Thiomers


| Selected Review Articles | Selected Clinical Trials

 


 

Selected Review Articles

 

Bernkop-Schnürch A. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems. Int J Pharm 2000;194(1):1-13.

Bernkop-Schnürch A. Thiomers: A new generation of mucoadhesive polymers. Adv Drug Deliv Rev 2004;57(11):1569-82.

Bernkop-Schnürch A., Krauland A.H., Leitner V.M., Palmberger T. Thiomers: potential excipients for non-invasive peptide delivery systems. Eur J Pharm Biopharm. 2004 Sep;58(2):253-63.

Albrecht K. and Bernkop-Schnürch A. Thiomers: forms, functions and applications to nanomedicine. Nanomedicine (Future Medicine journal) 2007 Feb;2(1):41-50.

Jere D., Arote R., Jiang H.L., Kim Y.K., Cho M.H., Cho C.S., Bioreducible polymers for efficient gene and siRNA delivery. Biomed Mater. 2009; 4(2):025020.

Bonengel S, Bernkop-Schnürch A. Thiomers—from bench to market. J Control Release. 2014 Dec 10;195:120-9.

Wirostko B., Mann B.K., Williams D.L., Prestwich G.D., Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel. Adv Wound Care (New Rochelle). 2014, 3(11):708-716.

Islam M.A., Park T.E., Reesor E., Cherukula K., Hasan A., Firdous J., Singh B., Kang S.K., Choi Y.J., Park I.K., Cho C.S. Mucoadhesive chitosan derivatives as novel drug carriers. Curr Pharm Des. 2015; 21(29):4285-309.

Ijaz M, Bernkop-Schnürch A. Preactivated thiomers: their role in drug delivery. Expert Opin Drug Deliv. 2015 Aug;12(8):1269-81.

Shah K.U., Shah S.U., Dilawar N., Khan G.M., Gibaud S., Thiomers and their potential applications in drug delivery. Expert Opin Drug Deliv. 2017; 14(5):601-610.

Duggan S., Cummins W., O' Donovan O., Hughes H., Owens E., Thiolated polymers as mucoadhesive drug delivery systems. Eur J Pharm Sci. 2017; 100:64-78.

Schattling P., Taipaleenmäki E., Zhang Y., Städler B., A polymer chemistry point of view on mucoadhesion and mucopenetration. Macromol Biosci. 2017; 17(9).


Selected Clinical Trials

 

Hornof M., Weyenberg W., Ludwig A. and Bernkop-Schnürch A., Mucoadhesive ocular insert based on thiolated poly(acrylic acid): development and in vivo evaluation in humans. J. Control. Release 2003, 89(3):419-28.

Local Tolerability of Chitosan-N-acetylcysteine;  https://clinicaltrials.gov/ct2/show/NCT01278784?term=chitosan&rank=4  

Assessment of Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Subjects While Wearing Contact Lenses and Before Insertion of Contact Lenses;  https://clinicaltrials.gov/ct2/show/NCT01747616?term=chitosan&draw=2&rank=15 

https://clinicaltrials.gov/ct2/show/NCT01753752?term=chitosan&draw=4&rank=26 Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation

https://clinicaltrials.gov/ct2/show/NCT01015209?term=chitosan&draw=3&rank=17 Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers

https://clinicaltrials.gov/ct2/show/NCT01887873?term=hyaluronan&rank=12 Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy Safety of Hyaluronan Thiomer i.o. Implant During Combined Phacoemulsification - Non Penetrating Deep Sclerectomy

Schmidl D, Werkmeister R, Kaya S, Unterhuber A, Witkowska KJ, Baumgartner R, Höller S, O'Rourke M, Peterson W, Wolter A, Prinz M, Schmetterer L, Garhöfer G., A Controlled, Randomized Double-Blind Study to Evaluate the Safety and Efficacy of Chitosan-N-Acetylcysteine for the Treatment of Dry Eye Syndrome. J. Ocul. Pharmacol. Ther., 2017 Jun;33(5):375-382.

Samprasit W, Kaomongkolgit R, Sukma M, Rojanarata T, Ngawhirunpat T, Opanasopit P. Mucoadhesive electrospun chitosan-based nanofibre mats for dental caries prevention. Carbohydr Polym. 2015 Mar 6;117:933-40. doi: 10.1016/j.carbpol.2014.10.026.

Kassem AA, Issa DA, Kotry GS, Farid RM., Thiolated alginate-based multiple layer mucoadhesive films of metformin for intra-pocket local delivery: in vitro characterization and clinical assessment. Drug Dev. Ind. Pharm. 2017 Jan;43(1):120-131.