Mag. Nadine J. Ortner, PhD

 

University Assistant (Post-Doc)

 

Email: Nadine.Ortner@uibk.ac.at

Phone: +43-(0)512-507 – 58815

 

Molecular Pharmacology of Voltage – Gated Calcium Channels – Group

 

Research interest: I am particularly interested in deciphering the role of voltage-gated Ca2+ channels in brain disorders such as Parkinson’s disease, autism spectrum disorder or epilepsies and their pharmacological modulation as a potential therapeutic intervention. For my studies I employ molecular (cloning, generation of stable cell lines), electrophysiological (heterologous expression systems, brain slices), immunohistochemical and pharmacological methods.

 

For publications in Pubmed click here (link: https://www.ncbi.nlm.nih.gov/pubmed/?term=Ortner+Nadine)

 

ORCID: https://orcid.org/0000-0003-3882-3283

 

 

Short Curriculum

Born: April 7, 1987

2001 – 2006       Commercial academy with focus on information technology, Villach, Austria

2006 – 2012       Diploma Program in Molecular Biology, University of Vienna, Austria

2012 – 2017       PhD Program Pharmaceutical Sciences, Department of Pharmacology and Toxicology, University of Innsbruck, Austria (external member of the FWF-funded excellence PhD program “Molecular Cell Biology and Oncology (MCBO)”)

2017 – 2019       Postdoctoral research fellow, Department of Pharmacology and Toxicology, University of Innsbruck, Austria

2019 – present University assistant, Erika-Cremer habilitation fellowship of the University of Innsbruck, Austria

 

 

 

Scientific awards / Fellowships / Research funding

2019    Habilitation fellowship of the Erika-Cremer excellence program of the University of Insbruck

2019    Poster & Travel Award (FASEB The Ion Channel Regulation Conference: Molecules to Disease, Lisbon)                           

2018    Tyrolean Science Fund (TWF) for the study of subtype-selective Inhibitors of voltage-gated Ca2+ channels

2017    Price by the Principality of Liechtenstein for scientific research at the University of Innsbruck

2017    Jubiläumsfonds by the University of Innsbruck and the Medical University of Innsbruck for sponsorship of scientific cooperation projects

2017    ALUMNI-I-MED Talk Prize (Life Science PhD Meeting Innsbruck, 2017)

2015    PHOENIX Pharmazie Wissenschaftspreis for the publication “Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators”, Nat Commun. 2014 Jun 19;5:3897

2015    MCBO Best paper Award 2015

 

 

List of publications

De novo CACAN1D Ca2+ channelopathies: Clinical phenotypes and molecular mechanism

Ortner NJ, Kaserer T, Copeland JN, Striessnig J

Pflugers Arch. 2020 Jun 24. doi: 10.1007/s00424-020-02418-w. Online ahead of print.

 

Ca2+ channel blockers

Striessnig J, Ortner NJ

In: Offermanns S., Rosenthal W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham; https://doi.org/10.1007/978-3-030-21573-6_34-1

 

Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder.

Hofer NT, Tuluc P, Ortner NJ, Nikonishyna YV, Fernándes-Quintero ML, Liedl KR, Flucher BE, Cox H, Striessnig J.

Mol Autism. 2020 Jan 8;11:4. doi: 10.1186/s13229-019-0310-4. eCollection 2020.

 

RBP2 stabilizes slow Cav1.3 Ca2+ channel inactivation properties of cochlear inner hair cells.

Ortner NJ, Pinggera A, Hofer NT, Siller A, Brandt N, Raffeiner A, Vilusic K, Lang I, Blum K, Obermair GJ, Stefan E, Engel J, Striessnig J.

Pflugers Arch. 2020 Jan;472(1):3-25. doi: 10.1007/s00424-019-02338-4. Epub 2019 Dec 17.

 

STAC proteins associate to the IQ domain of CaV1.2 and inhibit calcium-dependent inactivation.

Campiglio M, Costé de Bagneaux P, Ortner NJ, Tuluc P, Van Petegem F, Flucher BE.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1376-1381. doi: 10.1073/pnas.1715997115. Epub 2018 Jan 23.

 

Lower affinity of isradipine for L-type Ca2+ channels during substantia nigra dopamine neuron-like activity: implications for neuroprotection in Parkinson's disease.

Ortner NJ, Bock G, Dougalis A, Kharitonova M, Duda J, Hess S, Tuluc P, Pomberger T, Stefanova N, Pitterl F, Ciossek T, Oberacher H, Draheim H, Kloppenburg P, Liss B, Striessnig J.

J Neurosci. 2017 Jul 12;37(28):6761-6777. doi: 10.1523/JNEUROSCI.2946-16.2017. Epub 2017 Jun 7.

 

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.

Kaur G, Pinggera A, Ortner NJ, Lieb A, Sinnegger-Brauns MJ, Yarov-Yarovoy V, Obermair GJ, Flucher BE, Striessnig J.

J Biol Chem. 2015 Aug 21;290(34):21086-100. doi: 10.1074/jbc.M115.645671. Epub 2015 Jun 22.

 

L-type calcium channels as drug targets in CNS disorders.

Ortner NJ, Striessnig J.

Channels (Austin). 2016;10(1):7-13. doi: 10.1080/19336950.2015.1048936. Epub 2015 Jun 3. Review.

 

Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?

Striessnig J, Ortner NJ, Pinggera A.

Curr Mol Pharmacol. 2015;8(2):110-22. Review.

 

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.

Ortner NJ, Bock G, Vandael DH, Mauersberger R, Draheim HJ, Gust R, Carbone E, Tuluc P, Striessnig J

Nat Commun. 2014 Jun 19;5:3897. doi: 10.1038/ncomms4897.

 

C-terminal modulatory domain controls coupling of voltage-sensing to pore opening in Cav1.3 L-type Ca2+ channels.

Lieb A, Ortner NJ, Striessnig J

Biophys J. 2014 Apr 1;106(7):1467-75. doi: 10.1016/j.bpj.2014.02.017.

 

 

 

 

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