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Publications

Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH.(2019). Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.Nat Neurosci. 2019 Jan 7. doi: 10.1038/s41593-018-0295-x. [Epub ahead of print]

Thier MC, Hommerding O, Panten J, Pinna R, García-González D, Berger T, Wörsdörfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, Becker L, Milsom MD, Jauch A, Utikal J, Herrmann C, Monyer H, Edenhofer F, Trumpp A. (2018). Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells.Cell Stem Cell. 2019 Jan 3;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015. Epub 2018 Dec 20

Mertens J, Reid D, Lau S, Kim Y, Gage FH.(2018). Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases. Annu Rev Genet. 2018 Nov 23;52:271-293. doi: 10.1146/annurev-genet-120417-031534. Epub 2018 Sep 12.

Popp B, Krumbiegel M, Grosch J, Sommer A, Uebe S, Kohl Z, Plötz S, Farrell M, Trautmann U, Kraus C, Ekici AB, Asadollahi R, Regensburger M, Günther K, Rauch A, Edenhofer F, Winkler J, Winner B, Reis A.(2018). Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. Sci Rep. 2018 Nov 21;8(1):17201. doi: 10.1038/s41598-018-35506-0.

Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT.(2018) Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease.Neuron. 2018 Sep 5;99(5):925-940.e7. doi: 10.1016/j.neuron.2018.07.039.

Mekala SR, Wörsdörfer P, Bauer J, Stoll O, Wagner N, Reeh L, Loew K, Eckner G, Kwok CK, Wischmeyer E, Dickinson ME, Schulze H, Stegner D, Benndorf RA, Edenhofer F, Pfeiffer V, Kuerten S, Frantz S, Ergün S.(2018). Generation of Cardiomyocytes From Vascular Adventitia-Resident Stem Cells. Circ Res. 2018 Aug 31;123(6):686-699. doi: 10.1161/CIRCRESAHA.117.312526

Nose N, Werner RA, Ueda Y, Günther K, Lapa C, Javadi MS, Fukushima K, Edenhofer F, Higuchi T.(2018). Metabolic Substrate shift in human induced pluripotent stem cells during cardiac Differentiation: Functional assessment using in vitro radionuclide uptake assay.
Int J Cardiol. 2018 Oct 15;269:229-234. doi: 10.1016/j.ijcard.2018.06.089. Epub 2018 Jun 21.

Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH. (2018).Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. Cell Rep. 2018 May 29;23(9):2550-2558. doi: 10.1016/j.celrep.2018.04.105.

Klein T, Günther K, Kwok CK, Edenhofer F, Üçeyler N (2018). Generation of the human induced pluripotent stem cell line (UKWNLi001-A) from skin fibroblasts of a woman with Fabry disease carrying the X-chromosomal heterozygous c.708 G > C (W236C) missense mutation in exon 5 of the alpha-galactosidase-A gene.
Stem Cell Res. 2018 Aug;31:222-226. doi: 10.1016/j.scr.2018.08.009. Epub 2018 Aug 10.

Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH.(2018) Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile.
Cell Rep. 2018 May 29;23(9):2550-2558. doi: 10.1016/j.celrep.2018.04.105

Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok CK, Leonardi T, Booty LM, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Donegà M, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C, Pluchino S.(2018) Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation
Cell Stem Cell. 2018 Mar 1;22(3):355-368.e13. doi: 10.1016/j.stem.2018.01.020. Epub 2018 Feb 22.

Jansch C, Günther K, Waider J, Ziegler GC, Forero A, Kollert S, Svirin E, Pühringer D, Kwok CK, Ullmann R, Maierhofer A, Flunkert J, Haaf T, Edenhofer F, Lesch KP.(2018). Generation of a human induced pluripotent stem cell (iPSC) line from a 51-year-old female with attention-deficit/hyperactivity disorder (ADHD) carrying a duplication of SLC2A3. Stem Cell Res. 2018 Apr;28:136-140. doi: 10.1016/j.scr.2018.02.005. Epub 2018 Feb 13.

Jovanovic VM, Salti A, Tilleman H, Zega K, Jukic MM, Zou H, Friedel RH, Prakash N, Blaess S, Edenhofer F, Brodski C (2018). BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells. J Neurosci. 2018 Jan 10. pii: 1540-17. doi: 10.1523/JNEUROSCI.1540-17.2018. [Epub ahead of print]

Dobeš  J*, Edenhofer F*, Vobořil M, Brabec T, Dobešová M, Čepková A, Klein L, Rajewsky K, Filipp D. (2017) A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire. Eur J Immunol. 2017 Nov 30. doi: 10.1002/eji.201747267. *joint first authorship

Murken, J., Grimm, T., Holinski-Feder, E., Zerres, K. (ed.) Edenhofer, F., et.al.  Humangenetik, Thieme. (2017) Jan 31 DOI: 10.1055/b-005-143305

Forero A, Rivero O, Wäldchen S, Ku HP, Kiser DP, Gärtner Y, Pennington LS, Waider J, Gaspar P, Jansch C, Edenhofer F, Resink TJ, Blum R, Sauer M, Lesch KP (2017). Cadherin-13 Deficiency Increases Dorsal Raphe 5-HT Neuron Density and Prefrontal Cortex Innervation in the Mouse Brain. Front Cell Neurosci. 2017 Sep 26;11:307. doi: 10.3389/fncel.2017.00307. eCollection 2017.

Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, Sekaran T, Egert A, Ergün S, Schorle H, Pfeifer A, Edenhofer F, Willecke K.(2016),Stem Cells. 2016 Nov 21. Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies. doi: 10.1002/stem.2545. [Epub ahead of print]

Wörsdörfer P, Mekala SR, Bauer J, Edenhofer F, Kuerten S, Ergün S. (2016 Aug 3.)The vascular adventitia: An endogenous, omnipresent source of stem cells in the Body. Pharmacol Ther.  pii: S0163-7258(16)30142-5. doi: 10.1016/j.pharmthera.2016.07.017. [Epub ahead of print]

Safina D, Schlitt F, Romeo R, Pflanzner T, Pietrzik CU, Narayanaswami V, Edenhofer F, Faissner A. (2016) Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation. Glia. 2016 Aug;64(8):1363-80. doi: 10.1002/glia.23009. Epub 2016 Jun 3.

Schulze, M., S. Hoja, B. Winner, J. Winkler, F. Edenhofer, M. J. Riemenschneider (2016) Model testing of PluriTest® with next-generation sequencing data, Stem Cells Dev. 1;25(7):569-71. doi: 10.1089/scd.2015.0266. Epub 2016 Mar 15.

Münst, B., M. Thier, D. Winnemöller, M Helfen, R. P. Thummer, F Edenhofer. (2016) Nanog induces suppression of senescence via down-regulation of p27KIP1 expression, J Cell Sci. pii: jcs.167932. [Epub ahead of print]                                                                         

Scognamiglio et al., F. Edenhofer, P. Bertone, W. Huber, F. van der Hoeven, A. Smith and A. Trumpp (2016) Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause, Cell, 164(4), 668–680. http://doi.org/10.1016/j.cell.2015.12.033                                       

Bung, R, P. Wörsdörfer, M. Thier, K. Vogt, M. Gebhardt, F. Edenhofer (2015). Partial dedifferentiation of murine radial glia type neural stem cells by Brn2 and c-Myc yields early neuroepithelial progenitors, J Mol Biol S0022-2836(15)00622-1. doi: 10.1016/j.jmb.2015.10.028. [Epub ahead of print]                                                                                

Meyer S, P. Wörsdörfer, K. Günther, M. Thier, F. Edenhofer (2015) Derivation of adult human fibroblasts and their direct conversion into expandable neural progenitor cells. J. Visual. Exp., Jul 29;(101). doi: 10.3791/52831.

Mohr M, Tosun S, Arnold WH, Edenhofer F, Zänker KS, Dittmar T (2015) Quantification of cell fusion events human breast cancer cells and breast epithelial cells using a Cre-LoxP-based double fluorescence reporter system. Cell Mol Life Sci. Apr 22. [Epub ahead of print]

Harreither, E, H A Rydberg, H L Åmand, V Jadhav, L Fliedl, C Benda, M A Esteban, D Pei, N Borth, R Grillari-Voglauer, O Hommerding, F Edenhofer, B Nordén and J Grillari. (2014) Characterization of a novel cell penetrating peptide derived from human Oct4. Cell Regeneration, 3:2 doi:10.1186/2045-9769-3-2.                                                                                 

Kadari, A., Mekala, S., Wagner, N., Malan, D., Köth, J., Doll, K., Stappert, J., Eckert, D., Peitz, M., Matthes, J., Sasse, P., Herzig, S., Brüstle, O., Ergün, S. & F. Edenhofer (2014). Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling. Stem Cell Reviews and Reports. doi:10.1007/s12015-014-9564-6          

Kadari, A, Lu, M, Ming, Li, Sekaran, T., Thummer, R., Guyette, N., Chu, V. & Edenhofer, F (2014) Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human iPS cells. Stem Cell Res. Ther. Apr 8;5(2):47. 

Peitz M., B. Münst, R.P. Thummer, M. Helfen & F. Edenhofer. Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification. Stem Cell Res. 2014 Mar 5;12(3):680-689. doi: 10.1016/j.scr.2014.02.006.                      

Sekaran T, Thummer R, Edenhofer F. Exploring the Neural Reprogrammome using Bioinformatics Approaches. J Stem Cell Res Ther (2013) 3:146. doi: 10.4172/2157-7633.1000146

Hennen E, Safina D, Haussmann U, Wörsdörfer P, Edenhofer F, Poetsch A, Faissner A., A LewisX-glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice. J Biol Chem. (2013) Apr 24. [Epub ahead of print]

Zhang, R., H. K. Mjoseng, S. Pells, R. Besseling, S. Velugotla, N. G. Bauer, G. Tourniaire, C. R. E. Duffy, A. Serio, S. Greenhough, C. Armit, F. Edenhofer, R. Pethig, P. de Sousa & M. Bradley, A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells. Nature Communications (2013) 4, 1335–10. doi:10.1038/ncomms2341           

Kim BM, Thier MC, Oh S, Sherwood R, Kanellopoulou C, Edenhofer F, Choi MY. MicroRNAs are indispensable for reprogramming mouse embryonic fibroblasts into induced stem cell-like cells, PLoS One. (2012);7(6):e39239. Epub 2012 Jun 21.                               

Thier, M , P. Wörsdörfer, Y. B. Lakes, R. Gorris, S. Herms, T. Opitz, D. Seiferling, T. Quandel, P. Hoffmann, M. M. Nöthen, O. Brüstle & F. Edenhofer, Direct conversion of fibroblasts into tripotent neural stem cells, Cell Stem Cell (2012) 10(4):473-9. Epub 2012 Mar 22. Invited paper for the ‘Falling Walls’ Conference Berlin, 2012.                                                  

Haupt, S., J. Grützner, M.-C. Thier, F. Edenhofer, B. H. Rath, I. Laufenberg., M. Forgber, J. Eberhardt & O. Brüstle, Automated selection and harvesting of pluripotent stem cell colonies, Biotechnol Appl Biochem. (2012) Mar;59(2):77-87. doi: 10.1002/bab.1014.          

Thier, M., B. Münst, S. Mielke & F. Edenhofer, Cellular reprogramming employing recombinant Sox2 protein, Stem Cells Intern. (2012);2012:549846. Epub 2012 May 29.        

Haupt, S., L. Borghese, O. Brüstle & F. Edenhofer. Non-Genetic Modulation of Notch Activity by Artificial Delivery of Notch Intracellular Domain into Neural Stem Cells, Stem Cell Rev. Rep. (2012) Jan 31 [Epub ahead of print].      

Keramari, J. Razavi, K. A. Ingman, C. M. Ward, C. Patsch, F. Edenhofer & S. J. Kimber. Sox2 Is Essential for Formation of Trophectoderm in the Preimplantation Embryo, PLoS One (2010) Nov 12;5(11):e13952.                                                      

Thier, M, B. Münst & F. Edenhofer. Exploring refined conditions for reprogramming cells by recombinant Oct4 protein Int. J. Dev. Biol. 54 (2010) 1713-21.                            

Kiss E, Popovic ZV, Bedke J, Adams J, Bonrouhi M, Babelova A, Schmidt C, Edenhofer F, Zschiedrich I, Domhan S, Abdollahi A, Schäfer L, Gretz N, Porubsky S, & Gröne HJ.. Peroxisome Proliferator-Activated Receptor PPARg can Inhibit Chronic Renal Allograft Damage. Am J Pathol. 176 (2010) 2150-62. Epub 2010 Apr 2.                                                                                      

Patsch, C., M. Peitz, D.M. Otte, D. Kesseler, J. Jungverdorben, F.T. Wunderlich, O. Brustle, A. Zimmer & F. Edenhofer. Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells. Stem Cells 28 (2010) 894-902. Selected by Faculty of 1000 Biology – Most important advances in biology.

Stock, K., L. Nolden, F. Edenhofer, T. Quandel, O. Brustle. Transcription Factor-Based Modulation of Neural Stem Cell Differentiation Using Direct Protein Transduction. Cell. Mol. Life Sci. 67 (2010) 2439-49 Epub 2010 Mar 30.   

Borghese, L., Dolezalova, D., Opitz, T., Haupt, S., Leinhaas, A., Steinfarz, B., Koch, P., Edenhofer, F., Hampl, A., Brüstle, O. (2010) Inhibition of Notch signaling in human embryonic stem cell–derived neural stem cells delays G1/s phase transition and accelerates neuronal differentiation in vitro and in vivo. Stem Cells 28 (2010) 955-64.                    

Münst, B., C. Patsch & F. Edenhofer. Engineering cell-permeant proteins. J. Visual. Exp. (2009) Dec 28;(34). pii: 1627. doi: 10.3791/1627. www.jove.com, more than 32,000 views                                             

Capasso, P., M. Aliprandi, G. Ossolengo, F. Edenhofer & A. de Marco. Monodispersity of recombinant Cre recombinase correlates with its effectiveness in vivo. BMC Biotechnology (2009) Sep 11;9(1):80.                                                                                                                                                       

Anastassiadis, K., F. Jun, C Patsch, S. Hu, S. Weidlich, K. Duerschke, F. Buchholz, F. Edenhofer & A. F. Stewart, The site specific Dre/rox recombinase system displays excellent properties in E.coli, mammalian cells and mice. Dis Model Mech. 2009 Aug 19. [Epub ahead of print]

Lienenklaus, S., M. Cornitescu, N. Zietara, M. Lyszkiewicz, N. Gekara, J. Jablonska, F. Edenhofer, K. Rajewsky, D. Bruder, M. Hafner, P. Staeheli & S. Weiss, Novel reporter mouse reveals constitutive and inflammatory expression of IFN-b in vivo, J. Immunol. 183 (2009) 3229-3236.

Bosnali, M & Edenhofer, F. Generation of transducible transcription factors Oct4 and Sox2. Biol. Chem. 389 (2008) 851-861.                                                                                                                                           

Klotz L, Hucke S, Thimm D, Classen S, Gaarz A, Schultze J, Edenhofer F, Kurts C, Klockgether T, Limmer A, Knolle P, Burgdorf S. Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor {gamma} is mediated by up-regulation of B7H1. J. Immunol. 183 (2009) 129-136.                                             

Landry, J.R., S. Kinston, K. Knezevic, M. de Bruijn, N. Wilson, W.T. Nottingham, M. Peitz, F. Edenhofer, J.E. Pimanda, K. Ottersbach & B. Göttgens. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood 111 (2008) 3005-3014.                              

Peitz, M., R. Jäger, C. Patsch, A. Jäger, A. Egert, H. Schorle & F. Edenhofer. Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse ES cells. Genesis 45 (2007) 508-17.                                                                                           

Klotz, L., I. Dani, F. Edenhofer, L. Nolden, B.O. Evert, B. Paul, W. Kolanus, T. Klockgether, P. Knolle & L. Diehl. Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy. J. Immunol. 178 (2007) 2122-2131

*Haupt, S., F. Edenhofer, M. Peitz, A. Leinhaas & O. Brüstle. Stage specific conditional mutagenesis in mouse embryonic stem cell-derived neural cells and post-mitotic neurons by direct delivery of biologically active Cre recombinase. Stem Cells 25 (2007) 181-188.  §corresponding author, *authors contributed equally 

Tünnemann, G., R.M. Martin, S. Haupt, C. Patsch, F. Edenhofer & M.C. Cardoso. Cargo-dependent mode of uptake and bioavailability of TAT-containing proteins and peptides in living cells.  FASEB J. 20 (2006) 1775-1784.                                       

*Nolden, L., §*F. Edenhofer, S. Haupt, F. T. Wunderlich, H. Siemen & O. Brüstle. Site specific recombination in human ES cells induced by cell permeable Cre recombinase. Nature Methods 3 (2006) 461-467. §corresponding author, *authors contributed equally

Murakami, M, T. Ichisaka, M. Maeda, N. Oshiro, K. Hara, F. Edenhofer, H. Kiyama, K. Yonezawa & S. Yamanaka. mTOR is essential for proliferation and growth in early mouse embryos and embryonic stem cells. Mol. Cell. Biol. 24 (2004) 6710-6718.               

Badorf, M., F. Edenhofer, V. Dries, S. Kochanek & G. Schiedner. Efficient in vitro and in vivo excision of floxed sequences with a high-capacity adenoviral vector expressing Cre recombinase. Genesis 33 (2002) 119-124.                                                                 

Peitz, M., K. Pfannkuche, K. Rajewsky & §F. Edenhofer. Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Proc. Natl. Acad. Sci. USA 99 (2002) 4489-4494. §corresponding author                                                                                  

Wunderlich, F.T., H. Wildner, K. Rajewsky & §F. Edenhofer. New variants of inducible Cre recombinase: a novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility. Nucleic Acids Res. 29 (2001) e47.       §corresponding author           

*Rieger, R., *F. Edenhofer,  C. I. Lasmézas & S. Weiss. The human 37-kDa laminin receptor precursor interacts with the prion protein in eucaryotic cells. Nature Medicine 3 (1997) 1383-1388.
*authors contributed  equally                                                                              

Edenhofer, F., R. Rieger, M. Famulok, W. Wendler, S. Weiss & E.-L. Winnacker. Prion Protein PrPc interacts with molecular chaperones of the Hsp60 family. J. Virology  70 (1996) 4724-4728.                                                                                               

Weiss, S., R. Rieger, F. Edenhofer, E. Fisch & E.-L. Winnacker. Recombinant prion protein rPrP27-30 from the Syrian Golden Hamster reveals protease K sensitivity. Biochem. Biophys. Res. Commun. 219 (1996) 173-179.                                                     

Weiss, S., M. Famulok, F. Edenhofer, Y.-H. Wang, I.M. Jones, M. Groschup & E.-L. Winnacker. Overexpression of active Syrian golden hamster Prion Protein PrPc as a glutathione S-transferase fusion in heterologous systems. J. Virology 69 (1995) 4776-4783.