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PREFORMULATION AND POLYMORPHISM GROUP

Head: A. Univ.-Prof. Mag. pharm. Dr. rer. nat.
Ulrich J. Griesser

Institute of Pharmacy, Pharmaceutical Technology
University of Innsbruck
Innrain 52c, 6020 Innsbruck
Austria


 

The activities of the research group are focused at scientific and applied problems related to solid state properties of pharmaceuticals and other small organic molecules of high industrial relevance such as agro-chemicals. A major concern of our work is the development of methods, strategies and guidelines in the production and characterization of solid state forms and the systematic exploration of structure property relationships.

The phenomena that emerge from these activities are manifold and include amorphicity, order-disorder structures, plastic and liquid crystals, different types of polymorphism as well as different kinds of multicomponent crystals (hydrates, solvates, co-crystals, racemates).

The assessment of thermodynamic, kinetic and structural properties of the phases and phase transitions requires a broad methodology and various analytical techniques comprising among others thermal analysis and calorimetry (DSC, TGA, hot stage microscopy, microcalorimetry), vibrational spectroscopy (IR, Raman, NMR), X-ray diffraction (powder and single crystal), light and electron microscopy among others.