FOR SCHMIDHAMMER

RESEARCH

Research topics

Development of potential drugs - Highly potent opioid analgesics - Drugs for the treatment of addiction (opioid, cocaine and alcohol) – Immunosuppressive drugs - Drugs for the treatment of ileus and inflammatory bowel diseases

Synthesis of 14-alkoxymorphinans – mu, delta and kappa opioid receptor selective opioid agonists and antagonists as pharmacological tools

Synthetical investigations on opium alkaloids (e.g. thebaine, codeine, noscapine)

Improvement of synthetical procedures in drug development

Structure-activity relationship studies on newly developed compounds

Methodologies

Organic chemical methods

Medicinal chemistry methods

Structure elucidation (NMR, IR, MS)

Determination of pka, logP, logD

Research projects and grants (Recent funding)

2000 - 2005	European Community EU-5FP (QLRT-1999-02234)	Opioid Treatment of Chronic Pain and Inflammation of the Locomotor System
2000 - 2005	Ministry of Education, Science and Culture	Opioid Treatment of Chronic Pain and Inflammation of the Locomotor System
2002 - 2006	Austrian Science Fund FWF P15481	Novel Therapies of Chronic Pain: Peripherally Acting 14-Alkoxymorphinen Derivatives
2003 - 2004	CAST	BioMare
2004- 2005	Universität Innsbruck	Peripherally Acting Analgesics
2004 - 2008	AlcaSynn Pharmaceuticals GmbH	AlcaSynn_1
2005 - 2006	Tyrolean Science Fund 0404/140	New Therapies for Chronic Pain
2009 - 2012	Austrian Science Fund FWF P21350	Peripheral Opioid Receptors, a Target for Gut Diseases
2010 - 2013	Austrian Science Fund FWF TRP16-B18	Novel Opioid Antagonists for Bowel Motility Disorders
2011 - 2012	Austrian Federal Ministry of Economy Prize 2010	Development of New Opioid Analgesics with Reduced Side Effects