Group

Kathrin Breuker 



office: +43 512 507 57740
lab: +43 512 507 57799
kathrin.breuker@uibk.ac.at

CV

since 2019 associate Professor at the Institute of Organic Chemistry of the University of Innsbruck, Austria
2012 venia docendi in biophysical chemistry
since 2008
independent principal investigator and research group leader at the Institute of Organic Chemistry of the University of Innsbruck, Austria
2002 - 2008
independent principal investigator at the Institute of Organic Chemistry of the University of Innsbruck, Austria, and visiting scientist with Fred W. McLafferty at the Department of Chemistry and Chemical Biology at Cornell University, USA
2001 - 2002
postdoctoral research associate with Bernhard Kräutler, University of Innsbruck, Austria
1999 - 2000
postdoctoral research associate with Fred W. McLafferty, Cornell University, USA
1995 - 1999
Ph.D. student with Renato Zenobi, Eidgenössische Technische Hochschule (ETH) Zürich, Switzerland; thesis title: "Proton transfer reactions in matrix-assisted laser desorption/ionization mass spectrometry"
1993 - 1994

diploma student with Michael Karas and Franz Hillenkamp, Westfälische Wilhelms-Universität Münster, Germany; thesis title: "Studies on matrix-assisted laser desorption/ionization mass spectrometry: on the use of pulsed electrical fields for ion extraction in a time-of-flight mass spectrometer"

Memberships

member of the American Society for Mass Spectrometry (ASMS)

member of the Deutsche Gesellschaft für Massenspektrometrie (DGMS)

member of the Center for Molecular Biosciences Innsbruck (CMBI) / since 2004

member of the "Junge Kurie" of the "Österreichische Akademie der Wissenschaften" (ÖAW) / 2007-2015

member of the editorial advisory board, European Journal of Mass Spectrometry / 2003-2016

member of the editorial advisory board, ChemistryOpen / since 2012

member of the editorial board, Journal of American Society for Mass Spectrometry / 2013-2018

member of the editorial advisory board, ChemPlusChem / since 2015

member (presiding) of the committee for the 'MS in the life sciences' award of the DGMS / since 2017

Funding

FWF grant P30087 (2017-2021)

FWF grant P27347 (2015-2018)

FWF START grant Y372 (2008-2016)

FWF Elise-Richter grant V59 (2007-2008)

TWF grant UNI-0404/158 (2005-2007)

FWF Hertha-Firnberg grant T229 (2004-2007)

FWF grant P15767 (2002-2004)

 

Maria van Agthoven 

 

 Jovana Vusurovic 

Jovana Vusurovic

lab: +43 512 507 57742

Jovana.Vusurovic@uibk.ac.at

 

TALKS AND POSTER PRESENTATIONS

2018 J. Vusurovic, K. Breuker "Noncovalent RNA-ligand interactions probed by mass spectrometry" / 7th Annual CMBI Meeting, Vill, Austria, 19.09.2018-20.09.2018 (talk)

2018 J. Vusurovic, K. Breuker "Elucidation of paromomycin binding sites in an A site model of the 16S ribosomal RNA by native top-down MS" / 66th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), San Diego, CA, USA, 03.06.2018-07.06.2018 (poster)

2017 J. Vusurovic, K. Breuker " Binding of amino acids and dipeptides to RNA" / 9th ÖGMBT Annual Meeting & 8th Life Science Meeting Innsbruck, Austria, 25.09.2017-27.09.2017 (poster)

2017 J. Vusurovic, K. Breuker "Nonspecific versus specific binding of amino acids and dipeptides to RNA probed by electrospray ionization and collisionally activated dissociation" / 65th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), Indianapolis, IN, USA, 04.06.2017-08.06.2017 (poster)

2016 J. Vusurovic, K. Breuker "RNA-small molecule complexes as models for salt bridge and hydrogen bond interactions" / 64th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), San Antonio, TX, USA, 05.06.2016-09.06.2016 (poster)

2016 J. Vusurovic, K. Breuker "Competition for protons in the dissociation of RNA‐small molecule complexes" / 6th CMBI meeting, Gnadenwald, Austria (poster)

 

Matthias Halper 

Matthias Halper

lab: +43 512 507 57742
Matthias.Halper@uibk.ac.at

 

POSTER PRESENTATIONS

2018 M. Halper, K. Breuker "The effect of fixed-charge modifications on histone peptide fragmentation by ECD" / 7th Annual CMBI Meeting, Vill, Austria, 19.09.2018-20.09.2018 (poster)

2017 M. Halper, K. Breuker "Effect of histone peptide modifications on ionization and fragmentation by ECD and CAD" / 9th ÖGMBT Annual Meeting & 8th Life Science Meeting Innsbruck, Austria, 25.09.2017-27.09.2017 (poster)

2017 M. Halper, K. Breuker "Metal ion-, base-, and acid-catalyzed hydrolysis of total yeast RNA for Kendrick mass analysis of posttranscriptionally modified nucleotides" / 3rd International Mass Spectrometry School (IMSS), Dubrovnik, Croatia, 02.07.2017 - 08.07.2017 (poster)

2017 M. Halper, K. Breuker "Metal ion-, base-, and acid-catalyzed hydrolysis of total yeast RNA for Kendrick mass analysis of posttranscriptionally modified nucleotides" / 65th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), Indianapolis, IN, USA, 04.06.2017-08.06.2017 (poster)

 

STIPENDS AND AWARDS

2017 Doktoratsstipendium aus der Nachwuchsförderung der Universität Innsbruck, Austria

 

Giovanni Calderisi 

Giovanni Calderisi

lab: +43 512 507 57742
Giovanni.Calderisi@uibk.ac.at

 

TALKS AND POSTER PRESENTATIONS

2019 G. Calderisi, K. Breuker "A novel radical ion dissociation technique for MS characterization of RNA" / 67th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), Atlanta, GA, USA, 02.06.2017-06.06.2019 (talk)

2019 G. Calderisi, K. Breuker "A novel radical ion dissociation technique for MS characterization of RNA" / 7th MS J-Day, Bolzano, Italy, 27.05.2019 (talk)

2019 G. Calderisi, K. Breuker "A novel radical ion dissociation technique for MS characterization of RNA" / EU FT-ICR MS advanced users school, Lisbon, Portugal, 14.04.2019.-18.04.2019 April 2019 (poster and flash talk)

2018 G. Calderisi, K. Breuker "FT‐ICR MS and CAD as potential tools for the discovery of metal binding sites in RNA" / 7th Annual CMBI Meeting, Vill, Austria, 19.09.2018-20.09.2018 (poster)

2017 G. Calderisi, K. Breuker "ESI and CAD MS studies of Fe(II) binding to RNA mononucleotides" / 9th ÖGMBT Annual Meeting & 8th Life Science Meeting Innsbruck, Austria, 25.09.2017-27.09.2017 (poster)

2017 G. Calderisi, K. Breuker "ESI and CAD MS studies of Fe(II) binding to RNA mononucleotides" / 65th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), Indianapolis, IN, USA, 04.06.2017-08.06.2017 (poster)

 

STIPENDS AND AWARDS

2017 Undergraduate Student Travel Award, 65th ASMS conference, Indianapolis, IN, US

Undergraduate Student Travel Award, 65th ASMS conference, Indianapolis, IN, US

 

Michael Palasser 

Michael Palasser

lab: +43 512 507 57742
Michael.Palasser@uibk.ac.at

 

POSTER PRESENTATIONS

2019 M. Palasser, K. Breuker "RNA structure characterization by chemical probing and top-down mass spectrometry" / EU FT-ICR MS advanced users school, Lisbon, Portugal, 14.04.2019.-18.04.2019 April 2019 (poster)

2018 M. Palasser, K.J. Gallagher, S. Hughes, D.P.A. Kilgour, D. J. Clarke "Developing isotope depletion mass spectrometry for the analysis of proteins" / 7th Annual CMBI Meeting, Vill, Austria, 19.09.2018-20.09.2018 (poster)

 

STIPENDS AND AWARDS

2015 Poster award, 7th Annual CMBI Meeting, Vill, Austria

 

Sarah Viola Heel 

Sarah Viola Heel

lab: +43 512 507 57742
Sarah.Heel@student.uibk.ac.at

 

POSTER PRESENTATIONS

2019 S. Heel, K. Breuker "Studies on the stability and dissociation of tetramolecular RNA G-quadruplexes" / EU FT-ICR MS advanced users school, Lisbon, Portugal, 14.04.2019.-18.04.2019 April 2019 (poster)

 

Simon Chwatal (alumnus) 

Simon Chwatal


Heidelinde Glasner (alumna) 

Heidelinde Glasner

 

TALKS AND POSTER PRESENTATIONS

2017 H. Glasner, C. Riml, C. Falschlunger, R. Micura, K. Breuker "Nucleobase methylation can disrupt intramolecular nucleobase-phosphate interactions" / 9th ÖGMBT Annual Meeting & 8th Life Science Meeting Innsbruck, Austria, 25.09.2017-27.09.2017 (poster)

2017 H. Glasner, C. Riml, C. Falschlunger, R. Micura, K. Breuker "Characterization of intramolecular nucleobase-phosphate interactions by site-specific nucleobase methylation and collisionally activated dissociation" / 65th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), Indianapolis, IN, USA, 04.06.2017-08.06.2017 (poster)

2016 H. Glasner, C. Riml, C. Falschlunger, R. Micura, K. Breuker "Exploring the use of top-down mass spectrometry for the identification, localization, and relative quantitation of RNA nucleobase methylations" / 64th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), San Antonio, TX, USA, 05.06.2016-09.06.2016 (talk)

2016 H. Glasner, C. Riml, C. Falschlunger, R. Micura, K. Breuker "Characterization of RNA base methylations by top‐down mass spectrometry" / 6th CMBI meeting, Gnadenwald, Austria (poster)

2015 H. Glasner, V. Schwarz, C. Riml, R. Micura, K. Breuker "EDD and CAD for the identification, localization, and relative quantitation of base methylations of RNA" / 16th Austrian Chemistry Days, Innsbruck, Austria (poster)

2015 H. Glasner, B. Storch, E. Schneeberger, C. Riml, M.T. Rodgers, R. Micura, K. Breuker "The mechanism of RNA phosphodiester backbone cleavage by CAD and implications for the relative quantification of RNA modifications by top-down MS" / Nucleic Acids Workshop at the 63rd ASMS conference, St. Louis, MO, USA (workshop talk)

2015 H. Glasner, C. Riml, V. Schwarz, R. Micura, K. Breuker "Studies on the effect of modifications on RNA backbone cleavage by CAD and EDD" / 63rd ASMS conference, St. Louis, MO, USA (poster)

2014 H. Glasner, C. Riml, R. Micura, K. Breuker "Mechanistic studies of RNA backbone cleavage in electron detachment dissociation" / 6th Life Science Meeting of the Innsbruck Universities, Innsbruck, Austria (poster)

2014 H. Glasner, V. Schwarz, R. Micura, K. Breuker "Identification, localization, and relative quantitation of RNA modifications" / 11th Uppsala Conference on Electron Capture and Transfer Dissociation, Obergurgl, Austria (poster)

2013 H. Glasner, V. Schwarz, R. Micura, K. Breuker "Identification, localization, and relative quantitation of RNA modifications" / 5th Life Science Meeting of the Innsbruck Universities in cooperation with the 5th ÖGMBT Annual Meeting, Innsbruck, Austria (poster)

 

STIPENDS AND AWARDS

2018 "LFUI Best Student Paper Award 2018" for the article "Label-free, direct localization and relative quantitation of the RNA nucleobase methylations m6A, m5C, m3U, and m5U by top-down mass spectrometry" published in Nucleic Acids Research

2014 GÖCH-Förderungspreis für die besten Diplomarbeiten (Gesellschaft Österreichischer Chemiker), Austria

2014 Doktoratsstipendium aus der Nachwuchsförderung der Universität Innsbruck, Austria

2014 Poster award, 11th Uppsala Conference on Electron Capture and Transfer Dissociation, Obergurgl, Austria

2011 Scholarship for excellent students, University of Innsbruck, Austria

2008 Scholarship for excellent students, University of Innsbruck, Austria

 

Eva-Maria Schneeberger (alumna) 

Eva-Maria Schneeberger

 postdoc in the Steen laboratory

 

TALKS AND POSTER PRESENTATIONS

2018 E. Schneeberger, K. Breuker "Native top-down mass spectrometry puts a spotlight on RNA-protein and RNA-drug complexes" / 66th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), San Diego, CA, USA, 03.06.2018-07.06.2018 (talk)

2017 E. Schneeberger, K. Breuker "Native mass spectrometry elucidates stoichiometry and binding interfaces of TAR RNA-tat peptide complexes" / 9th ÖGMBT Annual Meeting & 8th Life Science Meeting Innsbruck, Austria, 25.09.2017-27.09.2017 (talk)

2017 E. Schneeberger, K. Breuker "Native top-down mass spectrometry reveals the stoichiometry and binding interfaces of TAR RNA-tat peptide complexes" / 3rd International Mass Spectrometry School (IMSS), Dubrovnik, Croatia, 02.07.2017 - 08.07.2017 (poster)

2017 E. Schneeberger, K. Breuker "Probing the stoichiometry and binding interfaces of retroviral RNA-peptide complexes by native top-down mass spectrometry" / 65th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), Indianapolis, IN, USA, 04.06.2017-08.06.2017 (poster)

2016 E. Schneeberger, K. Breuker "Characterization of RNA‐peptide binding interfaces by mass spectrometry" / 64th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), San Antonio, TX, USA, 05.06.2016-09.06.2016 (workshop talk)

2016 E. Schneeberger, K. Breuker "Site-specific characterization of binding interfaces in gaseous HIV-1 RNA-protein complexes" / 64th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS), San Antonio, TX, USA, 05.06.2016-09.06.2016 (poster)

2016 E. Schneeberger, K. Breuker "Characterization of RNA‐protein binding interfaces by mass spectrometry" / 6th CMBI meeting, Gnadenwald, Austria (talk)

2015 E. Schneeberger, K. Breuker "Probing charge sites in gaseous peptide ions by electron capture dissociation" / 16th Austrian Chemistry Days, Innsbruck, Austria (poster)

2015 E. Schneeberger, M. Schennach, K. Breuker "Mutual stabilization of helix structures in the three-helix bundle protein KIX studied by electron capture dissociation" / 63rd ASMS conference, St. Louis, MO, USA (poster)

2014 E. Schneeberger, M. Schennach, K. Breuker "Structural characterization and gas phase folding studies of protein segments from site-specific, acid-catalyzed hydrolysis" / 6th Life Science Meeting of the Innsbruck Universities, Innsbruck, Austria (poster)

 

STIPENDS AND AWARDS

2017 ASMS Fall Workshop Travel Stipend, American Society for Mass Spectrometry

 

Moritz Schennach (alumnus) 

Moritz Schennach

 

TALKS AND POSTER PRESENTATIONS

2015 M. Schennach, K. Breuker "The effect of solvent on the structure of gaseous KIX ions from electrospray ionization" / 16th Austrian Chemistry Days, Innsbruck, Austria (poster)

2014 M. Schennach, K. Breuker "Protein folding from a new (waterless) perspective" / 6th Life Science Meeting of the Innsbruck Universities, Innsbruck, Austria (talk)

2014 M. Schennach, K. Breuker "ECD reveals unusual and slow folding behavior of gaseous protein ions" / 11th Uppsala Conference on Electron Capture and Transfer Dissociation, Obergurgl, Austria (poster)

2013 M. Schennach, K. Breuker "Slow misfolding of proteins caused by dehydration" / 5th Life Science Meeting of the Innsbruck Universities in cooperation with the 5th ÖGMBT Annual Meeting, Innsbruck, Austria (poster)

2013 M. Schennach, K. Breuker "Protein unfolding & folding in the gas phase: Cytochrome c 9+ ions" / 61st ASMS conference, Minneapolis, MN, USA (poster)

2013 M. Schennach, K. Breuker "Protein unfolding & folding in the gas phase: Cytochrome c 9+ ions" / Sanibel conference, St. Pete Beach, FL, USA (poster)

2012 M. Schennach, K. Breuker "Unfolding and refolding of gaseous protein ions" / 4th Life Science Meeting of the Innsbruck Universities, Igls, Austria (poster)

 

STIPENDS AND AWARDS

2015 Research grant, TWF (Tiroler Wissenschaftsfonds)

2014 "LFUI Best Student Paper Award 2014" for the article "Proteins with Highly Similar Native Folds Can Show Vastly Dissimilar Folding Behavior When Desolvated" published in Angewandte Chemie as a "Hot Paper" as chosen by the Editors for its importance in a rapidly evolving field of high current interest

2013 Travel stipend, 61st ASMS conference, Minneapolis, MN, USA

2013 Travel stipend, Sanibel conference, St. Pete Beach, FL, USA

 

Barbara Storch (nee Ganisl, alumna) 

Barbara Storch

 

TALKS AND POSTER PRESENTATIONS

2015 B. Storch, K. Breuker "The effect of histone modifications on peptide ionization by ESI, and fragmentation by ECD and CAD" / 63rd ASMS conference, St. Louis, MO, USA (poster)

2014 B. Storch, T. Valovka, M. Hartl, K. Bister, K. Breuker "Detailed characterization of complex protein modification patterns by top-down mass spectrometry" / 11th Uppsala Conference on Electron Capture and Transfer Dissociation, Obergurgl, Austria (poster)

2013 B. Storch, T. Valovka, M. Hartl, K. Bister, K. Breuker "Detailed characterization of complex protein modification patterns by top-down mass spectrometry" / 5th Life Science Meeting of the Innsbruck Universities in cooperation with the 5th ÖGMBT Annual Meeting, Innsbruck, Austria (poster)

2013 B. Ganisl, K. Breuker "Detailed characterization of complex protein and RNA modification patterns by top-down mass spectrometry" / 61st ASMS conference, Minneapolis, MN, USA (talk)

2012 B. Ganisl, K. Breuker "Disulfide vs. Backbone Bond Cleavage in Electron Capture Dissociation of Proteins" 4th Life Science Meeting of the Innsbruck Universities, Igls, Austria (poster)

2012 B. Ganisl, K. Breuker "Disulfide vs. Backbone Bond Cleavage in Electron Capture Dissociation of Proteins" / 60th ASMS conference, Vancouver, Canada (poster)

2012 B. Ganisl, K. Breuker "Disulfide vs. Backbone Bond Cleavage in Electron Capture Dissociation of Proteins" / 9th UppCon, Charleston, SC, USA (poster)

2011 B. Ganisl, N. Coudevylle, M. Taucher, R. Konrat, K. Breuker "Top-Down Mass Spectrometry for Characterization of PTMs" / 3rd Lifescience Meeting of the Innsbruck Universities, Igls, Austria (poster)

2011 B. Ganisl, M. Taucher, K. Breuker "Backbone Cleavage Versus Sidechain Dissociation in Electron Detachment Dissociation (EDD) of Multiply Deprotonated Proteins" / 59th ASMS conference, Denver, CO, USA (poster)

2011 B. Ganisl, M. Taucher, K. Breuker "Charge as you like! Efficient Manipulation of Charge in (-)ESI of Proteins and RNA" / 8th Uppsala Conference on Electron Capture and Transfer Dissociation, Villars-sur-Ollon, Switzerland (poster)

2010 B. Ganisl, M. Taucher, K. Breuker "Collisionally Activated Dissociation (CAD) and Electron Detachment Dissociation (EDD) of Proteins in Negative Ion Mode Electrospray Ionization (ESI)" / 2nd Lifescience Meeting of the Innsbruck Universities, Igls, Austria (poster)

2010 B. Ganisl, M. Taucher, K. Breuker "Electron Detachment Dissociation (EDD) and Collisionally Activated Dissociation (CAD) for Top-Down Mass Spectrometry of Acidic Proteins" / 58th ASMS conference, Salt Lake City, UT, USA (poster)

 

STIPENDS AND AWARDS

2014 Research stipend from the "Peter und Traudl Engelhorn-Stiftung zur Förderung der Biotechnologie und Gentechnik"

2012 Travel stipend, 9th UppCon, Charleston, SC, USA

2012 Poster award, 4th Life Science Meeting of the Innsbruck Universities, Igls, Austria

2011 Travel stipend, 59th ASMS conference, Denver, CO, USA

2010 Travel stipend, 58th ASMS conference, Salt Lake City, UT, USA

2010 Undergraduate poster award, 58th ASMS conference, Salt Lake City, UT, USA

2009 Scholarship for excellent students, University of Innsbruck, Austria

 

Monika Taucher (nee Schöllnberger, alumna) 

Monika Taucher (nee Schöllnberger)

 

TALKS AND POSTER PRESENTATIONS

2012 M. Taucher, K. Breuker "Activated Ion Electron Detachment Dissociation of (t)RNA" /  60th ASMS conference, Vancouver, Canada (poster)

2011 M. Taucher, B. Ganisl, C. Riml, K. Breuker "Converting RNA into radicals in the gas phase" / 7th Meeting of PhD Students, Innsbruck, Austria (poster)

2011 M. Taucher, B. Ganisl, K. Breuker "Top-Down mass spectrometry for characterization of RNA modifications" / 14. Österreichische Chemietage, Linz, Austria (poster)

2011 M. Taucher, B. Ganisl, K. Breuker "Top-Down mass spectrometry for characterization of RNA modifications" / 3rd Life Science Meeting of the Innsbruck Universities, Igls, Austria (poster)

2011 M. Taucher, B. Ganisl, K. Breuker "Top-Down Mass Spectrometry of tRNA Reveals Sample Heterogeneity and Identifies/Localizes Posttranscriptional Modifications" / 59th ASMS Conference, Denver, CO, USA (poster)

2010 M. Taucher, B. Ganisl, K. Breuker "Top-Down MS of RNA/tRNA for the Identification and Localization of Posttranscriptional Modifications" / 6th Meeting of PhD Students, Innsbruck, Austria (poster)

2010 M. Taucher, B. Ganisl, K. Breuker "Identification, localization, and relative quantitation of pseudouridine in RNA by tandem mass spectrometry of hydrolysis products" 2nd Life Science Meeting of the Innsbruck Universities, Igls, Austria (poster)

2010 M. Taucher, B. Ganisl, K. Breuker "Identifizierung, Lokalisierung, und relative Quantifizierung von Pseudouridin in RNA mit Tandem-Massenspektrometrie von Hydrolyseprodukten" / Fachgruppensymposium FTMS der Deutschen Gesellschaft für Massenspektrometrie (DGMS), Mülheim an der Ruhr, Germany (talk)

2010 M. Taucher, K. Breuker "Collisionally Activated Dissociation (CAD) and Electron Detachment Dissociation (EDD) for Top-Down Mass Spectrometry of Ribonucleic Acids up to 61 nt" / 58th ASMS Conference, Salt Lake City, UT, USA (poster)

2009 M. Taucher, K. Breuker "Top-down Mass Spectrometry of RNA" / 1st Life Science Meeting of the Innsbruck Universities, Igls, Austria (poster)

2009 M. Schöllnberger, U. Rieder, K. Breuker "Top-down Mass Spectrometry of RNA" / CUSO Summer School, Villars-sur-Ollon, Switzerland (poster)

2009 M. Schöllnberger, U. Rieder, R. Micura, K. Breuker "Top-down Mass Spectrometry of Modified RNA" / 57th ASMS Conference, Philadelphia, PA, USA (poster)

 

STIPENDS AND AWARDS

2013 PhD award of the ÖGMBT, Austria

2011 Poster award of the "Gesellschaft Österreichischer Chemiker", Austria

2010 Travel stipend, 58th ASMS conference, Salt Lake City, UT, USA

 

Christian Riml (alumnus) 

Christian Riml

 

Owen S. Skinner (visiting scientist) 

Owen S. Skinner

postdoc in the Mootha laboratory

 

 

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