Institute of Biochemistry

Head:
Priv.-Doz. Dr. Eduard STEFAN

Administrative Manager:
Gabriele Reiter

Contact:
Institute of Biochemistry
University of Innsbruck
Center for Chemistry and Biomedicine (CCB)
Innrain 80-82, A-6020 Innsbruck, Austria 

T +43 512 507 57501
F +43 512 507 57599
biochemistry@uibk.ac.at
www.uibk.ac.at/biochemistry 

ccb4



Research Interest

Analyzing & Perturbing Pathological Protein Functions

We are investigating the functional role of oncoproteins & tumor-suppressors such as transcription factors (MYC:MAX or AP1 interactions), kinases (RAF:RAS interactions), and phosphatases (PP2A) in normal cell growth and in tumorigenesis. ... more » 

Systematic Quantifications of Molecular Interactions & Modifications

Cancer or neurodegenerative diseases can be thought of as pathological alterations of molecular interactions. We analyze molecular interactions which are relevant for physiological and pathological cellular communication (GPCR, MID1, RAF, PKA, PP2A, kinase scaffolds). ... more » 

Cell-based Biotechnology

We apply unique biotechnological approaches to study defined molecular interactions in distinct cellular settings (protein-fragment complementation assays [PCA]) and for novel expression/selection systems for downstream processing in the bacterial cell system (ACIB; NPro technology). ... more » 



Recent Publications

Myc and Ca2+/CaM signaling
... more » Oncotarget 8, 3327-3343 (2017)

Orphan receptor with kinase scaffolding function
... more » Proc. Natl. Acad. Sci. USA 113, 7786-7791 (2016)



 

This lab is a member of the CMBI