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Publications

  0000-0002-2177-983X

Int J Mol Sci 2022 (23) 8252. (open access)

doi: 10.3390/ ijms23158252

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Rainer T, Egger A-S, Zeindl R, Tollinger M, Kwiatkowski M; Müller, T*.

3D Printed high pressure resistant immobilized enzyme microreactor (µIMER) for protein analysis.

Anal Chem 2022 (94): 8580-8587. (open access)

doi: 10.1021/acs.analchem.1c05232

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Winkler D, Dietrich V, Griesser C, Shakibi-Nia N, Wernig E-M, Tollinger M, Kunze-Liebhäuser J*.

Formic acid reduction and CO₂ activation at Mo₂C – the important role of surface oxide.

Electrochem Sci Adv 2022 (2): e2100130. (open access)

doi: 10.1002/elsa.202100130

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Eidelpes R, Hofer F, Röck M, Führer S, Kamenik A, Liedl KR, Tollinger M*.

Structure and zeatin binding of the peach allergen Pru p 1.

J Agricult Food Chem 2021 (69): 8120-8129. (open access)

doi: 10.1021/acs.jafc.1c01876

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Oettl S, Bosello M, Marschall K, Gallmetzer A, Reyes-Dominguez Y, Kreutz C, Tollinger M, Robatscher P, Oberhuber M*.

J Agricult Food Chem 2021 (69): 14445-14448. (open access)

doi: 10.1021/acs.jafc.1c02847

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Rainer T, Eidelpes R, Tollinger M, Müller T*.

Microdroplet mass spectrometry enables extremely accelerated pepsin digestion of proteins.

J Am Soc Mass Spectrom 2021 (32): 1841-1845. (open access)

doi: 10.1021/jasms.1c00126

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Zeindl R, Tollinger M*.

NMR resonance assignments of the PR-10 allergens Act c 8 and Act d 8 from golden and green kiwifruit.

Biomol NMR Assign 2021 (15): 367-371. (open access)

doi: 10.1007/s12104-021-10031-w 

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Führer S, Kamenik AS, Zeindl R, Nothegger B, Hofer F, Reider N, Liedl KR, Tollinger M*.

Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens.

Sci Rep 2021 (11): 4173. (open access)

doi: 10.1038/s41598-021-83705-z

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Mateos B; Bernardo-Seisdedos G; Dietrich V; Zalba N; Ortega G; Peccati F; Jiménez-Osés G; Konrat R; Tollinger M, Millet O*. 

Cosolute modulation of protein oligomerization reactions in the homeostatic timescale.

Biophys J 2021 (120): 2067-2077. (open access)

doi: 10.1016/j.bpj.2021.03.020

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Nothegger B, Reider N, Covaciu CE, Cova V, Ahammer L, Eidelpes R, Unterhauser J, Platzgummer S, Raffeiner, E, Tollinger M, Letschka T,  Eisendle K*. 

Oral immunotherapy with apples: results of a phase II clinical pilot study.

Immun Inflamm Dis 2021 (9): 503-511. (open access)

doi: 10.1002/iid3.410

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Eidelpes R, Kim HJ, Glover JNM, Tollinger M*.

NMR resonance assignments of the FinO-domain of the RNA chaperone RocC.

Biomol NMR Assign 2021 (15): 61-64. (open access)

doi: 10.1007/s12104-020-09983-2

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Winter P, Stubenvoll S, Scheiblhofer S, Joubert IA, Strasser L, Briganser C, Soh WT, Hofer F, Kamenik AS, Dietrich V, Michelini S, Laimer J, Lackner P, Horejs-Hoeck J, Tollinger M, Liedl KR, Brandstetter J, Huber CG, Weiss R*. 

In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization.

Front Immunol 2020 (11): 1824. (open access)

doi: 10.3389/fimmu.2020.01824 

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Nothegger B, Reider N, Covaciu CE, Eidelpes R, Unterhauser J, Ahammer L, Tollinger M, Cova V, Letschka T, Platzgummer S, Eisendle K*. 

Allergen-specific immunotherapy with apples: Selected cultivars could be a promising tool for birch pollen allergy.

J Eur Acad Derma­tol Vene­rol 2020 (34): 1286-1292. (open access)

doi: 10.1111/jdv.16201

Discussed in: Bergmann K.-C.: Journal of the European Academy of Derma­tology and Vene­rology 2020 (34): 1130.

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Führer S, Zeindl R, Tollinger M*.

NMR resonance assignments of the four isoforms of the hazelnut allergen Cor a 1.04.

Biomol NMR Assign 2020 (14): 45-49. (open access)

doi: 10.1007/s12104-019-09918-6

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Salcher S, Spoden G, Hagenbuchner J, Führer S, Kaserer T, Tollinger M, Huber-Cantonati P, Gruber T, Schuster D, Gust R, Zwierzina H, Müller T, Kiechl Kohlendorfer U, Ausserlechner M*, Obexer P*.

A drug library screen identifies Carbenoxolone as novel FOXO inhibitor which overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma.

Oncogene 2020 (39): 1080-1097. (open access)

doi: 10.1038/s41388-019-1044-7

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Führer S, Tollinger M, Dunzendorfer-Matt T*.

Pathogenic mutations associated with Legius syndrome modify the Spred1 surface and are iInvolved in direct binding to the Ras inactivator Neurofibromin.

J Mol Biol 2019 (431): 3889-3899.

doi: 10.1016/j.jmb.2019.07.038

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Hofer F, Dietrich V, Kamenik A, Tollinger M, Liedl KR*.

pH-Dependent protonation of the Phl p 6 pollen allergen studied by NMR and cpH-aMD.

J Chem Theor Comput 2019 (15): 5716-5726. (open access)

doi: 10.1021/acs.jctc.9b00540

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Plangger R, Juen AR, Hoernes TP, Nußbaumer F, Kremser J, Strebitzer S, Klingler D, Erharter K, Tollinger M, Erlacher MD, Kreutz C*.

Branch site bulge conformationas in domain 6 determine functional sugar puckers in group II intron splicing.

Nucleic Acids Res 2019 (21): 11430-11440.  (open access)

doi: 10.1093/nar/gkz965

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Führer S, Trimmel S,  Breuker K, Tollinger M*.

NMR resonance assignments of the pathogenesis-related peach allergen Pru p 1.0101.

Biomol NMR Assign 2019 (13): 127-130. (open access)

doi: 10.1007/s12104-018-9864-x

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Strebitzer E, Nußbaumer F, Kremser J, Tollinger M, Kreutz C*.

Studying sparsely populated conformational states in RNA combining chemical synthesis and solution NMR spectroscopy.

Methods 2018 (148): 39-47. (open access)

doi: 10.1016/j.ymeth.2018.05.007

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Strebitzer E, Rangadurai A, Plangger R, Kremser J, Juen MA, Tollinger M, Al-Hashimi H, Kreutz C*.

5-oxyacetic modification destabilizes double helical stem structures and favors anionic Watson-Crick like cmo5U-G base pairs.

Chem Eur J 2018 (24): 18903-18906. (open access)

doi: 10.1002/chem.201805077

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Führer S, Ahammer L, Ausserbichler A, Scheffzek K, Dunzendorfer-Matt T*, Tollinger M*.

NMR resonance assignments of the EVH1 domain of Neurofibromin's recruitment factor Spred1.

Biomol NMR Assign 2017 (11): 305-308. (open access)

doi: 10.1007/s12104-017-9768-1

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Grutsch S, Fuchs JE, Ahammer L,  Kamenik AS, Liedl KR*, Tollinger M*.

Conformational flexibility differentiates naturally occurring Bet v 1 isoforms.

Int J Mol Sci 2017 (18): 1192. (open access)

doi: 10.3390/ijms18061192

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Ahammer L, Grutsch S, Kamenik AS, Liedl KR, Tollinger M*.

Structure of the major apple allergen Mal d 1.

J Agricult Food Chem 2017 (65): 1606-1612. (open access)

doi: 10.1021/acs.jafc.6b05752

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Ahammer L, Grutsch S, Wallner M, Ferreira F, Tollinger M*.

NMR resonance assignments of a hypoallergenic isoform of the major birch pollen allergen Bet v 1.

Biomol NMR Assign 2017 (11): 231-234. (open access)

doi: 10.1007/s12104-017-9754-7

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Nussbaumer F, Juen M, Gasser C, Kremser J, Mueller T, Tollinger M, Kreutz CK*.

Synthesis and incorporation of 13C-labeled DNA building blocks to probe structural dynamics of DNA by NMR.

Nucleic Acids Res 2017 (45): 9178-9192. (open access)

doi: 10.1002/nar/gkx592

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Moschen T, Grutsch S, Juen, MA, Wunderlich CH, Kreutz C*, Tollinger M*.

Measurement of ligand-target residence times by 1H relaxation dispersion NMR spectroscopy.

J Med Chem 2016 (59): 10788-10793. (open access)

doi: 10.1021/acs.jmedchem.6b01110

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Juen MA, Wunderlich CH, Nussbaumer F, Tollinger M, Kontaxis G, Konrat R, Hansen DF*, Kreutz CK*.

Excited states of nucleic acids probed by proton relaxation dispersion NMR spectroscopy.

Angew Chem Intl Ed Engl 2016 (55): 12008-12012. (open access)

doi: 10.1002/anie.201605870

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Ahammer L, Grutsch S, Tollinger M*.

NMR resonance assignments of the major apple allergen Mal d 1.

Biomol NMR Assign 2016 (10): 287-290. (open access)

doi: 10.1007/s12104-016-9685-8

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Grutsch S, Brüschweiler S, Tollinger M*.

NMR methods to study dynamic allostery.

PLoS Comput Biol 2016 (12): e1004620. (open access)

doi: 10.1371/journal.pcbi.1004620

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Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs J, Wallnöfer H, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J & Weiss R*.

Fold-stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen.

Journal of Allergy and Clinical Immunology 2016 (137): 1525-1534. (open access)

doi: 10.1016/j.jaci.2015.09.026 

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Kaderavek P, Grutsch S, Salvi N, Tollinger M, Zidek L, Bodenhausen G & Ferrage F*.

Cross-correlated relaxation measurements under adiabatic sweeps: determination of local order in proteins.

J Biomol NMR 2015 (63): 353-365. (open access)

doi: 10.1007/s10858-015-9994-8

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Moschen T, Wunderlich C, Kreutz C, Tollinger M*.

NMR resonance assignments of the archaeal ribosomal protein L7Ae in the apo form and bound to a 25 nt RNA.

Biomol NMR Assign 2015 (9): 177-180. (open access)

doi: 10.1007/s12104-014-9569-8

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Pummer BG*, Budke C, Augustin-Bauditz S, Niedermeier D, Felgitsch L, Kampf CJ, Huber RG, Liedl KR, Loerting T, Moschen T, Schauperl M, Tollinger M, Morris CE, Wex H, Grothe H, Pöschl U, Koop T, Fröhlich-Nowoisky J.

Ice nucleation by water-soluble macromolecules.

Athmos Chem Phys 2015 (15): 4077-4091. (open access)

doi: 10.5194/acp-15-4077-2015

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Moschen T, Wunderlich CH, Spitzer R, Levic J, Micura R, Tollinger M*, Kreutz C*.

Ligand-detected relaxation dispersion NMR spectroscopy: dynamics of preQ1-RNA binding.

Angew Chem Intl Ed Engl 2015 (54): 560-563.

doi: 10.1002/anie.201409779

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Grutsch S, Fuchs JE, Freier R, Kofler S, Bibi M, Asam C, Wallner M, Ferreira F, Brandstetter H, Liedl KR, Tollinger M*.

Ligand binding modulates structural dynamics and compactness of the major birch pollen allergen Bet v 1.0101.

Biophys J 2014 (107): 2963-2972. (open access)

doi: 10.1016/j.bpj.2014.10.062

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Morin S, Linnet TE, Lescanne M, Schanda P, Thompson G, Tollinger M, Teilum K, Gagne S, Marion D, Griesinger C, Blackledge M, d´Auvergne E*.

Relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data.

Bioinformatics 2014 (30): 2219-2220. (open access)

doi: 10.1093/bioinformatics/btu166

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Moschen T, Tollinger M*.

A kinetic study of domain swapping in Protein L.

Phys Chem Chem Phys 2014 (16): 6383-6390.

doi: 10.1039/C3CP54126F

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Palazzesi F, Barducci A, Tollinger M, Parrinello M*.

The allosteric communication pathways in the KIX domain.

Proc Natl Acad Sci USA 2013 (110): 14237-14242. (open access)

doi: 10.1073/pnas.1313548110

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Brüschweiler S, Konrat R, Tollinger M*.

Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic core.

ACS Chem Biol 2013 (8): 1600-1610. (open access)

doi: 10.1021/cb4002188

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Tollinger M, Sivertsen A, Meier B, Ernst M, Schanda P*.

Site-resolved measurement of microsecond to millisecond conformational-exchange processes in proteins by solid-state NMR spectroscopy.

J Am Chem Soc 2012 (134): 14800-14807. (open access)

doi: 10.1021/ja303591y

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Wunderlich C, Spitzer R, Santner T, Fauster K, Tollinger M, Kreutz C*.

Synthesis of 6-13C-pyrimidine nucleotides as spin labels for RNA dynamics.

J Am Chem Soc 2012 (134): 7558-7569.

doi:10.1021/ja302148g

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Kloiber K, Spitzer R, Grutsch S, Kreutz C, Tollinger M*.

Longitudinal exchange: an alternative strategy towards quantification of dynamics parameters in ZZ exchange spectroscopy.

J Biomol NMR 2011 (51): 123-129.

doi: 10.1007/s10858-011-9547-8

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Spitzer R, Kloiber K, Tollinger M, Kreutz C*.

Kinetics of DNA refolding via longitudinal exchange NMR spectroscopy.

ChemBioChem 2011 (12): 2007-2010.

doi: 10.1002/cbic.201100318

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Auer R, Tollinger M, Kuprov I, Konrat R, Kloiber K*.

Mathematical treatment of adiabatic fast passage pulses for the computation of nuclear spin relaxation rates in proteins with conformational exchange.

J Biomol NMR 2011 (51): 35-47. (open access)

doi: 10.1007/s10858-011-9539-8

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Coudevylle N, Geist L, Hoetzinger M, Tollinger M, Konrat R*.

Siderocalin Q83 exhibits differential slow dynamics upon ligand binding.

J Biomol NMR 2011 (51): 83-88.

doi: 10.1007/s10858-011-9543-z

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Kloiber K, Spitzer R, Tollinger M, Konrat R, Kreutz C*.

Probing RNA dynamics via longitudinal exchange and CPMG relaxation dispersion NMR spectroscopy using a sensitive 13C-methyl label.

Nucleic Acids Res 2011 (39): 4340-4351. (open access)

doi: 10.1093/nar/gkq1361

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Breuker K*, Brüschweiler S, Tollinger M.

Electrostatic stabilization of native protein structure in the gas phase. 

Angew Chem Intl Ed Engl 2011 (50): 873-877. (open access)

doi: 10.1002/ange.201005112

Discussed in: Barran PE: Angew Chem Intl Ed Engl 2011 (50): 3120-3122.

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Brüschweiler S, Schanda P, Kloiber K, Brutscher B, Kontaxis G, Konrat R, Tollinger M*.

Direct observation of the dynamic process underlying allosteric signal transmission. 

J Am Chem Soc 2009 (131): 3063-3068.

doi: 10.1021/ja809947w

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Schedlbauer A, Coudevylle N, Auer R, Kloiber K, Tollinger M, Konrat R*.

Auto-correlation analysis of NOESY data provides residue compactness for folded and unfolded proteins. 

J Am Chem Soc 2009 (131): 6038-6039.

doi: 10.1021/ja8074067

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Schedlbauer A, Auer R, Ledolter K, Tollinger M, Kloiber K, Lichtenecker R, Rüdisser S, Hommel U, Schmid W, Konrat R, Kontaxis G*.

Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment. 

J Biomol NMR 2008 (42): 111-127.

doi: 10.1007/s10858-008-9268-9

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Schanda P, Brutscher B, Konrat R, Tollinger M*.

Folding of the KIX domain: characterization of the equilibrium analog of a folding intermediate using 15N/13C relaxation dispersion and fast 1H/2H amide exchange NMR spectroscopy. 

J Mol Biol 2008 (380): 726-741.

doi: 10.1016/j.jmb.2008.05.040

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Marsh JA, Baker JM, Tollinger M, Forman-Kay JD*.

Calculation of residual dipolar couplings from disordered state ensembles using local alignment.

J Am Chem Soc 2008 (130): 7804-7805.

doi: 10.1021/ja802220c

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Tollinger M*, Kloiber K, Agoston B, Dorigoni C, Lichtenecker R, Schmid W, Konrat R.

An isolated helix persists in a sparsely populated form of KIX under native conditions.

Biochemistry 2006 (45): 8885-8893.

doi: 10.1021/bi0607305

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Tollinger M, Neale C, Kay LE, Forman-Kay JD*.

Characterization of the hydrodynamic properties of the folding transition state of an SH3 domain by magnetization transfer NMR spectroscopy.

Biochemistry 2006 (45): 6434-6445.

doi: 10.1021/bi060268o

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Tollinger M*, Kay LE, Forman-Kay JD.

Measuring pK(a) values in protein folding transition state ensembles by NMR spectroscopy.

J Am Chem Soc 2005 (127): 8904-8905.

doi: 10.1021/ja051942c

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Bezsonova I, Singer A, Choy WY, Tollinger M, Forman-Kay JD*.

Structural comparison of the unstable drkN SH3 domain and a stable mutant.

Biochemistry 2005 (44): 15550-15560.

doi: 10.1021/bi0512795

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Tollinger M, Crowhurst KA, Kay LE, Forman-Kay JD*.

Site-specific contributions to the pH dependence of protein stability.

Proc Natl Acad Sci USA 2003 (100): 4545-4550.

doi: 10.1073/pnas.0736600100

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Crowhurst KA, Tollinger M, Forman-Kay JD*.

Cooperative interactions and a non-native buried Trp in the unfolded state of an SH3 domain.

J Mol Biol 2002 (322): 163-178.

doi: 10.1016/S0022-2836(02)00741-6

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Tollinger M, Forman-Kay JD, Kay LE*.

Measurement of side-chain carboxyl pK(a) values of glutamate and aspartate residues in an unfolded protein by multinuclear NMR spectroscopy.

J Am Chem Soc 2002 (124): 5714-5717.

doi: 10.1021/ja020066p

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Tollinger M, Skrynnikov NR, Mulder FA, Forman-Kay JD, Kay LE*.

Slow dynamics in folded and unfolded states of an SH3 domain.

J Am Chem Soc 2001 (123): 11341-11352.

doi: 10.1021/ja011300z

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Choy WY, Tollinger M, Mueller GA, Kay LE*.

Direct structure refinement of high molecular weight proteins against residual dipolar couplings and carbonyl chemical shift changes upon alignment: an application to maltose binding protein.

J Biomol NMR 2001 (21): 31-40.

doi: 10.1023/A:1011933020122

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Hoffmann B, Tollinger M, Konrat R, Huhta M, Marsh EN, Kräutler B*.

A protein pre-organized to trap the nucleotide moiety of coenzyme B12: refined solution structure of the B12-binding subunit of glutamate mutase from Clostridium tetanomorphum.

Chembiochem 2001 (2): 643-655.

doi: 10.1002/1439-7633(20010903)2:9<643::AID-CBIC643>3.0.CO;2-J

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Eichmüller C, Tollinger M, Kräutler B, Konrat R*.

Mapping the ligand binding site at protein side-chains in protein-ligand complexes through NOE difference spectroscopy.

J Biomol NMR 2001 (20): 195-202.

doi: 10.1023/A:1011299009214

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Tollinger M, Eichmüller C, Konrat R, Huhta MS, Marsh EN, Kräutler B*.

The B12-binding subunit of glutamate mutase from Clostridium tetanomorphum traps the nucleotide moiety of coenzyme B12.

J Mol Biol 2001 (309): 777-791.

doi: 10.1023/A:1011299009214

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Konrat R*, Tollinger M.

Heteronuclear relaxation in time-dependent spin systems: 15N T1-rho dispersion during adiabatic fast passage.

J Biomol NMR 1999 (13): 213-221.

doi: 10.1023/A:1008324721356

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Tollinger M, Konrat R, & Kräutler B*. 

The structure of methylcob(II)alamin in aqueous solution - a water molecule as structuring element of the nucleotide loop.

Helv Chim Acta 1999 (82): 1596-1609.

doi: 10.1002/(SICI)1522-2675(19991006)82:10<1596::AID-HLCA1596>3.0.CO;2-K

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Kontaxis G, Riether D, Hannak R, Tollinger M, Kräutler, B*.

Electrochemical synthesis and structure analysis of neocoenzyme B12 - an epimer of coenzyme B12 with a remarkably flexible organometallic group.

Helv Chim Acta 1999 (82): 848-869.

doi: 10.1002/(SICI)1522-2675(19990609)82:6<848::AID-HLCA848>3.0.CO;2-L

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Zieger G, Sterk H, Bermel W, Konrat R, Tollinger M, Kräutler B, Werbelow, L.* 

Relaxation-induced polarization transfer and determination of methyl group 13C chemical shielding anisotropy.

J Phys Chem A 1999 (103): 5253-5258.

doi: 10.1021/jp990409e

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Tollinger M, Konrat R, Hilbert BH, Marsh EN, Kräutler B*.

How a protein prepares for B12 binding: structure and dynamics of the B12-binding subunit of glutamate mutase from Clostridium tetanomorphum.

Structure 1998 (6): 1021-1033.

doi: 10.1016/S0969-2126(98)00103-8