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Publications

 

All articles

Peer-reviewed publications can be found on  PubMed.

 

Selected articles

  1. Neukirch, K., Alsabil, K., Dinh, C., Bilancia, R., Raasch, M., Ville, A., Cerqua, I., Viault, G., Bréard, D., Pace, S., Temml, V., Brunner, E., Jordan, P.M., Marques, M.C., Loeser, K., Gollowitzer, A., Permann, S., Gerstmeier, J., Lorkowski, S., Stuppner, H., Garscha, U., Rodrigues, T., Bernardes, G.J.L., Schuster, D., Séraphin, D., Richomme, P., Rossi, A., Mosig, A., Roviezzo, F., Werz, O., Helesbeux, JJ., Koeberle, A. (2021) Exploration of long-chain vitamin E metabolites for the discovery of a highly potent, orally effective and metabolically stable 5-LOX inhibitor that limits inflammation. J Med Chem


  2. Van Anh, T.T., Mostafa, A., Rao, Z., Pace, S., Schwaiger, S., Kretzer, C., Temml, V., Giesel, C., Jordan, P.M., Bilancia, R., Weinigel, C., Rummler, S., Waltenberger, B., Hung, T., Rossi, A., Stuppner, H., Werz, O., Koeberle, A. (2021) From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution. Acta Pharm Sin B, 11, 1629-1647


  3. Espada, L., Dakhovnik, A., Chaudhari, P., Martirosyan, A., Miek, L., Poliezhaieva, T., Schaub, Y., Nair, A., Doring, N., Rahnis, N., Werz, O., Koeberle, A., Kirkpatrick, J., Ori, A., Ermolaeva, M. A. (2020) Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans. Nat Metab, 2, 1316-1331

  4. Pein, H., Ville, A., Pace, S., Temml, V., Garscha, U., Raasch, M., Alsabil, K., Viault, G., Dinh, C., Guilet, D., Troisi, F., Neukirch, K., König, S., Waltenberger, B., Stuppner, H., Wallert, M., Lorkowski, S., Weinigel, C., Rummler, S., Birringer, M., Sautebin, L., Helesbeux, JJ., Séraphin, D., Mosig, A., Schuster, D., Rossi, A., Richomme, P., Werz, O., Koeberle, A. (2018) Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nat Commun, 9, 3834

  5. Pein, H., Koeberle, S.C., Voelkel, M., Schneider, F., Rossi, A., Thürmer, M., Loeser, K., Sautebin, L., Morrison, H., Werz, O., Koeberle, A. (2017) Vitamin A regulates Akt signaling through the phospholipid fatty acid composition. FASEB J, 31, 4566-4577

  6. Koeberle, A., Pergola, C., Shindou, H., Koeberle, S.C., Shimizu, T., Laufer, S.A., Werz, O. (2015) Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis. FASEB J., 29, 2439-2449

  7. Koeberle, A., Eduardo, M., Appendino, G., Minassi, A., Weinigel, C., Barz, D., Caprioglio, D., Collado, J.A., Werz, O. (2014) SAR studies on curcumin’s pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. J Med Chem, 57, 5638- 5648

  8. Reker, D., Perna, A.M., Reutlinger, M., Schneider, P., Rodrigues, T., Mönch, B., Koeberle, A., Lamers, C., Gabler, M., Steinmetz, H., Müller, R., Schubert-Zsilavecz, M., Werz, O., Schneider, G. (2014) Revealing the macromolecular targets of complex natural products. Nat Chem, 6, 1072-1078

  9. Koeberle, A., Shindou, H., Koeberle S.C., Laufer S.A., Shimizu, T., Werz, O. (2013) Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding, Proc Natl Acad Sci U S A, 110, 2546-2551

  10. Koeberle, S.C., Romir, J., Fischer, S., Koeberle, A., Schattel, V., Albrecht, W., Grütter, C., Werz, O., Rauh, D., Stehle, T., Laufer, S. (2011) Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat Chem Biol, 25, 141-143
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