Alexander Heberle

Alexander Martin Heberle, PhD

Junior Group Leader, Post-Doctoral Researcher


Institute of Biochemistry
University of Innsbruck
Room no. L.03.032


Center for Chemistry and Biomedicine (CCB) Innrain 80-82, 6020 Innsbruck / Austria
Phone: +43 512 507 - 57521 | Fax: +43 512 507 - 57599
Email: Alexander.Heberle@uibk.ac.at



Publications 

Fricke AL, Mühlhäuser WWD, Reimann L, Zimmermann JP, Reichenbach C, Knapp B, Peikert CD, Heberle AM, Faessler E, Schäuble S, Hahn U, Thedieck K, Radziwill G, Warscheid B. Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes. J Proteome Res. 2023 Mar 3;22(3):768-789. doi: 10.1021/acs.jproteome.2c00505.

Abdellatif M, Eisenberg T, Heberle AM, Thedieck K, Kroemer G, Sedej S. Cardiac PI3K p110α attenuation delays aging and extends lifespan. 2022, Cell Stress, Vol. 6, No. 8, pp. 72 - 75; doi: 10.15698/cst2022.08.270 

Zhang Y, Dreyer B, Govorukhina N, Heberle AM, Končarević S, Krisp C, Opitz CA, Pfänder P, Bischoff R, Schlüter H, Kwiatkowski M, Thedieck K, Horvatovich PL. Comparative assessment of quantification methods for tumor tissue phosphoproteomics. 2021, PMID: 35880733, Anal Chem. DOI: 10.1021/acs.analchem.2c01036

Abdellatif M, Trummer-Herbst V, Heberle AM, Humnig A, Pendl T, Durand S, Cerrato G, Hofer SJ, Islam M, Voglhuber J, Ramos Pittol JM, Kepp O, Hoefler G, Schmidt A, Rainer PP, Scherr D, Von Lewinski D, Bisping E, McMullen JR, Diwan A, Eisenberg T, Madeo F, Thedieck K, Kroemer G, Sedej S. Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity. 2021, PMID: 35616058, Circulation, DOI: 10.1161/CIRCULATIONAHA.122.059863 

Cattelani C, Lesiak D, Liebscher G, Singer II, Stasyk T, Wallnöfer MH, Heberle AM, Corti C, Hess MW, Pfaller K, Kwiatkowski M, Pramstaller PP, Hicks AA, Thedieck K, Müller T, Huber LA, Guimaraes de Araujo ME, The SZT2 Interactome Unravels New Functions of the KICSTOR Complex. Cells 10 (10), 271, 1. https://doi.org/10.3390/cells10102711

Rehbein U, Prentzell MT,Cadena Sandoval M, Heberle AM, Henske EP, Opitz CA, Thedieck K. The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back. Frontiers in Cell and Developmental Biology, 3005, https://doi.org/10.3389/fcell.2021.751892 

Cadena Sandoval M*, Heberle AM*, Rehbein U, Barile C, Ramos Pittol, JM, Thedieck K. mTORC1 crosstalk with stress granules in aging and age-related diseases. Frontiers in Aging. 2021 September 28. DOI: 10.3389/fragi.2021.761333

Klionsky DJ, … Heberle AM … . Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2021 Feb 8. doi: 10.1080/15548627.2020.1797280

Heberle AM*, Rehbein U*, Rodriguez Peiris M*, Thedieck K. Finding new edges: systems approaches to MTOR signaling. Biochem Soc Trans. 2021 Feb 5; doi: 10.1042/BST20190730

Prentzell MT, Rehbein U, Cadena Sandoval M, De MeulemeesterAS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, CDemetriades C, Figlia G, Genomics England Research Consortium, Guimaraesde Araujo ME, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell. 2021 Feb 4; doi: 10.1016/j.cell.2020.12.024 

Heberle AM*, Razquin Navas P*, Langelaar-Makkinje M, Kasack K, Sadik A, Faessler E, Hahn U, Marx-Stoelting P, Opitz CA, Sers C, Heiland I§, Schäuble S§, Thedieck K§. The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner. Life Sci Alliance. 2019 Mar 28;2(2). 

Diosa-Toro M, Troost B, van de Pol D, Heberle AM, Urcuqui-Inchima S, Thedieck K, Smit JM. Tomatidine, a novel antiviral compound towards dengue virus. Antiviral Res. 2019 Jan;161:90-99.

Shafiee Kamalabad M, Heberle AM, Thedieck K, Grzegorczyk M. Partially non-homogeneous dynamic Bayesian networks based on Bayesian regression models with partitioned design matrices. Bioinformatics. 2018 Nov 5.

Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MATM, Baumeister R, Hansen M, Thedieck K§. Polo-like kinase 1 inhibits mTOR complex 1 and promotes autophagy Autophagy. 2017 Jan 19:0. doi: 10.1080/15548627.2016.1263781. (IF 11.958)

Dalle Pezze P*, Ruf S*, Sonntag AG*, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tölle RC, Schwarz JJ, Horvatovich P, Fäßler E, Schäuble S, Hahn U, Shanley DP§,
Thedieck K§. A systems study reveals concurrent activation of AMPK and mTOR by amino acids. Nature Communications. 2016 Nov 21; 7: 13254. (IF 12.001)

Heberle AM, Prentzell MT, van Eunen K, Bakker BM, Grellscheid SN, Thedieck K§. Molecular mechanisms of mTOR regulation by stress. Molecular and Cellular Oncology. 2014 Dec 3;2(2):e970489.

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