RESEARCH



Research topics
Development of potential drugs - Highly potent opioid analgesics - Drugs for the treatment of addiction (opioid, cocaine and alcohol) – Immunosuppressive drugs - Drugs for the treatment of ileus and inflammatory bowel diseases

 

Synthesis of 14-alkoxymorphinans – mu, delta and kappa opioid receptor selective opioid agonists and antagonists as pharmacological tools

Synthetical investigations on opium alkaloids (e.g. thebaine, codeine, noscapine)

Improvement of synthetical procedures in drug development

Structure-activity relationship studies on newly developed compounds

 
 
Methodologies
Organic chemical methods
Medicinal chemistry methods
Structure elucidation (NMR, IR, MS)
Determination of pka, logP, logD

 

Research projects and grants (Recent funding)

2000 - 2005

European Community EU-5FP (QLRT-1999-02234)

Opioid Treatment of Chronic Pain and Inflammation of the Locomotor System

2000 - 2005

Ministry of Education, Science

and Culture

Opioid Treatment of Chronic Pain and Inflammation of the Locomotor System

2002 - 2006

Austrian Science Fund
FWF P15481

Novel Therapies of Chronic Pain: Peripherally Acting 14-Alkoxymorphinen Derivatives

2003 - 2004

CAST

BioMare

2004- 2005

Universität Innsbruck

Peripherally Acting Analgesics

2004 - 2008

AlcaSynn Pharmaceuticals GmbH

AlcaSynn_1

2005 - 2006

Tyrolean Science Fund
0404/140

New Therapies for Chronic Pain

2009 - 2012

Austrian Science Fund
FWF P21350

Peripheral Opioid Receptors, a Target for Gut Diseases

2010 - 2013

Austrian Science Fund
FWF TRP16-B18

Novel Opioid Antagonists for Bowel Motility Disorders

2011 - 2012 Austrian Federal Ministry of Economy Prize 2010 Development of New Opioid Analgesics with Reduced Side Effects
 
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