Andreas Bernkop-Schnürch

Univ.-Prof. Mag. pharm. Dr. rer. nat.

Head

E-Mail: Andreas.Bernkop@uibk.ac.at
Phone: +43 512 507-58600
Fax: +43 512 507-58699
Bernkop 

Original Papers and Congress Contributions:

Original Research Articles:

  1. Bernkop-Schnürch, A.; Dünnhaupt, S. (2012). Chitosan based drug delivery systems. Eur. J. Pharm. Biopharm., 81, 463-469.
  2. Boonpisuttinant, K.; Manosroi, A.; Rahmat, D.; Manosroi, J. (2012). In Vitro Intestinal Membrane Permeation Enhancement of Thai Anti-Cancer Recipe Aqueous Extracts Loaded inThiolated-Chitosan Nanoparticles. Adv. Sci. Lett. 16, 183-192.
  3. Dünnhaupt, S.; Barthelmes, J.; Iqbal, J.; Perera, G.; Thurner, C.C.; Friedl, H.; Bernkop-Schnürch, A. (2012). In vivo evaluation of an oral drug delivery system for peptides based on S-protected thiolated chitosan. J. Control. Rel., 160, 477-485.
  4. Dünnhaupt, S.; Barthelmes, J.; Rahmat, D.; Leithner, K.; Thurner, C.C.; Friedl, H.; Bernkop-Schnürch, A. (2012). S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: Evaluation of permeation enhancing and efflux pump inhibitory properties. Mol. Pharm., 9(5), 1331-1341.
  5. Dünnhaupt, S.; Barthelmes, J.; Thurner, C.C.; Waldner, C.; Sakloetsakun, D.; Bernkop-Schnürch, A. (2012). S-protected thiolated chitosan: synthesis and in vitro characterization. Carbohydr Polym., 90(2), 765-772.
  6. Erb, R.; Leithner, K.; Bernkop-Schnürch, A.; Oberacher, H. (2012). Phosphorothioate Oligonucleotide Quantification by μ-Liquid Chromatography-Mass Spectrometry. AAPS Journal, 14(4), 728-737.
  7. Gradauer, K.; Vonach, C.; Leitinger, G.; Kolb, D.; Fröhlich, E.; Roblegg, E.; Bernkop-Schnürch, A.; Prassl, R. (2012). Chemical coupling of thiolated chitosan to preformed liposomes improves mucoadhesive properties. Int. J. Nanomedicine, 7, 2523-2534.
  8. Hauptstein, S.; Bernkop-Schnürch, A. (2012). Thiomers and thiomer-based nanoparticles in protein and DNA drug delivery. Expert Opinion Drug Deliv., 9(9), 1069-1081.
  9. Hintzen, F.; Laffleur, F.; Sakloetsakun, D.; Leithner, K.; Bernkop-Schnürch, A. (2012). In situ gelling properties of anionic thiomers. Drug Dev. Ind. Pharm., 38 (12), 1479-1485.
  10. Hintzen, F.; Laffleur, F.; Sarti, F.; Shahnaz, G.; Bernkop-Schnürch, A. (2012). Thiomers: Influence of molar mass on in situ gelling properties. Int. J. Pharm., 436, 120-126.
  11. Iqbal, J.; Shahnaz, G.; Dünnhaupt, S.; Müller, C.; Hintzen, F.; Bernkop-Schnürch, A. (2012). Preactivated thiomers as mucoadhesive polymers for drug delivery. Biomaterials, 33, 1528-1535.
  12. Iqbal, J.; Shahnaz, G.; Perera, G.; Hintzen, F.; Sarti, F.; Bernkop-Schnürch, A. (2012). Thiolated chitosan: Development and in vivo evaluation of an oral delivery system for leuprolide. Eur. J. Pharm. Biopharm., 80, 95-102.
  13. Laffleur, F.; Bernkop-Schnürch, A. (2012). Thiomers: promising platform for macromolecular drug delivery. Future Med. Chem. 4(17), 2205-2216.
  14. Rahmat, D.; Khan, M.I.; Shahnaz, G.; Sakloetsakun, D.; Perera, G.; Bernkop-Schnürch, A. (2012). Synergistic effects of conjugating cell penetrating peptides and thiomers.
    On non-viral transfection efficiency. Biomaterials, 33, 2321-2326.
  15. Rahmat, D.; Sakloetsakun, D.; Shahnaz, G.; Sarti, F.; Laffleur, F.; Bernkop-Schnürch, A. (2012). HEC-cysteamine conjugates: Influence of degree of thiolation on efflux pump inhibitory and permeation enhancing properties. Int. J. Pharm., 422, 40-46.
  16. Sakloetsakun, D.; Dünnhaupt, S.; Barthelmes, J.; Pfaller, W.; Bernkop-Schnürch, A. (2012). In situ crosslinkable thiolated chitosan as scaffold material for tissue engineering. Adv. Mat. Res., 506, 335-338.
  17. Sarti, F.; Iqbal, J.; Müller, C.; Shahnaz, G.; Rahmat, D.; Bernkop-Schnürch, A. (2012). Poly(acrylic acid)-cysteine for oral vitamin B12 delivery. Anal. Biochem., 420, 13-19.
  18. Shahnaz, G.; Iqbal, J.; Rahmat, D.; Perera, G.; Laffleur, F.; Rossi, D.; Bernkop-Schnürch, A. (2012). Development and in vivo characterization of a novel peptide drug delivery system providing extended plasma half life. J. Control. Rel., 157, 375-382.
  19. Shahnaz, G.; Vetter, A.; Barthelmes, J.; Rahmat, D.; Laffleur, F.; Iqbal, J.; Perera, G.; Schlocker, W.; Dünnhaupt, S.; Augustijns, P.; Bernkop-Schnürch, A. (2012). Thiolated chitosan nanoparticles for the nasal administration of leuprolide: Bioavailability and pharmacokinetic characterization. Int. J. Pharm., 428, 164-170.
  20. Solhi, L.; Schönbichler, S.A.; Dünnhaupt, S.; Barthelmes, J.; Friedl, H.; Huck, C.W.; Bernkop-Schnürch, A. (2012). Synthesis and In Vitro Characterization of a Preactivated Thiomer via Polymerization Reaction. Biomacromolecules, 13(10), 3054-3063.
  21. Vetter, A.; Augustijns, P.; Bernkop-Schnürch, A. (2012). Solubilizing agents in nasal formulations and their effect on ciliary beat frequency. Toxicol. in vitro, 26, 150-156.
  22. Wang, X.; Iqbal, J.; Rahmat, D.; Bernkop-Schnürch, A. (2012). Preactivated thiomers: Permeation enhancing properties. Int. J. Pharm., 438, 217-224.
  23. Baloglu, E.; Ay Senyıgıt, Z.; Karavana, S.Y.; Vetter, A.; Metın, D.Y.; Hilmioglu Polat, S.; Guneri, T.; Bernkop-Schnürch, A. (2011). In vitro evaluation of mucoadhesive vaginal tablets of antifungal drugs prepared with thiolated polymer and development of a new dissolution technique for vaginal formulations Chem.Pharm.Bull., 59, 952-958.
  24. Barthelmes, J.; Dünnhaupt, S.; Hombach, J.; Bernkop-Schnürch, A. (2011). Thiomer nanoparticles: Stabilization via covalent cross-linking. Drug Deliv., 18, 613-619.
  25. Barthelmes, J.; Perera, G.; Hombach, J.; Dünnhaupt, S.; Bernkop-Schnürch, A. (2011). Development of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder. Int. J. Pharm., 416, 339-345.
  26. Dudas, J.; Idler, C.; Sprinzl,G.; Bernkop-Schnuerch, A.; Riechelmann, H. (2011). Identification of HN-1-Peptide Target in Head and Neck Squamous Cell Carcinoma Cells. ISRN Oncology Article ID 140316, 10 pages
    doi:10.5402/2011/140316
  27. Dünnhaupt, S.; Barthelmes, J.; Hombach, J.; Sakloetsakun, D.; Arkhipova, V.; Bernkop-Schnürch, A. (2011). Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa. Int. J. Pharm., 408, 191-199.
  28. Hoyer, H.; Hombach, J.; Perera, G.; Thaurer, M.; Bernkop-Schnürch, A. (2011). Synthesis and in vitro characterization of a novel PAA-ATP conjugate. Drug Dev. Ind. Pharm., 37, 300-309.
  29. Iqbal, J.; Sakloetsakun, D.; Bernkop-Schnürch, A. (2011). Thiomers: Inhibition of cytochrome P450 activity. Eur. J. Pharm. Biopharm., 78, 361-365.
  30. Iqbal, J.; Sarti, F.; Perera, G.; Bernkop-Schnürch, A. (2011). Development and in vivo evaluation of an oral drug delivery system for paclitaxel. Biomaterials, 32, 170-175.
  31. Iqbal, J.; Vigl, C.; Moser, G.; Gasteiger, M.; Perera, G.; Bernkop-Schnürch, A. (2011). Development and in vivo evaluation of a new oral nanoparticulate dosage form for leuprolide based on polyacrylic acid. Drug Deliv., 18, 432-440.
  32. Leithner, K.; Grabovac, V.; Albrecht, K.; Hombach, J.; Klima, G.; Bernkop-Schnürch, A. (2011). Permeation studies on freshly excised rat gastric mucosa: influence of pH. Drug Dev. Ind. Pharm., 37, 518-525.
  33. Llabot, J.M.; Salman, H.; Millotti, G.; Bernkop-Schnürch, A.; Allemandi, D.; Manuel Irache, J. (2011). Bioadhesive properties of poly(anhydride) nanoparticles coated with different molecular weights chitosan. J. Microencap., 28, 455-463.
  34. Martien, R.; Hoyer, H.; Perera, G.; Bernkop-Schnürch, A. (2011). An oral oligonucleotide delivery system based on a thiolated polymer: Development and in vitro evaluation. Eur. J. Pharm. Biopharm., 78, 355-360.
  35. Millotti, G.; Perera, G.; Vigl, C.; Pickl, K.; Sinner, F.M.; Bernkop-Schnürch, A. (2011). The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery. Drug Deliv., 18, 190-197.
  36. Palmberger, T.; Augustijns, P.; Vetter, A.; Bernkop-Schnürch, A. (2011). Safety assessment of thiolated polymers: effect on ciliary beat frequency in human nasal epithelial cells. Drug Dev. Ind. Pharm., 37, 1455-1462.
  37. Perera, G.; Barthelmes, J.; Vetter, A.; Krieg, C.; Uhlschmied, C.; Bonn, G.K.; Bernkop-Schnürch, A. (2011). Thiolated polycarbophil/glutathione: Defining its potential as a permeation enhancer for oral drug administration in comparison to sodium caprate. Drug Deliv., 18, 415-423.
  38. Rahmat, D.; Sakloetsakun, D.; Shahnaz, G.; Perera, G.; Kaindl, R.; Bernkop-Schnürch, A. (2011). Design and synthesis of a novel cationic thiolated polymer. Int. J. Pharm., 411, 10-17.
  39. Sakloetsakun, D.; Iqbal, J.; Millotti, G.; Vetter, A.; Bernkop-Schnürch, A. (2011). Thiolated chitosans: influence of various sulfhydryl ligands on permeation-enhancing and P-gp inhibitory properties. Drug Dev. Ind. Pharm., 37, 648-655.
  40. Sarti, F.; Barthelmes, J.; Iqbal, J.; Hintzen, F.; Bernkop-Schnürch, A. (2011). Intestinal enzymatic metabolism of drugs. J. Pharm. Pharmacol., 63, 392-399.
  41. Sarti, F.; Bernkop-Schnürch, A. (2011). Chitosan and Thiolated Chitosan. Adv. Polym. Sci., 243, 93-110.
  42. Sarti, F.; Perera, G.; Hintzen, F.; Kottib,K.; Karageorgioub, V.; Kammonab, O.; Kiparissides, C.; Bernkop-Schnürch, A. (2011). In vivo evidence of oral vaccination with PLGA nanoparticles containing the immunostimulant monophosphoryl lipid A. Biomaterials, 32, 4052-4057.
  43. Senyigit, Z.A.; Vetter, A.; Guneri, T.; Bernkop-Schnürch, A. (2011). A comprehensive in vitro and in vivo evaluation of thiolated matrix tablets as a gastroretentive delivery system. Drug Deliv., 18, 405-414.
  44. Shahnaz, G.; Hartl, M.; Barthelmes, J.; Leithner, K.; Sarti, F.; Hintzen, F.; Rahmat, D.; Salvenmoser, W.; Bernkop-Schnürch, A. (2011). Uptake of phenothiazines by the harvested chylomicrons ex vivo model: Influence of self-nanoemulsifying formulation design. Eur. J. Pharm. Biopharm., 79, 171-180.
  45. Vetter, A.; Reinisch, A.; Strunk, D.; Kremser, C.; Hahn, H.W.; Huck, C.W.; Ostermann, T.; Leithner, K.; Bernkop-Schnürch, A. (2011). Thiolated polyacrylic acid-modified iron oxide nanoparticles for in vitro labeling and MRI of stem cells. J. Drug Targ., 19, 562-572.
  46. Albrecht, K.; Greindl, M.; Deutel, B.; Kremser, C.; Wolf, C.; Talasz, H.; Stollenwerk, M.; Debbage, P.; Bernkop-Schnürch, A. (2010). In vivo investigation of thiomer-polyvinylpyrrolidon nanoparticles using magnetic resonance imaging. J. Pharm. Sci., 99, 2008-2017.
  47. Hoyer, H.; Schlocker, W.; Greindl, M.; Ostermann, T.; Bernkop-Schnürch, A. (2010). Preparation and evaluation of thiomer nanoparticles via high pressure homogenization. J. Microencap., 27, 487-495.
  48. Iqbal, J.; Hombach, J.; Matuszczak, B.; Bernkop-Schnürch, A. (2010). Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitor. J. Control. Rel., 147, 62-69.
  49. Millotti, G.; Hoyer, H.; Engbersen, J.F.J.; Bernkop-Schnürch, A. (2010). 6-mercaptonicotinamide- functionalized chitosan: A potential excipient for mucoadhesive drug delivery systems. J. Drug Del. Sci.Tech., 20, 181-186.
  50. Millotti, G.; Samberger, C.; Fröhlich, E.; Sakloetsakun, D.; Bernkop-Schnürch, A. (2010). Chitosan-4-mercaptobenzoic acid: synthesis and characterization of a novel thiolated chitosan. J. Mater. Chem., 20, 2432-2440.
  51. Perera, G.; Barthelmes, J.; Bernkop-Schnürch, A. (2010). Novel pectin-4-aminothiophenole conjugate microparticles for colon-specific drug delivery. J. Control. Rel., 145, 240-246.
  52. Perera, G.; Hombach, J.; Bernkop-Schnürch, A. (2010). Hydrophobic thiolation of pectin with 4-aminothiophenol: Synthesis and in vitro characterization. AAPS PharmSciTech., 11, 174-180.
  53. Sakloetsakun, D.; Perera, G.; Hombach, J.; Millotti, G.; Bernkop-Schnürch, A. (2010). The impact of vehicles on the mucoadhesive properties of orally administered nanoparticles: a cas. AAPS PharmSciTech., 11, 1185-1192.
  54. Sarti, F.; Staaf, A.; Sakloetsakun, D.; Bernkop-Schnürch, A. (2010). Thiolated hydroxyethylcellulose:synthesis and in vitro evaluation. Eur. J. Pharm. Biopharm., 76, 421-427.
  55. Senyigit, Z.A.; Vetter, A.; Guneri, T.; Bernkop-Schnürch, A. (2010). Gastroretentive particles formulated with thiomers: development and in vitro evaluation. J. Drug Targ., 18, 362-372.
  56. Shahnaz, G.; Perera, G.; Sakloetsakun, D.; Rahmat, D.; Bernkop-Schnürch, A. (2010). Synthesis, Characterization, Mucoadhesion and Biocompatibility of Thiolated Carboxymethyldextran-Cysteine Conjugate. J. Control. Rel., 144, 32-38.
  57. Vetter, A.; Bernkop-Schnürch, A. (2010). Nasal delivery of antisense oligonucleotides: in vitro evaluation of a thiomer/glutathione microparticulate delivery system. J. Drug Targ., 18, 303-312.
  58. Vetter, A.; Martien, R.; Bernkop-Schnürch, A. (2010). Thiolated polycarbophil as an adjuvant for permeation enhancement in nasal delivery of antisense oligonucleotides. J. Pharm. Sci., 99, 1427-1439.
  59. Vetter, A.; Perera, G.; Leithner, K.; Klima, G.; Bernkop-Schnürch, A. (2010). Development and in vivo bioavailability study of an oral fondaparinux delivery system. Eur. J. Pharm. Sci., 41, 489-497.
  60. Biasutto, L.; Marotta, E.; Mattarei, A.; Beltramello, S.; Caliceti, P.; Salmaso, S. Bernkop-Schnürch, A.; Garbisa, S; Zoratti, M.; Paradisi, C. (2009). Absorption and metabolism of resveratrol carboxyesters and methanesulfonate by explanted rat intestinal segments. Cellular Physiology and Biochemistry, 24, 557-566.
  61. Figueiras, A.; Hombach, J.; Veiga, F.; Bernkop-Schnürch A. (2009). In vitro evaluation of natural and methylated cyclodextrins as buccal permeation enhancing systems for omeprazole delivery. Eur. J. Pharm. Biopharm., 71, 339-345.
  62. Greindl, M.; Föger, F.; Hombach, J.; Bernkop-Schnürch, A. (2009). In vivo evaluation of thiolated poly(acrylic acid) as a drug absorption modulator for MRP2 efflux pump substrates. Eur. J. Pharm. Biopharm., 72, 561-566.
  63. Hombach, J.; Bernkop-Schnürch, A. (2009). Chitosan solutions and particles: Evaluation of their permeation enhancing potential on MDCK cells used as blood brain barrier model. Int. J. Pharm., 376, 104-109.
  64. Hombach, J.; Palmberger, T.; Bernkop-Schnürch, A. (2009). Development and in vitro evaluation of a mucoadhesive vaginal delivery system for nystatin. J. Pharm. Sci., 98, 555-564.
  65. Hoyer, H.; Greindl, M.; Bernkop-Schnürch, A. (2009). Design and in vivo evaluation of a patch system based on thiolated polymers. J. Pharm. Sci., 98, 620-627.
  66. Millotti, G.; Samberger, C.; Fröhlich, E.; Bernkop-Schnürch, A. (2009). Chitosan-graft-6-mercaptonicotinic acid: synthesis, characterization, and biocompatibility. Biomacromolecules, 10, 3023-3027.
  67. Perera, G.; Greindl, M.; Palmberger, T.; Bernkop-Schnürch, A. (2009). Insulin-loaded poly(acrylic acid)-cysteine nanoparticles: stability studies towards digestive enzymes of the intestine. Drug Deliv., 16, 254-260.
  68. Sakloetsakun D.; Hombach J.; Bernkop-Schnürch, A. (2009). In situ gelling properties of chitosan-thioglycolic acid conjugate in the presence of oxidizing agents. Biomaterials, 30, 6151-6157.
  69. Thaurer, M.H.; Deutel, B.; Schlocker, W.; Bernkop-Schnürch, A. (2009). Development of nanoparticulate drug delivery systems based on thiolated poly(acrylic acid). J. Microencap., 26, 187-194.
  70. Vigl, C.; Leithner, K.; Albrecht, K.; Bernkop-Schnürch, A. (2009). The efflux pump inhibitory properties of (thiolated) polyallylamines. J. Drug Del. Sci.Tech., 19, 405-411.
  71. Werle, M.; Takeuchi, H.; Bernkop-Schnürch, A. (2009). Modified Chitosans for oral drug delivery. J. Pharm. Sci., 98, 1643-1656.
  72. Deutel, B.; Greindl, M.; Thaurer, M.; Bernkop-Schnürch, A. (2008). Novel insulin thiomer nanoparticles: in vivo evaluation of an oral drug delivery system. Biomacromolecules, 9, 278-285.
  73. Föger, F.; Kopf, A.; Loretz, B.; Albrecht, K.; Bernkop-Schnürch, A. (2008). Correlation of in vitro and in vivo models for the oral absorption of peptide drugs. Amino Acids, 35, 233-241.
  74. Föger, F.; Malaivijitnond,. S.; Wannaprasert, T.; Huck, C.; Bernkop-Schnürch, A.; Werle, M. (2008). Effect of a thiolated polymer on oral paclitaxel absorption and tumor growth in rats. J. Drug Targ., 16, 149-155.
  75. Grabovac, V.; Föger, F.; Bernkop-Schnürch, A. (2008). Design and in vivo evaluation of a patch delivery system for insulin based on thiolated polymers. Int. J. Pharm., 348, 169-174.
  76. Hombach, J.; Hoyer, H.; Bernkop-Schnürch, A. (2008). Thiolated chitosans: Development and in vitro evaluation of an oral tobramycin sulphate delivery system. Eur. J. Pharm. Sci., 33, 1-8.
  77. Hoyer, H.; Schlocker, W.; Kafedjiiski, K.; Bernkop-Schnürch, A. (2008). Preparation and evaluation of microparticles from thiolated polymers via air jet milling. Eur. J. Pharm. Biopharm., 69, 476-485.
  78. Kremser, C.; Albrecht, K.; Greindl, M.; Wolf, C.; Debbage, P.; Bernkop-Schnürch, A. (2008). In vivo determination of time and location at which mucoadhesive drug delivery systems disintegrate in the gastrointestinal tract. Magn. Reson. Imaging, 26, 638-643.
  79. Martien, R.; Loretz, B.; Sandbichler, A.M.; Bernkop-Schnürch, A. (2008). Thiolated chitosan nanoparticles: transfection study in the Caco-2 differentiated cell culture. Nanotechnology, 19, 045101 (9pp).
  80. Palmberger, T.; Hombach, J.; Bernkop-Schnürch, A. (2008). Thiolated chitosan: Development and in vitro evaluation of an oral delivery system for acyclovir. Int. J. Pharm., 348, 54-60.
  81. Petter, Ch.; Heigl, N.; Bachmann, St.; Huck-Pezzei, V.; Najam-ol-Haq, M.; Bakry, R.; Bernkop-Schnürch, A.; Bonn, G.; Huck, Ch. (2008). Near infrared spectroscopy compared to liquid chromatography coupled to mass spectrometry and capillary electrophoresis as a detection tool for peptide reaction monitoring. Amino Acids, 34, 605-616.
  82. Schmitz, T.; Grabovac, V.; Palmberger, T.F.; Hoffer, M.H.; Bernkop-Schnürch, A. (2008). Synthesis and characterization of a chitosan-N-acetyl cystein conjugate. Int. J. Pharm., 347, 79-85.
  83. Schmitz, T.; Hombach, J.; Bernkop-Schnürch, A. (2008). Chitosan-N-acetyl cysteine conjugates: In vitro evaluation of permeation enhancing and P-glycoprotein inhibiting properties. Drug Deliv., 15, 245-252.
  84. Tsiklauri, L.; Hoyer, H.; Chkhikvadze, G.; Vachnadze, V.; Tsagareishvili, G.; Bakuridze, A.; Bernkop-Schnurch, A. (2008). Role of P-glycoproteins (P-gp) in the transepithelial transport of indoline alkaloids from Vinca herbaceae. Khim.-Farm. Zhurnal, 42, 29-32.
  85. Werle, M.; Kolmar, H.; Albrecht, R.; Bernkop-Schnürch, A. (2008). Characterisation of the barrier caused by luminally secreted gastro-intestinal proteolytic enzymes for two novel cystine-knot microproteins. Amino Acids, 35, 195-200.
  86. Bernkop-Schnürch, A. and Schmitz, Th. (2007). Presystemic metabolism of orally administered peptide drugs and strategies to overcome it. Curr. Drug Metab., 8, 509-517.
  87. Föger, F., Kafedjiiski, K., Hoyer, H., Loretz, B. and Bernkop-Schnürch, A. (2007). Enhanced transport of P-glycoprotein substrate saquinavir in presence of thiolated chitosan. J. Drug Targ., 15, 132-139.
  88. Grabovac, V. and Bernkop-Schnürch, A. (2007). Development and in vitro evaluation of surface modified poly(lactide-co-glycolide) nanoparticles with chitosan-4-thiobutylamidine. Drug Dev. Ind. Pharm., 33, 767-774.
  89. Grabovac, V., Schmitz, Th., Föger, F. and Bernkop-Schnürch, A. (2007). Papain: An effective permeation enhancer for orally administered low molecular weight heparin. Pharm. Res., 24, 1001-1006.
  90. Greimel, A., Del Curto, M. D., D’Antonio, M. and Bernkop-Schnürch, A. (2007). Transport characteristics of a beta sheet breaker peptide across excised bovine nasal mucosa. Drug Dev. Ind. Pharm., 33, 71-77.
  91. Greimel, A., Werle, M. and Bernkop-Schnürch, A. (2007). Oral peptide delivery: in vitro evaluation of thiolated alginate / poly(acrylic acid) microparticles. J. Pharm. Pharmacol., 59, 1191-1198.
  92. Hoyer, H., Föger, F., Kafedjiiski, K., Loretz, B., and Bernkop-Schnürch, A. (2007). Design and evaluation of a new gastrointestinal mucoadhesive patch system containing chitosan-glutathione. Drug Dev. Ind. Pharm., 33, 1289-1296.
  93. Kafedjiiski, K., Föger, F., Hoyer, H., Werle, M. and Bernkop-Schnürch, A. (2007). Evaluation of in vitro enzymatic degradation of various thiomers and cross-linked thiomers. Drug Dev. Ind. Pharm., 33, 199-208.
  94. Kafedjiiski, K., Jetti, R., Föger, F., Hoyer, H., Werle, M., Hoffer, M., and Bernkop-Schnürch, A. (2007). Synthesis and in vitro evaluation of thiolated hyaluronic acid for mucoadhesive drug delivery. Int. J. Pharm., 343, 48-58.
  95. Loretz, B. and Bernkop-Schnürch, A. (2007). In vitro cytotoxity testing of non-thiolated and thiolated chitosan nanoparticles for oral gene delivery. Nanotoxicology, 1, 139-148.
  96. Loretz, B., Thaler, M. and Bernkop-Schnürch, A. (2007). Role of sulfhydryl groups in transfection? A case study with chitosan-NAC nanoparticles. Bioconjugate Chemistry, 18, 1028-1035.
  97. Martien, R., Loretz, B., Thaler, M., Majzoob, S. and Bernkop-Schnürch, A. (2007). Chitosan-thioglycolic acid conjugate: An alternative carrier for oral non-viral gene delivery? J. Biomed. Mat. Res. A., 82, 1-9.
  98. Palmberger, T. F., Albrecht, K, Loretz, B., and Bernkop-Schnürch, A. (2007). Thiolated polymers: Evaluation of the influence of the amount of covalently attached l-cysteine to poly(acrylic acid). Eur. J. Pharm. Biopharm., 66, 405-412.
  99. Schmitz, T., Bravo-Osuna, I., Vauthier, C., Ponchel, G., Loretz, B. and Bernkop-Schnürch, A. (2007). Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system. Biomaterials, 28, 524-531. 2006
  100. Werle, M, Hsu, Y. T., Chang, F. C., Lee, Ch. H. (2007). Analytical Methods for the Characterisation of Multifunctional Polymers for Oral Drug Delivery. Current Pharmaceutical Analysis, 3, 111-116.
  101. Werle, M., Kafedjiiski, K., Kolmar H. and Bernkop-Schnürch, A. (2007). Evaluation and improvement of the properties of the novel cystine-knot microprotein McoEeTI for oral administration. Int. J. Pharm., 332, 72-79.
  102. Werle, M., Kolmar, H., and Bernkop-Schnürch, A. (2007). Relation between scaffold size and membrane bound enzyme caused degradation of two novel cystine knot microproteins. Letters in Drug Design & Discovery, 4, 33-36.
  103. Werle, M., Loretz, B., Entstrasser, D. and Föger, F. (2007). Design and evaluation of a chitosan-aprotinin conjugate for the peroral delivery of therapeutic peptides and proteins susceptible to enzymatic degradation. J. Drug Targ., 15, 327-333.
  104. Albrecht, K., Greindl, M.; Kremser, C.; Wolf, C.; Debbage, P. and Bernkop-Schnürch, A. (2006). Comparative in vivo mucoachesion studies of thiomer formulations using magnetic resonance imaging and fluorescence detection. J. Control. Rel., 115, 78-84.
  105. Albrecht, K., Zirm, E.J., Palmberger, T.F., Schlocker, W. and Bernkop-Schnürch, A. (2006). Preparation of thiomer microparticles and in vitro evaluation of parameters influencing their mucoadhesive properties. Drug Dev. Ind. Pharm., 32, 1149-1157.
  106. Bernkop-Schnürch, A. (2006). Oral delivery of therapeutic peptides: Barriers and strategies to overcome them. J. Drug Targ., 14, 107-108.
  107. Bernkop-Schnürch, A., Heinrich, A. and Greimel, A. (2006). Development of a novel method for the preparation of submicron particles based on thiolated chitosan. Eur. J. Pharm. Biopharm., 63, 166-172.
  108. Bernkop-Schnürch, A., Obermair, K., Greimel, A. and Palmberger Th. F. (2006). In vitro evaluation of the potential of thiomers for the nasal administration of Leu-enkephalin. Amino Acids, 30, 417-423.
  109. Bernkop-Schnürch, A., Weithaler, A., Albrecht, K. and Greimel, A.
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  110. Bravo-Osuna, I., Schmitz, Th., Bernkop-Schnürch, A., Vauthier, Ch. and Ponchel, G. (2006). Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles. Int. J. Pharm., 316, 170-175.
  111. Föger, F., Hoyer, H., Kafedjiiski, K., Thaurer, M. and Bernkop-Schnürch, A (2006). In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein. Biomaterials, 27, 5855-5860.
  112. Föger, F., Noonpakdee, W., Loretz, B., Joojuntr, S., Salvenmoser, W. and Bernkop-Schnürch, A. (2006). Inhibition of malarial topoisomerase II in Plasmodium falciparum by antisense nanoparticles. Int. J. Pharm., 319, 139-146.
  113. Föger, F., Schmitz, T. and Bernkop-Schnürch, A. (2006). In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. Biomaterials, 27, 4250-4255.
  114. Grabovac, V. and Bernkop-Schnürch, A. (2006). Improvement of the intestinal membrane permeability of low molecular weight heparin by complexation with stem bromelain. Int. J. Pharm., 326, 153-159.
  115. Greimel, A., Del Curto, M. D., D’Antonio, M., Palmberger, Th., Sprinzl, G. M. and Bernkop-Schnürch, A. (2006). In vitro evaluation of thiomer microparticles for nasal drug delivery. J. Drug Del. Sci.Tech., 16, 103-108.
  116. Greindl, M. and Bernkop-Schnürch, A. (2006). Development of a novel method for the preparation of thiolated polyacrylic acid nanoparticles. Pharm. Res., 23, 2183-2189.
  117. Huck, Ch. W., Pezzei, V., Schmitz, Th., Bonn, G.K. and Bernkop-Schnürch, A. (2006). Oral peptide delivery: Are there remarkable effects on drugs through sulfhydryl conjugation? J. Drug Targ., 14, 117-125.
  118. Kafedjiiski, K., Hoffer, M., Werle, M.and Bernkop-Schnürch, A. (2006). Improved synthesis and in vitro characterization of chitosan-thioethylamidine conjugate. Biomaterials, 27, 127-135.
  119. Krauland, A., Guggi, D., and Bernkop-Schnürch, A. (2006). Thiolated chitosan microparticles: A vehicle for nasal peptide drug delivery. Int. J. Pharm., 307, 270-277.
  120. Krauland, A., Leitner, V. M., Grabovac, V. and Bernkop-Schnürch, A. (2006). In vivo evaluation of a nasal insulin delivery system based on thiolated chitosan. J. Pharm. Sci., 95, 2463-2472.
  121. Langoth, N., Kahlbacher, H., Schöffmann, G., Schmerold, I., Schuh, M., Franz, S., Kurka, P. and Bernkop-Schnürch A. (2006). Thiolated chitosans: Design and in vivo evaluation of a mucoadhesive buccal peptide drug delivery system. Pharm. Res., 23, 573-579.
  122. Loretz, B. and Bernkop-Schnürch, A. (2006). In vitro evaluation of chitosan-EDTA conjugate polyplexes as nanoparticulate gene delivery system. AAPS Journal, 8, E756-E764.
  123. Loretz, B., Föger, F. A., Werle, M. and Bernkop-Schnürch, A. (2006). Oral gene delivery: Strategies to improve stability of pDNA towards intestinal digestion. J. Drug Targ., 14, 311-319.
  124. Majzoob, S., Atyabi, F., Dorkoosh, F., Kafedjiiski, K., Loretz, B., and Bernkop-Schnürch, A. (2006). Pectin-cysteine conjugate: synthesis and in-vitro evaluation of its potential for drug delivery. J. Pharm. Pharmacol., 58, 1601-1610.
  125. Martien, R., Loretz, B., and Bernkop-Schnürch, A. (2006). Oral gene delivery: Design of polymeric carrier systems shielding towards intestinal enzymatic attack. Biopolymers, 83, 327-336.
  126. Schlocker, W., Gschließer, S. and Bernkop-Schnürch, A. (2006). Evaluation of the potential of air jet milling for peptide-loaded microparticle preparation. Eur. J. Pharm. Biopharm., 62, 260-266.
  127. Schmitz, T., Huck, C.W. and Bernkop-Schnürch, A. (2006). Characterisation of the thiol-disulphide chemistry of desmopressin by LC, µ-LC, LC-ESI-MS and Maldi-Tof. Amino Acids, 30, 35-42.
  128. Werle, M. and Bernkop-Schnürch, A. (2006). Strategies to improve plasma half life time of peptide and protein drugs. Amino Acids, 30, 351-367.
  129. Werle, M., Samhaber A. and Bernkop-Schnürch, A. (2006). Degradation of teriparatide by gastro-intestinal proteolytic enzymes. J. Drug Targ., 14, 109-115.
  130. Werle, M., Schmitz, Th., Huang, H.-L., Wentzel, A., Kolmar, H. and Bernkop-Schnürch A. (2006). The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery. J. Drug Targ., 14, 137-146.
  131. Bernkop-Schnürch, A. (2005). Mucoadhesive polymers: strategies, achievements and future challenges. Adv. Drug Del. Rev., 57, 1553-1555.
  132. Bernkop-Schnürch, A., Pinter, Y., Guggi, D., Kahlbacher, H., Schöffmann, G., Schuh, M., Schmerold, I., Del Curto, M.D., D'Antonio, M., Esposito, P. and Huck, Ch. (2005). The use of thiolated polymers as carrier matrix in oral peptide delivery - Proof of concept. J. Control. Rel., 106, 26-33.
  133. Grabovac, V., Guggi, D., and Bernkop-Schnürch, A. (2005). Comparison of the mucoadhesive properties of various polymers. Adv. Drug Del. Rev., 57, 1713-1723.
  134. Guggi, D. and Bernkop-Schnürch, A. (2005). Improved paracellular uptake by the combination of different types of permeation enhancers. Int. J. Pharm., 288, 141-150.
  135. Imam, M.E. and Bernkop-Schnürch, A. (2005). Controlled drug delivery systems based on thiolated chitosan microspheres. Drug Dev. Ind. Pharm., 31, 557-565.
  136. Kafedjiiski, K., Föger, F., Werle, M. and Bernkop-Schnürch, A. (2005). Synthesis and in vitro evaluation of a novel chitosan-glutathione conjugate. Pharm. Res., 22, 1480-1488.
  137. Kafedjiiski, K., Krauland, A.H., Hoffer, M.H. and Bernkop-Schnürch, A. (2005). Synthesis and in vitro evaluation of a novel thiolated chitosan. Biomaterials, 26, 819-826.
  138. Kafedjiiski, K., Werle, M., Föger, F. and Bernkop-Schnürch, A. (2005). Synthesis and in vitro characterization of a novel poly(acrylic acid)-glutathione conjugate. J. Drug Del. Sci.Tech., 15, 411-417.
  139. Krauland, A., Hoffer, M.H., and Bernkop-Schnürch, A. (2005). Viscoelastic properties of a new in situ gelling thiolated chitosan conjugate. Drug Dev. Ind. Pharm., 31, 885-893.
  140. Langoth, N., Bernkop-Schnürch, A. and Kurka, P. (2005). The inhibitory effect of glutathione towards buccal enzymatic degradation of therapeutic peptides (leu-enkephalin, luteinizing hormone-releasing hormone and pituitary adenylate cyclase activating peptide). J. Drug Del. Sci.Tech., 15, 435-438.
  141. Langoth, N., Bernkop-Schnürch, A. and Kurka, P. (2005). In vitro evaluation of various buccal permeation enhancing systems for PACAP (pituitary adenylate cyclase-activating polypeptide). Pharm. Res., 22, 2045-2050.
  142. Langoth, N., Kalbe, J. and Bernkop-Schnürch, A. (2005). Development of a mucoadhesive and permeation enhancing buccal delivery system for PACAP (pituitary adenylate cyclase-activating polypeptide). Int. J. Pharm., 296, 103-111.
  143. Maculotti, K., Genta, I., Perugini, P., Imam,M., Bernkop-Schnürch, A. and Pavanetto, F. (2005). Preparation and in vitro evaluation of thiolated chitosan microparticles. J. Microencap., 22, 459-470.
  144. Schmitz, T., Leitner, V., Bernkop-Schnürch, A. (2005). Oral heparin delivery: Design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system. J. Pharm. Sci., 94, 966-973.
  145. Werle, M., Schmitz T., Wentzel A., Kolmar H. and Bernkop-Schnürch A. (2005). In vitro evaluation of the enzymatic stability and permeation behaviour of microbodies: novel carriers for oral peptide drug delivery? Pharmacia, 52, 126-127.
  146. Bernkop-Schnürch, A., Guggi, D., and Pinter, Y.  (2004). Thiolated chitosans: development and in vivo evaluation of a mucoadhesive permeation enhancing oral drug delivery system. J. Control. Rel., 94, 177-186.
  147. Bernkop-Schnürch, A., König, V., Leitner, V., Krauland, A. and Brodnik, I.  (2004). Preparation and characterisation of thiolated poly(methacrylic acid) - starch compositions. Eur. J. Pharm. Biopharm., 57, 219-224.
  148. Bernkop-Schnürch, A., Leitner, V., and Moser, V.  (2004). Synthesis and in vitro characterisation of a poly(acrylic acid)-homocysteine conjugate. Drug Dev. Ind. Pharm., 30, 1-8.
  149. Bernkop-Schnürch, A., Reich-Rohrwig, E., Marschütz, M., Schuhbauer H. and Kratzel, M.  (2004). Development of a sustained release dosage form for alpha-lipoic acid. II. Evaluation in human volunteers. Drug Dev. Ind. Pharm., 30, 35-42.
  150. Bernkop-Schnürch, A., Schuhbauer H., Clausen, A.E. and Hanel, R.  (2004). Development of a sustained release dosage form for alpha-lipoic acid. I. Design and in vitro evaluation. Drug Dev. Ind. Pharm., 30, 27-34.
  151. Caliceti, P. Salmaso, S., Walker, G. and Bernkop-Schnürch, A.  (2004). Development and in vivo evaluation of an oral insulin-PEG delivery system. Eur. J. Pharm. Sci., 22, 315-323.
  152. Guggi, D., Langoth, N., Hoffer, M.H., Wirth, M. and Bernkop-Schnürch, A. (2004). Comparative evaluation of cytotoxicity of a glucosamine-TBA conjugate and a chitosan-TBA conjugate Int. J. Pharm., 278, 353-360.
  153. Guggi, D., Marschütz, M.K., and Bernkop-Schnürch, A.  (2004). Matrix tablets based on thiolated poly(acrylic acid): pH-dependent variation in disintegration and mucoadhesion. Int. J. Pharm., 274, 97-105.
  154. Krauland, A. and Bernkop-Schnürch, A.  (2004). Thiomers: Development and in vitro evaluation of a peroral microparticulate peptide delivery system. Eur. J. Pharm. Biopharm., 57, 181-187.
  155. Krauland, A., Guggi, D. and Bernkop-Schnürch, A.  (2004). Oral insulin delivery: The potential of thiolated chitosan-insulin tablets on non-diabetic rats. J. Control. Rel., 95, 547-555.
  156. Leitner, V., Guggi, D. and Bernkop-Schnürch, A.  (2004). Thiomers in noninvasive polypeptide delivery: In vitro and in vivo characterization of a polycarbophil-cysteine/glutathione gel formulation for human growth hormone J. Pharm. Sci., 93, 1682-1691.
  157. Leitner, V.M. and Bernkop-Schnürch, A. (2004). Polymer-enzyme inhibitor conjugates: influence of the molecular mass on the inhibition of membrane-bound aminopeptidase N activity J. Drug Del. Sci.Tech., 14, 495-498.
  158. Leitner, V.M., Guggi, D., Krauland, A.H. and Bernkop-Schnürch, A. (2004). Nasal delivery of human growth hormone: in vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system. J. Control. Rel., 100, 87-95.
  159. Roldo, M., Hornof, M., Caliceti, P. and Bernkop-Schnürch, A.  (2004). Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: Synthesis and in vitro evaluation. Eur. J. Pharm. Biopharm., 57, 115-121.
  160. Bernkop-Schnürch, A., Egger, C. Elhassan, I.M. and Krauland, A.  (2003). Preparation and in vitro characterization of poly(acrylic acid)-cysteine mircoparticles. J. Control. Rel., 93, 29-38.
  161. Bernkop-Schnürch, A., Hornof, M. and Zoidl, T.  (2003). Thiolated polymers – thiomers: modification of chitosan with 2-iminothiolane. Int. J. Pharm., 260, 229-237.
  162. Bernkop-Schnürch, A., Telsnig. J. and Hornof, M.  (2003). Development and in vitro evaluation of a mucoadhesive oral delivery system for antisense oligonucleotides. Sci. Pharm., 71, 165-177.
  163. Guggi, D. and Bernkop-Schnürch, A. (2003). In vitro evaluation of polymeric excipients protecting calcitonin against degradation by intestinal serine proteases. Int. J. Pharm., 252, 187-196.
  164. Guggi, D., Kast, C.E., and Bernkop-Schnürch, A.  (2003). In vivo evaluation of an oral salmon calcitonin-delivery system based on a thiolated chitosan carrier matrix. Pharm. Res., 20, 1989-1994.
  165. Guggi, D., Krauland, A.H., and Bernkop-Schnürch, A.  (2003). Systemic peptide delivery via the stomach: in vivo evaluation of an oral dosage form for salmon calcitonin. J. Control. Rel., 92, 125-135.
  166. Hornof, M.D., Kast, C.E., and Bernkop-Schnürch, A.  (2003). In vitro evaluation of the viscoelastic properties of chitosan - thioglycolic acid conjugates. Eur. J. Pharm. Biopharm., 55, 185-190.
  167. Hornof, M.D., Weyenberg, W., Ludwig, A., and Bernkop–Schnürch, A.  (2003). A mucoadhesive ocular insert: Development and in vivo evaluation in humans. J. Control. Rel., 89, 419-428.
  168. Imam, M.E., Hornof, M., Valenta, C., and Bernkop-Schnürch, A.  (2003). Evidence for the interpenetration of mucoadhesive polymers into the mucus gel layer. STP Pharma Sci., 13, 171-176.
  169. Kast, C.E., Frick, W., Losert, U. and Bernkop-Schnürch, A.  (2003). Chitosan-thioglycolic acid conjugate: A new scaffold material for tissue engineering? Int. J. Pharm., 256, 183-189.
  170. Kast, C.E., Guggi, D., Langoth, N. and Bernkop-Schnürch, A.  (2003). Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil. Pharm. Res., 20, 931-936.
  171. Krauland, A., Leitner, V. M. and Bernkop-Schnürch, A.  (2003). Improvement in the in situ gelling properties of deacetylated gellan gum by the immobilization of thiol groups. J. Pharm. Sci., 92, 1234-1241.
  172. Langoth, N., Kalbe, J. and Bernkop-Schnürch, A.  (2003). Development of buccal drug delivery systems based on a thiolated polymer. Int. J. Pharm., 252, 141-148.
  173. Leitner, V., Marschütz, M., and Bernkop-Schnürch, A.  (2003). Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass. Eur. J. Pharm. Sci., 18, 89-96.
  174. Leitner, V., Walker, G.F., and Bernkop-Schnürch, A.  (2003). Thiolated polymers: Evidence for the formation of disulphide bonds with mucus glycoproteins. Eur. J. Pharm. Biopharm., 56, 207-214.
  175. Bernkop-Schnürch, A., Hornof, M.D., Kast, C.E. and Langoth N. (2002). Thiolated polymers: Stability of thiol moieties under different storage conditions. Sci. Pharm., 70, 331-339.
  176. Clausen, A.E., Kast, C.E. and Bernkop-Schnürch, A.  (2002). The role of glutathione in the permeation enhancing effect of thiolated polymers. Pharm. Res., 19, 602-608.
  177. Hornof, M.D. and Bernkop-Schnürch, A. (2002). In vitro evaluation of the permeation enhancing effect of polycarbophil - cysteine conjugates on the cornea of rabbits. J. Pharm. Sci., 91, 2588-2592.
  178. Kast, C.E. and Bernkop-Schnürch, A.  (2002). Influence of the molecular mass on the permeation enhancing effect of different poly(acrylates). STP Pharma Sci., 12, 351-356.
  179. Kast, C.E., and Bernkop-Schnürch, A.  (2002). Polymer-cystamine conjugates: New mucoadhesive excipients for drug delivery? Int. J. Pharm., 234, 91-99.
  180. Kast, C.E., Valenta, C., Leopold, M. and Bernkop-Schnürch, A.  (2002). Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clotrimazole. J. Control. Rel., 81, 347-354.
  181. Marschütz, M.K., and Bernkop-Schnürch, A.  (2002). Thiolated polymers: Advance in mucoadhesion by use of in-situ crosslinking poly(acrylic acid)-cysteine conjugates. Eur. J. Pharm. Sci., 15, 387-394.
  182. Marschütz, M.K., Zauner, W., Mattner, F., Otava, A., Buschle, M. and Bernkop-Schnürch, A.  (2002). Improvement of the enzymatic stability of a cytotoxic T-lymphocyte epitope model peptide for its oral administration. Peptides, 23, 1727-1733.
  183. Valenta, C., Marschütz, M., Egyed, Ch., and Bernkop-Schnürch, A.  (2002). Evaluation of the inhibitory effect of thiolated poly(acrylates) on vaginal membrane bound aminopeptidase N. J. Pharm. Pharmacol., 54, 603-610.
  184. Walker, G.F., Langoth, N., and Bernkop-Schnürch, A. (2002). Peptidase activity on the surface of the porcine buccal mucosa. Int. J. Pharm., 233, 141-147.
  185. Bernkop-Schnürch, A. and Hopf, Th.E.  (2001). Synthesis and In vitro evaluation of chitosan-thioglycolic acid conjugates. Sci. Pharm., 69, 109-118.
  186. Bernkop-Schnürch, A., Clausen, A.E., and Hnatyszyn, M.  (2001). Thiolated polymers: Synthesis and in vitro evaluation of polymer-cysteamine conjugates. Int. J. Pharm., 226, 185-194.
  187. Bernkop-Schnürch, A., Kast, C.E., and Richter, M.F.  (2001). Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine. J. Control. Rel., 71, 277-285.
  188. Bernkop-Schnürch, A., Zarti, H., and Walker, G.F.  (2001). Thiolation of polycarbophil enhances its inhibition of soluble and intestinal brush border membrane bound aminopeptidase N. J. Pharm. Sci., 90, 1907-1914.
  189. Clausen, A.E., and Bernkop-Schnürch, A.  (2001). Thiolated carboxymethylcellulose: In vitro evaluation of its permeation enhancing effect on peptide drugs. Eur. J. Pharm. Biopharm., 51, 25-32.
  190. Clausen, A.E., and Bernkop-Schnürch, A.  (2001). in vitro evaluation of matrix tablets based on tiolated polycarbophil. Pharm. Ind., 63, 312-317.
  191. Clausen, A.E., and Bernkop-Schnürch, A.  (2001). Direct compressible polymethacrylic acid-starch compositions for site specific drug delivery. J. Control. Rel., 75, 93-102.
  192. Kast, C.E., and Bernkop-Schnürch, A.  (2001). Thiolated polymers: Development and in vitro evaluation of chitosan-thioglycolic acid conjugates. Biomaterials, 22, 2345 - 2352.
  193. Marschütz, M.K., Puttipipatkhachorn, S., and Bernkop-Schnürch, A.  (2001). Design and in vitro evaluation of a mucoadhesive oral delivery system for a model (poly)peptide antigen. Pharmazie, 56, 724-729.
  194. Marschütz, M.K., Veronese, F.M., and Bernkop-Schnürch, A.  (2001). Influence of the spacer on the inhibitory effect of different polycarbophil-protease inhibitor conjugates. Eur. J. Pharm. Biopharm., 52, 137-144.
  195. Valenta, C., Kast, E.C., Harich, I., and Bernkop-Schnürch, A.  (2001). Development and in vitro evaluation of a mucoadhesive vaginal delivery system for progesterone. J. Control. Rel., 77, 323-332.
  196. Valenta, C., Walzer, A., Clausen, A.E., and Bernkop-Schnürch, A.  (2001). Thiolated polymers: Development and evaluation of transdermal delivery systems for progesterone. Pharm. Res., 18, 211-216.
  197. Bernkop-Schnürch, A. and Gilge, B.  (2000). Anionic mucoadhesive polymers as auxiliary agents for the peroral administration of (poly)peptide drugs: influence of the gastric fluid. Drug Dev. Ind. Pharm., 26, 107-113.
  198. Bernkop-Schnürch, A. and Steininger, S.  (2000). Synthesis and characterisation of mucoadhesive thiolated polymers. Int. J. Pharm., 194, 239-247.
  199. Bernkop-Schnürch, A. and Thaler, S.  (2000). Polycarbophil-cysteine conjugates as platforms for oral (poly)peptide delivery systems. J. Pharm. Sci., 89, 901-909.
  200. Bernkop-Schnürch, A., Giovanelli, R., and Valenta, C.  (2000). Peroral administration of enzymes: Strategies to improve the galenic of dosage forms for trypsin and bromelain. Drug Dev. Ind. Pharm., 26, 115-121.
  201. Bernkop-Schnürch, A., Scholler, S., and Biebel, R.G.  (2000). Development of controlled drug release systems based on polymer-cysteine conjugates. J. Control. Rel., 66, 39-48.
  202. Clausen, A.E., and Bernkop-Schnürch, A.  (2000). In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil. J. Pharm. Sci., 89, 1253-1261.
  203. Kratzel, M. and Bernkop-Schnürch, A.  (2000). Valaminols, probably the most simplified peptide-analogs acting as pepsin inhibitors. Peptides, 21, 289-293.
  204. Marschütz, M.K. and Bernkop-Schnürch, A.  (2000). Oral peptide drug delivery: Polymer-inhibitor conjugates protecting insulin from enzymatic degradation. Biomaterials, 21, 1499-1507.
  205. Marschütz, M.K., Caliceti, P., and Bernkop-Schnürch, A.  (2000). Design and in vivo evaluation of an oral delivery system for insulin. Pharm. Res., 17, 1468-1474.
  206. Bernkop-Schnürch, A. and Freudl, J.  (1999). Comparative in vitro study of different chitosan-complexing agent conjugates. Pharmazie, 54, 369-371.
  207. Bernkop-Schnürch, A., Brandt U.-M., and Clausen, A.  (1999). Synthese und in Vitro Evaluierung von Chitosan-Cystein Konjugaten. Sci. Pharm., 67, 197-208.
  208. Bernkop-Schnürch, A., Kirchmayer, R. and Kratzel, M.  (1999). Synthesis, development and in vitro evaluation of drug delivery systems with protective effect towards pepsinic degradation. J. Drug Targ., 7, 55-63.
  209. Bernkop-Schnürch, A., Schwarz, V., and Steininger, S.  (1999). Polymers with thiol groups: A new generation of mucoadhesive polymers? Pharm. Res., 16, 876-881.
  210. Bernkop-Schnürch, A., Valenta, C., and Daee, S.M.  (1999). Peroral polypeptide delivery: A comparative in vitro study of mucolytic agents. Arzneimittelforschung., 49, 799-803.
  211. Kratzel, M., Hiessböck, R., and Bernkop-Schnürch, A.  (1999). Auxiliary agents for the peroral administration of peptide and protein drugs: Synthesis and evaluation of novel pepstatin analogues. J. Med. Chem., 41, 2339-2344.
  212. Valenta., C., Nowack, E., and Bernkop-Schnürch, A.  (1999). Deoxycholate-hydrogels: Novel drug carrier systems for topical use. Int. J. Pharm., 185, 103-111.
  213. Bernkop-Schnürch, A., and Krajicek, M.E.  (1998). Mucoadhesive polymers as platforms for peroral peptide delivery and absortion: Synthesis and evaluation of different chitosan-EDTA conjugates. J. Control. Rel., 50, 215-223.
  214. Bernkop-Schnürch, A., and Pasta, M.  (1998). Intestinal peptide and protein delivery: Novel bioadhesive drug carrier matrix shielding from enzymatic attack. J. Pharm. Sci., 87, 430-434.
  215. Bernkop-Schnürch, A., and Scerbe-Saiko, A.  (1998). Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins. Pharm. Res., 15, 263-269.
  216. Bernkop-Schnürch, A., Humenberger, C., and Valenta, C.  (1998). Basic studies on bioadhesive delivery systems for peptide and protein drugs. Int. J. Pharm., 165, 217-225.
  217. Bernkop-Schnürch, A., Krauland, A., and Valenta, C.  (1998). Development and in vitro evaluation of a drug delivery system based on chitosan-EDTA BBI conjugate. J. Drug Targ., 6, 207-214.
  218. Bernkop-Schnürch, A., Krist, S., Vehabovic, M., and Valenta, C.  (1998). Synthesis and evaluation of lysozyme derivatives exhibiting an enhanced antimicrobial action. Eur. J. Pharm. Sci., 6, 301-306.
  219. Kratzel, M., Schlichtner, B., Kirchmayer, R. and Bernkop-Schnürch, A.  (1998). Simplified pepstatins: Synthesis and evaluation of N-terminally modified analogues. J. Med. Chem., 42, 2041-2045.
  220. Valenta., C., Christen, B., and Bernkop-Schnürch, A.  (1998). Chitosan-EDTA conjugate: A novel polymer for topical used gels. J. Pharm. Pharmacol., 50, 445-452.
  221. Valenta., C., Schwarz, E.G., and Bernkop-Schnürch, A.  (1998). Lysozyme caffeic acid conjugates: possible novel preservatives for dermatics. Int. J. Pharm., 174, 125-132.
  222. Bernkop-Schnürch, A., and Apprich, I.  (1997). Synthesis and evaluation of a modified mucoadhesive polymer protecting from alpha-chymotrypsinic degradation. Int. J. Pharm., 146, 247-254.
  223. Bernkop-Schnürch, A., and Göckel, N.C.  (1997). Development and analysis of a polymer protecting from luminal enzymatic degradation caused by alpha-chymotrypsin. Drug Dev. Ind. Pharm., 23, 733-740.
  224. Bernkop-Schnürch, A., and Marschütz, M.  (1997). Development and in vitro evaluation of systems to protect peptide drugs from aminopeptidase N. Pharm. Res., 14, 181-185.
  225. Bernkop-Schnürch, A., Bratengeyer, I., and Valenta, C.  (1997). Development and in vitro evaluation of a drug delivery system protecting from trypsinic degradation. Int. J. Pharm., 157, 17-25.
  226. Bernkop-Schnürch, A., Gabor, F., and Spiegl, P.  (1997). Bacterial adhesins as a drug carrier: covalent attachment of K99 fimbriae to 6-methylprednisolone. Pharmazie, 52, 41-44.
  227. Bernkop-Schnürch, A., Paikl, Ch., and Valenta, C.  (1997). Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N. Pharm. Res., 14, 917-922.
  228. Bernkop-Schnürch, A., Schwarz, G.H., and Kratzel M.  (1997). Modified mucoadhesive polymers for the peroral administration of mainly elastase degradable therapeutic (poly)peptides. J. Control. Rel., 47, 113-121.
  229. Gabor, F., Bernkop-Schnürch, A., and Hamilton, G.  (1997). Bioadhesion to the intestine by means of E. coli K99-fimbriae: Gastrointestinal stability and specificity of adherence. Eur. J. Pharm. Sci., 5, 233-242.
  230. Valenta, C., Bernkop-Schnürch, A. and Schwartz, M.  (1997). Modification of lysozyme with cinnamaldehyde: A strategy for constructing novel biopreservatives for dermatics. Int. J. Pharm., 148, 131-137.
  231. Bernkop-Schnürch, A. and Fragner, R.  (1996). Investigations into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration. Pharm. Sciences, 2, 361-363.
  232. Bernkop-Schnürch, A., and Dundalek, K.  (1996). Novel bioadhesive drug delivery system protecting (poly)peptides from gastric enzymatic degradation. Int. J. Pharm., 138, 75-83.
  233. Bernkop-Schnürch, A., Valenta, C., and Gatterwe, V.  (1996). In vitro skin permeation studies of the lantibiotic nisin. Eur. J. Pharm. Biopharm., 42, 336-339.
  234. Valenta, C., Bernkop-Schnürch, A., and Rigler, H.P.  (1996). The anti-staphylococcal effect of nisin in a suitable vehicle, a potential therapy for atopic dermatitis. J. Pharm. Pharmacol., 48, 988-991.
  235. Valenta, C., Bernkop-Schnürch, A., and Teltscher, C.  (1996). Nisin, ein potentielles Konservierungsmittel in topischen Zubereitungen. Pharmazie, 51, 119-122.
  236. Bernkop-Schnürch, A., and Valenta, C.  (1995). Untersuchungen zur mikrobiellen Stabilität von magistral hergestellten hydrophilen Cremes und Gelen. ÖAZ, 49, 926-929.
  237. Bernkop-Schnürch, A., Gabor, F., Szostak, M.P., and Lubitz, W.  (1995). An adhesive drug delivery system based on K99-fimbriae. Eur. J. Pharm. Sci., 3, 293-299.
  238. Bernkop-Schnürch, A., Gabor, F., Szostak, M.P., and Lubitz, W.  (1995). Production of adhesive drug carriers using recombinant DNA-technology. Sci. Pharm., 63, 159-166.
  239. Bernkop-Schnürch, A., Valenta, C. and Urban, U. (1995). Microbiological stability of iIndividually prepared dermatica. Sci. Pharm., 63, 65-70.
  240. Valenta, C., and Bernkop-Schnürch, A. (1993). Untersuchungen von Kontaminationsrisken bei der Herstellung von magistralen Augentropfen. ÖAZ, 47, 141-143.
  241. Kopp, B., Bauer, W.P., and Bernkop-Schnürch, A. (1992). Analysis of some Malaysian dart poisons. J. Ethnopharmacol., 36, 57-62.

 

Book contributions:

  • Hombach, J.; Bernkop-Schnürch, A. (2010). Mucoadhesive drug delivery systems. Handbook of Experimental Pharmacology Ed Monika Schäfer-Korting Springer Heidelberg. 202-220
  • Bernkop-Schnürch, A. (2009). Low molecular mass permeation enhancers in oral delivery of molecular drugs. Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends. 85-101.
  • Vetter, A.; Bernkop-Schnürch, A. (2009). Bioadhesive Delivery Systems. Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development, 218-234.
  • Bernkop-Schnürch, A. (2008). Thiolated chitosans in non-invasive drug delivery. Natural-based polymers for biomedical applications. 624-643.
  • Werle, M. and Bernkop-Schnürch*, A. (2007). Inhibition of enzymes and secretory transport. Enhancement in drug delivery Elka Touitou and Brian W. Barry CRC Press 85-109.
  • Bernkop-Schnürch*, A. (2002). Mucoadhesive polymers. Polymeric Biomaterials. 2nd edition (Ed. Severian Dumitriu) Marcel Dekker, New York. 147-165.


Reviews:

  • Sakloetsakun, D.; Bernkop-Schnürch, A. (2010). Thiolated Chitosans. J. Drug Del. Sci.Tech., 20, 63-69.
  • Hoyer, H.; Perera, G.; Bernkop-Schnürch, A. (2010). Noninvasive delivery systems for peptides and proteins in osteoporosis therapy: a retroperspective. Drug Dev. Ind. Pharm., 36, 31-44.
  • Baloglu, E.; Senyigit, Z.A.; Karavana, S.Y.; Bernkop-Schnürch, A. (2009). Strategies to prolong the intravaginal residence time of drug delivery systems. J. Pharm.Pharmaceut.Sci., 12, 312-336.
  • Werle, M.; Bernkop-Schnürch, A. (2008). Thiolated chitosans: useful excipients for oral drug delivery. J. Pharm. Pharmacol., 60, 273-281.
  • Albrecht, K. and Bernkop-Schnürch, A. (2007). Thiomers: forms, functions and applications to nanomedicine. Nanomedicine, 2, 41-50.
  • Bernkop-Schnürch, A. and Grabovac V. (2006). Polymeric efflux pump inhibitors in oral drug delivery. Am. J. Drug. Deliv., 4, 263-272.
  • Bernkop-Schnürch, A. and Greimel, A. (2005). Thiomers: The next generation of mucoadhesive polymers. Am. J. Drug. Deliv., 3, 141-154.
  • Langoth, N. and Bernkop-Schnürch, A. (2005). The use of multifunctional polymers as auxiliary agents in non-invasive peptide delivery. Am. Pharm. Rev., 8, 80-84.
  • Bernkop-Schnürch, A. (2005). Thiomers: A new generation of mucoadhesive polymers. Adv. Drug Del. Rev., 57, 1569-1582.
  • Bernkop-Schnürch, A. (2005). Mucoadhesive systems in oral drug delivery. Drug Discovery Today: Technologies, 2, 83-87.
  • Bernkop-Schnürch, A., Clausen ,A.E. and Guggi, D. (2004). The use of auxiliary agents to improve the mucosal uptake of peptides. Med. Chem. Rev., 1, 1-10.
  • Bernkop-Schnürch, A., Krauland, A.H., Leitner, V.M. and Palmberger, Th. (2004). Thiomers: potential excipients for non-invasive peptide delivery systems. Eur. J. Pharm. Biopharm., 58, 253-263.
  • Bernkop-Schnürch, A., Hoffer, M. and Kafedjiiski, K. (2004). Thiomers for oral delivery of hydrophilic macromolecular drugs. Expert Opinion Drug Deliv., 1, 87-98.


*author for correspondence