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Targeting ferroptosis at the intersection of cancer and inflammation


Ferroptosis is a regulated form of necrotic cell death that is relevant to both degenerative disease and cancer and is closely associated with inflammation. Pleiotropic physiological processes, such as polyunsaturated fatty acid and phospholipid metabolism, modulate the sensitivity to ferroptosis, which is triggered by iron-dependent lipid peroxidation. The regulation of ferroptosis is incompletely understood, as are the mechanisms by which oxidized phospholipids trigger cell death. Small molecules have been shown to interfere with ferroptosis, thereby opening the door to exciting new approaches for pharmacological intervention. 

 Ferroptosis Overview

Koeberle et al., 2023, Med. Res. Rev.

Team:  Julia Grander, Zhigang Rao, Fengting Su, Leonhard Bereuter


  • Impact of the immune microenvironment on ferroptotic cancer cell death
  • Unraveling pro- and anti-ferroptotic mechanisms of natural products to define ferroptotic signaling pathways
  • Discovery of anti-tumoral and pro-regenerative natural products targeting ferroptosis
  • Lipid metabolic mechanisms in EMT/ZEB1-dependent ferroptosis


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