Vitamin E metabolites in immunoregulation and stress adaption
In vitro screening fails to identify natural products that are converted into bioactive metabolites in gut, liver or peripheral tissues. To address this challenge, we i) quantify metabolites at postulated target sites, ii) isolate or (semi)synthesize promising candidates in collaboration, and iii) study their biological functions in interdisciplinary approaches. A recent highlight was our discovery that immunomodulatory functions of vitamin E are mediated by endogenous metabolites that limit inflammation.
Team: Sijia Liao, Konstantin Neukirch, Stephan Permann
Subprojects
- 5-lipoxygenase as immunoregulatory target of human endogenous vitamin E metabolites
- Endogenous metabolites of α-tocopherol as double-edged swords in the regulation of inflammatory stress
- Dual Inhibitors inspired from vitamin E: towards vitamin E analogs that relieve inflammation by targeting mPGES-1 and 5-lipoxygenase without impeding resolution (DIVE)
