Research

Research in the Breuker group is focused on larger biomolecules including proteins and nucleic acids, and utilizes a special type of mass spectrometer: FT-ICR MS (Fourier transform-ion cyclotron resonance mass spectrometer). The FT-ICR instrument offers unique capabilities such as ultra-high resolving power and mass accuracy. Moreover, biomolecular ions and their complexes can be stored in the FT-ICR cell and subjected to gas phase reactions, for example, with electrons. We use this instrument to study biomolecular structure, folding, interactions, and reactivity, and to develop new approaches for the localization of ribonucleic acid (RNA) modifications and the characterization of RNA complexes with proteins and small molecule ligands.

 

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