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Vitamin E metabolites in immunoregulation and stress adaption

 

In vitro screening fails to identify natural products that are converted into bioactive metabolites in gut, liver or peripheral tissues. To address this challenge, we i) quantify metabolites at postulated target sites, ii) isolate or (semi)synthesize promising candidates in collaboration, and iii) study their biological functions in interdisciplinary approaches. A recent highlight was our discovery that immunomodulatory functions of vitamin E are mediated by endogenous metabolites that limit inflammation.

 


Team:  Sijia Liao, Konstantin Neukirch, Stephan Permann

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