Protein Function and Activity
Recent publications (protein function and activity)
Führer S, Tollinger M, Dunzendorfer-Matt T*.
Pathogenic mutations associated with Legius syndrome modify the Spred1 surface and are iInvolved in direct binding to the Ras inactivator Neurofibromin.
J Mol Biol 2019 (431) 3889-3899.
doi: 10.1016/j.jmb.2019.07.038
Moschen T, Grutsch S, Juen, MA, Wunderlich CH, Kreutz C*, Tollinger M*.
Measurement of ligand-target residence times by 1H relaxation dispersion NMR spectroscopy.
J Med Chem 2016 (59): 10788-10793. (open access)
10.1021/acs.jmedchem.6b01110
Grutsch S, Brüschweiler S, Tollinger M*.
NMR methods to study dynamic allostery.
PLoS Comput Biol 2016 (12): e1004620. (open access)
doi: 10.1371/journal.pcbi.1004620
Moschen T, Wunderlich CH, Spitzer R, Levic J, Micura R, Tollinger M*, Kreutz C*.
Ligand-detected relaxation dispersion NMR spectroscopy: dynamics of preQ1-RNA binding.
Angew Chem Intl Ed Engl 2015 (54): 560-563.
doi: 10.1002/anie.201409779
Palazzesi F, Barducci A, Tollinger M, Parrinello M*.
The allosteric communication pathways in the KIX domain.
Proc Natl Acad Sci USA 2013 (110): 14237-14242. (open access)
doi: 10.1073/pnas.1313548110
Brüschweiler S, Konrat R, Tollinger M*.
Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core.
ACS Chem Biol 2013 (8): 1600-1610. (open access)
doi: 10.1021/cb4002188