Latest Research in Chromaffin Cell Biology
Chromogranin B plays an essential role in post-endoplasmic reticulum sorting of dense-core vesicle cargo
Chandramouli Mukherjee, Palki Chauksey, Mohima Mukherjee, Sushma Dagar, Souren Sadhukhan, Judith Klumperman, Bhavani Shankar Sahu
Journal of Cell Science (2026)
Keywords: Chromogranin B, Dense-core vesicles, Cargo sorting, SNARE machinery, ER stress, Regulated exocytosis
Chromaffin Versus Platelet Granules: What We Have Learned From Chromaffin Cells for Human Studies
Ricardo Borges
Journal of Neurochemistry (2026)
Keywords: Biological amines, Secretory Vesicles, Parkinson's Disease
Exocytosis, Endocytosis, and Replenishment of the Immediately Releasable Pool of Secretory Vesicles. Possible Physiological Relevance in Chromaffin Cells
Fernando D. Marengo
Journal of Neurochemistry (2026)
Keywords: Chromaffin cells, Endocytosis, Exocytosis, P/Q channels, Secretion, Vesicle Replenishment, voltage-dependent Ca2+ channels
Copper (Cu2+) Inhibits Voltage-Dependent Ionic Currents While Enhancing Neurotransmitter Release in Bovine Chromaffin Cells
Víctor Varea-Tierno, Victoria Jiménez Carretero, Minerva Reyes Almodóvar, Javier Hernández Campano, María Arribas Tejedor, Ricardo de Pascual, Jesús M Hernández-Guijo
Pharmaceuticals (Basel) (2026)
Keywords: copper, chromaffin cells, patch-clamp, calcium currents, neurotransmitter release, cellular excitability, calcium channels, sodium channels
Profiling Endogenous Opioid Peptide Release from Adrenal Chromaffin Cells
Jenna M Berger, J Dylan Denison, A Chathuri De Alwis, Hannah P Sumner, Gregory S McCarty, Elena V Romanova, Jonathan V Sweedler, Leslie A Sombers
ACS Chemical Neuroscience (2026)
Keywords: FSCV; carbon-fiber microelectrode; dense-core vesicles; exocytosis; fast-scan cyclic voltammetry; mass spectrometry; peptidomics; proenkephalin; secretory vesicles
Stac2 genetic deletion alters mouse chromaffin cells' CaV channel composition, increases membrane excitability and reduces vesicle exocytosis
Stefanie M Geisler, Noelia Jacobo-Piqueras, Tamara Theiner, Ryoichi S Taguchi, Laura E Häfele, Marta Campiglio, Petronel Tuluc
The Journal of Physiology (2026)
Keywords: Stac; calcium channel; mouse chromaffin cells.
Na+ Uptake Triggered in Adrenal Chromaffin Cells by a 5-ns Electric Pulse is Facilitated by Ca2+ Influx Via an L-Type-Like Ca2+ Channel Independent of Changes in Membrane Potential
Lisha Yang, Josette Zaklit, Thomas W Gould, Gale L Craviso, Normand Leblanc
The Journal of Membrane Biology (2026)
Keywords: Chromaffin cells; L-type-like Ca2+ channel; NALCN; Nanosecond electric pulses; TRPC4/5 channel.
GCaMP6f-expressing chromaffin cells in murine adrenal slices exhibit dynamic spontaneous calcium responses that do not require nerve input
Nicole M Procacci, Gale L Craviso, Normand Leblanc, Josette Zaklit, Jihwan Yoon, Salah A Baker, Thomas W Gould
Cell Calcium (2026)
Keywords: Adrenal; Calcium; Ca2+; Catecholamine; Chromaffin; Spontaneous
Inhibitory Activity of Calcium and Sodium Ion Channels of Neurotoxic Protoplaythoa variabilis V-Shape Helical Peptide Analogs and Their Neuroprotective Effect In Vitro
Ariane Teixeira Dos Santos, Victoria Jiménez Carretero, Jorge Hernández Campano, Ricardo de Pascual, Nan Xu 3, Simon Ming-Yuen Lee, Clarence Tsun Ting Wong, Gandhi Rádis-Baptista, Jesús Miguel Hernández-Guijo
Pharmaceuticals (Basel) (2026)
Keywords: cnidarian peptide; Protopalythoa variabilis; PpVα peptides; chromaffin cells; cellular excitability; calcium channels; sodium channels
Muscarine, Pituitary Adenylate Cyclase Activating Polypeptide, and Angiotensin II-Evoked Secretion in Adrenal Medullary Chromaffin Cells With a Major Focus on TRPC Channels
Masumi Inoue, Keita Harada
Journal of Neurochemistry (2026)
Keywords: Transient receptor potential canonical (TRPC), Muscarinic Stimulation, Secretion
SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla
Alice Santambrogio, Yasmine Kemkem, Thea L. Willis, Ilona Berger, Maria Eleni Kastriti, Louis Faure, John P. Russell, Emily J. Lodge, Val Yianni, Bence Kövér, Rebecca J. Oakey, Barbara Altieri, Stefan R. Bornstein, Charlotte Steenblock, Igor Adameyko & Cynthia L. Andoniadou
Nature Communications (2025)
Keywords: Adult Stem Cells; Differentiation; Stem Cells
Morphological, Histological and Ultrastructural Characterization of the Common Dolphin’s Adrenal Glands
Paula Alonso-Almorox, Alfonso Blanco, Ignacio Molpeceres-Diego, Raiden Grandía-Guzmán, Diego Llinás Rueda, Manuel Arbelo, Antonio Fernández
Veterinary Sciences (2026)
Keywords: Delphinus delphis, cetaceans, adrenal gland, HPA axis, adrenal morphology, ultrastructure, stress physiology, neuroendocrine system
AI guided discovery of a murine model of asymptomatic Alzheimer's disease
Suborno Jati, Sahar Taheri, Satadeepa Kal, Subhash C Sinha, Brian P Head, Sushil K Mahata, Debashis Sahoo
Acta Neuropathologica Communications (2026)
Keywords: Aging; Asymptomatic AD; Boolean implication; Chromogranin A; Preventive therapeutic strategies; Sex-specific resilience; Systems biology
Chromogranin A deficiency attenuates tauopathy by altering epinephrine-alpha-adrenergic receptor signaling in PS19 mice
Suborno Jati, Daniel Munoz-Mayorga, Shandy Shahabi, Kechun Tang, Yuren Tao, Dennis W Dickson, Irene Litvan, Gourisankar Ghosh, Sushil K Mahata, Xu Chen
Nature Communications (2026)
Keywords: Cognitive neuroscience, Dementia, Alzheimer's disease
Phaeochromocytomas and paragangliomas harbour tumour-initiating SOX2+ stem cells
Yasmine Kemkem, Mark Quinn, Bence Kövér, Alice Santambrogio, James Kaufman-Cook, Olivia Sherwin, Laura D Scriba, Dimitria Brempou, Miriam Vazquez Segoviano, Dylan Cameron, Ilona Berger, Wen Ng, Daisuke Nonaka, Marily Theodoropoulou, Christina Pamporaki, Paul V Carroll, Louise Izatt, J Paul Chapple, Stefan R Bornstein, Nicole Bechmann, Charlotte Steenblock, Rebecca J Oakey, Cynthia L Andoniadou
Endocrine Related Cancer (2026)
Keywords: PPGL, PCC, PGL, stem cells, SOX2, sustentacular cells, tumour-initiating cells, cancer stem cells, phaeochromocytoma, paraganglioma
Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling
Elke M Muntjewerff, Dali Epremidze, Mariya Nezhyva, Satadeepa Kal, Theresa V Rohm, Kechun Tang, Kailash Singh, Daniel Espes, Suborno Jati, Marleen Bootsma, Atef Mahmoud Mannaa, Hiromi Ikebuchi, Anna M Nilsson, Mahadevan Rajasekaran, Per E Andrén, Erik T Jansson, Sushil K Mahata, Gustaf Christoffersson
Communications Biology (2025)
Keywords: Chromogranin A (CgA), catestatin (CST), knockout mice, pancreas, metabolic phenotype
Beyond the brain: early autonomic dysfunction in Alzheimer's disease
Carmen Nanclares, Inés Colmena, Alicia Muñoz-Montero, Andrés M Baraibar, Ricardo de Pascual, Aneta Wojnicz, Ana Ruiz-Nuño, Antonio G García, Adrián Gironda-Martínez, Luis Gandía
Acta Neuropathologica Communications (2025)
Keywords: Alzheimer´s disease; Chromaffin cells; Catecholamine release; Peripheral dysfunction; Electrophysiology; Neuropsychiatric symptoms.
Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas
Petra Bullova, Peng Cui, Maria Arceo, Jiacheng Zhu, Wenyu Li, Monika Plescher, Valentin Poltorachenko, Katerina Stripling, Christian Santangeli, Lidiya Mykhaylechko, Maria Eleni Kastriti, Catharina Larsson, C.Christofer Juhlin, Michael Mints & Susanne Schlisio
npj precision oncology (2025)
Keywords: Cancer stem cells; Endocrine cancer; Tumour heterogeneity
Neurons, Neurotransmitter release, Neuropeptides
A multitransmitter, synaptic specification-segregated calyx-like synapse linking pontine pituitary adenylate cyclase-activating polypeptide neurons to forebrain-extended amygdala
Limei Zhang, Vito S Hernández, David M Giraldo, Sunny Z Jiang, Juan C León-Contreras, Rong Ye, Shiliang Zhang, Martin K H Schäfer, Rafael A Barrio, Rogelio Hernández-Pando, Sabine Schoenherr, Francesco Ferraguti, Lee E Eiden
PNAS Nexus (2026)
Keywords: calyx of Held, Ach, glutamate, neuropeptides, GluD1.
α-Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons
Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone, Silvia De Marchis, Andrea Marcantoni, Valentina Carabelli
The Journal of Physiology (2026)
Keywords: alpha-synuclein; Cav2.2. channels; diamond-based micro-electrode arrays; quantal dopamine release; spontaneous firing.