Innovative Therapeutic Modalities: Opportunities and Challenges", April 21, 2016, Bern, Switzerland.

Revoltella S., Waltenberger B., Baraldo G., Kohl C., Kohl R., Jansen-Dürr P., Stuppner H. Alpine plants in cosmetics. “6th CMBI Meeting”, March 3-4, 2016, Gnadenwald, Austria.

Skaltsounis A.L., Mikros E., Stuppner H., Rollinger J.M., Wolfender J.L., Cuendet M. Integrated technologies for the discovery and development of cosmeceutical agents from plant biodiversity – NATPROTEC project. Presented by Waltenberger B. within the “48. Wissenschaftlichen Fortbildungswoche der Apothekerkammer“, February 22-26, 2015, Schladming, Austria.

Waltenberger B., Liers J., Temml V., Garscha U., Werz O., Schuster D., Stuppner H. Pharmacophore modeling and virtual screening for soluble epoxide hydrolase (sEH) inhibitors. “International Symposium Natural Products & Drug Discovery – Future Perspectives”, November 13-14, 2014, Vienna, Austria.

Winekenstädde D., Angelis A., Waltenberger B., Schwaiger S., Tchoumtchoua J., König S., Werz O., Aligiannis N., Skaltsounis A.L., Stuppner H. Sedum sediforme: Phytochemical composition and the 5-lipoxygenase (5-LO) inhibitor myricitrin. “International Symposium Natural Products & Drug Discovery – Future Perspectives”, November 13-14, 2014, Vienna, Austria.

Khan S.Y., Awad E.M., Oszwald A., Waltenberger B., Stuppner H., Breuss J.M. The NF-κB inhibitor plumericin inhibits senescence associated SA Beta-gal activity, ICAM-1 expression and ROS production and promotes nitric oxide bioavailability in stress-induced endothelial cells. “International Symposium Natural Products & Drug Discovery – Future Perspectives”, November 13-14, 2014, Vienna, Austria.

Temml V., Kutil Z., Romp E., Garscha U., Waltenberger B., Stuppner H., Werz O., Schuster D. Search for new dual inhibitors of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase with pharmacophore modeling. “20th EuroQSAR Understanding Chemical-Biological Interactions”, August 31 - September 4, 2014, St. Petersburg, Russia.

Waltenberger B., Stuppner H. Drugs from Nature Targeting Inflammation - Entzündungshemmende Arzneistoffe aus der Natur. „47. Wissenschaftliche Fortbildungswoche für ApothekerInnen - Medikationsmanagement bei chronischen Erkrankungen“, February 23-28, 2014, Schladming, Austria.

Fakhrudin N., Waltenberger B., Cabaravdic M., Atanasov A.G., Heiss E.H., Grzywacz A.M., Mihaly-Bison J., Breuss J.M., Rollinger J.M., Bochkov V., Stuppner H., Dirsch V. Discovery of plumericin as a novel potent NF-κB inhibitor from Himatanthus sucuuba. “61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research”, September 1-5, 2013, Münster, Germany.

Oettl S.K., Gerstmeier J., Wiechmann K., Bauer J., Atanasov A.G., Malainer C., Heiss E.H., Waltenberger B., Remias D., Boustie J., Dirsch V.M., Stuppner H., Werz O., Rollinger J.M. Anti-inflammatory depsides from Cetrelia monachorum potently targeting mPGES-1, 5-LO and NF-κB. “61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research”, September 1-5, 2013, Münster, Germany.

Atanasov A.G., Fakhrudin N., Waltenberger B., Cabaravdic M., Heiss E.H., Noha S., Grzywac A.M., Mihaly-Bison J., Schuster D., Breuss J.M.,Rollinger J.M., Bochkov V., Stuppner H., Dirsch V.M. Plumericin isolated from Himatanthus sucuuba is a novel potent NF‐κB inhibitor directly targeting IKK‐β. „3rd EMBO Conference Series on Cellular Signaling & Molecular Medicine”, May 25-29, 2012, Dubrovnik, Croatia.

Waltenberger B., Mihály-Bison J., Gelbrich T., Griesser U.J., Bochkov V.N., Binder B.R., Rollinger J.M., Stuppner H. Phytochemical investigation of Himatanthus sucuuba bark leading to the identification of novel and anti-inflammatory compounds. “59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research”, 4.-9. September 2011, Anatalya, Türkei, und “3rd Life Science Meeting Innsbruck Universities”, September 23-24, 2011, Igls, Austria.

Waltenberger B., Wiechmann K., Bauer J., Markt P., Noha S.M., Wolber G., Rollinger J.M., Werz O., Schuster D., Stuppner H. Microsomal prostaglandin E2 synthase-1 (mPGES-1): Pharmacophore modeling and virtual screening leading to novel acidic inhibitors. “Joint Meeting of the Austrian and German Pharmaceutical Societies”, September 20-23, 2011, Innsbruck, Austria.

Waltenberger B., Wiechmann K., Schuster D., Wolber G., Rollinger J.M., Werz O., Stuppner H. In silico discovery of novel acidic microsomal prostaglandin E2 synthase-1 inhibitors. “2nd Life Science Meeting Innsbruck Universities”, September 24-25, 2010, Igls, Austria.

Waltenberger B., Schuster D., Paramapojn S., Gritsanapan W., Wolber G., Rollinger J.M., Stuppner H. In silico strategy for the identification of cyclooxygenase inhibitors from the Thai medicinal mixture Prasaplai. “58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research”, August 29 – September 2, 2010, Berlin, Germany.

Waltenberger B., Schuster D., Paramapojn S., Gritsanapan W., Wolber G., Rollinger J.M., Stuppner H. Identification of cyclooxygenase inhibitors from Prasaplai, a Thai traditional medicine, via virtual parallel screening. “Life Science Meeting Innsbruck Universities”, September 18-19, 2009, Igls, Austria.

 

top