Publications

 
An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation
Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I, Liu X, Hong S, Pauler FM, Penz T, Brandstetter M, Barbieux C, Berishvili E, Heuser T, Bock C, Riedel CG, Meyer D, Distel M, Hecksher-Sørensen J, Li J, Kubicek S.
Mol Metab. 2021 Aug 25:101329. DOI:  10.1016/j.molmet.2021.101329. Epub ahead of print
 
 
Generation of an hiPSC-1 knock-in line expressing TY1-tagged MNX1-protein together with mScarlet
Temocin O, Regele D, Sathianathan M, Überbacher C, Hartl M, Edenhofer F, Meyer D.
Stem Cell Res. 2021 Sep 2;56:102522. DOI: 10.1016/j.scr.2021.102522. Epub ahead of print.
 
 
Inducible Mosaic Cell Labeling Provides Insights Into Pancreatic Islet Morphogenesis
Freudenblum J, Meyer D and Kimmel RA (2020)
Cell Dev. Biol. 8:586651. DOI: 10.3389/fcell.2020.586651 
 
 
Shock waves promote spinal cord repair via TLR3
Gollmann-Tepeköylü C, Nägele F, Graber M, et al. 
JCI Insight. 2020;5(15):134552. Published 2020 Aug 6. DOI Pubmed
 
 
Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium
Tschaikner P, Enzler F, Torres-Quesada O, Aanstad P, Stefan E. 
Cells 2020 Jan 3;9(1). pii: E118. doi: 10.3390/cells9010118.  Pubmed
 
 
 
FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical Regulation
Fischer P, Chen H, Pacho F, Rieder D, Kimmel RA, Meyer D.
BMC Biology 2019 Jul 30;17(1):61. DOI: 10.1186/s12915-019-0683-z. Pubmed
 
 
Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets
Emfinger CH, Lőrincz R, Wang Y, York NW, Singareddy SS, Ikle JM, Tryon RC, McClenaghan C, Shyr ZA, Huang Y, Reissaus CA, Meyer D, Piston DW, Hyrc K, Remedi MS, Nichols CG.
Physiological Reports 2019 Jun;7(11):e14101. DOI: 10.14814/phy2.14101. Pubmed
 

In vivo monitoring of intracellular Ca2+ dynamics in the pancreatic β-cells of zebrafish Embryos
Lorincz R, Emfinger CH, Walcher A, Giolai M, Krautgasser C, Remedi MS, Nichols CG, Meyer D.
Islets 2018;10(6):221-238. (DOI) 2018.1540234. Epub 2018 Dec 6. Pubmed
 

In vivo imaging  of  emerging  endocrine cells reveals a requirement for PI3K­-regulated motility  in  pancreatic  islet morphogenesis
Freudenblum J, Iglesias JA, Hermann M, Walsen T, Wilfinger A, Meyer D, Kimmel RA.
Development 2018 Feb 8:145(3). (DOI) Pubmed
 
 
Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and Regeneration
Facchinello, N; Tarifeño-Saldivia, E; Grisan, E; Schiavone, M; Peron, M; Mongera, A; Ek, O; Schmitner, N; Meyer, D; Peers, B; Tiso, N; Argenton, F; (2017)
Scientific Reports 2017; 7: 9605. Published online 2017 Aug 29. (DOI) Pubmed 
 
 
Ptf1a+, ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae
Schmitner, Nicole; Kohno, Kenji; Meyer, Dirk (2017)
 
 
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
Li, J; Casteels, T; Frogne,T; Ingvorsen, C; Honoré, C; Courtney, M; et. al (2017)
CELL 2017 Jan 12;168(1-2):86-100.e15. Epub 2016 Dec 1. (DOI) Pubmed  
 
 
Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm
Ott, Elisabeth; Wendik, Björn; Srivastava, Monika; Pacho, Frederic; Töchterle, Sonja; Salvenmoser, Willibald; Meyer, Dirk (2016)
Developmental Biology 411/1, S. 101 - 114. (DOI) Pubmed
 
 
Partial dedifferentiation of murine radial glia type neural stem cells by Brn2 and c-Myc yields early neuroepithelial progenitors
Bung, Raffaela; Wörsdörfer, Philipp; Thier, Marc Christian; Vogt, Kathrin; Gebhardt, Martina; Edenhofer, Frank (2016)
JOURNAL OF MOLECULAR BIOLOGY 428/7, S. 1476 - 1483. (DOI) Pubmed
 
 
Zebrafish Pancreas as a Model for Development and Disease
Kimmel, R.A.; Meyer, D. (2016) 
Methods in Cell Biology 2016; 134:431-61; Epub 2016 March 17 (DOI)  Pubmed
 
 
In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs
Röck, R; Bachmann, V; Bhang, HC; Malleshaiah, M; Raffeiner, P; Mayrhofer, JE; Tschaikner, PM; Bister, K; Aanstad, P; Pomper, MG; Michnick, SW; Stefan, E (2015)
Scientific Reports 5, Art. No. 11133. (DOI) Pubmed
 
 
Hybrid ultrahigh resolution optical coherence / photoacoustic microscopy
Hermann, B.; Liu, M.; Schmitner, N.; Maurer, B.; Meyer, D.; Weninger, W. J.; Drexler, W. (2015)
Proceedings of the Society of Photo-optical Instrumentation Engineers (SPIE) 9323, No. 93232N. (DOI) (Weblink)
 
 
Partial dedifferentiation of murine radial glia type neural stem cells by Brn2 and c-Myc yields early neuroepithelial progenitors
Bung, R.; Wörsdörfer, P.; Thier, M.C.; Vogt, K.; Gebhardt, M.; Edenhofer, F. (2015)
JOURNAL OF MOLECULAR BIOLOGY (DOI) Pubmed
 
 
A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish
Astone M., Pizzi M., Peron M., Domenichini A., Guzzardo V., Töchterle S., Tiso N., Rugge M., Meyer D., Argenton F.,
Vettori A. (2015) 
PLoS One. 2015 Dec 22;10(12):e0145178. doi: 10.1371/journal.pone.0145178. eCollection 2015. Pubmed
 
 
Nmnat1-Rbp7 Is a Conserved Fusion-Protein That Combines NAD+ Catalysis of Nmnat1 with Subcellular Localization of Rbp7
Chen H., Babino D., Schoenbichler SA., Arkhipova V., Töchterle S., Martin F., Huck CW., von Lintig J., Meyer D.(2015) 
PLoS One. 2015 Nov 30;10(11):e0143825. doi: 10.1371. Pubmed
 
  
Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic Treatment
Kimmel, R.A., Dobler, S., Schmitner, N., Walsen, T., Freudenblum, J., and Meyer, D. (2015)
Sci. Rep. 5, 14241 Pubmed
 
 
A Smad3 transgenic reporter   reveals TGF-beta control of zebrafish spinal cord development
Casari A, Schiavone M, Facchinello N, Vettori A, Meyer D, Tiso N, Moro E, Argenton F. (2014) 
Dev Biol. 2014 Oct 5 Pubmed
 
 
In vivo three dimensional dual wavelength photoacoustic tomography imaging of the far red fluorescent protein E2-Crimson expressed in adult zebrafish
Liu, M., Schmitner, N., Sandrian, M.G., Zabihian, B., Hermann, B., Salvenmoser, W., Meyer, D., Drexler, W., (2013)
Biomedical Optics Express, Vol. 4, Issue 10, pp. 1846-1855. doi: 10.1364/BOE.4.001846. OpticsInfoBase
 
 
Simultaneous three-dimensional photoacoustic and laser-ultrasound tomography
Wurzinger G., Nuster R., Schmitner N., Gratt S., Meyer D., Paltauf G. (2013) 
Biomedical Optics Express. 2013 Jul 19;4(8):1380-9. doi: 10.1364/BOE.4.001380. Pubmed
 
 
High-speed panoramic light-sheet microscopy reveals global endodermal cell Dynamics
Schmid B, Shah G, Scherf N, Weber M, Thierbach K, Campos CP, Roeder I, Aanstad P, Huisken J. (2013)
Nat Commun. 2013 Jul 24;4:2207. Doi: 10.1038/ncomms3207.Pubmed
 
 
Hybrid photoacoustic and ultrasound section imaging with optical ultrasound detection
Nuster R, Schmitner N, Wurzinger G, Gratt S, Salvenmoser W, Meyer D, Paltauf G. (2013) 
 J Biophotonics. 2013 May 5. DOI: 10.1002/jbio.201200223. PubMed
 
 
Cell type and tissue specific function of islet genes in zebrafish pancreas development
Wilfinger, A., Arkhipova, V., Meyer D.
Dev. Biol. (2013) Volume 378, Issue 1, 1 June 2013, Pages 25–37. doi: 10.1016/j.ydbio.2013.03.009.  Pubmed
 
 
Collective mesendoderm migration relies on an intrinsic directionality signal transmitted through cell contacts
Dumortier, JG, Martin, S., Meyer, D., Rosa, FM, David, NB (2012)
Proceedings of the National Academy of Sciences, PNAS, 0027-8424, DOI: 10.1073/pnas.1205870109 Pubmed
 
 
Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling
Stueckemann, T., Wegleiter, T., Stefan, E., Naegele, O., Tarbashevich, K., Boeck, G., Raz, E., and Aanstad, P. (2012) 
Development 139, 2711-2720, DOI: 10.1242/dev.074930 Pubmed
 
 
Characterization and regulation of the hb9/mnx1 beta-cell progenitor specific enhancer in zebrafish
Arkhipova V., Wendik B., Devos N., Ek O., Peers B., Meyer D. (2012) 
Dev Biol. 2012 May 1;365(1):290-302. Epub 2012 Mar 9. DOI: 101016, Pubmed
 
 
Photoacoustic section imaging using an elliptical acoustic mirror and optical detection
Nuster R., Gratt S.,  Passler K., Meyer D., and Paltauf G.
J. Biomed. Opt. 17, 030503 (2012), DOI:10.1117/1.JBO.17.3.030503. Pubmed
 
 
Fast Homozygosity Mapping and Identification of a Zebrafish ENU-Induced Mutation by Whole-Genome Sequencing
Voz ML, Coppieters W., Manfroid I., Baudhuin A., Von Berg V., Charlier C., Meyer D., Driever W., Martial JA, Peers B.  (2012)
PLoS One. 2012;7(4):e34671. Epub 2012 Apr 4. Pubmed
 
 
Requirement for Pdx1 in specification of latent endocrine progenitors in zebrafish
Kimmel RA, Onder L, Wilfinger A, Ellertsdottir E, Meyer D. (2011)
BMC Biol. 2011 Oct 31;9:75. Pubmed
 

Distinct expression patterns of dickkopf genes during late embryonic development of Danio rerio
Untergasser, G., Martowicz, A., Hermann, M., Töchterle, S., Meyer, D. (2011)
Gene Expr Patterns. 2011 Aug 26. Pubmed
 
 
On the Use of Frequency-Domain Reconstruction Algorithms for Photoacoustic Imagings
Schulze, R., Zangerl, G.,  Holotta, M.,  Handle, F., Meyer, D., Nuster, R.,  Paltauf, G., Scherzer, O.  
J Biomed Opt. 2011 Aug;16(8):086002. Pubmed
 
 
Efficiency of translation termination in humans is highly dependent upon nucleotides in the neighbourhood of a (premature) termination codon
Pacho F., Zambruno G., Calabresi V., Kiritsi D., Schneider H. (2011) 
J Med Genet. 2011 Sep;48(9):640-4. Pubmed
 
 
Molecular regulation of pancreas development in zebrafish
Kimmel, R., Meyer, D. (2010)
Methods Cell Biol 100, 261-80 PubMed 
 
 
The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling
Aanstad, P., Santos N., Corbit K. C., Scherz P. J.  Trinh L. A., Salvenmoser W., Huisken J., Reiter J. F., Stainier D. Y. R. (2009) 
Current Biology19, 1034-1039 PubMed
 
 
PlexinA3 restricts spinal exit points and branching of trunk motor nerves in embryonic zebrafish
Feldner, J., Reimer, M.M., Schweitzer, J., Wendik, B., Meyer, D., Becker, T., Becker, C.G. (2007)
Journal of Neuroscience 27/18, 4978-4983 PubMed
 
 
Nodal signaling activates differentiation genes during zebrafish gastrulation
Bennett, J.T., Joubin, K., Cheng, S., Aanstad, P., Herwig, R., Clark, M., Lehrach, H., and Schier, A.F. (2007) 
Dev. Biol. 304(2), 525-540 PubMed 
 
 
Expression of rasgef1b in zebrafish
Epting, D., Vorwerk, S., Hageman, A., and Meyer, D. (2007) 
Gene Expr. Patterns. 7, 389-395 PubMed
 
 
Vertebrate Smoothened functions at the primary cilium
Corbit, K.C., Aanstad, P., Singla, V., Norman, A.R., Stainier, D.Y., and Reiter, J.F. (2005)
Nature. 437(7061):1018-1021 PubMed
 
 
Neuromuscular synapses can form in vivo by incorporation of initially aneural postsynaptic specializations
Flanagan-Steet, H., Fox, M.A., Meyer, D., and Sanes, J.R. (2005) 
Development. 132, 4471-4481 PubMed
 
 
Expression profiling and comparative genomics identify a conserved regulatory region controlling midline expression in the zebrafish embryo
Dickmeis, T., Plessy, C., Rastegar, S., Aanstad, P., Herwig, R., Chalmel, F., Fischer, N., and Strähle, U. (2004) 
Genome Res. 14(2), 228-238 PubMed
 
 
Zebrafish mnx genes in endocrine and exocrine pancreas formation
Wendik, B., Maier, E., Meyer, D. (2004) 
Dev. Biol. 268, 372-83 PubMed  
 
 
Evolutionary conserved role of ptf1a in the exocrine pancreatic fate
Zecchin, E. Mavropoulos, A., Devos, N.,. Filippi, A., Tiso, N., Meyer, D., Peers, B., Bortolussi, M., Argenton, F. (2004) 
Dev. Biol. 268, 174-84. PubMed  
 
 
Prep1.1 has essential genetic functions in hindbrain development and neural crest cells differentiation
Deflorian, G., Tiso, N. , Ferretti, E. , Meyer, D. , Blasi, F. , Bortolussi, M., Argenton, F. (2004) 
Development 131, 613-627 PubMed   
 
 
The Mix family homeodomain gene bonnie and clyde functions with other components of the Nodal signaling pathway to regulate neural patterning in zebrafish
Trinh, L., A., Meyer, D. and Stainier, D. Y. (2003)
Development 130, 4989-98. PubMed  
 
 
An expression pattern screen for genes involved in the induction of the posterior nervous system of zebrafish
Yoda, H., Momoi, A., Esguerra, C. V., Meyer, D., Driever, W., Kondoh, H. and Furutani-Seiki, M. (2003).
Differentiation 71, 152-62. PubMed  
 
 
Expression of the helix-loop-helix gene id3 in the zebrafish embryo
Dickmeis, T., Rastegar, S., Lam, C.S., Aanstad, P., Clark, M., Fischer, N., Rosa, F., Korzh, V., and Strähle, U. (2002) 
Development 113(1), 99-109 PubMed
 
 
Guidance of primordial germ cell migration by the chemokine SDF-1
Doitsidou, M., Reichman-Fried, M., Stebler, J., Koprunner, M., Dorries, J., Meyer, D., Esguerra, C. V., Leung, T. and Raz, E. (2002)
Cell 111, 647-59. PubMed  
 
 
Zebrafish smad7 is regulated by Smad3 and BMP signals
Pogoda H-M, Meyer D (2002) 
DevDyn 224,  334-349 PubMed  
 
 
Identification of nodal signaling targets by array analysis of induced complex probes
Dickmeis, T., Aanstad, P., Clark, M., Fischer, N., Herwig, R., Mourrain, P., Blader, P., Rosa, F., Lehrach, H., and Strähle, U. (2001) 
DevDyn 222(4), 571-580 PubMed
 
 
A crucial component of the endoderm formation pathway, CASANOVA, is encoded by a novel sox-related gene
Dickmeis, T., Mourrain, P., Saint-Etienne, L., Fischer, N., Aanstad, P., Clark, M., Strähle, U., and Rosa, F. (2001) 
Genes Dev.. 15(12), 1487-1492 PubMed 
 
 
Expression of the anti-dorsalizing morphogenetic protein gene in the zebrafish embryo
Dickmeis, T., Rastegar, S., Aanstad, P., Clark, M., Fischer, N., Korzh, V., and Strähle, U. (2001) 
Dev. Genes Evol.. 211(11), 568-572 PubMed 
 
 
Expression of brain subtype creatine kinase in the zebrafish embryo
Dickmeis, T., Rastegar, S., Aanstad, P., Clark, M., Fischer, N., Plessy, C., Rosa, F., Korzh, V., Strähle, U. (2001) 
Mech. Dev.. 109(2), 409-412 PubMed 
 
 
Statistical evaluation of differential expression on cDNA nylon arrays with replicated experiments
Herwig, R., Aanstad, P., Clark, M., and Lehrach, H. (2001) 
Nucleic Acids Res.. 29(23), U1-U9 PubMed 
 
 
The gene schmalspur functions in mesoderm formation in zebrafish, and interacts with notail and spadetail
Rojo, C., Ellertsdottir, E., Pogoda, H. M. and Meyer, D. (2001)
Int. J. Dev. Biol. 45, 157-S158
 
 
Pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer
Belting HG, Hauptmann G, Meyer D, Abdelilah-Seyfried S, Chitnis A, Eschbach C, Soll I, Thisse, C, Thisse B, Artinger KB, Lunde K, Driever W (2001)
Development 128, 4165-76 PubMed  
 
 
The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation
Pogoda H-M, Solnica-Krezel L, Driever W, Meyer D. (2000) 
Curr Biol. 10, 1041-9. PubMed   
 
 
Predictability of dorso-ventral asymmetry in the cleavage stage zebrafish embryo: an analysis using lithium sensitivity as a dorso-ventral marker
Aanstad, P. and Whitaker, M. (1999) 
Mech. Dev.. 88(1), 33-41 PubMed
 
 
Vg1 RBP intracellular distribution and evolutionarily conserved expression suggest multiple roles during development
Zhang, Q., Yaniv, K., Oberman, F., Wolke, U., Git, A., Fromer, M., Taylor, W.L., Meyer, D., Standart, N., Raz,
E.and Joel K. Yisraeli (1999)
Mech Dev. 88, 101-106 PubMed  
 
 
Genetic analysis of pattern formation in the zebrafish neural plate
Driever, W., Solnica-Krezel, L. Abdelilah, S., Meyer, D. and Stemple D. (1997) 
Embryonic Pattern Formation. CSHSQR, 62, 523-34 (Review) PubMed  
 
 
 
Isoform-specific expression and function of neuregulin
Meyer, D., Yamaai, T., Garratt, A., Riethmacher-Sonnenberg, E., Kane, D., Theill, L.E. and Birchmeier, C. (1997)
Development, 124, 3575-3586 PubMed 
 
 
Multiple essential functions of neuregulin in development
Meyer, D. and Birchmeier, C. (1995) 
Nature, 378, 386-390 PubMed 
 
 
Sequential requirement for hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland
Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K.M., Birchmeier, C. and Birchmeier, W. (1995)
J. Cell. Biol. 131, 215-226 PubMed  
 
 
Factors Controlling Growth, Motility, and Morphogenesis of Normal and Malignant Epithelial Cells
Birchmeier, C., Meyer, D. and Riethmacher, D. (1995) 
Int. Rev. Cytol. 160, 221-266 (Review) PubMed 
 
 
Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development
Meyer, D. and Birchmeier, C. (1994) 
Proc. Natl. Acad. Sci. USA 91, 1064-1068 PubMed 
 
 
Scatter Factor/Hepatocyte Growth Factor and its Receptor, the c-met Tyrosine Kinase, can Mediate a Signal Exchange Between Mesenchyme and Epithelia During Mouse Embryogenesis
Sonnenberg, E., Meyer, D., Weidner, M. and Birchmeier, C. (1993)
J. Cell. Biol. 123, 223-235 PubMed  
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