Publications

Google Scholar Citations / ORCID / Kathrin Breuker


75) E. Fuchs, C. Falschlunger, R. Micura, K. Breuker: The effect of adenine protonation on RNA phosphodiester backbone bond cleavage elucidated by deaza-nucleobase modifications and mass spectrometryNucleic Acids Res. 47, 7223-7234 (2019) OPEN ACCESS ARTICLE


74) M. Hartl, S. Glasauer, S. Gufler, A. Raffeiner, K. Puglisi, K. Breuker, K. Bister, B. Hobmayer: Differential regulation of myc homologs by Wnt/β‐catenin signaling in the early metazoan Hydra, FEBS J. 286, 2295-2310 (2019) OPEN ACCESS ARTICLE


73) J. Vušurović, K. Breuker: The relative strength of noncovalent interactions and covalent backbone bonds in gaseous RNA-peptide complexes, Anal. Chem. 91, 1659-1664 (2019) OPEN ACCESS ARTICLE


72) S. Führer, S. Trimmel, K. Breuker, M. Tollinger: NMR resonance assignments of the pathogenesis-related peach allergen Pru p 1.0101, Biomol. NMR Assign. 13, 127-130 (2019) OPEN ACCESS ARTICLE


71) E.M. Schneeberger, K. Breuker: Replacing H+ by Na+ or K+ in phosphopeptide anions and cations prevents electron capture dissociation, Chem. Sci. 9, 7338-7353 (2018) OPEN ACCESS ARTICLE


70) K. Breuker: Raw protein from the top down, Nat. Chem. 10, 114-116 (2018)


69) J. Vušurović, E.M. Schneeberger, K. Breuker: Interactions of protonated guanidine and guanidine derivatives with multiply deprotonated RNA probed by electrospray ionization and collisionally activated dissociation, ChemistryOpen 6, 739-750 (2017) OPEN ACCESS ARTICLE


68) J. Kremser, E. Strebitzer, R. Plangger, M.A. Juen, F. Nußbaumer, H. Glasner, K. Breuker, C. Kreutz: Chemical synthesis and NMR spectroscopy of long stable isotope labelled RNA, Chem. Commun. 53, 12938-12941 (2017) OPEN ACCESS ARTICLE


67) O.S. Skinner, M.O. McAnally, R.P. Van Duyne, G.C. Schatz, K. Breuker, P.D. Compton, N.L. Kelleher: Native electron capture dissociation maps to Iron-binding channels in horse spleen Ferritin, Anal. Chem. 89, 10711-10716 (2017) OPEN ACCESS ARTICLE


66) H. Glasner, C. Riml, R. Micura, K. Breuker: Label-free, direct localization and relative quantitation of the RNA nucleobase methylations m6A, m5C, m3U, and m5U by top-down mass spectrometry, Nucleic Acids Res. 45, 8014-8025 (2017) OPEN ACCESS ARTICLE


65) E.M. Schneeberger, K. Breuker: Native top-down mass spectrometry of TAR RNA in complex with a wild-Type tat peptide for binding site mapping, Angew. Chem. 129, 1274-1278 (2017); Angew. Chem. Int. Ed. 56, 1254-1258 (2017) OPEN ACCESS ARTICLE


64) M. Schennach, E.M. Schneeberger, K. Breuker: Unfolding and folding of the three-helix bundle protein KIX in the absence of solvent, J. Am. Soc. Mass Spectrom. 27, 1079-1088 (2016) OPEN ACCESS ARTICLE


63) A.I. Cabedo Martinez, K. Weinhäupl, W.K. Lee, N.A. Wolff, B. Storch, S. Żerko, R. Konrat, W. Koźmiński, K. Breuker, F. Thévenod, N. Coudevylle: Biochemical and structural characterization of the interaction between the Siderocalin NGAL/LCN2 and the N-terminal domain of its endocytic receptor SLC22A17, J. Biol. Chem. 291, 2917-2930 (2016) OPEN ACCESS ARTICLE


62) T.P. Hoernes, N. Clementi, K. Faserl, H. Glasner, K. Breuker, H. Lindner, A. Hüttenhofer, M. Erlacher: Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code, Nucleic Acids Res. 44, 852-862 (2016) OPEN ACCESS ARTICLE


61) A.G. Flamm, A.L. Le Roux, B.M. López, B. Storch, K. Breuker, R. Konrat, M. Pons, N. Coudevylle: N-lauroylation during the expression of recombinant N-myristoylated proteins. Implications and solutions, ChemBioChem, 17, 82-89 (2016) OPEN ACCESS ARTICLE


60) M. Kosutic, S. Neuner, A. Ren, S. Flür, C. Wunderlich, E. Mairhofer, N. Vusurovic, J. Seikowski, K. Breuker, C. Höbartner, D.J. Patel, C. Kreutz, R. Micura: A mini-twister variant and residues/cations impacting on the phosphodiester cleavage chemistry of this ribozyme class, Angew. Chem. 127, 15343-15348 (2015); Angew. Chem. Int. Ed. 54, 15128-15133 (2015)


59) C. Riml, H. Glasner, M.T. Rodgers, R. Micura, K. Breuker: On the mechanism of RNA phosphodiester backbone cleavage in the absence of solvent, Nucleic Acids Res. 43, 5171-5181 (2015) OPEN ACCESS ARTICLE


58) M. Schennach, K. Breuker: Probing protein structure and folding in the gas phase by electron capture dissociation, J. Am. Soc. Mass Spectrom. 26, 1059-1067 (2015) OPEN ACCESS ARTICLE


57) K. Breuker: Characterization of ribonucleic acids and their modifications by Fourier transform ion cyclotron resonance mass spectrometry, book chapter in "Nucleic Acids in the Gas Phase" (Physical Chemistry in Action 2014), edited by Valérie Gabelica, pp 185-202, Springer Berlin Heidelberg (August 2014)


56) K. Breuker: Structure Characterization of Biomolecules (Editorial) ChemistryOpen 3, 137 (2014) OPEN ACCESS ARTICLE


55) M. Hartl, S. Glasauer, T. Valovka, K. Breuker, B. Hobmayer, K. Bister: Hydra myc2, a unique pre-bilaterian member of the myc gene family, is activated in cell proliferation and gametogenesis Biology Open 3, 397-407 (2014) OPEN ACCESS ARTICLE


54) M. Schennach, K. Breuker: Proteins with highly similar native folds can show vastly dissimilar folding behavior when desolvated Angew. Chem. 126, 168-172 (2014); Angew. Chem. Int. Ed. 53, 164-168 (2014) OPEN ACCESS ARTICLE


53) T. Valovka, M. Schönfeld, P. Raffeiner, K. Breuker, T. Dunzendorfer-Matt, M. Hartl, K. Bister: Transcriptional control of DNA replication licensing by Myc Sci. Rep. 3, Article number: 3444 (2013) OPEN ACCESS ARTICLE


52) R. Micura, C. Kreutz, K. Breuker: A personal perspective on chemistry-driven RNA research Biopolymers 99, 1114-1123 (2013)


51) O.S. Skinner, K. Breuker, F.W. McLafferty: Charge site mass spectra: Conformation-sensitive components of the electron capture dissociation spectrum of a protein J. Am. Soc. Mass Spectrom. 24, 807-810 (2013)


50) B. Ganisl, K. Breuker: Does electron capture dissociation cleave protein disulfide bonds? ChemistryOpen 1, 260-268 (2012) OPEN ACCESS ARTICLE


49) M. Taucher, K. Breuker: Characterization of modified RNA by top-down mass spectrometry Angew. Chem. 124, 11451-11454 (2012); Angew. Chem. Int. Ed. 51, 11289-11292 (2012) OPEN ACCESS ARTICLE


48) O.S. Skinner, F.W. McLafferty, K. Breuker: How Ubiquitin unfolds after transfer into the gas phase J. Am. Soc. Mass Spectrom. 23, 1011-1014 (2012) OPEN ACCESS ARTICLE


47) K. Breuker, O.S. Skinner, F.W. McLafferty: Femtosecond laser vaporization that preserves protein-folded structure: an unproven idea Proc. Natl. Acad. Sci. USA 109, E206 (2012) OPEN ACCESS ARTICLE


46) B. Ganisl, M. Taucher, C. Riml, K. Breuker: Charge as you like! Efficient manipulation of negative ion net charge in electrospray ionization of proteins and nucleic acids Eur. J. Mass Spectrom. 17, 333-343 (2011) OPEN ACCESS ARTICLE


45) B. Ganisl, T. Valovka, M. Hartl, M. Taucher, K. Bister, K. Breuker: Electron detachment dissociation for top-down mass spectrometry of acidic proteins Chem. Eur. J. 17, 4460-4469 (2011) OPEN ACCESS ARTICLE


44) K. Breuker, S. Brüschweiler, M. Tollinger: Electrostatic stabilization of a native protein structure in the gas phase Angew. Chem. 123, 903-907 (2011); Angew. Chem. Int. Ed. 50, 873-877 (2011) OPEN ACCESS ARTICLE


43) M. Taucher, B. Ganisl, K. Breuker: Identification, localization, and relative quantitation of pseudouridine in RNA by tandem mass spectrometry of hydrolysis products Int. J. Mass Spectrom. 304, 91-97 (2011) OPEN ACCESS ARTICLE


42) M. Taucher, K. Breuker: Top-down mass spectrometry for sequencing of larger (up to 61 nt) RNA by CAD and EDD J. Am. Soc. Mass Spectrom. 21, 918-929 (2010) OPEN ACCESS ARTICLE


41) M. Hartl, A.M. Mitterstiller, T. Valovka, K. Breuker, B. Hobmayer, K. Bister: Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra Proc. Natl. Acad. Sci. USA 107, 4051-4056 (2010) OPEN ACCESS ARTICLE


40) M. Taucher, U. Rieder, K. Breuker: Minimizing base loss and internal fragmentation in collisionally activated dissociation of multiply deprotonated RNA J. Am. Soc. Mass Spectrom. 21, 278-285 (2010) OPEN ACCESS ARTICLE


39) F.W. McLafferty, S. Castro, K. Breuker: Multi-step evolution of protein conformation on electrospray into the gas phase Eur. J. Mass Spectrom. 16, 437-442 (2010)


38) X. Kong, C. Lin, G. Infusini, H.B. Oh, H. Jiang, K. Breuker, C.C. Wu, O.P. Charkin, H.C. Chang, F.W. McLafferty: Numerous isomers of serine octamer ions characterized by infrared photodissociation spectroscopy ChemPhysChem 10, 2603-2606 (2009)


37) K. Breuker, F.W. McLafferty: Stepwise evolution of native protein structure with electrospray into the gas phase, 10-12 to 102 s Proc. Natl. Acad. Sci. USA 105, 18145-18152 (2008) OPEN ACCESS ARTICLE


36) M.Z. Steinberg, R. Elber, F.W. McLafferty, R.B. Gerber, K. Breuker: Early structural evolution of native Cytochrome c after solvent removal ChemBioChem 9, 2417-2423 (2008)


35) K. Breuker, M. Jin, X. Han, H. Jiang, F.W. McLafferty: Top-down identification and characterization of biomolecules by mass spectrometry J. Am. Soc. Mass Spectrom. 19, 1045-1053 (2008) OPEN ACCESS ARTICLE


34) F.W. McLafferty, K. Breuker, M. Jin, X. Han, G. Infusini, H. Jiang, X. Kong, T.P. Begley: Top-down mass spectrometry, a powerful complement to the high capabilities of proteolysis proteomics FEBS J. 274, 6256-6268 (2007) OPEN ACCESS ARTICLE


33) M.Z. Steinberg, K. Breuker, R. Elber, R.B. Gerber: The dynamics of water evaporation from partially solvated Cytochrome c in the gas phase Phys. Chem. Chem. Phys. 9, 4690-4697 (2007)


32) X. Han, M. Jin, K. Breuker, F.W. McLafferty: Extending top-down mass spectrometry to proteins with masses greater than 200 kilodaltons Science 314, 109-112 (2006)


31) K. Breuker: Protein structure and folding in the gas phase: Ubiquitin and Cytochrome c. book chapter no. 5 in "Principles of mass spectrometry applied to biomolecules" edited by Chava Lifshitz and Julia Laskin, John Wiley & Sons, Inc. (October 2006)


30) K. Breuker: Segmental charge distributions of Cytochrome c on transfer into the gas phase Int. J. Mass Spectrom. 253, 249-255 (2006)


29) H. Zhai, X. Han, K. Breuker, F.W. McLafferty: Consecutive ion activation for top down mass spectrometry: Improved protein sequencing by nozzle skimmer dissociation Anal. Chem. 77, 5777-5784 (2005)


28) K. Breuker, F.W. McLafferty: The thermal unfolding of native Cytochrome c in the transition from solution to gas phase probed by native electron capture dissociation Angew. Chem. 117, 4989-4992 (2005); Angew. Chem. Int. Ed. 44, 4911-4914 (2005)


27) H.-B. Oh, C. Ling, H.Y. Hwang, H. Zhai, K. Breuker, V. Zabrouskov, B.K. Carpenter, F.W. McLafferty: Infrared photodissociation spectroscopy of electrosprayed ions in a Fourier transform mass spectrometer J. Am. Chem. Soc. 127, 4076-4083 (2005)


26) K. Breuker: The study of protein-ligand interactions by mass spectrometry - a personal view Int. J. Mass Spectrom. 239, 33-41 (2004)


25) K. Breuker, H.-B. Oh, C. Ling, B.K. Carpenter, F.W. McLafferty: Nonergodic and conformational control of the electron capture dissociation of protein cations Proc. Natl. Acad. Sci. USA 101, 14011-14016 (2004) OPEN ACCESS ARTICLE


24) C. Höbartner, H. Mittendorfer, K. Breuker, R. Micura: Triggering of RNA secondary structure by a functionalized nucleobase Angew. Chem. 116, 4012-4015 (2004); Angew. Chem. Int. Ed. 43, 3922-3925 (2004)


23) M. Narayan, G. Xu, D.R. Ripoll, H. Zhai, K. Breuker, C. Wanjalla, H.J. Leung, A. Navon, E. Welker, F.W. McLafferty, H.A. Scheraga: Dissimilarity in the reductive unfolding pathways of two ribonuclease homologues J. Mol. Biol. 338, 795-809 (2004)


22) K. Breuker: New mass spectrometric methods for the quantification of protein-ligand binding in solution Angew. Chem. 116, 22-25 (2004); Angew. Chem. Int. Ed. 43, 22-25 (2004)


21) K. Breuker, F.W. McLafferty: Native electron capture dissociation for the structural characterization of noncovalent interactions in native Cytochrome c Angew. Chem. 115, 5048-5052 (2003); Angew. Chem. Int. Ed. 42, 4900-4904 (2003)


20) M. Oberhuber, J. Berghold, K. Breuker, S. Hörtensteiner, B. Kräutler: Breakdown of chlorophyll: A nonenzymatic reaction accounts for the formation of the colorless "nonfluorescent" chlorophyll catabolites Proc. Natl. Acad. Sci. USA 100, 6910-6915 (2003) OPEN ACCESS ARTICLE


19) K. Breuker, R. Knochenmuss, A. Stortelder, J. Zhang, R. Zenobi: Thermodynamic control of final ion distributions in MALDI: in-plume proton transfer reactions Int. J. Mass Spectrom. 226, 211-222 (2003)


18) H.-B. Oh, K. Breuker, S.-K. Sze, Y. Ge, B.K. Carpenter, F.W. McLafferty: Secondary and tertiary structures of gaseous protein ions characterized by electron capture dissociation mass spectrometry and photofragment spectroscopy Proc. Natl. Acad. Sci. USA 99, 15863-15868 (2002) OPEN ACCESS ARTICLE


17) J. Berghold, K. Breuker, M. Oberhuber, S. Hörtensteiner, B. Kräutler: Chlorophyll breakdown in spinach: on the structure of five nonfluorescent chlorophyll catabolites Photosynth. Res. 74, 109-119 (2002)


16) K. Breuker, H.-B. Oh, D.M. Horn, B.A. Cerda, F.W. McLafferty: Hydrogen atom loss in electron capture dissociation: A FT-ICR study with single isotopomeric ubiquitin ions Eur. J. Mass Spectrom. 8, 177-180 (2002)


15) K. Breuker, H.-B. Oh, D.M. Horn, B.A. Cerda, F.W. McLafferty: Detailed unfolding and folding of gaseous ubiquitin ions characterized by electron capture dissociation J. Am. Chem. Soc. 124, 6407-6420 (2002)


14) B.A. Cerda, D.M. Horn, K. Breuker, F.W. McLafferty: Sequencing of specific copolymer oligomers by electron capture dissociation mass spectrometry J. Am. Chem. Soc. 124, 9287-9291 (2002)


13) D.M. Horn, K. Breuker, A.J. Frank, F.W. McLafferty: Kinetic intermediates in the folding of gaseous protein ions characterized by electron capture dissociation J. Am. Chem. Soc. 123, 9792-9799 (2001)


12) B.A. Cerda, K. Breuker, D.M. Horn, F.W. McLafferty: Charge/radical site initiation versus Coulombic repulsion for cleavage of multiply charged ions. Charge solvation in poly(alkene glycol) ions J. Am. Soc. Mass Spectrom. 12, 565-570 (2001)


11) F.W. McLafferty, D.M. Horn, K. Breuker, Y. Ge, M.A. Lewis, B. Cerda, R.A. Zubarev, B.K. Carpenter: Electron capture dissociation of gaseous multiply charged ions by Fourier-transform ion cyclotron resonance J. Am. Soc. Mass Spectrom. 12, 245-249 (2001)


10) R. Knochenmuss, A. Stortelder, K. Breuker, R. Zenobi: Secondary ion-molecule reactions in matrix-assisted laser desorption/ionization J. Mass Spectrom. 35, 1237-1245 (2000)


9) E. Stevenson, K. Breuker, R. Zenobi: Internal energies of analyte ions generated from different matrix-assisted laser desorption/ionization matrices J. Mass Spectrom. 35, 1035-1041 (2000)


8) B.A. Cerda, D.M. Horn, K. Breuker, B.K. Carpenter, F.W. McLafferty: Electron capture dissociation of multiply-charged oxygenated cations. A nonergodic process Eur. J. Mass Spectrom. 5, 335-338 (1999)


7) K. Breuker, R. Knochenmuss, R. Zenobi: Proton transfer reactions of MALDI matrix monomers and dimers J. Am. Soc. Mass Spectrom. 10, 1111-1123 (1999)


6) U. Baumann, M. Benz, E. Pletscher, M. Siegfried, K. Breuker, R. Zenobi: Biodegradation of sugar alcohol ethoxylates Tenside, Surfactants, Deterg. 36, 288-293 (1999)


5) K. Breuker, R. Knochenmuss, R. Zenobi: The gas-phase basicities of deprotonated MALDI matrix molecules Int. J. Mass Spectrom. 184, 25-38 (1999)


4) K. Breuker, R. Knochenmuss, R. Zenobi: Matrix-assisted laser desorption/chemical ionization with reagent ion generation directly from a liquid matrix Int. J. Mass Spectrom. 176, 149-159 (1998), Best Student Paper Award 1999 for the best paper on technique development.


3) R. Knochenmuss, V. Karbach, U. Wiesli, K. Breuker, R. Zenobi: The matrix suppression effect in matrix-assisted laser desorption/ionization: Application to negative ions and further characteristics Rapid Commun. Mass Spectrom. 12, 529-534 (1998)


2) R.J.J.M. Steenvoorden, K. Breuker, R. Zenobi: The gas-phase basicities of matrix-assisted laser desorption/ionization matrices Eur. J. Mass Spectrom. 3, 339-346 (1997)


1) F. Dubois, R. Knochenmuss, R.J.J.M. Steenvoorden, K. Breuker, R. Zenobi: On the mechanism and control of salt-induced resolution loss in matrix-assisted laser desorption/ionization Eur. J. Mass Spectrom. 2, 167-172 (1996)

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