Dr. Jörg Striessnig


Professor, Chairman

Email: joerg.striessnig@uibk.ac.at
Phone: +43-(0)512-507 - 58800
Fax: +43-(0)512-507 - 58899

Molecular Pharmacology of Voltage - Gated Calcium Channels - Group

For publications in Pubmed click here



 Short Curriculum

born: May 14, 1959

1977 - 1982 Medical School, University of Innsbruck
1983 Internship, Internal Medicine; University Hospital Innsbruck
1984 - 1989 University Assistant, Department of Biochemical Pharmacology, Medical School, University of Innsbruck, Austria
1989 - 1991 Visiting Assistant Professor, Department of Pharmacology, University of Washington, Seattle, USA
1991 Habilitation (Pharmacology and Toxicology), University of Innsbruck
1991 - 1998 Assistant Professor, Department of Biochemical Pharmacology, University of Innsbruck
1994 License as "Facharzt" for Pharmacology and Toxicology
1998 Associate Professor, Department of Biochemical Pharmacology, University of Innsbruck
2001 Full Professor and Chairman of the Department of Pharmacology and Toxicology, Institute of Pharmacy, Natural Sciences Faculty, University of Innsbruck, Austria
2004 Corresponding member of the Austrian Academy of Sciences (Section for Mathematics and the Natural Sciences)
2007 Member of the German Academy of Sciences "Leopoldina"


Teaching Experience

  • Medical and Pharmacy students
    • seminars / lectures in pharmacology, toxicology, clinical pharmacy and pharmacology
    • small group teaching in pharmacology and toxicology
    • physiology and pathophysiology for pharmacy students
  • School of Nursing
    • lectures in pharmacology and toxicology
  • Graduate program "Molecular Cell Biology"
    • lectures and seminars on "signal transduction, receptors and electrical excitability"
  • Continuing education of pharmacists and physicians
    • lectures and seminars on clinical pharmacology and drug therapy


Scientific Awards

  • Science award of the Ärztekammern für Tirol und Vorarlberg (1988)
  • Award of a Max-Kade Fellowship from the Austrian Academy of Sciences (1989 - 1991)
  • Science award from the City of Innsbruck (1992, 2002)
  • International Albrecht Fleckenstein Award (2000)
  • Co - awardee on awards for young members of the research group (HOECHST awards 1997, 1998, 2000)
  • Wulf - Vater Dihydropyridine - award (1998)
  • Research Award for Scientific Excellence (Innsbruck Universities, 2011)
  • Tyrolean Research Award 2012
  • Phoenix Award in Pharmaceutical Sciences (Pharmacology and Clinical Pharmacology, 2015)


Other activities

1998 -
Member of the Ethics Committee of the Medical Faculty of the University of Innsbruck
2003 -
Member of the Academic Senate of the Leopold-Franzens University in Innsbruck
2001 – 2019 Coordinator of the Cooperative Neuroscience Research Network "Cell Signaling in Chronic CNS Disorders" (FWF SFB-F44)
since 2000
total research funding > EUR 4.1 mio


Evaluation of publication record (as of 06/2016, ISI)

Number of citations of own publications (total): > 10,283

Number of citations of own publications (2015): 675

h - Index: 57

Total number of articles in PubMed: >168


Selected publications

Striessnig J, Murphy BJ, Catterall WA (1991)
"The dihydropyridine receptor of L-type Ca2+ channels: Identification of binding domains for (+)-[3H]PN200-110 and [3H]azidopine within the α1 subunit"
Proc Natl Acad Sci (USA): 88: 10769-10773

Kraus RL, Sinnegger MJ, Glossmann H, Hering S, Striessnig J (1998)
"Familial hemiplegic migraine mutations change α1A Ca2+ channel kinetics"
J Biol Chem: 273: 5586-5590

Striessnig J, Grabner M, Mitterdorfer J, Hering S, Sinnegger MJ, Glossmann H (1998)
"Structural basis of drug binding to L-type Ca2+ channels"
Trends Pharmacol Sci: 19: 108-115

Platzer J, Engel J, Schrott-Fischer A, Stephan K, Bova S, Chen H, Zheng H, Striessnig J (2000)
"Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels"
Cell: 102: 89-97

Koschak A, Reimer D, Huber IG, Grabner M, Glossmann H, Engel J, Striessnig J (2001)
"α1D (Cav1.3) subunits can form L-type Ca2+ channels activating at negative voltages"
J Biol Chem: 276: 22100-22106

Pietrobon D, Striessnig J (2003)
"Neurobiology of migraine"
Nature Rev Neurosci: 4: 386-398

Koschak A, Reimer D, Walter D, Hoda J-C, Heinzle T, Grabner M, Striessnig J (2003)
"Cav1.4α1 subunits can form slowly inactivating dihydropyridine - sensitive L-type Ca2+ channels lacking Ca2+ - dependent inactivation"
J Neurosci: 23: 6041-6049

Sinnegger-Brauns MJ, Hetzenauer A, Huber IG, Renström E, Wietzorrek G, Berjukov S, Cavalli M, Walter D, Koschak A, Waldschütz R, Hering S, Bova S, Rorsman P, Pongs O, Singewald S, Striessnig J (2004)
"Cav1.3 L-type Ca2+-channels: Role for isoform-specific regulation of mood behavior, pancreatic β - cell and cardiovascular function"
J Clin Invest: 113: 1430-1439

Singh A, Hamedinger D, Hoda JC, Gebhart M, Koschak A, Romanin C, Striessnig J (2006)
"C-terminal modulator controls Ca2+-dependent gating of Cav 1.4 L-type calcium channels"
Nature Neurosci: 9: 1108-1116

Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nurnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nurnberg P, Striessnig J, Bolz HJ (2011)
"Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness"
Nature Neurosci: 14: 77-84

Bock G, Gebhart M, Scharinger A, Jangsangthong W, Busquet P, Poggiani C, Sartori S, Mangoni ME, Sinnegger-Brauns MJ, Herzig S, Striessnig J, Koschak A (2011)
"Functional Properties of a Newly Identified C-terminal Splice Variant of Cav1.3 L-type Ca2+ Channels."
J Biol Chem 286:42736-48

Azizan EA, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S, Bochukova EG, Zhao W, Shaikh LH, Brighton CA, Teo AE, Davenport AP, Dekkers T, Tops B, Kusters B, Ceral J, Yeo GS, Neogi SG, McFarlane I, Rosenfeld N, Marass F, Hadfield J, Margas W, Chaggar K, Solar M, Deinum J, Dolphin AC, Farooqi IS, Striessnig J, Nissen P, Brown MJ (2013)
"Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension."
Nat Genet 45:1055-60

Ortner N, Bock G, Vandael DH, Mauersberger R, Draheim HJ, Gust R, Carbone E, Tuluc P Striessnig J (2014)
"Pyrimidine 2, 4, 6-triones are a new class of voltage-gated L-type calcium channel activators."
Nat Commun, Jun 19;5:3897. doi: 10.1038/ncomms4897

Pinggera A, Lieb A, Benedetti B, lampert M, Monteleone S, Liedl KR, Tuluc P, Striessnig J (2015)
CACNA1D de novo mutations in autism spectrum disorders activate Cav1.3 L-type Ca2+ channels.
Biol Psychiatry 77: 816-822

Zamponi GW, Striessnig J, Koschak A, Dolphin AC (2015)
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.
Pharmacol. Rev. 67, 821–870


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