Transcriptional control of mesoderm patterning in zebrafish

Patrick Fischer, Dirk Meyer 



In early vertebrate development TGF-beta (Transforming Growth Factor beta) signaling factors of the Nodal and BMP families have essential functions during formation and patterning of the three germ layers endoderm, mesoderm and ectoderm. The aim of our research is to understand how cells read this patterning signals and how cells translate these extrinsic signals into intrinsic cell differentiation programs. A major focus of our current studies is on the molecular and genetic interactions of the transcription factors FoxH1, Mixer and Ntl.

 

Research_Mesoderm



 

Selected Publications

Chen, H.; Babino, D; Schoenbichler, SA.; Arkhipova, V; Töchterle, S; Martin, F; Huck, CW; von Lintig, J; Meyer, D (2015): Nmnat1-Rbp7 Is a Conserved Fusion-Protein That Combines NAD+ Catalysis of Nmnat1 with Subcellular Localization of Rbp7.
In: PLoS One 10/11, S. e0143825. (DOI) (Weblink)

Dumortier, JG, Martin, S., Meyer, D., Rosa, FM, David, NB (2012) Collective mesendoderm migration relies on an intrinsic directionality signal transmitted through cell contacts. Proceedings of the National Academy of Sciences, PNAS, 0027-8424, DOI: 10.1073/pnas.1205870109 Pubmed

Epting, D., Vorwerk, S., Hagemann, A., Meyer, D. (2007) Expression of rasgef1b in zebrafish. Gene Expr Patterns 7:389-95

Keegan, BR., Meyer, D., Yelon, D. (2004) Organization of cardiac chamber progenitors in the zebrafish blastula. Development 131, 3081-91

Trinh, L., Meyer, D. and Stainier, D. Y. (2003) The Mix family homeodomain gene bonnie and clyde functions with other components of the Nodal signaling pathway to regulate neural patterning in zebrafish. Development 130, 4989-98

Pogoda, H. M. and Meyer, D. (2002) Zebrafish Smad7 is regulated by Smad3b and BMP signals. Dev Dyn 224, 334-49

Pogoda, H. M. Solnica-Krezel, L., Driever, W., Meyer, D. (2002) The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation. Curr Biol. 10:1041-9