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Comparative Microbiome Analysis

CoMA is a pipeline for amplicon sequencing data analysis with input files in fastq format. The pipeline represents a series of steps from the processing of the supplied data to the computation of results.



CoMA 2.0 (VirtualBox): [zipped; 7,26 GB]

CoMA 2.0 (Singularity): CoMA_2.0.tar.gz [2,31 GB]

CoMA 2.0 (Linux installer): [3 KB]

CoMA 1.0 (VirtualBox): [zipped; 5,77 GB]

Documentation: CoMA 2.0 Manual [1,12 MB]


There have been some problems with the download of CoMA 2.0 lately. This problem has now been fixed and the download should work properly again. If you still experience difficulties, please contact the CoMA support:

NOTE: The files "" and "" must be unzipped before being used in VirtualBox!


If you use CoMA for any published research, please include the following citation:

Hupfauf S, Etemadi M, Fernández-Delgado Juárez M, Gómez-Brandón M, Insam H, et al. (2020) CoMA – an intuitive and user-friendly pipeline for amplicon-sequencing data analysis. PLOS ONE 15(12): e0243241.



If there are any problems with the installation or the use of CoMA please contact

Software list

CoMA is a pipeline for NGS data analysis, using various applications, tools and scripts originating from internal and external sources (open-source third party software). Within this section, all external tools are listed. Please follow the web links if you want to get more information on a specific tool. Keep in mind that some of these tools may also be using third party software, for more information consult the prevailing manuals.

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