Seybold Anna Dr. 

PI/Head of EM Facility

Adresse:
Institut für Zoologie
Universität Innsbruck
Technikerstr. 25
6020 Innsbruck
Österreich

Raum: 7/17
Telefon: +43 512 507-51850
E-Mail: Anna.Seybold@uibk.ac.at

Elmilab-Team:

Our electron microscopy facility currently consists of a Zeiss Libra 120 EF-TEM and a new Tescan Clara SBF-SEM, as well as preparation labs. For more details see:

 

https://www.uibk.ac.at/de/zoology/forschung/facilities/elektronenmikroskopie/

 

https://forschungsinfrastruktur.bmfwf.gv.at/de/fi/rasterelektronenmikroskop-tescan-clara-inkl-zubehor_5597

Research Interest:

We are using advanced imaging techniques to explore invertebrates with remarkable capacities for survival such as extreme regeneration or adaptation to harsh environments. We are also interested in exploring the impact of therapeutic useful nanoparticles, but also microplastic and other pollutants on cells, tissues and organisms on an ultrastructural level.

Teaching:

Master's Programme Molecular Cell and Developmental Biology

Winter semester (October):

  • Elective Module 1: Histology and Cytology (7.5 ECTS-Credits, 5 h)
    • 719018 Methods in Histology and Microscopy (VO)
    • 719026 Methods of Histology and Scanning Electron Microscopy (VU)
Master’s Programme Zoology

Summer semester (March):

  • Elective Module 3: Ultrastructure of the Cell (7.5 ECTS-Credits, 5 h)
    • 719524 Introduction to Electron Microscopy (VO)
    • 719525 Transmission Electron Microscopy (VU)

Short CV:

PeriodDescription
Since 2022PI/Head of EM Facility, Inst. of Zoology, University of Innsbruck, Austria
2018-2022Researcher on Ultrastructure of Marine Invertebrates, Michael Sars Centre and Dept. of Geology, University of Bergen, Norway
2016-2018Postdoc on Cryo-EM of Macromolecular Complexes, BMLS, Frankfurt, Germany
2011-2015PhD on Adaptation to Extreme Environments, Dep. of Biochemistry and Zoology, University of Otago, Dunedin, New Zealand
2006-2011MSc in Molecular Cell- and Developmental Biology, MSc thesis on Regeneration of Hydra Aggregates, University of Innsbruck, Austria

Publications:

  • Truszkowska M, Reisenberger E, Kali G, Stengel D; Saleh A, SeyboldA, Bernkop-Schnürch A. Exploring glutathione-decorated micelles for drug delivery: a promise for enhanced cellular uptake. Colloids Surf. B: Biointerfaces. doi.org/10.1016/j.colsurfb.2025.114664

 

  • Gavgani FM, Kraus JEM, November J, Seybold AC, Lerstad B, Hausen H, Layden MJ, Rentzsch F. Ectopic head regeneration after nervous system ablation in a sea anemone. bioRxiv, 2025. doi.org/10.1101/2025.02.04.636403

 

  • Kali G, Mayer A, To D, Truszkowska M, Seybold A, Braun D, Plangger R, Gallei M, Bernkop-Schnürch A. Polycaprolactone/a-Cyclodextrin Polyrotaxanes with Cellular Uptake Enhancing Properties. J Mater Chem B, 2025. doi: 10.1039/D4TB02451F

 

  • Seybold A, Kumar S, Tumu S, Hausen H. Cilio-motor neurons pioneer the main routes of the CNS in the marine annelid Malacoceros fuliginosus. Front Neurosci, 2025. doi.org/10.3389/fnins.2024.1439897

 

  • Stengel D, DuyguÖzdal Z, Truszkowska M, Saleh A, Seybold A, Bernkop-Schnürch A. Limited cellular uptake of liposomes: Might thiolated phospholipids hold the key? Int J Pharm, 2024. doi: 10.1016/j.ijpharm.2024.124812

 

  • Blanco Massani M, To D, Meile S, Schmelcher M, Gintsburg D, Coraça-Huber DC, Seybold A, Loessner M, Bernkop-Schnürch A. Enzyme-responsive nanoparticles: Enhancing endolysins’ ability to eradicate staphylococcus aureus biofilm. J Mater Chem B, 2024. doi: 10.1039/d4tb01122h

 

  • To D, Blanco Massani M, Coraça-Huber DC, Seybold A, Ricci F, Zöller K, Bernkop-Schnürch A. Antibiotic-polyphosphate nanocomplexes: A promising system for effective biofilm eradication. Int J Nanomedicine, 2024. doi: 10.2147/IJN.S473241

 

  • Hock N, To D, Armengol ES, Summonte S, Seybold A, Federer C, Bernkop-Schnürch A. Design of biodegradable nanoparticles for enzyme-controlled ultra-long-acting drug release. J Drug Deliv Sci Technol, 2023. doi: 10.1016/j.jddst.2023.105085

 

  • Akkuş-Dağdeviren ZB, Saleh A, Schöpf C, Truszkowska M, Bratschun-Khan D, Fürst A, Seybold A, Offterdinger M, Marx F, Bernkop-Schnürch A. Phosphatase degradable nanoparticles: a game-changing approach for the delivery of antifungal proteins. J Coll Int Sci, 2023. doi: 10.1016/j.jcis.2023.05.051

 

  • Knoll P, Francesco Racaniello G, Laquintana V, Veider F, Saleh A, Seybold A, Denora N, Bernkop-Schnürch A. Lipid-based nanoparticles: Enhanced cellular uptake via surface thiolation. Int J Pharm, 2023. doi: 10.1016/j.ijpharm.2023

 

  • Sikora M*, Ermel UH*, Seybold A*, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS. The structure of the desmosome derived from molecular dynamics simulations and cryo-electron tomography. PNAS, 2020. doi: 10.1073/pnas.2004563117 *Shared first author

 

  • Lewis JD, Caldara AL, Zimmer SE, Stahley SN, Seybold A, Strong NL, Frangakis AS, Levental I, Wahl JK 3rd, Mattheyses AL, Sasaki T, Nakabayashi K, Hata K, Matsubara Y, Ishida-Yamamoto A, Amagai M, Kubo A, Kowalczyk AP. The desmosome is a mesoscale lipid raft-like membrane domain. Mol Biol Cell, 2019. doi: 10.1091/mbc.E18-10-0649

 

  • Seybold A, Wharton D, Thorne M, Marshall C. Investigating trehalose in the Antarctic nematode Panagrolaimus sp. DAW1. Biol Open, 2017. doi: 10.1242/bio.023341

 

  • Thorne M, Seybold A, Marshall C, Wharton D. Molecular snapshot of an intracellular freezing event in the Antarctic nematode Panagrolaimus sp. DAW1. Cryobiology, 2017. doi: 10.1016/j.cryobiol.2017.01.003

 

  • Seybold A, Wharton D, Thorne M, Marshall C. Establishing RNAi in a non-model organism: the Antarctic nematode Panagrolaimus sp. DAW1. PLoS ONE, 2016. doi: 10.1371/journal.pone.0166228

 

  • Seybold A, Salvenmoser W, Hobmayer B. Sequential development of apical-basal and planar polarity in reaggregating Hydra epitheliomuscular cells. Dev Biol, 2016.doi: 10.1016/j.ydbio.2016.02.022
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