Martina Höckner

Associate Prof.

Address:
Department of Zoology
University of Innsbruck
Technikerstr. 25
6020 Innsbruck
Austria

Room: 6/09
Phone: +43 512 507-51878
e-mail: martina.hoeckner@uibk.ac.at

Publications

Contributions to Books / Journals

Journal Article (Original Paper)

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  Aigner, G.P.; Nenning, P.; Fiechtner, B.; Srut, M.; Höckner, M. (2022): DNA Methylation and Detoxification in the Earthworm Lumbricus terrestris Exposed to Cadmium and the DNA Demethylation Agent 5-Aza-2′-deoxycytidine.
  In: Toxics 10/2, No. 100. (DOI) (Web link)
  
  
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  Gerhard P. Aigner, G.P.; Pittl, V.; Fiechtner, B.; Egger, B.; Srut, M.; Höckner, M. (2022): Common mechanisms cannot explain time- and dose-dependent DNA methylation changes in earthworms exposed to cadmium.
  In: Science of the Total Environment 812, No. 151468. (DOI) (Web link)
  
  
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  Srut, M.; Peer, B.; Fiechtner, B.; Egg, M.; Sandbichler, A.M.; Höckner, M. (2022): Aging Cell Culture - Genetic and Metabolic Effects of Passage Number on Zebrafish Z3 Cells.
  In: Cellular Physiology and Biochemistry 56, pp. 50 - 65. (Full-text) (DOI) (Web link)
  
  
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  Höckner, M.; Piechnik, C.A,.; Fiechtner, B.; Weinberger, B.; Tomanek, L. (2020): Cadmium-Related Effects on Cellular Immunity Comprises Altered Metabolism in Earthworm Coelomocytes.
  In: International Journal of Molecular Sciences 21/2, No. 599. (DOI) (Web link)
  
  
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  Drechsel, V.; Fiechtner, B.; Höckner, M. (2019): Promoter activity of earthworm metallothionein in mouse embryonic fibroblasts.
  In: Molecular Biology Reports 46/6, pp. 6371 - 6379. (Full-text) (DOI) (Web link)
  
  
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  Šrut, M.; Menke, S.; Höckner, M.; Sommer, S. (2019): Earthworms and cadmium - Heavy metal resistant gut bacteria as indicators for heavy metal pollution in soils?
  In: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 171, pp. 843 - 853. (DOI) (Web link)
  
  
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  Drechsel, V.; Schauer, K.; Šrut, M.; Höckner, M. (2017): Regulatory plasticity of earthworm wMT-2 gene expression.
  In: International Journal of Molecular Sciences 18/6, Nr. 1113. (Full-text) (DOI)
  
  
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  Piechnik, C.A.; Höckner, M.; de Souza, M.R.; Donatti, L.; Tomanek, L. (2017): Time course of lead induced proteomic changes in gill of the Antarctic limpet Nacella Concinna (Gastropoda: Patellidae).
  In: Journal of Proteomics 151, pp. 145 - 161. (DOI)
  
  
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  Šrut, M.; Drechsel, V.; Höckner, M. (2017): Low levels of Cd induce persisting epigenetic modifications and acclimation mechanisms in the earthworm Lumbricus terrestris.
  In: PLoS One 12/4, Nr. e0176047. (Full-text) (DOI)
  
  
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  Höckner, Martina; Dallinger, Reinhard; Stürzenbaum, Stephen R. (2015): Metallothionein gene activation in the earthworm (Lumbricus rubellus).
  In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460/3, pp. 537 - 542. (DOI) (Web link)
  
  
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  Höckner, M.; Spreiz, A.; Frühmesser, A.; Tzschach, A.; Dufke, A.; Rittinger, O.; Kalscheuer, V.; Singer, S.; Erdel, M.; Fauth, C.; Grossmann, V.; Utermann, G.; Zschocke, J.; Kotzot, D. (2012): Parental origin of de novo cytogenetically balanced reciprocal non-Robertsonian translocations.
  In: Cytogenetic and Genome Research 136/4, pp. 242 - 245. (DOI) (Web link)
  
  
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  Höckner, Martina; Stefanon, Karin; de Vaufleury, Annette; Monteiro, Freddy; Pérez-Rafael, Silvia; Palacios, Oscar; Capdevila, Mercé; Atrian, Silvia; Dallinger, Reinhard (2011): Physiological relevance and contribution to metal balance of specific and non-specific Metallothionein isoforms in the garden snail, Cantareus aspersus.
  In: Biometals 24/6, pp. 1079 - 1092. (DOI)
  
  
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  Palacio, Oscar; Pagani, Ayelen; Pérez-Rafael, Silvia; Egg, Margit; Höckner, Martina; Brandstätter, Anita; Capdevila, Mercé; Atrian, Silvia; Dallinger, Reinhard (2011): Shaping mechanisms of metal specificity in a family of metazoan metallothioneins: evolutionary differentiation of mollusc metallothioneins.
  In: BMC Biology 9/4, pp. 1 - 20. (DOI)
  
  
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  Egg, M.; Höckner, M.; Brandstätter, A.; Schuler, D.; Dallinger, R. (2009): Structural and bioinformatic analysis of the Roman snail Cd-Metallothionein gene uncovers molecular adaptation towards plasticity in coping with multifarious environmental stress.
  In: Molecular Ecology 18/11, pp. 2426 - 2443.
  
  
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  Höckner, M.; Stefanon, K.; Schuler, D.; Fantur, R.; de Vaufleury, A.; Dallinger, R. (2009): Coping with Cadmium Exposure in Various Ways: The Two Helicid Snails Helix pomatia and Cantareus aspersus Share the Metal Transcription Factor-2, but Differ in Promoter Organization and Transcription of Their Cd-Metallothionein Genes.
  In: Journal of Experimental Zoology Part A: Ecological and Integrative Physiology 311A/10, pp. 776 - 786.
  
  

Journal Article (Review)

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  Sandbichler, A.M.; Höckner, M. (2016): Cadmium Protection Strategies-A Hidden Trade-Off?
  In: International Journal of Molecular Sciences 17/1, No. 139. (DOI) (Web link)
  
  
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  Dallinger, Reinhard; Höckner, Martina (2013): Evolutionary concepts in ecotoxicology: tracing the genetic background of differential cadmium sensitivities in invertebrate lineages.
  In: ECOTOXICOLOGY 22/5, pp. 767 - 778. (DOI) (Web link)
  
  
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  Höckner, Martina; Dallinger, Reinhard; Stürzenbaum, Stephen R. (2011): Nematode and snail metallothioneins.
  In: Journal of Biological Inorganic Chemistry 16/7, pp. 1057 - 1065. (DOI) (Web link)
  
  

Journal Article (Other)

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  Stürzenbaum, Stephen R.; Hoeckner, Martina; Panneerselvam, Arun; Levitt, James; Bouillard, Jean-Sebastien; Taniguchi, Shohei; Dailey, Lea Ann; Khanbeigi, Rah Ahmad; Thanou, Maya; Rosca, Elena; Suhling, Klaus; Zayats, Anatoly; Green, Mark (2013): Biosynthesis of luminescent quantum dots in an earthworm.
  In: Nature Nanotechnology 8, pp. 57 - 60. (DOI) (Web link)
  
  

Journal Article (Meeting-Abstract)

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  HÖCKNER, Martina; Dallinger, Reinhard; Stürzenbaum, Stephen (2012): Studying MT regulation in Lumbricus rubellus, the red earthworm, suggests novel activation mechanisms.
  In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 163/Suppl., p. S30. (DOI) (Web link)
  
  
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  Dallinger, Reinhard; Höckner, Martina; Egg, Margit; Palacios, Oscar; Capdevila, Mercé; Pagani, Ayelen; Atrian, Silvia (2010): Structural and functional differentiation of gastropod metallothioneins has been achieved by evolution of metal-specific isoform families.
  In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 157/Supplement 1, p. S35. (DOI)
  
  
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  Dallinger, Reinhard; Egg, Margit; Höckner, Martina; Schuler, Dietmar; Atrian, Silvia; Capdevila, Mercé (2009): Molecular adaptation to cope with environmental stress of terrestrial gastropod Cadmium-metallothioneins: High metal specificity at the protein level combines with multifunctionality of genes.
  In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 154A/1 (Suppl.), p. S33.
  
  
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  Höckner, Martina; Schuler, Dietmar; Stefanon, Karin; Fantur, Rainer; de Vaufleury, Annette; Dallinger, Reinhard (2009): Metal-dependent transcription of metallothionein isoform genes in the terrestrial snail Cantareus aspersus.
  In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 154A/1 (Suppl.), p. S5.
  
  
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  Höckner, Martina; Stefanon, Karin; Schuler, Dietmar; Fantur, Rainer; De Vaufleury, Annette; Dallinger, Reinhard (2009): Differing transcription patterns of Cd-metallothionein genes in two terrestrial gastropod species are related to divergences in promoter structure and function.
  In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 154A/1 (Suppl.), p. S24.
  
  
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  Schuler, Dietmar; Höckner, Martina; Prader, Angelika; Dallinger, Reinhard (2009): Biomphalaria glabrata embryonic cells as a model system for toxicological and molecular studies of stress-induced expression of metallothionein genes.
  In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 154A/1 (Suppl.), pp. S15 - S16.
  
  
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  Atrian, Silvia; Pagani, Ayleen; Capdevila, Mercé; Palacios, Oscar; Egg, Margit; Höckner, Martina; Dallinger, Reinhard (2008): Perfect adaptation to cope with metal stress and trace element homeostasis: Metal specificity is a fundamental structural feature of snail metallothioneins.
  In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 151A/1 (Suppl.), p. 520.
  
  
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  Dallinger, Reinhard; Egg, Margit; Höckner, Martina; Schuler, Dietmar (2008): Understanding the functioning of a Gene: Ability of the Cd-Metallothionein of Roman snail (Helix pomatia L.) to cope with Multiple Environmental Stress.
  In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY 151A/1 (Suppl.), p. 520.
  
  

Proceedings Article (Abstract)

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  Aigner, G.P.; Pittl, V.; Egger, B.; Fiechtner, B.; Srut, M.; Höckner, M. (2021): Mechanisms of time and dose dependent DNA methylation landscape changes in earthworms exposed to cadmium.
  In: Österreichische Gesellschaft für Molekulare Biowissenschaften und Biotechnologie: 13th ÖGMBT Annual Meeting "From Molecular Machines to Translational Medicine". Abstract Book. September 20 - October 14, 2021. Österreichische Gesellschaft für Molekulare Biowissenschaften und Biotechnologie (ÖGMBT)., p. 136. (Web link)
  
  
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  Aigner, G.P.; Pittl, V.; Egger, B.; Fiechtner, B.; Srut, M.; Höckner, M. (2021): Mechanisms of time and dose dependent DNA methylation landscape changes in earthworms exposed to cadmium.
  In: Society for Experimental Biology: SEB 2021 Virtual Conference 2021.Abstract Book. 29 June - 8 July 2021. London: The Society for Experimental Biology., pp. 150 - 151. (Web link)
  
  
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  DALLINGER, Reinhard; HÖCKNER, Martina (2012): How evolutionary concepts may enhance exotoxicology: tracing the genetic background of differential cadmium sensitivities in invertebrates.
  In: 6th SETAC World Congress. Extended Abstracts. Brussels: SETAC Europe., Vol. Extended Abstracts "Ecotoxicology" Part 1, pp. 131 - 132. (Web link)
  
  

Lectures

Presentations at Conferences, Symposia, etc.

Conference Lecture (Upon Registration)

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  Lecturer(s): Aigner, G.P. Co-author(s): Pittl, V.; Egger, B.; Srut, M.; Fiechtner, B.; Höckner, M.: Mechanisms of time and dose dependent DNA methylation landscape changes in earthworms exposed to cadmium.
  13th ÖGMBT Annual Meeting "From molecular machines to translational medicine”, Wien (online), 2021-09-28. (Web link)
  
  
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  Lecturer(s): Aigner, G. P. Co-author(s): Pittl, V.; Fiechtner, B.; Egger, B.; Srut, M.; Höckner, M.: Mechanisms of time and dose dependent DNA methylation landscape changes in earthworms exposed to cadmium.
  SEB 2021 Annual Conference, Lancaster, 2021-07-07. (Web link)
  
  
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  Lecturer(s): Drechsel, V. Co-author(s): Höckner, M.: Activation of earthworm metallothionein in a cell culture system.
  SEB (Society for Experimental Biology) Florence 2018, Florenz, 2018-07-05. (Web link)
  
  
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  Lecturer(s): Höckner, M. Co-author(s): Drechsel, V.; Srut, M.; Schuster, M.: Coping strategies in earthworms to low levels of Cadmium.
  30th ESCPB Congress, Barcelona, 2016-09-06. (Web link)
  
  
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  Lecturer(s): Srut, M. Co-author(s): Drechsel, V.; Niloofar, N.; Salvatore, M.; Höckner, M.: Epigenetic alterations in heavy metal stressed earthworms.
  30th ESCPB Congress, Barcelona, 2016-09-05. (Web link)
  
  
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  Lecturer(s): Höckner, M. Co-author(s): Schauer, K.; Drechsel, V.; Srut, M.; Dallinger, R.; Stürzenbaum, S.: Stress induced Metallothionein transcription and regulation in earthworms.
  SEB (Society for Experimental Biology) Prague 2015, Prag, 2015-06-30. (Web link)
  
  
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  Lecturer(s): Höckner, M. Co-author(s): Zuzow, M.J.; Tomanek, L.: Proteomic response of L. rubellus, the red earthworm, to metal stress under different soil temperatures.
  SETAC Europe 24th Annual Meeting, Basel, 2014-05-14. (Web link)
  
  
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  Lecturer(s): Höckner, M. Co-author(s): Dallinger, R.; Stürzenbaum, S.: Studying MT regulation in L. rubellus, the red earthworm, suggests novel activation mechanisms.
  28th ESCPB Congress of the New European Society for Comparative Physiology and Biochemistry, Bilbao, 2012-09-04. (Web link)
  
  
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  Lecturer(s): Atrian, Silvia Co-author(s): Pagani, Ayleen; Capdevila, Mercé; Palacios, Oscar; Egg, Margit; Höckner, Margit; Dallinger, Reinhard: Evolutionary diversification of snail metallothioneins is driven by extreme metal specificity of isoforms combined with cell-specific expression.
  5th Annual Meeting of the Center of Molecular Biosciences (CMBI), Igls, 2008-09-26.
  
  
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  Lecturer(s): EGG, M.; HÖCKNER, M.; DALLINGER, R.: Vom Protein zum Gen – das Biomarker-Potential der Metallothionein-Antwort in der Weinbergschnecke und dessen ökologische Relevanz.
  10. SETAC GLB – Meeting, Basel, 2005-09-29.
  
  

Poster Presentation

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  Lecturer(s): Drechsel, V. Co-author(s): Höckner, M.: Activation of Metallothionein in MTF1 -/- cells.
  Life Science PhD Meeting Innsbruck 2018, Innsbruck, 2018-04-05. (Web link)
  
  
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  Lecturer(s): Drechsel, V. Co-author(s): Schauer, K.; Srut, M.; Höckner, M.: Molecular stress response in Lumbricus terrestris.
  The Society for Experimental Biology Annual Meeting (SEB Gothenburg 2017), Göteborg, 2017-07-05. (Web link)
  
  
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  Lecturer(s): Drechsel, V. Co-author(s): Srut, M.; Höckner, M.: Molecular stress response in Lumbricus terrestris.
  Life Science PhD Meeting Innsbruck 2017, Innsbruck, 2017-04-18. (Web link)
  
  
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  Lecturer(s): Srut, Maja Co-author(s): Drechsel, V.; Höckner, M.: Epigenetic signatures as sensitive tool in soil ecotoxicology: alterations and relation to biomarker response in heavy metal stressed earthworms.
  SETAC/iEOS Joint Focused Topic Meeting Omics and Epigenetics, Ghent / Gent, 2016-09-12. (Web link)
  
  
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  Lecturer(s): Dallinger, Reinhard; Höckner, Martina; Schuler, Dietmar; Egg, Margit; Atrian, Silvia; Capdevial, Mercé: Understanding multifunctionality of terrestrial gastropod Cadmium-Metallothioneins: High metal specificity of expressed protein is complemented by response plasticity at the gene level.
  1st Life Science Meeting, Igls, 2009-09-18.
  
  
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  Lecturer(s): Höckner, Martina; Schuler, Dietmar; Stefanon, Karin; Fantur, Rainer; de Vaufleury, Annette; Dallinger, Reinhard: A quantitative study based on Real-time detection PCR reveals specific expression patterns and metal-dependent upregulation of Metallothionein genes in the brown garden snail (Cantareus aspersus).
  1st Life Science Meeting, Igls, 2009-09-18.
  
  
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  Lecturer(s): Schuler, Dietmar; Höckner, Martina; Prader, Angelika; Dallinger, Reinhard: Biomphalaria glabrata embryonic cells as a model system for analysis of metal-induced stress and metal-dependent expression of invertebrate Metallothionein genes.
  1st Life Science Meeting, Igls, 2009-09-18.
  
  
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  Lecturer(s): Egg, Margit; Höckner, Martina; Brandstätter, Anita; Schuler, Dietmar; Dallinger, Reinhard: Plasticity in coping with multifarious Environmental Stress by Roman Snail Populations is linked to the structure and responsiveness of the Cd-Metallothionein Gene: a bioinformatic analysis.
  5th Annual Meeting of the Center of Molecular Biosciences (CMBI), Igls, 2008-09-26.
  
  
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  Lecturer(s): Stefanon, Karin; Höckner, Martina; Schuler, Dietmar; Fantur, Rainer; de Vaufleury, Annette; Dallinger, Reinhard: Metal-specific expression of Metallothionein isoform genes of the brown garden snail (Cornu aspersum): a quantitative study based on Real-Time detection PCR.
  5th Annual Meeting of the Center of Molecular Biosciences (CMBI), Igls, 2008-09-26.
  
  
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  Lecturer(s): DALLINGER, R.; EGG, M.; HÖCKNER, M.; SCHULER, D.: The Cd-Metallothionein of the Roman snail Helix pomatia: Specific adaptation of a gene to cope with multifarious environmental stress.
  4th Annual Meeting of the Center of Molecular Biosciences (CMBI), Igls, 2007-09-29.
  
  
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  Lecturer(s): EGG, M.; HÖCKNER, M.; DALLINGER, R.: The Cd-metallothionein gene of Helix pomatia: An evolutionary key to the understanding of complex stress response?
  2nd Annual Meeting of the Center for Molecular Biosciences (CMBI), Vill, 2005-09-30.
  
  
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  Lecturer(s): Egg, Margit; Höckner, Martina; Dallinger, Reinhard: Analysis of gene control regions of Cd- and Cu-metallothionein isoforms from Helix pomatia reveal remarkable structural features suggesting complex regulatory functions.
  1st Annual Meeting of the Center for Molecular Biosciences (CMBI), Vill, 2004-10-01.
  
  

Guest Lectures

Guest Lecture

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  Lecturer(s): Egg, M.; Höckner, M.; Dallinger, R.: The Cd-Metallothionein gene of Helix pomatia: a prime example for gene functioning?
  Universität Zürich, Zürich, 2005-12-01.
  
  

Presentations for the general public

Public Lecture

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  Höckner, M.; Piechnik, C.A.; Aigner, G.P.: Wie schützt sich der Regenwurm im Boden vor schädlichen Substanzen bzw. Erregern?
  Lange Nacht der Forschung, Innsbruck, 2022-05-20. (Web link)
  
  

Projects, scholarships and other third-party funds

Research Projects

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  Höckner, Martina: Regenwurm MTs in Stressantwort und angeborenem Immunsystem.
  Fonds zur Förderung der wissenschaftlichen Forschung (FWF), Einzelprojekt
  2021-01-01 - 2023-12-31
  
  
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  Srut, Maja; Höckner, Martina: Heavy metal induced epigenetic modifications.
  Fonds zur Förderung der wissenschaftlichen Forschung (FWF), Lise-Meitner-Programm für ForscherInnen aus dem Ausland
  2019-05-08 - 2024-05-07
  
  
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  Höckner, Martina: Grasfroschmonitoring im Fotschertal.
  Österreichische Bundesforste AG
  2016-05-01 - 2022-07-31
  
  
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  Höckner, Martina: Genetik und Epigenetik von Regenwürmern in Cd-belasteten Böden.
  Leopold-Franzens-Universität Innsbruck - Vizerektorat für Forschung, Nachwuchsfördermittel aus der Nachwuchsförderung der LFU
  2015-01-01 - 2015-12-31
  
  
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  Höckner, Martina: Cellular localization and detection of protein levels of MT isoforms in three gastropod species in control and stress exposed samples.
  Tiroler Wissenschaftsförderung (TWF)
  2014-07-01 - 2016-06-30
  
  

Scholarships

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  Höckner, Martina: Application of proteomics to study the response to different environmental stressors in the sentinel organism L. rubellus.
  Council for International Exchange of Scholars - Fulbright Commission, Fulbright Stipendium
  2013-07-01 - 2013-10-31
  
  
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  Höckner, Martina: Basal and metal induced transcriptional regulation of L. rubellus Metallothionein.
  Fonds zur Förderung der wissenschaftlichen Forschung (FWF), Erwin-Schrödinger-Auslandsstipendium
  2011-02-01 - 2012-08-31
  
  

Academic Activities and Achievements

Doctoral Theses / Postdoctoral Qualifications

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  Höckner, Martina: Verleihung der Lehrbefugnis für das Fach "Zoologie" (2018). (Web link)
  
  

Supervision of Student Theses

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  Höckner, Martina; Hinterleitner, Silvia: Schauer, Karl Joseph: wMT2 Genexpression nach Cadmium Belastung in Lumbricus terrestris und wissenschaftliches Arbeiten als Kompetenz in Bezug auf die vorwissenschaftliche Arbeit (2014 - 2016).