Marcel Kwiatkowski

Marcel Kwiatkowski

Ass.-Prof. Dr. rer. nat.

Institute of Biochemistry
University of Innsbruck
Room no. L.03.013

Center for Chemistry and Biomedicine (CCB) Innrain 80-82, 6020 Innsbruck / Austria
Phone: +43 512 507 - 57527 | Fax: +43 512 507 - 57599

  Functional Proteomics and Metabolomics


*equally contributing     °corresponding author


Kwiatkowski M, Hotze M, Schumacher J, Asif AR, Pittol JMR, Brenig B, Ramljak S, Zischler H, Herlyn H. Protein speciation is likely to increase the chance of proteins to be determined in 2-DE/MS. Electrophoresis. 2022 Mar 14. Online ahead of print. PMID: 35285965.

Klont F, Horvatovich P, Bowler RP, van Rikxoort E, Charbonnier JP, Kwiatkowski M, Lynch DA, Humphries S, Bischoff R, Ten Hacken NHT, Pouwels SD. Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans. Respir Res. 2022 Jan 24;23(1):15. doi: 10.1186/s12931-022-01934-w. PMID: 35073932.

Mirzania F, Moridi Farimani M, Sarrafi Y, Nejad Ebrahimi S, Troppmair J, Kwiatkowski M, Stuppner H, Alilou M. New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism. Front Chem. 2022 Jan 20;9:783292. doi: 10.3389/fchem.2021.783292. eCollection 2021. PMID: 35127644


Cattelani C, Lesiak D, Liebscher G, Singer II, Stasyk T, Wallnöfer MH, Heberle AM, Corti C, Hess MW, Pfaller K, Kwiatkowski M, Pramstaller PP, Hicks AA, Thedieck K, Müller T, Huber LA, Eca Guimaraes de Araujo M. The SZT2 Interactome Unravels New Functions of the KICSTOR Complex. Cells. 2021 Oct 9;10(10):2711. doi: 10.3390/cells10102711. PMID: 34685691.

Russo S, Kwiatkowski M, Govorukhina N, Bischoff R, Melgert BN. Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites. Front. Immunol., doi: 10.3389/fimmu.2021.746151.

Dietze J, van Pijkeren A, Egger AS, Ziegler M, Kwiatkowski M°, Heiland I°. Natural isotope correction improves analysis of protein modification dynamics. Anal Bioanal Chem. 2021 Oct 27. doi: 10.1007/s00216-021-03732-7. Online ahead of print.

Klont F, Kwiatkowski M, Faiz A, van den Bosch T, Pouwels SD, Dekker FJ, ten Hacken NHT, Horvatovich P, Bischoff R. Adsorptive Microtiter Plates As Solid Supports in Affinity Purification Workflows. J. Proteome Res. 2021. Just accepted.

van Pijkeren A, Dietze J, Brotons AS, Egger AS, Lijster T, Barcaru A, Hotze M, Kobler P, Dekker FJ, Horvatovich P, Melgert BN, Ziegler M, Thedieck K, Heiland I, Bischoff R, Kwiatkowski M°. Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes-a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS. Anal. Chem. 2021 Sep 28;93(38):12872-12880. doi: 10.1021/acs.analchem.1c01359.

Bartkowiak K, Heidrich I, Kwiatkowski M, Banys-Paluchowski M, Andreas A, Wurlitzer M, Geffken M, Voß H, Zeller T, Blankenberg S, Peine S, Joosse SA, Müller V, Schlüter H, Oliveira-Ferrer L, Pantel K. Circulating Cellular Communication Network Factor 1 Protein as a Sensitive Liquid Biopsy Marker for Early Detection of Breast Cancer. Clin. Chem. 2021 Aug 30;hvab153. doi: 10.1093/clinchem/hvab153.

Sánchez Brotons A, Eriksson JO, Kwiatkowski M, Wolters JC, Kema IP, Barcaru A, Kuipers F, Bakker SJL, Bischoff R, Suits F, Horvatovich P. Pipelines and Systems for Threshold-Avoiding Quantification of LC-MS/MS Data. Anal. Chem. 2021, 93, 32, 11215–11224. doi: 10.1021/acs.analchem.1c01892. PMID: 34355890.

Hofmann BT, Picksak AS, Kwiatkowski M, Grupp K, Jücker M, Bachmann K, Mercanoglu B, Izbicki JR, Kahlert C, Bockhorn M, Güngör C, Ewald F, Wolters-Eisfeld G. Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer. Glycobiology. 2021 Aug 18;cwab088. doi: 10.1093/glycob/cwab088. PMID: 34420045. Online ahead of print.

Orfanoudaki M, Hartmann A, Alilou M, Mehic N, Kwiatkowski M, Jöhrer K, Nguyen Ngoc H, Hensel A, Greil R, Ganzera M. Cytotoxic Compounds of Two Demosponges (Aplysina aerophoba and Spongia sp.) from the Aegean Sea. Biomolecules. 2021 May; 11(5): 723. Published online 2021 May 12. doi: 10.3390/biom11050723.

Rauch J, Barton J, Kwiatkowski M, Wunderlich M, Steffen P, Moderzynski K, Papp S, Höhn K, Schwanke H, Witt S, Richardt U, Mehlhoop U, Schlüter H, Pianka V, Fleischer B, Tappe D, Osterloh A. GroEL is an immunodominant surface-exposed antigen of Rickettsia typhi. PLoS One. 2021 Jun 10;16(6):e0253084. doi: 10.1371/journal.pone.0253084. eCollection 2021. PMID: 3411121

Heikaus L, Hidayah S, Gaikwad M, Kotasinska M, Richter V, Kwiatkowski M, Schlüter H. Sample Displacement Batch Chromatography of Proteins. Methods Mol Biol. 2021;2178:285-299. doi: 10.1007/978-1-0716-0775-6_19. PMID: 33128756

Senatore E, Chiuso F, Rinaldi L, Intartaglia D, Delle Donne R, Pedone E, Catalanotti B, Pirone L, Fiorillo B, Moraca F, Giamundo G, Scala G, Raffeiner A, Torres-Quesada O, Stefan E, Kwiatkowski M, van Pijkeren A, Morleo M, Franco B, Garbi C, Conte I, Feliciello A. EMBO J. 2021 May 2:e106503. doi: 10.15252/embj.2020106503.

Bartkowiak K, Heidrich I, Kwiatkowski M, Gorges TM, Andreas A, Geffken M, Verpoort K, Müller V, Schlüter H, Pantel K. Cysteine-Rich Angiogenic Inducer 61: Pro-Survival Function and Role as a Biomarker for Disseminating Breast Cancer Cells. Cancers (Basel). 2021 Feb 2;13(3):563. doi: 10.3390/cancers13030563.


Heikaus L, Hidayah S, Gaikwad M, Kotasinska M, Richter V, Kwiatkowski M, Schlüter H. Sample Displacement Batch Chromatography of Proteins. Methods Mol Biol. 2021;2178:285-299. PMID: 33128756 

Kwiatkowski M, Asifb AR, Schumacher J, Brenig B, Zischler H, Herlyn H. Intra-Protein Coevolution Is Increasingly Functional with Greater Proximity to Fertilization – Assessing the Share of Functional Coevolution inside Proteins. Cytogenetic and Genome Research. 2020;160(6):295-308. PMID: 32683365. 

Wegrzyn AB, Herzog K, Gerding A, Kwiatkowski M, Wolters JC, Dolga AM, van Lint AEM, Wanders RJA, Waterham HR, Bakker BM. Fibroblast-specific genome-scale modelling predicts an imbalance in amino acid metabolism in Refsum disease. FEBS J. 2020 Mar 11. PMID: 32160399.


van Pijkeren A, Bischoff R, Kwiatkowski M°. Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture. Analyst. 2019 Nov 18;144(23):6812-6833

Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, Jähn K, Long C, Schlüter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, Wijnen A, Mohammad K, Guise T, Taipaleenmäki H, Hesse E. TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone. Nat Commun. 2019 Mar 22;10(1):1354.

Krutilin A, Maier S, Schuster R, Kruber S, Kwiatkowski M, Robertson WD, Hansen NO, Miller RJD, Schlüter H. Sampling of Tissues with Laser Ablation for Proteomics: Comparison of Picosecond Infrared Laser and Microsecond Infrared Laser. J Proteome Res. 2019 Jan 29; 18(3):1451-1457.

Hänel L, Kwiatkowski M, Heikaus L, Schlüter H. Mass spectrometry-based intraoperative tumor diagnostics. Future Science OA. 2019; Vol. 5 No. 3


Kwiatkowski M, Krösser D, Wurlitzer M, Steffen P, Barcaru A, Krisp C, Horvatovich P, Bischoff R, Schlüter H. Application of Displacement Chromatography to Online Two-Dimensional Liquid Chromatography Coupled to Tandem Mass Spectrometry Improves Peptide Separation Efficiency and Detectability for the Analysis of Complex Proteomes. Anal Chem. 2018 Aug 21;90(16):9951-9958.

Pouwels SD, Klont F, Kwiatkowski M, Wiersma VR, Faiz A, van den Berge M, Horvatovich P, Bischoff R, Ten Hacken NHT. Cigarette Smoking Acutely Decreases Serum Levels of the Chronic Obstructive Pulmonary Disease Biomarker sRAGE. Am J Respir Crit Care Med. 2018 Dec 1;198(11):1456-1458.


Gleißner L*, Kwiatkowski M*, Myllynen L, Steffen P, Petersen C, Rothkamm K, Schlüter H, Kriegs M. Analyzing the influence of kinase inhibitors on DNA repair by differential proteomics of chromatin-interacting proteins and nuclear phospho-proteins. Oncotarget. 2017 Nov 10;8(67):110983-110993.

van den Bosch T, Kwiatkowski M, Bischoff R, Dekker FJ. Targeting transcription factor lysine acetylation in inflammatory airway diseases. Epigenomics. 2017; 9(7) 1013-1028.

Georgieva D, Hildebrand D, Simas R, Coronado MA, Kwiatkowski M, Schlüter H, Arni R, Spencer P, Betzel C. Protein profile analysis of two Australian snake venoms by one-dimensional gel electrophoresis and MS/MS experiments. Curr Med Chem. 2017, doi: 10.2174/0929867324666170601073148.

Rösch K, Kwiatkowski M, Schlüter H, Herker E. Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis. J Vis Exp. 2017 Apr 17;(122).


Rösch K, Kwiatkowski M, Hofmann S, Schöbel A, Grüttner C, Wurlitzer M, Schlüter H, Herker E. Quantitative Lipid Droplet Proteome Analysis Identifies Annexin A3 as a Cofactor for HCV Particle Production. Cell Rep. 2016 Sep 20;16(12):3219-31.

Kwiatkowski M, Wurlitzer M, Kiani P, Nimer R, Omidi M, Bußmann T, Bartkowiak K, Kruber S, Uschold S, Steffen P, Lübberstedt J, Küpker N, Petersen H, Knecht R, Hansen NO, Robertson WD, Miller RJD, Schlüter H. Homogenization of human tissues via picosecond-infrared laser (PIRL) ablation: Giving a closer view on the in-vivo composition of protein species as compared to mechanical homogenization. J Proteomics. 2016. 134:193-202

Steffen P, Kwiatkowski M, Robertson WD, Zarrine-Afsar A, Deterra D, Richter V, Schlüter H. Protein species as diagnostic markers. J Proteomics. 2016; 134:5-18.

Szameit K, Berg K, Kruspe S, Valentini E, Magbanua E, Kwiatkowski M, Chauvot de Beauchêne I, Krichel B, Schamoni K, Uetrecht C, Svergun DI, Schlüter H, Zacharias M, Hahn U. Structure and target interaction of a G-quadruplex RNA-aptamer. RNA Biol. 2016; 13(10):973-987.

Petersen H, Tavakoli F, Kruber S, Münscher A, Gliese A, Hansen NO, Uschold S, Eggert D, Robertson WD, Gosau T, Sehner S, Kwiatkowski M, Schlüter H, Schumacher U, Knecht R, Miller RJ. Comparative study of wound healing in rat skin following incision with a novel picosecond infrared laser (PIRL) and different surgical modalities. Lasers Surg Med. 2016; 48(4):385-91.


Kwiatkowski M, Wurlitzer M, Omidi M, Ling R, Kruber S, Nimer R, Robertson W, Horst A, Miller RJ Dwayne, Schlüter H. Ultrafast extraction of proteins from tissues using desorption by impulsive vibrational excitation. Angew Chem Int Ed Engl. 2015;54(1):285-8.

Myllynen L*, Kwiatkowski M*, Gleißner L, Riepen B, Hoffer K, Wurlitzer M, Petersen C, Dikomey E, Rothkamm K, Schlüter H, Kriegs M. Quantitative proteomics unveiled: Regulation of DNA double strand break repair by EGFR involves PARP1. Radiotherapy and Oncology. 2015;116(3):423-30.

Bartkowiak K, Kwiatkowski M, Buck F, Gorges T. M, Nilse L, Assmann V, Andreas A, Müller V, Wikman H, Riethdorf S, Schlüter H., Pantel K. Disseminated tumor cells persist in the bone marrow of breast cancer patients through sustained activation of the unfolded protein response. Cancer Res. 2015 Dec 15;75(24):5367-77.

Schulze J, Kwiatkowski M, Borner J, Schlüter H, Bruchhaus I, Burmester T, Spielmann T, Pick C. The Plasmodium falciparum exportome contains non-canonical PEXEL/HT proteins: PEXEL/HT plasticity. Molecular Microbiology. 2015; 97(2):301-14.

Tiedke J, Borner J, Beeck H, Kwiatkowski M, Schmidt H, Thiel R, Fabrizius A, Burmester T. Evaluating the Hypoxia Response of Ruffe and Flounder Gills by a Combined Proteome and Transcriptome Approach. PLoS ONE. 2015; 10(8):e0135911.


Christner M, Trusch M, Rohde H, Kwiatkowski M, Schlüter H, Wolters M, Aepfelbacher M, Hentschke M. Rapid MALDI-TOF mass spectrometry strain typing during a large outbreak of Shiga-Toxigenic Escherichia coli. PLoS One. 2014; 9(7):e101924.

Steurer S, Singer JM, Rink M, Chun F, Dahlem R, Simon R, Burandt E, Stahl P, Terracciano L, Schlomm T, Wagner W, Höppner W, Omidi M, Kraus O, Kwiatkowski M, Doh O, Fisch M, Soave A, Sauter G, Wurlitzer M, Schlüter H, Minner S. MALDI imaging-based identification of prognostically relevant signals in bladder cancer using large-scale tissue microarrays. Urol Oncol. 2014;32(8):1225-33.

Munawar A, Trusch M, Georgieva D, Hildebrand D, Kwiatkowski M, Behnken H, Harder S, Arni R, Spencer P, Schlüter H, Betzel C. Elapid snake venom analyses show the specificity of the peptide composition at the level of genera Naja and Notechis. Toxins (Basel). 2014 ;6(3):850-68.

Kotasinska M, Richter V, Kwiatkowski M, Schlüter H. Sample displacement batch chromatography of proteins Methods Mol Biol. 2014;1129:325-38. doi: 10.1007/978-1-62703-977-2_24.


Quaas A, Bahar AS, von Loga K, Seddiqi AS, Singer JM, Omidi M, Kraus O, Kwiatkowski M, Trusch M, Minner S, Burandt E, Stahl P, Wilczak W, Wurlitzer M, Simon R, Sauter G, Marx A, Schlüter H. MALDI imaging on large-scale tissue microarrays identifies molecular features associated with tumour phenotype in oesophageal cancer. Histopathology. 2013;63(4):455-62.

Steurer S, Borkowski C, Odinga S, Buchholz M, Koop C, Huland H, Becker M, Witt M, Trede D, Omidi M, Kraus O, Bahar AS, Seddiqi AS, Singer JM, Kwiatkowski M, Trusch M, Simon R, Wurlitzer M, Minner S, Schlomm T, Sauter G, Schlüter H. MALDI mass spectrometric imaging based identification of clinically relevant signals in prostate cancer using large-scale tissue microarrays. Int J Cancer. 2013; 133(4):920-8.

Marxen JC, Pick C, Kwiatkowski M, Burmester T. Molecular characterization and evolution of haemocyanin from the two freshwater shrimps Caridina multidentata (Stimpson, 1860) and Atyopsis moluccensis (De Haan, 1849). J Comp Physiol B. 2013; 183(5):613-24.


Trusch M, Tillack K, Kwiatkowski M, Bertsch A, Ahrends R, Kohlbacher O, Martin R, Sospedra M, Schlüter H. Displacement chromatography as first separating step in online two-dimensional liquid chromatography coupled to mass spectrometry analysis of a complex protein sample--the proteome of neutrophils. J Chromatogr A. 2012; 1232:288-94.

Ahrends R, Lichtner B, Buck F, Hildebrand D, Trusch M, Kotasinska M, Kohlbacher O, Kwiatkowski M, Wagner M, Trusch M, Schlüter H. Comparison of displacement versus gradient mode for separation of a complex protein mixture by anion-exchange chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2012; 901:34-40.

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