By Nancy Pomarici
We are pleased to present a new article by N. Pomarici, F. Waibl, P. Quoika, A. Bujotzek, G. Georges, M. Fernández-Quintero and K. Liedl about stability of the antigen binding fragments in monoclonal antibodies. In this work, the authors study how different pairings of heavy and light chain germlines influence the stability of Fab fragments, using molecular dynamics simulations. They reveal that the CDR loops, together with the interface interactions, play a central role in stabilizing the overall structure. This study can have a massive impact on the design of novel and better performing biotherapeutics.
For more information: https://doi.org/10.1007/s10822-023-00501-9