Protein Function and Activity 

Recent publications (protein function and activity)

Moschen T, Grutsch S, Juen, MA, Wunderlich CH, Kreutz C*, Tollinger M*.

Measurement of ligand-target residence times by 1H relaxation dispersion NMR spectroscopy.

J Med Chem 2016 (59): 10788-10793. (open access)

10.1021/acs.jmedchem.6b01110

Grutsch S, Brüschweiler S, Tollinger M*.

NMR methods to study dynamic allostery.

PLoS Comput Biol 2016 (12): e1004620. (open access)

doi: 10.1371/journal.pcbi.1004620

Moschen T, Wunderlich CH, Spitzer R, Levic J, Micura R, Tollinger M*, Kreutz C*.

Ligand-detected relaxation dispersion NMR spectroscopy: dynamics of preQ1-RNA binding.

Angew Chem Intl Ed Engl 2015 (54): 560-563.

doi: 10.1002/anie.201409779

Palazzesi F, Barducci A, Tollinger M, Parrinello M*.

The allosteric communication pathways in the KIX domain.

Proc Natl Acad Sci USA 2013 (110): 14237-14242. (open access)

doi: 10.1073/pnas.1313548110

Brüschweiler S, Konrat R, Tollinger M*.

Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core.

ACS Chem Biol 2013 (8): 1600-1610. (open access)

doi: 10.1021/cb4002188