em. o.Univ.-Prof. Dr. Bernhard Kräutler
Institute of Organic Chemistry &
Center of Molecular Biosciences (CMBI)
University of Innsbruck
Innrain 80/82
6020 Innsbruck, Austria
tel: +43-676-872552000
fax: +43-512-507-57799
e-mail: bernhard.kraeutler@uibk.ac.at
Our main research interests concern the ‘Pigments of Life’, among them chlorophyll and vitamin B12: their discovery, their chemical and biological synthesis, their biologically important structure and chemical reactivity, as well as their biological functions, based on which, applications in the life sciences and in medicine are investigated.
The Kräutler group is a founding member of the ‘Center for Molecular Biosciences Innsbruck’ (CMBI).
curriculum vitae (pdf), list of publications (pdf)
Exploring the Chemistry of Vitamin B12 Biology
Eschenmoser Lecture 2023
Laboratory of Organic Chemistry ETH Zürich, Switzerland,
Mai 8th, 2023
Eschenmoser Lecture 2023
The Magic of Cobalt and Corrin
Keynote lecture
Tetrapyrrole Discussion Group Meeting,
University of Kent, Canterbury, April 26th, 2023
The Switchings of B12
Gordon Research Conference on Vitamin B12 and Corphins
Queen's College, Oxford, UK, September 18th 2005
Taming the Tiger - A Tale of the Pigments of Life
Plenary Lecture
International Conference on Porphyrins and Phthalocyanines, New Orleans, USA, Juli 15th 2004
B12 - an Organometallic Chameleon
Gordon Research Conference on Cobalamins,
Colby College, Waterville, USA, Juli 10th 2003
The Pigments of Life
7th Schrödinger Lecture
Trinity College, Dublin; Ireland; Oktober 27th 2001
Chlorophyll Breakdown - A Global Biological Phenomenon as a Molecular Paleobotanical Looking-Glass
Organisch/Biologisch-Chemisches Kolloquium
TU Berlin Dec, 7th, 2023
Novel chemistry of chlorophyll breakdown in vacular plants
Plenary lecture
Intl. Conf. Tetrapyrroles, Photosynthesis and Photosynthetic Organisms (ICTPPO),
Shizuoka, Japan, Sept 20th, 2023
Phyllochromobilins – ubiquitous natural photoswitches in higher plants
Gordon Research Conference on Photosensory Receptors & Signal Transduction,
Lucca, Italy, March 5th , 2018
News on Phyllobilins - The Bilin-Type Chlorophyll Catabolites
Gordon Research Conference - Chemistry and Biology of Tetrapyrroles,
Salve Regina University, Newport, RI, July 21st, 2014
The Yin-Yang of Chlorophyll
Plenary Lecture
International Conference on Porphyrins and Phthalocyanines, Jeju-Island, Korea, July 4th, 2012
News on an Old Puzzle - Chlorophyll Breakdown in Leaves and Fruit
Eli Lilly Lecture
Recent Advances in Synthesis and Chemical Biology IX, Dublin, December 10th 2010
Blue Blushes of Bananas - Revelations of Overlooked Natural Tetrapyrroles
GE Healthcare / Royal Soc. of Chem. Lecture, Cardiff University, UK, September 28th 2009
Vom Verschwinden des Chlorophylls
Deutsche Akademie der Naturforscher Lepoldina, Halle/Saale, Germany, April 28th 2009
pdf
Zur Herbstverfärbung - Wie die Natur das Grün aus den Blättern holt
Loschmidt-Lecture
11. Österreichische Chemietage, Leoben, September 19th 2005
Books - Edited Book-Sections (pdf)
recent publication highlights
Steffen Jockusch and Bernhard Kräutler
H/D-Isotope sensitive dual fluorescence of the corrin-ligand of vitamin B12
ChemComm 61, 3904-3907 (2025)
Theresia Erhart; Christian Nadegger; Stefan Vergeiner; Christoph Kreutz; Thomas Müller; Bernhard Kräutler
Novel Types of Phyllobilins in a Fern - Molecular Reporters of the Evolution of Chlorophyll Breakdown in the Paleozoic Era
Chem. Eur. J. 2024, e202401288
Karl Gruber, Vanessa Csitkovits, Andrzej Łyskowski, Christoph Kratky and Bernhard Kräutler
Structure-Based Demystification of Radical Catalysis by a Coenzyme B12-dependent Enzyme – Crystallographic Study of Glutamate Mutase with Cofactor Homologues
Angew. Chem. Int. Ed. 61, e202208295 (2022)
Christoph Kieninger, Klaus Wurst, Maren Podewitz, Maria Stanley, Evelyne Deery, Andrew Lawrence, Klaus R. Liedl, Martin J Warren and Bernhard Kräutler
Replacement of the Cobalt-Center of Vitamin B12 by Nickel - Nibalamin and Nibyric Acid Prepared from Metal-Free B12-Ligands Hydrogenobalamin and Hydrogenobyric Acid
Angew. Chem. Int. Ed. 59, 20129 –20136 (2020)
Christoph Kieninger, Evelyne Deery, Andrew D. Lawrence, Maren Podewitz, Klaus Wurst, Emi Nemoto-Smith, Florian J. Widner, Joseph A. Baker, Steffen Jockusch, Christoph R. Kreutz, Klaus R. Liedl, Karl Gruber, Martin J. Warren & Bernhard Kräutler
The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B12-Cofactors for Catalysis
Angew. Chem. Int. Ed. 58, 10756-10760 (2019)
Theresia Erhart, Stefan Vergeiner, Bernhard Kräutler and Thomas Müller
Chlorophyll Breakdown in a Fern – Discovery of Carbon-Skeleton Rearranged Phyllobilin Isomers
Angewandte Chemie Int. Ed. 57, 14937-14941 (2018)
Chengjie Li, Klaus Wurst, Steffen Jockusch, Karl Gruber, Maren Podewitz, Klaus R. Liedl, Bernhard Kräutler
Chlorophyll-Derived Yellow Phyllobilins of Higher Plants are Medium-Responsive, Chiral Photoswitches
Angew. Chem. Int. Ed. 55, 15760-15765, (2016)
F. J. Widner, A. D. Lawrence, E. Deery, D. Heldt, S. Frank, K. Gruber, K. Wurst, M. J. Warren, B. Kräutler
Total Synthesis, Structure and Biological Activity of Adenosylrhodibalamin - the Nonnatural Rhodium Homologue of Coenzyme B12
Angew. Chem. Int. Ed. 55, 11281-11289, (2016)
B. Kräutler
Breakdown of Chlorophyll in Higher Plants - Phyllobilins as Abundant, Yet Hardly Visible Signs of Ripening, Senescence and Cell Death (Review)
Angew. Chem. Int. Ed., 55, 4882-4907(2016), Angew. Chem., 128, 4964-4990 (2016)
B. Kräutler
Antivitamins B12 - A Structure- and Reactivity-Based Concept
Chem. Eur. J., 21, 11280-11287 (2015)
Recent Group History and key publications
Markus Wiedemair, Christoph Kieninger, Klaus Wurst, Maren Podewitz, Evelyne Deery, Martin J. Warren & Bernhard Kräutler
Solution, Crystal and in-Silico Structures of the OrganometallicVitamin B12-Derivative Acetylcobalamin and of its Novel Rhodium- Analogue Acetylrhodibalamin
Helv. Chim. Acta 106, e202200158 (2023)
Florian J.Widner, C. Kieninger, K. Wurst, Evelyne Deery, Andrew D. Lawrence, Martin J. Warren and Bernhard Kräutler
Synthesis, Spectral Characterization and Crystal Structure of Chloro-Rhodibalamin – A Synthesis Platform for Rhodium Analogues of Vitamin B12 and for Rh-Based Antivitamins B12
Synthesis 53, 332-337 (2021)
Markus Wiedemair, B.K. Anjani Pandey
Christoph Kieninger, Theresia Erhart, B.K.
Simone Moser, Theresia Erhart and Bernhard Kräutler
Phyllobilins from senescence associated chlorophyll breakdown in leaves of basil (Ocimum basilicum) show increased abundance upon herbivore attack
J. Agr. Food Chem. 68, 7132-7142 (2020)
Christoph Kieninger, Klaus Wurst, Maren Podewitz, Maria Stanley, Evelyne Deery, Andrew Lawrence, Klaus R. Liedl, Martin J Warren and Bernhard Kräutler
Replacement of the Cobalt-Center of Vitamin B12 by Nickel - Nibalamin and Nibyric Acid Prepared from Metal-Free B12-Ligands Hydrogenobalamin and Hydrogenobyric Acid
Angew. Chem. Int. Ed. 59, 20129-20136 (2020)
Christoph Kieninger, Evelyne Deery, Andrew D. Lawrence, Maren Podewitz, Klaus Wurst, Emi Nemoto-Smith, Florian J. Widner, Joseph A. Baker, Steffen Jockusch, Christoph R. Kreutz, Klaus R. Liedl, Karl Gruber, Martin J. Warren & Bernhard Kräutler
The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B12-Cofactors for Catalysis
Angew. Chem. Int. Ed. 58, 10756-10760 (2019)
Theresia Erhart, Stefan Vergeiner, Bernhard Kräutler and Thomas Müller
Chlorophyll Breakdown in a Fern – Discovery of Carbon-Skeleton Rearranged Phyllobilin Isomers
Angew. Chem. Int. Ed., 57, 14937-14941 (2018); Angew. Chem 130, 15153-15157 (2018)
F. J. Widner, A. D. Lawrence, E. Deery, D. Heldt, S. Frank, K. Gruber, K. Wurst, M. J. Warren, B. Kräutler
Total Synthesis, Structure and Biological Activity of Adenosylrhodibalamin - the Nonnatural Rhodium Homologue of Coenzyme B12
Angew. Chem. Int. Ed. 55, 11281-11289, (2016)
front: Clemens Vergeiner, B.K., Simone Moser, Christopher Brenig, Theresia Erhart;
back: Gerhard Scherzer, Thomas Müller, Florian Widner, Christoph Kieninger
front: Clemens Vergeiner, Mathias Roiser, Miriam Hunger, B.K., Florian Widner, Mathias Scherl
back: Thomas Müller, Theresia Erhart, Markus Ruetz, Iris Süssenbacher, Martin Fechtel. Gerhard Scherzer, Chengjie Li, Xiujun Liu
Chengjie Li, Klaus Wurst, Steffen Jockusch, Karl Gruber, Maren Podewitz, Klaus R. Liedl, Bernhard Kräutler
Chlorophyll-Derived Yellow Phyllobilins of Higher Plants are Medium-Responsive, Chiral Photoswitches
Angew. Chem. Int. Ed. 55, 15760-15765, (2016)
M. Scherl, T. Müller, C. R. Kreutz, R. G. Huber, E. Zass, K. R. Liedl, B. Kräutler
Chlorophyll Catabolites in Fall Leaves of the Wych Elm Tree Present a Novel Glycosylation Motif, Chem. Eur. J. 22, 9498-9503 (2016)
I. Süssenbacher, S. Hörtensteiner, B. Kräutler
A Dioxobililn-Type Fluorescent Chlorophyll Catabolite as a Transient Early Intermediate of the Dioxobilin-Branch of Chlorophyll Breakdown in Arabidopsis thaliana, Angew. Chem. Int. Ed., 54, 13777-13781(2015)
C. Vergeiner, M. Ulrich, C. Li, X. Liu, T. Müller, B. Kräutler
Stereo- and Regioselective Phyllobilane Oxidation in Leaf Homogenates of the Peace Lily (Spathiphyllum wallisii) – Hypothetical Endogenous Path to Yellow Chlorophyll Catabolites, Chem. Eur. J., 21, 136-149 (2015)
M. Hunger, E. Mutti, A. Rieder, B. Enders, E. Nexo, B. Kräutler
An Organometallic B12-DNA-Conjugate-Synthesis, Structure Analysis & Studies of Binding to Human B12-Transporter Proteins
Chem. Eur. J., 20, 13103-13107 (2014)
M. Ruetz, C. Gherasim, K. Gruber, S. Fedosov, R. Banerjee, B. Kräutler
Radical Synthesis Opens Access to Organometallic Aryl-Cobaltcorrins: 4-Ethylphenylcobalamin, a Potential “Antivitamin B12”
Angew. Chem. Int. Ed., 52, 2606-2610 (2013)
M. Ruetz, S. Fedosov, B. Kräutler
Reconstitution of the B12-Macrocycle by Radical Ring Closure of a Blue Secocorrin Angew. Chem. Int. Ed., 51, 6780-6784 (2012)
S. Banala, R. Huber, T. Müller, M. Fechtel, K. Liedl, B. Kräutler
Porphyrin-LEGO: Synthesis of a Hexafullereno-Diporphyrin Using Porphyrins Programmed for [4+2]-Cycloaddition
ChemmComm, 48, 4359-4361 (2012)
T. Müller, M. Rafelsberger, C. Vergeiner, B. Kräutler
A Dioxobilane as Product of a Divergent Path of Chlorophyll Breakdown in Norway Maple
Angew. Chem. Int. Ed. 50, 10463-10733 (2011)
B. Kräutler, B. Puffer
More Radical Magic with B12: B12-catalyzed, Light-induced Cleavage of DNA Angew. Chem. Int. Ed., 50, 9791-9792 (2011)
Srinivas Banala, Mathias Scherl, Florian Widner, Thomas Müller, Gerhard Scherzer, Markus Ruetz, Barbara Enders (né Puffer), Martin Fechtel, B.K., Clemens Vergeiner, Iris Süssenbacher, Silke Ruck (from left to right)
M. Ulrich, S. Moser, T. Müller, B. Kräutler
How the Colourless ‚Nonfluorescent’ Chlorophyll Catabolites Rust
Chemistry – A Europ. J., 17, 2330 – 2334 (2011)
S. Moser, T. Müller, A. Holzinger, C. Lütz, S. Jokusch, N. J. Turro & B. Kräutler
Fluorescent chlorophyll catabolites in bananas light up blue halos of cell death Proc. Natl. Acad. Sci., USA, 106, 15538-15542 (2009)
S. Banala, T. Rühl, K. Wurst, B. Kräutler
Blackening Porphyrins by Conjugating with Quinones
Angew. Chem. Int. Ed 48, 599-603 (2009)
S. Moser, T. Müller, M.-O. Ebert, S. Jockusch, N. J. Turro & B. Kräutler
Blue Luminescence of Ripening Bananas.
Angew. Chem. Int. Ed., 47, 8954-8957 (2008)
Discovery, structure analysis, synthesis and biological chemistry of vitamin B12 and antivitamin B12 (applying electro-synthesis and supramolecular design; in cooperation with Austrian and foreign research teams).
Recent publications
Steffen Jockusch and Bernhard Kräutler
H/D-Isotope sensitive dual fluorescence of the corrin-ligand of vitamin B12
ChemComm 61, 3904-3907 (2025)
Ricardo Pérez-Castaño, Juan Aranda, Florian J. Widner, Christoph Kieninger, Evelyne Deery, Martin J. Warren, Modesto Orozco, Montserrat Elías-Arnanz, S. Padmanabhan, and Bernhard Kräutler
The Rhodium Analogue of Coenzyme B12 as an Anti-Photoregulatory Ligand Inhibiting Bacterial CarH Photoreceptors
Angew. Chem. Int. Ed. 63, e202401626 (2024)
Karl Gruber, Vanessa Csitkovits, Andrzej Łyskowski, Christoph Kratky and Bernhard Kräutler
Structure-Based Demystification of Radical Catalysis by a Coenzyme B12-dependent Enzyme – Crystallographic Study of Glutamate Mutase with Cofactor Homologues
Angew. Chem. Int. Ed. 61, e202208295 (2022)
Alexandra Tsybizova, Christopher Brenig, Christoph Kieninger, Bernhard Kräutler, Peter Chen
Surprising Homolytic Gas Phase Co−C Bond Dissociation Energies of Organometallic Aryl-Cobinamides Reveal Notable Non-Bonded Intramolecular Interactions
Chem. – Eur. J. 27, 7252-7264 (2021)
Christoph Kieninger, Evelyne Deery, Andrew D. Lawrence, Maren Podewitz, Klaus Wurst, Emi Nemoto-Smith, Florian J. Widner, Joseph A. Baker, Steffen Jockusch, Christoph R. Kreutz, Klaus R. Liedl, Karl Gruber, Martin J. Warren & Bernhard Kräutler
The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B12-Cofactors for Catalysis
Angew. Chem. Int. Ed. 58, 10756-10760 (2019)
Markus Ruetz, A. Shanmuganathan, Carmen Gherasim, A. Karasik, Robert Salchner, Christoph Kieninger, Klaus Wurst, Ruma Banerjee, Markos Koutmos and Bernhard Kräutler
Antivitamin B12 Inhibition of Human B12-Processing Enzyme CblC - Crystal Structure of Abortive Ternary Complex with Cosubstrate Glutathione
Angew. Chem. Int. Ed. 56, 7387-7392 (2017)
Marissa B. Guzzo, Hoa T. Nguyen, Thanh H. Pham, Monika Wyszczelska-Rokiel, Hieronim Jakubowski, Kerstin A. Wolff, Sam Ogwang, Joseph L. Timpona, Soumya Gogula, Michael R. Jacobs, Markus Ruetz, Bernhard Kräutler, Donald W. Jacobsen, Guo-Fang Zhang, Liem Nguyen
Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs
PLOS Pathogens, DOI: 10.1371/journal.ppat.1005949
F. J. Widner, A. D. Lawrence, E. Deery, D. Heldt, S. Frank, K. Gruber, K. Wurst, M. J. Warren, B. Kräutler
Total Synthesis, Structure and Biological Activity of Adenosylrhodibalamin - the Nonnatural Rhodium Homologue of Coenzyme B12
Angew. Chem. Int. Ed. 55, 11281-11289, (2016)
B. Kräutler
Antivitamins B12 - A Structure- and Reactivity-Based Concept
Chem. Eur. J., 21, 11280-11287 (2015)
M. Hunger, E. Mutti, A. Rieder, B. Enders, E. Nexo, B. Kräutler
An Organometallic B12-DNA-Conjugate-Synthesis, Structure Analysis & Studies of Binding to Human B12-Transporter Proteins
Chem. Eur. J., 20, 13103-13107 (2014)
E. Mutti, M. Ruetz, H. Birn, B. Kräutler, E. Nexo
4-Ethylphenyl-cobalamin impairs tissue uptake of vitamin B12 and causes vitamin B12 deficiency in mice
PLOS one, 8, e75312 (2013)
Discovery, structure analysis, synthesis and biological chemistry in the area of chlorophyll breakdown (using electrosynthesis and enzymology; in cooperation with Austrian and foreign research teams).
Recent publications
Clemens Vergeiner and Bernhard Kräutler
Blue Fluorescent Chlorophyll Catabolites from Banana Leaves Hypermodified with Terpenoidic Groups Related to Abscisic Acid
Helvetica Chimica Acta 2025, e202500042
Theresia Erhart; Christian Nadegger; Stefan Vergeiner; Christoph Kreutz; Thomas Müller; Bernhard Kräutler
Novel Types of Phyllobilins in a Fern - Molecular Reporters of the Evolution of Chlorophyll Breakdown in the Paleozoic Era
Chem. Eur. J. 2024, e202401288
Simone Moser, Theresia Erhart and Bernhard Kräutler
Phyllobilins from senescence associated chlorophyll breakdown in leaves of basil (Ocimum basilicum) show increased abundance upon herbivore attack
J. Agr. Food Chem. 68, 7132-7142 (2020)
Iris Süssenbacher, Damian Menghini, Gerhard Scherzer, Kathrin Salinger, Theresia Erhart, Simone Moser, Clemens Vergeiner, Stefan Hörtensteiner, Bernhard Kräutler
Cryptic chlorophyll breakdown in non-senescent green Arabidopsis thaliana leaves
Photosynthesis Research, 142, 69-85 (2019)
Theresia Erhart, Stefan Vergeiner, Bernhard Kräutler and Thomas Müller
Chlorophyll Breakdown in a Fern – Discovery of Carbon-Skeleton Rearranged Phyllobilin Isomers
Angew. Chem. Int. Ed., 57, 14937-14941 (2018); Angew. Chem 130, 15153-15157 (2018)
Chengjie Li, Klaus Wurst, Steffen Jockusch, Karl Gruber, Maren Podewitz, Klaus R. Liedl, Bernhard Kräutler
Chlorophyll-Derived Yellow Phyllobilins of Higher Plants are Medium-Responsive, Chiral Photoswitches
Angew. Chem. Int. Ed. 55, 15760-15765, (2016), DOI: 10.1002/anie.201609481
B. Kräutler
Breakdown of Chlorophyll in Higher Plants - Phyllobilins as Abundant, Yet Hardly Visible Signs of Ripening, Senescence and Cell Death (Review)
Angew. Chem. Int. Ed. 55, 4882-4907(2016), Angew. Chem., 128, 4964-4990 (2016)
I. Süssenbacher, S. Hörtensteiner, B. Kräutler
A Dioxobililn-Type Fluorescent Chlorophyll Catabolite as a Transient Early Intermediate of the Dioxobilin-Branch of Chlorophyll Breakdown in Arabidopsis thaliana
Angew. Chem. Int. Ed., 54, 13777-13781(2015), Angew. Chem., 127, 13981-13985 (2015),
M. Roiser, T. Müller, B. Kräutler
Colorless Chlorophyll Catabolites in Senescent Florets of Broccoli (Brassica oleracea var. Italica)
J. Agric. Food Chem., 63, 1385-1392 (2015)
C. Li, M. Ulrich, K. Wurst, T. Müller, B. Kräutler
Blue Transition Metal Complexes of a Natural Bilin-Type Chlorophyll Catabolite
Chem. Sci., 5, 3388-3395, (2014)
Design, synthesis and structural investigations in solution and in the solid state (solid state chemistry, supramolecular design and crystal design; in cooperation with Austrian and foreign research teams).
Recent publications
Radu A. Talmazan, Klaus. R. Liedl, Bernhard Kräutler and Maren Podewitz
The intermolecular anthracene-transfer in a regiospecific antipodal C60 difunctionalization
Org. & Biomol. Chem. 18, 4090-4103 (2020)
S. Banala, K. Wurst, B. Kräutler
Panchromatic π-Extended Porphyrins from Conjugation with Quinones
ChemPlusChem, 81, 477-488, (2016), DOI: 10.1002/cplu.201600115
S. Banala, R. Huber, T. Müller, M. Fechtel, K. Liedl, B. Kräutler
Porphyrin-LEGO: Synthesis of a Hexafullereno-Diporphyrin Using Porphyrins Programmed for [4+2]-Cycloaddition
ChemmComm, 48, 4359-4361 (2012)
in the News:
LEGO mit farbigen Molekülen
i-point, Universität Innsbruck, April 2012
S. Banala, T. Rühl, K. Wurst, B. Kräutler
Blackening Porphyrins by Conjugating with Quinones
Angew. Chem. Int. Ed 48, 599-603 (2009), Angew. Chem. 121, 607-611 (2009)
A. Duarte-Ruiz, K. Wurst, B. Kräutler
The Orthogonal (e, e, e)-tris-Adduct of 9, 10-Dimethylanthracene with C60-Fullerene - a hidden Corner Stone of Fullerene Chemistry
Helv. Chim. Acta 91, 1401-1408 (2008)
A. Rieder, B. Kräutler
Loading a Porphyrin with Fullerene-Units
J. Am. Chem. Soc. 122, 9050-9051 (2000)
Current and recent projects
A key publication
Karl Gruber, Vanessa Csitkovits, Andrzej Łyskowski, Christoph Kratky and Bernhard Kräutler
Structure-Based Demystification of Radical Catalysis by a Coenzyme B12-dependent Enzyme – Crystallographic Study of Glutamate Mutase with Cofactor Homologues
Angew. Chem. Int. Ed. 61, e202208295 (2022)
Highlights:
Das Geheimnis der Radikal-Katalyse mit Co-Enzym B12
i-point, Universität Innsbruck, Oktober 2022
Ein Herz aus Nickel
i-point, Universität Innsbruck, September 2020
A key publication
Christoph Kieninger, Evelyne Deery, Andrew D. Lawrence, Maren Podewitz, Klaus Wurst, Emi Nemoto-Smith, Florian J. Widner, Joseph A. Baker, Steffen Jockusch, Christoph R. Kreutz, Klaus R. Liedl, Karl Gruber, Martin J. Warren & Bernhard Kräutler
The Hydrogenobyric Acid Structure Reveals the Corrin Ligand as an Entatic State Module Empowering B12-Cofactors for Catalysis
Angew. Chem. Int. Ed. 2019, 58, 10756-10760
Highlights:
Spiel mit den chemischen Elementen
i-point, Universität Innsbruck, Oktober 2019
Vitamin B12: Helix-Molekül mit eingespanntem Kobalt-Ion
i-point, Universität Innsbruck, Juni 2019
Der Kobold im Vitamin B12
i-point, Universität Innsbruck, August 2016
Antivitamin B12 als Wolf im Schafspelz
i-point, Universität Innsbruck, Juli 2017
Chemiker erzeugen Antivitamin B12
i-point, Universität Innsbruck, März 2013
A key publication:
B. Kräutler
Breakdown of Chlorophyll in Higher Plants - Phyllobilins as Abundant, Yet Hardly Visible Signs of Ripening, Senescence and Cell Death
Angew. Chem. Int. Ed. 2016, 55, 4882-4907, Angew. Chem. 2016, 128, 4964-4990
Highlights:
Molekulares Fossil
i-point, Universität Innsbruck, November 2018
Photoschalter im Herbstlaub
i-point, Universität Innsbruck, Dezember 2016
key publication:
Chengjie Li, Klaus Wurst, Steffen Jockusch, Karl Gruber, Maren Podewitz, Klaus R. Liedl, Bernhard Kräutler
Chlorophyll-Derived Yellow Phyllobilins of Higher Plants are Medium-Responsive, Chiral Photoswitches
Angew. Chem. Int. Ed. 2016, 55, 15760-15765, DOI: 10.1002/anie.201609481; Angew. Chem. 2016, 128, 15992-15997
Highlights:
Blattgrün: immer bunter
i-point, Universität Innsbruck, November 2015
Rätselhaftes Intermezzo
i-point, Universität Innsbruck, August 2015
Chlorophyllabbau: Weiteres Puzzlestück entdeckt
i-point, Universität Innsbruck, Dezember 2014
Chlorophyll: Keineswegs dasselbe in Grün
i-point, Universität Innsbruck, Juli 2013
Farbenspiele im Ahornblatt
FAZ(Frankfurter Allgemeine Zeitung), Natur und Wissenschaft, October 2011
Die erstaunliche Herbstfärbung des Spitzahorns
Spiegel online, October 2011
Die andere Hand im Spitzahorn
i-point, Universität Innsbruck, October 2011
In Nord- und Südtirol wichtige Kulturpflanzen wie Äpfel, Marille, Zwetschke und Weinrebe können von bakteriellen Pathogenen befallen werden, den sogenannten Phytoplasmen. Die dabei auftretenden Pflanzenkrankheiten (wie Apfeltriebsucht, Steinobstvergilbung und Vergilbungskrankheiten der Rebe) verursachen große wirtschaftliche Schäden und können derzeit nur durch Rodung oder tiefgreifenden Beschnitt bekämpft werden.
Ein gemeinsames Symptom dieser Pflanzenkrankheiten ist ein frühes Gelbwerden der Blätter. Dieses wird vom Chlorophyll-Abbau hervorgerufen, der ähnlich auch bei der Herbstfärbung auftritt, und ist ein Zeichen einer durch das Pathogen induzierten Seneszenz der Blätter. Ziel dieses Projektes ist die Identifikation der Kataboliten in infizierten Blättern, die als Produkte des Chlorophyll-Abbaus entstehen. Diese Studien können dazu führen, dass die Infektionen früh erkannt werden und damit neue diagnostische Werkzeuge zur Früherkennung von Phytoplasmosen zur Verfügung stehen. Ein eindeutiger Nachweis der Infektion ist derzeit nur mittels molekularbiologischer Methoden möglich oder anhand der Symptome, die oft erst mehrere Jahre nach der Infektion auftreten.
In diesem Projekt werden die Kataboliten während der Herbstfärbung und bei der Phytoplasmen-induzierten Vergilbung bei Apfel, Rebe und Steinobst verglichen: Unterschiede in der Menge und molekularen Struktur der Chlorphyll-Kataboliten können Rückschlüsse auf eine Infektion liefern. Wenn sich die Hypothese dieses Projekts bestätigt, kann der Pathogenbefall von Nutzpflanzen womöglich schon früh mit den empfindlichen spektroskopischen Methoden erkannt werden.
Am Blattgrün kranke Nutzpflanzen erkennen
i-point, Universität Innsbruck, April 2015
Das Geheimnis des goldenen Herbstes
i-point, Universität Innsbruck, October 2017
Literatur:
Theresia Erhart, Cecilia Mittelberger, Xiujun Liu, Maren Podewitz, Chengjie Li, Gerhard Scherzer, Gertrud Stoll, Josep Valls, Peter Robatscher, Klaus R. Liedl, Michael Oberhuber, and Bernhard Kräutler
Novel Types of Hypermodified Fluorescent Phyllobilins from Breakdown of Chlorophyll in Senescent Leaves of Grapevine (Vitis vinifera)
Chem. Eur. J. 2018, 24, 17268 – 17279
Mittelberger, H. Yalcinkaya, C. Pichler, J. Gasser, G. Scherzer, T. Erhart, S. Schumacher, B. Holzner, K. Janik, P. Robatscher,T. Müller, B. Kräutler, and M. Oberhuber
Pathogen-Induced Leaf Chlorosis: Products of ChlorophyllBreakdown Found in Degreened Leaves of Phytoplasma-InfectedApple (Malus × domestica Borkh.) and Apricot (Prunus armeniaca L.)Trees Relate to the Pheophorbide a Oxygenase/Phyllobilin PathwayJ. Agr. Food Chem. 2017, 65, 2651-2660
T. Erhart, C. Mittelberger, C. Vergeiner, G. Scherzer, B. Holzner, P. Robatscher, M. Oberhuber, B. Kräutler
Chlorophyll catabolites in Senescent Leaves of the Plum Tree (Prunus domestica)
Chem. & Biodiv. 2016,13, 1441-1453, DOI: 10.1002/cbdv.201600181
M. Oberhuber, C. Pichler, G. Stoll, P. Robatscher, H. Yalcinkaya, C. Vergeiner, B. Kräutler
Apfeltriebsucht, Vergilbungskrankheiten der Rebe und Steinobstvergilbung
Obstbau - Weinbau, 49, 225-226 (2012)
Projetkleiter: Univ.-Prof. Dr. Bernhard Kräutler, Universität Innsbruck
Projektpartner: Dir. Dr. Michael Oberhuber, Research Center Laimburg, Italien, Research Center Laimburg
Finanzierung: Dieses Interreg-Projekt wurde aus Universitäts-, Tiroler Landes- und EU-Mitteln finanziert
Administrative Functions at the University of Innsbruck
- Head of the Institute of Organic Chemistry (1993 - 1996, 2001 - 2004, 2008 - 2013)
- Vice Dean of Studies at the Faculty of Natural Sciences (2001 - 2003)
- Dean of the Faculty of Chemistry and Pharmacy (2004 - 2006)
- Head of the Center for Molecular Biosciences Innsbruck (2008)
Membership in Scientific Academies
- Corresponding member of the Austrian Academy of Sciences (1999 - 2009)
- Full member of the Austrian Academy of Sciences (since 2009)
- Member of the Deutsche Akademie der Naturforscher Leopoldina (since 2006)
Membership in Editorial Boards
- Chemistry & Biodiversity (Editorial Advisory Board)
Membership in Scientific Societies
- Austrian Chemical Society (Gesellschaft Österreichicher Chemiker),
- Member of the Board (1991 - 1994), Vice-President (1994 - 1998), 2001 - 2002),
- President (1999 - 2000)
- German Chemical Society (Gesellschaft Deutscher Chemiker)
- Swiss Chemical Society (Schweizerische Chemische Gesellschaft)
- International Society of Porphyrins and Phthalocyanines (Austrian Representative)
- Hans Fischer Gesellschaft, München
Scientific Congresses organized
Natural Porphyrinoid Pigments
Symposium at the 12th Intl. Conf. Porphyrins and Phthalocyanines (ICPP-12),
Madrid (Spain), July 2022
Natural Porphyrinoid Pigments
Symposium at the 11th Intl. Conf. Porphyrins and Phthalocyanines (ICPP-11),
Virtual meeting, June-July 2021
Natural Porphyrinoid Pigments
Symposium at the 10th Intl. Conf. Porphyrins and Phthalocyanines (ICPP-10),
Munich (Germany), July 2018
Natural Porphyrinoid Pigments – Structure, Function and Synthesis
Symposium at the 9th Intl. Conf. Porphyrins and Phthalocyanines (ICPP-9),
Nanjing (China), July 2016
Natural Porphyrinoid Pigments – Structure, Function and Synthesis
Symposium at the 8th Intl. Conf. Porphyrins and Phthalocyanines (ICPP-8),
Istanbul (Turkey), June 2014
Natural Porphyrinoid Pigments – Structure, Function and Synthesis
Symposium at the 7th Intl. Conf. Porphyrins and Phthalocyanines (ICPP-7),
Jeju-Island (South Korea), July 2012)
Natural Porphyrinoid Pigments – Structure, Function and Synthesis
Symposium at the 6th Intl. Conf. Porphyrins and Phthalocyanines (ICPP-6),
New Mexico (USA), July 2010
Gordon Research Conference on Vitamin B12 and Corphins
University of Oxford, UK, August 2009 (chairman)
Gordon Research Conference on Vitamin B12 and Corphins
University of New England, Biddeford, USA, July 2007 (vice chairman)
41th EUCHEM Conference on Stereochemistry
Bürgenstock, Switzerland, May 2006 (president)
40th EUCHEM Conference on Stereochemistry
Bürgenstock, Switzerland, May 2005 (vice president)
9. Österreichische Chemietage
Innsbruck, September 2000 (president and chairman)
5th European Symposium on Vitamin B12 and B12-Proteins
Marburg (Germany), September 2000 (co-chairman)
34th European Symposium on Bioorganic Chemistry
Chemistry and Chemical Biology of Oligonucleotides, May 2000 (chairman)
33rd European Symposium on Bioorganic Chemistry
May 1999 (vice chairman)
4th European Symposium on Vitamin B12 and B12-Proteins
Innsbruck, September 1996 (chairman)
Igler MS Tage, Perspectives in Analytical and Biostructural Mass Spectrometry
Igls (Innsbruck), Obergurgl, 1995, 1997, 1999, 2001, 2003, 2005, 2007, 2009 (chairman)
Igler NMR Tage, Perspectives in Biostructural NMR-Spectroscopy
Igls (Innsbruck), Obergurgl, 1994, 1996, 1998, 2000, 2002, 2004, 2006 (chairman)