Martina Höckner

Ass. Prof.

Martina Höckner


Adresse:
Institut für Zoologie
Universität Innsbruck

Technikerstr. 25
6020 Innsbruck
Österreich

Raum: 6/20
Telefon: +43 512 507-51878
E-Mail: martina.hoeckner@uibk.ac.at

Aktuelle Forschung


Environmental stress and gene regulation in earthworms

 

   Molecular stress response

   Metallothioneins

   Stress signaling pathways

 earthworm 

 

Weiter Details finden Sie unter:

Umweltstress und Genregulation

 Aktuelle Mitarbeiter

 Victoria Drechsel

 


Lebenslauf

Ab September 2012

Assistenzprofessur am Institut für Zoologie, Leopold Franzens Universität Innsbruck

Jan 2011 – Aug 2012

Schrödinger Stipendium, King’s College London Transcriptional regulation of L. rubellus Metallothionein

Juli 2007 – Juli 2010

PostDoc in einem FWF geförderten Projekt in Reinhard Dallingers group at the Institute for Zoology, Leopold Franzens University of Innsbruck

Juli 2005 – Juni 2007

Doktorarbeit am Department für Medizinische Genetik, Molekulare und klinische Pharmakologie, Medizinische Universität Innsbruck; Whole Genome Amplification from Microdissected Chromosomes for Investigation of the Parental Origin of Rare Chromosomal Rearrangements, Betreuer: Prof. Dr. Gerd Utermann

April 2004 – April 2005

Diplomarbeit am Institut für Zoologie and Limnologie, Universität Innsbruck, Partial sequencing and analysis of the copper metallothionein gene from Helix pomatia

Förderungen & Stipendien

Jul – Okt 2013

Fulbright Stipendium - Environmental Proteomics Laboratory, California Polytechnic State University, San Luis Obispo

Jan 2011 – Aug 2012

Schrödinger Stipendium (FWF) Projekt J3124-B12; King’s College London

Januar 2007

Förderung vom Tiroler Wissenschaftsfond (TWF)


Publikationen

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Drechsel, V.; Schauer, K.; Šrut, M.; Höckner, M. (2017): Regulatory plasticity of earthworm wMT-2 gene expression.
    In: International Journal Of Molecular Sciences 18/6, Nr. 1113. (DOI)

  • Piechnik, C.A.; Höckner, M.; de Souza, M.R.; Donatti, L.; Tomanek, L. (2017): Time course of lead induced proteomic changes in gill of the Antarctic limpet Nacella Concinna (Gastropoda: Patellidae).
    In: Journal of Proteomics 151, S. 145 - 161. (DOI)

  • Šrut, M.; Drechsel, V.; Höckner, M. (2017): Low levels of Cd induce persisting epigenetic modifications and acclimation mechanisms in the earthworm Lumbricus terrestris.
    In: PLoS One 12/4, Nr. e0176047. (DOI)

  • Höckner, Martina; Dallinger, Reinhard; Stürzenbaum, Stephen R. (2015): Metallothionein gene activation in the earthworm (Lumbricus rubellus).
    In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460/3, S. 537 - 542. (DOI) (Weblink)

  • Höckner, M.; Spreiz, A.; Frühmesser, A.; Tzschach, A.; Dufke, A.; Rittinger, O.; Kalscheuer, V.; Singer, S.; Erdel, M.; Fauth, C.; Grossmann, V.; Utermann, G.; Zschocke, J.; Kotzot, D. (2012): Parental origin of de novo cytogenetically balanced reciprocal non-Robertsonian translocations.
    In: CYTOGENETIC AND GENOME RESEARCH 136/4, S. 242 - 245. (DOI) (Weblink)

  • Höckner, Martina; Stefanon, Karin; de Vaufleury, Annette; Monteiro, Freddy; Pérez-Rafael, Silvia; Palacios, Oscar; Capdevila, Mercé; Atrian, Silvia; Dallinger, Reinhard (2011): Physiological relevance and contribution to metal balance of specific and non-specific Metallothionein isoforms in the garden snail, Cantareus aspersus.
    In: Biometals 24/6, S. 1079 - 1092. (DOI)

  • Palacio, Oscar; Pagani, Ayelen; Pérez-Rafael, Silvia; Egg, Margit; Höckner, Martina; Brandstätter, Anita; Capdevila, Mercé; Atrian, Silvia; Dallinger, Reinhard (2011): Shaping mechanisms of metal specificity in a family of metazoan metallothioneins: evolutionary differentiation of mollusc metallothioneins.
    In: BMC Biology 9/4, S. 1 - 20. (DOI)

  • Egg, M.; Höckner, M.; Brandstätter, A.; Schuler, D.; Dallinger, R. (2009): Structural and bioinformatic analysis of the Roman snail Cd-Metallothionein gene uncovers molecular adaptation towards plasticity in coping with multifarious environmental stress.
    In: Molecular Ecology 18/11, S. 2426 - 2443.

  • Höckner, M.; Stefanon, K.; Schuler, D.; Fantur, R.; de Vaufleury, A.; Dallinger, R. (2009): Coping with Cadmium Exposure in Various Ways: The Two Helicid Snails Helix pomatia and Cantareus aspersus Share the Metal Transcription Factor-2, but Differ in Promoter Organization and Transcription of Their Cd-Metallothionein Genes.
    In: Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 311A/10, S. 776 - 786.

Zeitschriftenaufsatz (Review)
  • Sandbichler, A.M.; Höckner, M. (2016): Cadmium Protection Strategies-A Hidden Trade-Off?
    In: International Journal Of Molecular Sciences 17/1, No. 139. (DOI) (Weblink)

  • Dallinger, Reinhard; Höckner, Martina (2013): Evolutionary concepts in ecotoxicology: tracing the genetic background of differential cadmium sensitivities in invertebrate lineages.
    In: ECOTOXICOLOGY 22/5, S. 767 - 778. (DOI) (Weblink)

  • Höckner, Martina; Dallinger, Reinhard; Stürzenbaum, Stephen R. (2011): Nematode and snail metallothioneins.
    In: Journal of Biological Inorganic Chemistry 16/7, S. 1057 - 1065. (DOI) (Weblink)

Zeitschriftenbeitrag (anderer)
  • Stürzenbaum, Stephen R.; Hoeckner, Martina; Panneerselvam, Arun; Levitt, James; Bouillard, Jean-Sebastien; Taniguchi, Shohei; Dailey, Lea Ann; Khanbeigi, Rah Ahmad; Thanou, Maya; Rosca, Elena; Suhling, Klaus; Zayats, Anatoly; Green, Mark (2013): Biosynthesis of luminescent quantum dots in an earthworm.
    In: Nature Nanotechnology 8, S. 57 - 60. (DOI) (Weblink)

Zeitschriftenbeitrag (Meeting-Abstract)
  • HÖCKNER, Martina; Dallinger, Reinhard; Stürzenbaum, Stephen (2012): Studying MT regulation in Lumbricus rubellus, the red earthworm, suggests novel activation mechanisms.
    In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 163/Suppl., S. S30. (DOI) (Weblink)

  • Dallinger, Reinhard; Höckner, Martina; Egg, Margit; Palacios, Oscar; Capdevila, Mercé; Pagani, Ayelen; Atrian, Silvia (2010): Structural and functional differentiation of gastropod metallothioneins has been achieved by evolution of metal-specific isoform families.
    In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 157/Supplement 1, S. S35. (DOI)

  • Dallinger, Reinhard; Egg, Margit; Höckner, Martina; Schuler, Dietmar; Atrian, Silvia; Capdevila, Mercé (2009): Molecular adaptation to cope with environmental stress of terrestrial gastropod Cadmium-metallothioneins: High metal specificity at the protein level combines with multifunctionality of genes.
    In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 154A/1 (Suppl.), S. S33.

  • Höckner, Martina; Schuler, Dietmar; Stefanon, Karin; Fantur, Rainer; de Vaufleury, Annette; Dallinger, Reinhard (2009): Metal-dependent transcription of metallothionein isoform genes in the terrestrial snail Cantareus aspersus.
    In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 154A/1 (Suppl.), S. S5.

  • Höckner, Martina; Stefanon, Karin; Schuler, Dietmar; Fantur, Rainer; De Vaufleury, Annette; Dallinger, Reinhard (2009): Differing transcription patterns of Cd-metallothionein genes in two terrestrial gastropod species are related to divergences in promoter structure and function.
    In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 154A/1 (Suppl.), S. S24.

  • Schuler, Dietmar; Höckner, Martina; Prader, Angelika; Dallinger, Reinhard (2009): Biomphalaria glabrata embryonic cells as a model system for toxicological and molecular studies of stress-induced expression of metallothionein genes.
    In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 154A/1 (Suppl.), S. S15 - S16.

  • Atrian, Silvia; Pagani, Ayleen; Capdevila, Mercé; Palacios, Oscar; Egg, Margit; Höckner, Martina; Dallinger, Reinhard (2008): Perfect adaptation to cope with metal stress and trace element homeostasis: Metal specificity is a fundamental structural feature of snail metallothioneins.
    In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 151A/1 (Suppl.), S. 520.

  • Dallinger, Reinhard; Egg, Margit; Höckner, Martina; Schuler, Dietmar (2008): Understanding the functioning of a Gene: Ability of the Cd-Metallothionein of Roman snail (Helix pomatia L.) to cope with Multiple Environmental Stress.
    In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 151A/1 (Suppl.), S. 520.

Beitrag in Proceedingsband (Abstract)
  • DALLINGER, Reinhard; HÖCKNER, Martina (2012): How evolutionary concepts may enhance exotoxicology: tracing the genetic background of differential cadmium sensitivities in invertebrates.
    In: 6th SETAC World Congress. Extended Abstracts. Brussels: SETAC Europe, Bd. Extended Abstracts "Ecotoxicology" Part 1, S. 131 - 132. (Weblink)



Vorträge

Präsentationen auf Kongressen, Tagungen o.Ä.

Konferenzvortrag (auf Einreichung / Anmeldung)
  • Vortragende/r: Höckner, M. Co-AutorInnen: Drechsel, V.; Srut, M.; Schuster, M.: Coping strategies in earthworms to low levels of Cadmium.
    30th ESCPB Congress, Barcelona, 06.09.2016. (Weblink)

  • Vortragende/r: Srut, M. Co-AutorInnen: Drechsel, V.; Niloofar, N.; Salvatore, M.; Höckner, M.: Epigenetic alterations in heavy metal stressed earthworms.
    30th ESCPB Congress, Barcelona, 05.09.2016. (Weblink)

  • Vortragende/r: Höckner, M. Co-AutorInnen: Schauer, K.; Drechsel, V.; Srut, M.; Dallinger, R.; Stürzenbaum, S.: Stress induced Metallothionein transcription and regulation in earthworms.
    SEB (Society for Experimental Biology) Prague 2015, Prag, 30.06.2015. (Weblink)

  • Vortragende/r: Höckner, M. Co-AutorInnen: Zuzow, M.J.; Tomanek, L.: Proteomic response of L. rubellus, the red earthworm, to metal stress under different soil temperatures.
    SETAC Europe 24th Annual Meeting, Basel, 14.05.2014. (Weblink)

  • Vortragende/r: Höckner, M. Co-AutorInnen: Dallinger, R.; Stürzenbaum, S.: Studying MT regulation in L. rubellus, the red earthworm, suggests novel activation mechanisms.
    28th ESCPB Congress of the New European Society for Comparative Physiology and Biochemistry, Bilbao, 04.09.2012. (Weblink)

  • Vortragende/r: Atrian, Silvia Co-AutorInnen: Pagani, Ayleen; Capdevila, Mercé; Palacios, Oscar; Egg, Margit; Höckner, Margit; Dallinger, Reinhard: Evolutionary diversification of snail metallothioneins is driven by extreme metal specificity of isoforms combined with cell-specific expression.
    5th Annual Meeting of the Center of Molecular Biosciences (CMBI), Igls, 26.09.2008.

  • Vortragende/r: EGG, M.; HÖCKNER, M.; DALLINGER, R.: Vom Protein zum Gen – das Biomarker-Potential der Metallothionein-Antwort in der Weinbergschnecke und dessen ökologische Relevanz.
    10. SETAC GLB – Meeting, Basel, 29.09.2005.

Posterpräsentation
  • Vortragende/r: Drechsel, V. Co-AutorInnen: Srut, M.; Höckner, M.: Molecular stress response in Lumbricus terrestris.
    Life Science PhD Meeting Innsbruck 2017, Innsbruck, 18.04.2017. (Weblink)

  • Vortragende/r: Srut, Maja Co-AutorInnen: Drechsel, V.; Höckner, M.: Epigenetic signatures as sensitive tool in soil ecotoxicology: alterations and relation to biomarker response in heavy metal stressed earthworms.
    SETAC/iEOS Joint Focused Topic Meeting Omics and Epigenetics, Ghent / Gent, 12.09.2016. (Weblink)

  • Vortragende/r: Dallinger, Reinhard; Höckner, Martina; Schuler, Dietmar; Egg, Margit; Atrian, Silvia; Capdevial, Mercé: Understanding multifunctionality of terrestrial gastropod Cadmium-Metallothioneins: High metal specificity of expressed protein is complemented by response plasticity at the gene level.
    1st Life Science Meeting, Igls, 18.09.2009.

  • Vortragende/r: Höckner, Martina; Schuler, Dietmar; Stefanon, Karin; Fantur, Rainer; de Vaufleury, Annette; Dallinger, Reinhard: A quantitative study based on Real-time detection PCR reveals specific expression patterns and metal-dependent upregulation of Metallothionein genes in the brown garden snail (Cantareus aspersus).
    1st Life Science Meeting, Igls, 18.09.2009.

  • Vortragende/r: Schuler, Dietmar; Höckner, Martina; Prader, Angelika; Dallinger, Reinhard: Biomphalaria glabrata embryonic cells as a model system for analysis of metal-induced stress and metal-dependent expression of invertebrate Metallothionein genes.
    1st Life Science Meeting, Igls, 18.09.2009.

  • Vortragende/r: Egg, Margit; Höckner, Martina; Brandstätter, Anita; Schuler, Dietmar; Dallinger, Reinhard: Plasticity in coping with multifarious Environmental Stress by Roman Snail Populations is linked to the structure and responsiveness of the Cd-Metallothionein Gene: a bioinformatic analysis.
    5th Annual Meeting of the Center of Molecular Biosciences (CMBI), Igls, 26.09.2008.

  • Vortragende/r: Stefanon, Karin; Höckner, Martina; Schuler, Dietmar; Fantur, Rainer; de Vaufleury, Annette; Dallinger, Reinhard: Metal-specific expression of Metallothionein isoform genes of the brown garden snail (Cornu aspersum): a quantitative study based on Real-Time detection PCR.
    5th Annual Meeting of the Center of Molecular Biosciences (CMBI), Igls, 26.09.2008.

  • Vortragende/r: DALLINGER, R.; EGG, M.; HÖCKNER, M.; SCHULER, D.: The Cd-Metallothionein of the Roman snail Helix pomatia: Specific adaptation of a gene to cope with multifarious environmental stress.
    4th Annual Meeting of the Center of Molecular Biosciences (CMBI), Igls, 29.09.2007.

  • Vortragende/r: EGG, M.; HÖCKNER, M.; DALLINGER, R.: The Cd-metallothionein gene of Helix pomatia: An evolutionary key to the understanding of complex stress response?
    2nd Annual Meeting of the Center for Molecular Biosciences (CMBI), Vill, 30.09.2005.

  • Vortragende/r: Egg, Margit; Höckner, Martina; Dallinger, Reinhard: Analysis of gene control regions of Cd- and Cu-metallothionein isoforms from Helix pomatia reveal remarkable structural features suggesting complex regulatory functions.
    1st Annual Meeting of the Center for Molecular Biosciences (CMBI), Vill, 01.10.2004.

Gastvorträge

Gastvortrag
  • Vortragende/r: Egg, M.; Höckner, M.; Dallinger, R.: The Cd-Metallothionein gene of Helix pomatia: a prime example for gene functioning?
    Universität Zürich, Zürich, 01.12.2005.



Projekte, Stipendien und sonstige Drittmittel

Projekte

  • Höckner, Martina: Grasfroschmonitoring im Fotschertal.
    Österreichische Bundesforste AG
    01.05.2016 - 30.04.2021

  • Höckner, Martina: Genetik und Epigenetik von Regenwürmern in Cd-belasteten Böden.
    Leopold-Franzens-Universität Innsbruck - Vizerektorat für Forschung, Nachwuchsfördermittel aus der Nachwuchsförderung der LFU
    01.01.2015 - 31.12.2015

  • Höckner, Martina: Cellular localization and detection of protein levels of MT isoforms in three gastropod species in control and stress exposed samples.
    Tiroler Wissenschaftsfonds (TWF)
    01.07.2014 - 30.06.2016

Stipendien

  • Höckner, Martina: Application of proteomics to study the response to different environmental stressors in the sentinel organism L. rubellus.
    Council for International Exchange of Scholars - Fulbright Commission, Fulbright Stipendium
    01.07.2013 - 31.10.2013

  • Höckner, Martina: Basal and metal induced transcriptional regulation of L. rubellus Metallothionein.
    Fonds zur Förderung der wissenschaftlichen Forschung (FWF), Erwin-Schrödinger-Auslandsstipendium
    01.02.2011 - 31.08.2012



Akademische Leistungen

Betreuung von Abschlussarbeiten

  • Höckner, Martina; Hinterleitner, Silvia: Schauer, Karl Joseph: wMT2 Genexpression nach Cadmium Belastung in Lumbricus terrestris und wissenschaftliches Arbeiten als Kompetenz in Bezug auf die vorwissenschaftliche Arbeit (2014 - 2016).