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Research at the Interface of Inflammation, Cancer and Lipid Signaling

 

The MPI's research at the crossroads of inflammation, cancer, lipid metabolism and lipid signaling aims to elucidate the molecular mechanisms of natural products with a special focus on phytochemicals. We apply (bio)analytical, biochemical and molecular pharmacological techniques to discover innovative drug targets and to develop phytopharmaceuticals and biogenic lead structures. We also use natural products to investigate the physiological function of their targets in cellular processes related to chronic inflammation and programmed cell death. Key for our interdisciplinary research is a powerful chromatographic and mass spectrometric bioanalytics of lipids (i.e., targeted lipidomics), which allows us to unravel the largely unexplored interplay between lipid metabolism, signal transduction and homeostasis.


 Research

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