| Selected Review Articles | Selected Clinical Trials



Selected Review Articles


Bernkop-Schnürch A. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems. Int J Pharm (2000) 194(1):1-13.

Bernkop-Schnürch A. Thiomers: A new generation of mucoadhesive polymers. Adv Drug Deliv Rev (2004) 57(11):1569-82.

Bernkop-Schnürch A., Krauland A.H., Leitner V.M., Palmberger T. Thiomers: potential excipients for non-invasive peptide delivery systems. Eur J Pharm Biopharm. (2004) Sep;58(2):253-63.

Albrecht K. and Bernkop-Schnürch A. Thiomers: forms, functions and applications to nanomedicine. Nanomedicine (Future Medicine journal) (2007) Feb;2(1):41-50.

Jere D., Arote R., Jiang H.L., Kim Y.K., Cho M.H., Cho C.S., Bioreducible polymers for efficient gene and siRNA delivery. Biomed Mater. (2009) 4(2):025020.

Bonengel S, Bernkop-Schnürch A. Thiomers—from bench to market. J Control Release. (2014) Dec 10;195:120-9.

Wirostko B., Mann B.K., Williams D.L., Prestwich G.D., Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel. Adv Wound Care (New Rochelle). (2014) 3(11):708-716.

Islam M.A., Park T.E., Reesor E., Cherukula K., Hasan A., Firdous J., Singh B., Kang S.K., Choi Y.J., Park I.K., Cho C.S. Mucoadhesive chitosan derivatives as novel drug carriers. Curr Pharm Des. (2015) 21(29):4285-309.

Ijaz M, Bernkop-Schnürch A. Preactivated thiomers: their role in drug delivery. Expert Opin Drug Deliv. (2015) Aug;12(8):1269-81.

Shah K.U., Shah S.U., Dilawar N., Khan G.M., Gibaud S., Thiomers and their potential applications in drug delivery. Expert Opin Drug Deliv. (2017) 14(5):601-610.

Duggan S., Cummins W., O' Donovan O., Hughes H., Owens E., Thiolated polymers as mucoadhesive drug delivery systems. Eur J Pharm Sci. (2017) 100:64-78.

Schattling P., Taipaleenmäki E., Zhang Y., Städler B., A polymer chemistry point of view on mucoadhesion and mucopenetration. Macromol Biosci. (2017) 17(9).

Griesser J., Hetényi G., Bernkop-Schnürch A., Thiolated Hyaluronic Acid as Versatile Mucoadhesive Polymer: From the Chemistry Behind to Product Developments—What Are the Capabilities?  Polymers (2018) 10(3):243


Selected Clinical Trials


Hornof M., Weyenberg W., Ludwig A. and Bernkop-Schnürch A., Mucoadhesive ocular insert based on thiolated poly(acrylic acid): development and in vivo evaluation in humans. J. Control. Release (2003) 89(3):419-28. (2009) Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers

Assessment of Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Subjects While Wearing Contact Lenses and Before Insertion of Contact Lenses; (2011) 

 Local Tolerability of Chitosan-N-acetylcysteine; (2011)  

Hoeller S, Hornof M, Schmetterer L and Garhoefer G, Safety and tolerability of chitosan-N-acetylcysteine eye drops in healthy young volunteers. Investig. Ophtalmol. Visual Sci. 52 (2011) 3841. (2012) Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy (2012) Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation

Samprasit W, Kaomongkolgit R, Sukma M, Rojanarata T, Ngawhirunpat T, Opanasopit P. Mucoadhesive electrospun chitosan-based nanofibre mats for dental caries prevention. Carbohydr Polym. (2015) Mar 6;117:933-40. doi: 10.1016/j.carbpol.2014.10.026.

Kassem AA, Issa DA, Kotry GS, Farid RM. Thiolated alginate-based multiple layer mucoadhesive films of metformin for intra-pocket local delivery: in vitro characterization and clinical assessment. Drug Dev. Ind. Pharm. (2017) Jan;43(1):120-131.

Schmidl D, Werkmeister R, Kaya S, Unterhuber A, Witkowska KJ, Baumgartner R, Höller S, O'Rourke M, Peterson W, Wolter A, Prinz M, Schmetterer L, Garhöfer G., A Controlled, Randomized Double-Blind Study to Evaluate the Safety and Efficacy of Chitosan-N-Acetylcysteine for the Treatment of Dry Eye Syndrome. J. Ocul. Pharmacol. Ther., (2017) Jun;33(5):375-382.

Cagini C, Torroni G, Fiore T, Cerquaglia A, Lupidi M, Aragona and Iaccheri B. Tear film stability in Sjögren syndrome patients treated with hyaluronic acid versus crosslinked hyaluronic acid-based eye drops. J. Ocul. Pharmacol. Ther., 33 (2017) 539-542.

Messina M, Dua HS, Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology. Int. Ophthalmol. (2018) Mar 16. doi: 10.1007/s10792-018-0843-0.

Lorenz K, Garhofer G, Hoeller S, Peterson W, Vielnascher RM, Schoenfeld, ZI, Prinz M. Long-term management of dry eye by once-daily use of Chitosan-N-Acetylcysteine (Lacrimera®) eye drops. Journal of Clinical Ophthalmology, 2 (2018) 47-54.

Durrie DS, Wolsey D, Thompson V, Assang C, Mann B, Wirostko B. Ability of a new crosslinked polymer ocular bandage gel to accelerate reepithelialization after photorefractive keratectomy. J Cataract Refract Surg. (2018) Mar;44(3):369-375. doi: 10.1016/j.jcrs.2018.01.018.

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