Dr. Alexandra Koschak


Associate Professor

Email: alexandra.koschak@uibk.ac.at
Phone: +43-(0)512-507 - 58807
Fax: +43-(0)512-507 - 2931


Molecular sensory physiology group


For publications in Pubmed click here


Short Curriculum
Born: May 29, 1972, Innsbruck, Austria


1995 - 1996 Studies in Biology, University of Innsbruck
1996 - 1998 Doctoral thesis, Department of Biochemical Pharmacology, Medical School, University of Innsbruck, Austria
1999 - 2001 Postdoctoral research fellow, Department of Biochemical Pharmacology, Medical School, University of Innsbruck, Austria
2001 - 2007 University Assistant, Department of Pharmacology and Toxicology, LFU, Innsbruck, Austria

Visiting Scientist, at the University of Tübingen, Germany and the University of Padova, Italy
2007 - 2008 Assistant Professor, Department of Pharmacology and Toxicology, LFU, Innsbruck, Austria
2008 Habilitation (Cell biology)
2009 Associate Professor, Department of Pharmacology and Toxicology, LFU, Innsbruck, Austria
2011 - 2014 Full Professor for "Molecular Sensory Physiology and Pharmacology", Center for Physiology and Pharmacology, Medical University Vienna, Austria
March 2015 Head of "Molecular Sensory Physiology and Pharmacology" Group and Associate Professor, Department of Pharmacology and Toxicology, LFU, Innsbruck, Austria


Teaching Experience
Pharmacy students General pharmacology, Cellular physiology and pathophysiology, Biology for Pharmacists, Seminars and practical course in pharmacogenetics
Medical students Sensory neurophysiology
Graduate Programs Innsbruck University Innsbruck “Pharmaceutical Sciences”, Medical University Innsbruck “Molecular Cell Biology and Oncology” (MCBO)
Graduate Programs Vienna (Supervisor) Medical University Vienna “Molecular Signal Transduction” (MolSignTans) and “Neuroscience” at the Brain Research Center


Scientific Awards
2002 Scientific Award of the City of Innsbruck
2003 Dr. Otto-Seibert Scientific Award (University of Innsbruck)
2009 Heribert-Konzett Award (Austrian Pharmacological Society)
2011 Otto-Löwi Award (Austrian Neuroscience association)


Research funding (since 2010)
2010-2014 FWF P225828: “CaV1.3 C-terminal Protein-Protein Interaction Drugability”
2010-2014 Co-applicant SFB-F44: “Cell signalling in chronic CNS disorders” 
2014-2017 FWF P26881: “Cav1.4 L-Type Calcium Channels in Retinal Function-  Lessons from Channelopathies”
2017-2019 FWF P29359: “L-Type Calcium Channels in Rod Bipolar Cells”
2016-2019
Innovative Training Network funded by the European Commission's Horizon 2020 programme: “switchBoard - In the Eye of the Observer: Visual Processing at the Heart of the Retina”


Selected publications

Original papers and reviews

1: Seitter H, Koschak A. Relevance of tissue specific subunit expression in channelopathies. Neuropharmacology. 2017; PMID: 28669898.

2: Zamponi GW, Striessnig J, Koschak A, Dolphin AC. The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential. Pharmacol Rev. 2015; PMID: 26362469.

3: Knoflach D, Schicker K, Glösmann M, Koschak A. Gain-of-function nature of Cav1.4 L-type calcium channels alters firing properties of mouse retinal ganglion cells. Channels (Austin). 2015; PMID: 26274509.

4: Burtscher V, Schicker K, Novikova E, Pöhn B, Stockner T, Kugler C, Singh A, Zeitz C, Lancelot ME, Audo I, Leroy BP, Freissmuth M, Herzig S, Matthes J, Koschak A. Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2. 2014; PMID: 24796500.

5: Knoflach D, Kerov V, Sartori SB, Obermair GJ, Schmuckermair C, Liu X, Sothilingam V, Garcia Garrido M, Baker SA, Glösmann M, Schicker K, Seeliger M, Lee A, Koschak A. Cav1.4 IT mouse as model for vision impairment in human congenital stationary night blindness type 2. Channels (Austin). 2013; PMID: 240516722485.

6: Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nürnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nürnberg P, Striessnig J, Bolz HJ. Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness. Nat Neurosci. 2011; PMID: 21131953.

7: Koschak A, Obermair GJ, Pivotto F, Sinnegger-Brauns MJ, Striessnig J, Pietrobon D. Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells. J Neurosci.; PMID: 17409250.

8: Singh A, Hamedinger D, Hoda JC, Gebhart M, Koschak A, Romanin C, Striessnig J. C-terminal modulator controls Ca2+-dependent gating of Cav1.4 L-type Ca2+ channels. Nat Neurosci.; PMID: 16921373.

9: Koschak A, Reimer D, Walter D, Hoda JC, Heinzle T, Grabner M, Striessnig J. Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation. J Neurosci. 2003; PMID: 12853422.

10: Koschak A, Reimer D, Huber I, Grabner M, Glossmann H, Engel J, Striessnig J. alpha1D (Cav1.3) subunits can form L-type Ca2+ channels activating at negative voltages. J Biol Chem. 2011; PMID:

11285265.

 

Book

“Pathologies of Calcium Channels” Editors: Weiss, Norbert; Koschak, Alexandra (2014). ISBN 978-3-642-40282-1 (Springer).


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