Chirality effects in clusters from chiral samples in helium nanodroplets (P31149)

funded by FWF

Principal Investigator: Paul Scheier
Duration: 01.05.2018 – 30.04.2023 (approval date: 05.03.2018)
Scientific fields:

55% Chemistry,

45% Physics, Astronomy
Keywords: helium nanodroplets, peptide bond formation, cluster, circular dichroism, homochirality, chirality

Summary:

The present experimental proposal aims at a deeper understanding of the influence of chirality on molecular cluster formation. For some specific amino acids, a strong preference of clusters consisting of only one enantiomer has been reported, even if they were sampled from a 1:1 mixture of both chiral forms. We could confirm this observation for amino acid clusters formed in superfluid helium droplets, although the cluster formation process was very different from formation in water or other solvents. In previous experiments, where clusters of amino acids were bombarded with keV ions or low-energy electrons, the loss of neutral fragments with a mass of 18 atomic mass units was observed. This is likely the loss of a water molecule, which may indicate formation of a peptide bond. Clusters of amino acids frozen onto a dust grain in cold interstellar clouds are expected to be exposed to ions or electrons in the above mentioned energy range. Thus, peptide bond formation via such simple and universal processes would be of relevance for astrochemistry and astrobiology and maybe even for the beginning of live on Earth.

Final Report (blank)

List of publications:

  1. E. Zunzunegui-Bru, E. Gruber, T. Lázaro, M. Bartolomei, M.I. Hernández, J. Campos-Martínez, T. González-Lezana, S. Bergmeister, F. Zappa, P. Scheier, R. Pérez de Tudela, J. Hernández-Rojas, and J. Bretón, Observation of Multiple Ordered Solvation Shells in Doped Helium Droplets: The Case of HeNCa2+. J. Phys. Chem. Lett. 14 (2023) 3126–3131; DOI: 10.1021/acs.jpclett.3c00224
  2. L. Tiefenthaler, P. Scheier, E Erdmann, N.F. Aguirre, S. Díaz-Tendero, T.F.M. Luxford and J. Kocišek, Non-Ergodic Fragmentation upon Collision Induced Activation of Cysteine-Water Cluster Cations. Phys. Chem. Chem. Phys. 25 (2023) 5361–5371 (front cover); DOI: 10.1039/D2CP04172C
  3. S. Kollotzek, J. Campos-Martínez, M. Bartolomei, F. Pirani, L. Tiefenthaler, M.I. Hernández, T. Lazaro, E. Zunzunegui-Bru, T. Gonzalez-Lezana, J. Hernández-Rojas, J. Bretón, O. Echt, and P. Scheier, Helium nanodroplets as an efficient tool to investigate hydrogen attachment to alkali cations. Phys. Chem. Chem. Phys. 25 (2023) 462–470; DOI: 10.1039/D2CP03841B
  4. M. Kappe, F. Calvo, J. Schöntag, H. Bettinger, S. Krasnokutski, M. Kuhn, E. Gruber, F. Zappa, P. Scheier, and O. Echt, Solvation of large polycyclic aromatic hydrocarbons in helium: Cationic and anionic hexabenzocoronene. Molecules 27 (2022) 6764 (14 pages); DOI: 10.3390/molecules27196764
  5. M. Kappe, A. Schiller, S.A. Krasnokutski, M. Ončák, P. Scheier, and E.M. Cunningham, Electronic spectroscopy of cationic adamantane clusters and dehydrogenated adamantane in helium droplets. Phys. Chem. Chem. Phys. 24 (2022) 23142–23151 (hot article); DOI: 10.1039/D2CP03523E
  6. S. Bergmeister, S. Kollotzek, F. Calvo, E. Gruber, F. Zappa, P. Scheier, and O. Echt, Adsorption of Helium and Hydrogen on Triphenylene and 1,3,5-Triphenylbenzene. Molecules 27 (2022) 4937 (13 pages); DOI: 10.3390/molecules27154937
  7. A.J. Feinberg, F. Laimer, R.M.P. Tanyag, B. Senfftleben, Y. Ovcharenko, S. Dold, M. Gatchell, S.M.O. O’Connell-Lopez, S. Erukala, C.A. Saladrigas, B.W. Toulson, A. Hoffman, B. Kamerin, R. Boll, A. De Fanis, P. Grychtol, T. Mazza, J. Montano, K. Setoodehnia, D. Lomidze, R. Hartmann, P. Schmidt, A. Ulmer, A. Colombo, M. Meyer, T. Möller, D. Rupp, O. Gessner, P. Scheier, A.F. Vilesov, X-Ray Diffractive Imaging of Highly Ionized Helium Nanodroplets. Phys. Rev. Research 4 (2022) L022063 (6 pages); DOI: 10.1103/PhysRevResearch.4.L022063
  8. S. Kollotzek, F. Izadi, M. Meyer, S. Bergmeister, F. Zappa, S. Denifl, O. Echt, P. Scheier, and E. Gruber, Stabilization of phenanthrene anions in helium nanodroplets. Phys. Chem. Chem. Phys. 24 (2022) 11662–11667; DOI: 10.1039/d2cp00991a
  9. S. Kollotzek, O. Lushchikova, L. Tiefenthaler, F. Zappa, and P. Scheier, Efficient formation of size selected clusters upon pickup of dopants into multiply charged helium droplets. Int. J. Mol. Sci. 23 (2022) 3613 (15 pages); DOI: 10.3390/jms23073613
  10. E. Gruber, S. Kollotzek, S. Bergmeister, F. Zappa, M. Ončák, P. Scheier, and O. Echt, Phenanthrene: Establishing lower and upper bounds to the binding energy of a very weakly bound anion. Phys. Chem. Chem. Phys. 24 (2022) 5138–5143; DOI: 10.1016/S0021-9673(00)88920-7
  11. P. Martini, S. Albertini, F. Laimer, M. Meyer, M. Gatchell, O. Echt, F. Zappa, and P. Scheier, Splashing of large helium nanodroplets upon surface collisions. Phys. Rev. Lett. 127 (2021) 263401, (5 pages); DOI: 10.1103/PhysRevLett.127.263401
  12. S. Kollotzek, F. Calvo, S. Krasnokutski, F. Zappa, P. Scheier, and O. Echt, Adsorption of helium on a charged propeller molecule: Hexaphenylbenzene. Eur. Phys. J. D 75 (2021) 299 (8 pages); DOI: 10.1140/epjd/s10053-021-00301-6
  13. A. Schiller, M. Meyer, P. Martini, F. Zappa, S.A. Krasnokutski, F. Calvo, and P. Scheier, Adsorption of Helium on Small Cationic PAHs: Influence of Hydrocarbon Structure on the Microsolvation Pattern. J. Phys. Chem. A 125 (2021) 7813-7824 (front cover); DOI: 10.1021/acs.jpca.1c05150
  14. F. Laimer, F. Zappa, and P. Scheier, Size and Velocity Distribution of Negatively Charged Helium Nanodroplets. J. Phys. Chem. A 125 (2021) 7662-7669; DOI: 10.1021/acs.jpca.1c05619
  15. F. Duensing, E. Gruber, P. Martini, M. Goulart, M. Gatchell, B. Rasul, O. Echt, F. Zappa, M. Mahmoodi-Darian, P. Scheier, Complexes with atomic gold ions: efficient bis-ligand formation. Molecules 26 (2021) 3484 (15 pages); DOI: 10.3390/molecules26123484
  16. M. Bartolomei, T González-Lezana, M. I. Hernández, J. Campos-Martínez, P. Martini, P. Scheier, R. Pérez de Tudela, J. Hernández-Rojas and J Bretón, Ca+ ions solvated in helium. Molecules 26 (2021) 3642 (13 pages); DOI: 10.3390/molecules26123642
  17. M. Meyer, P. Martini, A. Schiller, F. Zappa, S.A. Krasnokutski, and P. Scheier, Electronic spectroscopy of anthracene cations and protonated anthracene in the search for carriers of diffuse interstellar bands. Astrophys. J. 913 (2021) 136 (8 pages); DOI: 10.3847/1538-4357/abf93e
  18. S. Albertini, E. Gruber, F. Zappa, S. Krasnokutskiy, F. Laimer, and P. Scheier, Chemistry and Physics of Dopants Embedded in Helium Droplets. Mass Spectrom. Rev. 41 (2021) 529–567; DOI: 10.1002/mas.21699
  19. S. Kollotzek, S. Bergmeister, L. Tiefenthaler, S. Albertini, E. Gruber, F. Zappa, P. Scheier, and O. Echt, On the Stability of Neon Cluster Ions – Evidence for Isomeric Structures. Int. J. Mass Spectrom. 462 (2021) 116528 (11 pages); DOI: 10.1016/j.ijms.2021.116528
  20. F. Laimer, F. Zappa, P. Scheier, and M. Gatchell, Multiply Charged Helium Droplet Anions. Chem. Eur. J. 27 (2021), 7283-7287; DOI: 10.1002/chem.202005004
  21. S. Albertini, F. Hechenberger, S. Kollotzek, L. Tiefenthaler, P. Martini, M. Kuhn, A. Menzel, E. Jabbour Al Maalouf, H. Schöbel, M. Mahmoodi-Darian, and P. Scheier, Phosphorus cluster cations formed in doped helium nanodroplets are different. Int. J. Mass Spectrom. 459 (2021) 116472 (6 pages); DOI: 10.1016/j.ijms.2020.116472
  22. L. Tiefenthaler, S. Kollotzek, A.M. Ellis, P. Scheier, and O. Echt, Proton transfer at subkelvin temperatures. Phys. Chem. Chem. Phys. 22 (2020) 28165-28172; DOI: 10.1039/d0cp05174h
  23. L. Tiefenthaler, S. Kollotzek, M. Gatchell, K. Hansen, P. Scheier, and O. Echt, Isotope enrichment in neon clusters grown in helium nanodroplets. J. Chem. Phys. 153 (2020) 164305 (11 pages); DOI: 10.1063/5.0028056
  24. L. Tiefenthaler, M. Oncák, S. Kollotzek, J. Kocišek, and P. Scheier, Dissociation of Valine Cluster Cations. J. Phys. Chem. A 124 (2020) 8439–8445; DOI: 10.1021/acs.jpca.0c07208
  25. T. González-Lezana, O. Echt, M. Gatchell, M. Bartolomeia, J. Campos-Martínez, and P. Scheier, Solvation of ions in helium. Int. Rev. Phys. Chem. 39 (2020) 465–516; DOI: 10.1080/0144235X.2020.1794585
  26. L. Tiefenthaler, J. Kočišek, and P. Scheier, Cluster Ion Polymerization of Serine and Tryptophan, the Water Loss Channel. Eur. Phys. J. D 74 (2020) 85; DOI: 10.1140/epjd/e2020-10014-y
  27. L. Tiefenthaler, J. Ameixa, P. Martini, S. Albertini, L. Ballauf, M. Zankl, M. Goulart, F. Laimer, K. von Haeften, F. Zappa, and P. Scheier, An intense source for cold cluster ions of a specific composition. Rev. Sci. Instrum. 91 (2020) 033315; DOI: 10.1063/1.5133112
  28. L. Lundberg, P. Bartl, C. Leidlmair, P. Scheier, and M. Gatchell, Protonated and Cationic Helium Clusters. Molecules 25 (2020) 1066; DOI: 10.3390/molecules25051066
  29. M. Mahmoodi-Darian, E. Jabbour Al Maalouf, S. Zöttl, P. Scheier, and O. Echt, Electron Attachment and Electron Ionization of Helium Droplets Containing Clusters of C60 and Formic Acid. Int. J. Mass Spectrom. 450 (2020) 116293; DOI: 10.1016/j.ijms.2020.116293
  30. P. Martini, F. Hechenberger, M. Goulart, J. Zelger, P. Scheier, and M. Gatchell, Mixed cationic clusters of nitrogen and hydrogen. J. Chem. Phys. 152 (2020) 014303; DOI: 10.1063/1.5140850
  31. M. Mahmoodi-Darian, P. Martini, L. Tiefenthaler, J. Kočišek, P. Scheier, and O. Echt, Solvation of Silver Ions in Noble Gases He, Ne, Ar, Kr, and Xe. J. Phys. Chem. A 123 (2019) 10426-10436: DOI: 10.1021/acs.jpca.9b09496
  32. L. Kranabetter, N.K. Bersenkowitsch, P. Martini, M. Gatchell, M. Kuhn, F. Laimer, A. Schiller, M.K. Beyer, M. Ončák, and P. Scheier, Considerable matrix shift in the electronic transitions of helium-solvated cesium dimer cation Cs2Hen+. Phys. Chem. Chem. Phys. 21 (2019) 25362-25368, editors pick; DOI: 10.1039/c9cp04790e
  33. P. Martini, L. Kranabetter, M. Goulart, B. Rasul, M. Gatchell, P. Scheier, and O. Echt, Atomic Gold Ions Clustered with Noble Gases: Helium, Neon, Argon, Krypton, and Xenon. J. Phys. Chem. A 123 (2019) 9505-9513; DOI: 10.1021/acs.jpca.9b06715
  34. F. Laimer, L. Kranabetter, L. Tiefenthaler, S. Albertini, F. Zappa, A.M. Ellis, M. Gatchell, and P. Scheier, Highly Charged Droplets of Superfluid Helium. Phys. Rev. Lett. 123 (2019) 165301; DOI: 10.1103/PhysRevLett.123.165301
  35. M. Nihamkin, A. Kaiser, I. Nemtsov, P. Martini, P. Scheier, Y. Mastaic, and Y. Toker, Chiral recognition via abundances of mixed chiral clusters. Int. J. Mass Spectrom. 446 (2019) 116215; DOI: 10.1016/j.ijms.2019.116215
  36. M. Gatchell, P. Martini, A. Schiller, and P. Scheier, Protonated Clusters of Neon and Krypton. J. Am. Soc. Mass Spectrom. 30 (2019) 2632–2636; DOI: 10.1007/s13361-019-02329-w
  37. L. Lundberg, P. Martini, M. Goulart, M. Gatchell, D.K. Bohme, and P. Scheier, Hydrogenated Gold Clusters from Helium Nanodroplets: Cluster Ionization and Affinities for Protons and Hydrogen Molecules. J. Am. Soc. Mass Spectrom. 30 (2019) 1906–1913; DOI: 10.1007/s13361-019-02235-1
  38. J. Ortiz de Zárate, M. Bartolomei, T. González-Lezana, J. Campos-Martínez, M.I. Hernández, R. Pérez de Tudel. J. Hernández-Rojas, J. Bretón, F. Pirani, L. Kranabetter, P. Martini, M. Kuhn, F. Laimer, and P. Scheier, Snowball formation for Cs+ solvation in molecular hydrogen and deuterium. Phys. Chem. Chem. Phys. 21 (2019) 15662-15668; DOI: 10.1039/C9CP02017A
  39. P. Martini, M. Goulart, L. Kranabetter, N. Gitzl, B. Rasul, P. Scheier, and O. Echt, Charged Clusters of C60 and Au or Cu: Evidence for Stable Sizes and Specific Dissociation Channels. J. Phys. Chem. A 123 (2019) 4599-4608; DOI: 10.1021/acs.jpca.9b02768
  40. R. Pérez de Tudela, P. Martini, M. Goulart, P. Scheier, F. Pirani, J. Hernández-Rojas, J. Bretón, J. Ortiz de Zárate, M. Bartolomei, T. González-Lezana, M.I. Hernández, J. Campos-Martínez, and P. Villarreal, A combined experimental and theoretical investigation of Cs+ ions solvated in HeN clusters. J. Chem. Phys. 150 (2019) 154304; DOI: 10.1063/1.5092566
  41. M. Gatchell, P. Martini, F. Laimer, M. Goulart, F. Calvo, and P. Scheier, Spectroscopy of corannulene cations in helium nanodroplets. Faraday Discuss. 217 (2019) 276-289; DOI: 10.1039/C8FD00178B
  42. M. Mahmoodi-Darian, M.L. Lundberg, S. Zöttl, P. Scheier, and O. Echt, Electron Attachment and Electron Ionization of Formic Acid Clusters Embedded in Helium Nanodroplets. J. Am. Soc. Mass Spectrom. 30 (2019) 787–795; DOI: 10.1007/s13361-018-02124-z
  43. P. Martini, L. Kranabetter, M. Goulart, M. Kuhn, M. Gatchell, D.K. Bohme and P. Scheier, Formation of positive and negative clusters of gold atoms inside helium nanodroplets close to zero K. Int. J. Mass Spectrom. 434 (2018) 136-141; DOI: 10.1016/j.ijms.2018.09.020
  44. A. Mauracher, O. Echt, A.M. Ellis, S. Yang, D.K. Bohme, J. Postler, A. Kaiser, S. Denifl, and P. Scheier, Cold Physics and Chemistry: Collisions, Ionization and Reactions inside Helium Nanodroplets Close to Zero K. Phys. Rep. 751 (2018) 1–90; DOI: 10.1016/j.physrep.2018.05.001


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