SCIENTIFIC PUBLICATIONS

2025

• Ozge Gunduz-Cinar, Eva Maria Fritz, Maya Xia, Elise Van Leer, Nevin Crow, Andrew Holmes and Nicolas Singewald (2025): Altered Dopamine Signaling in Extinction-Deficient Mice. In: eNeuro 20 November 2025, 12(11) ENEURO.0174-25.2025, DOI: 10.1523/ENEURO.0174-25.2025
• Matthias Ganglberger, Lucia Zanetti , Anna-Sophia Egger, Alexander Günter, Bettina Wagner  Soumaya Belhadj, Regine Mühlfriedel, Dagmar Knoflach, Emilio Casanova, Thomas Rülicke, Mathias W Seeliger, Marcel Kwiatkowski , Hartwig Seitter, Alexandra Koschak (2025): Quantitative proteomics identifies potential molecular adaptations in mouse models of congenital stationary night blindness type 2. In: Mol Cell Proteimics, Nov 10:101462. DOI: 10.1016/j.mcpro.2025.101462
• Pelizzari S, Campiglio M, Fernández-Quintero ML, Heiss MC, Tuluc P, Flucher BE (2025): Divergent actions of CaV1.1 voltage-sensing domain III in activating EC coupling and channel gating, In: Biophys J. 2025 Oct 9:S0006-3495(25)00662-9. doi: 10.1016/j.bpj.2025.10.011. Online ahead of print.PMID: 41069104
• Tuinte WE, Török E, Tuluc P, Fattori F, D'Amico A, Campiglio M. 2025): A biallelic mutation in CACNA2D2 associated with developmental and epileptic encephalopathy affects calcium channel-dependent as well as synaptic functions of α2δ-2., In: JCI Insight. 2025 Aug 8;10(15):e191053. doi: 10.1172/jci.insight.191053. eCollection 2025 Aug 8.PMID: 40779452, In: J Gen Physiol. 2025 Sep 1;157(5):e202513769. doi: 10.1085/jgp.202513769. Epub 2025 Aug 4. PMID: 40758065
• Heiss MC, Fernández-Quintero ML, Campiglio M, El Ghaleb Y, Pelizzari S, Loeffler JR, Liedl KR, Tuluc P, Flucher BE 82025): Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation.
• El Ghaleb Y, Fernández-Quintero ML, Campiglio M, Tuluc P, Höing AS, Kortüm F, Motazacker MM, Jansen IE, Elting MW, Plomp AS, Fischer AM, Siu VM, Kutsche K, Flucher BE (2025): STAC3 binding to CaV1.1 II-III loop is nonessential but critically supports skeletal muscle excitation-contraction coupling. In: PLoS Genet. 2025 Aug 18;21(8):e1011828. doi: 10.1371/journal.pgen.1011828. eCollection 2025 Aug. PMID: 40825030 
• Haddad S, Ablinger C, Stanika R, Hessenberger M, Campiglio M, Ortner NJ, Tuluc P, Obermair GJ (2025):A biallelic mutation in CACNA2D2 associated with developmental and epileptic encephalopathy affects calcium channel-dependent as well as synaptic functions of α2δ-2, In: 
  J Neurochem. 2025 Jan;169(1):e16197. doi: 10.1111/jnc.16197. Epub 2024 Aug 19. PMID: 39161180
• Ganglberger, Matthias; Koschak, Alexandra (2025):Exploring the potential for gene therapy in Cav1.4 related retinal channelophathies. In: Channels, Volume 19, NO 1. DOI: 10.1080/19336950.2025.2480089
• Haddad, Sabrin; Ablinger, Cornelia; Stanika, Ruslan; Hessenberger, Manuel; Campiglio, Marta; Ortner, Nadine J; Tuluc, Petronel; Obermair, Gerald J (2025): A biallelic mutation in CACNA2D2 associated with developmental and epileptic encephalopathy affects calcium channel-dependent as well as synaptic functions of alpha(2)delta-2In: Journal of Neurochemistry 169/1, No. e16197. DOI: 10.1111/jnc.16197
• Ebner, Karl; Fontebasso, Veronica; Ferro, Federico; Singewald, Nicolas; Hannibal, Jens (2025): PACAP regulates neuroendocrine and behavioral stress responses via CRF-containing neurons of the rat hypothalamic paraventricular nucleus. In: Neuropsychopharmacology 50, S. 5196 - 530. DOI: 10.1038/s41386-024-02016-9

2024

• Dannenberg, F; Von Moers, A; Bittigau, P; Lange, J; Wiegand, S; Török, F; Stölting, G; Striessnig, J; Motazacker, MM; Broekema, MF; Schuelke, M; Kaindl, AM; Scholl, UI; Ortner, NJ (2024):A Novel De Novo Gain-of-Function CACNA1D Variant in Neurodevelopmental Disease With Congenital Tremor, Seizures, and Hypotonia. In: Neurology-Genetics 10/5, No. e200186. DOI: 10.1212/NXG.0000000000200186
• Del Rivero Morfin, Pedro J; Chavez, Diego Scala; Jayaraman, Srinidhi; Yang, Lin; Geisler, Stefanie M; Kochiss, Audrey L; Tuluc, Petronel; Colecraft, Henry M; Marx, Steven O; Liu X, Shawn; Rajadhyaksha, Anjali M; Ben-Johny, Manu (2024): A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings. In: Science Advances 10/44, No. eadq3374.DOI: 10.1126/sciadv.adq3374
• Geisler, Stefanie M; Ottaviani, Matteo M; Jacobo-Piqueras, Noelia; Theiner, Tamara; Mastrolia, Vincenzo; Guarina, Laura; Ebner, Karl; Obermair, Gerald J; Carbone, Emilio; Tuluc, Petronel (2024): Deletion of the α2δ-1 calcium channel subunit increases excitability of mouse chromaffin cells. In: The Journal of Physiology (London) 602/15, S. 3793 - 3814. DOI: 10.1113/JP285681
• Jacobo-Piqueras, Noelia; Theiner, Tamara; Geisler, Stefanie M; Tuluc, Petronel (2024): Molecular mechanism responsible for sex differences in electrical activity of mouse pancreatic β-cells. In: JCI Insight 9/6, No. e171609. DOI 10.1172/jci.insight.171609
• Pelizzari, Simone; Heiss, Martin C.; Fernández-Quintero, Monica; Ghaleb, Yoursra El; Liedl, Klaus R.; Tuluc, Petronel; Campiglio, Marta; Flucher, Bernhard E (2024): CaV1.1 voltage-sensing domain III exclusively controls skeletal muscle excitation-contraction coupling. In: Nature Communications 15/1, Nr. 7440. DOI: 10.1038/s41467-024-51809-5
• Sartori, Simone B; Keil, Thomas MV; Kummer, Kai; Murphy, Conor P; Gunduz-Cinar, Ozge; Kress, Michaela; Ebner, Karl; Holmes, Andrew; Singewald, Nicolas (2024):Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex. In: Translational Psychiatry 14/1, No. 11. DOI: 10.1038/s41398-023-02708-8
• Tang, Xuechen; Ortner, Nadine J; Nikonishyna, Yuliia; Fernández-Quintero, Monica L; Kokot, Janik; Striessnig, Jörg; Liedl, Klaus R (2024): Pathogenicity of de novo CACNA1D Ca2+ channel variants predicted from sequence co-variation. In: European Journal of Human Genetics 32, S. 1065 - 1073. DOI: 10.1038/s41431-024-01594-y
• Theiner, Tamara; Ortner, Nadine J; Oberacher, Herbert; Stojanovic, Gospava; Tuluc, Petronel; Striessnig, Jörg (2024): Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study. In: Channels 18/1, No. 2335469. DOI: 10.1080/19336950.2024.2335469
• Török, Ferenc; Salamon, Sarah; Ortner, Nadine J; Fernández-Quintero, Monica L; Matthes, Jan; Striessnig, Jörg (2024): Inactivation induced by pathogenic Cav1.3 L-type Ca2+-channel variants enhances sensitivity for dihydropyridine Ca2+ channel blockers. In: British Journal of Pharmacology 182/1, S. 181 - 197. DOI: 10.1111/bph.17357
• Ugursu, B; Sah, A; Sartori, S; Popp, O; Mertins, P; Dunay, IR; Kettenmann, H; Singewald, N; Wolf, SA (2024): Microglial sex differences in innate high anxiety and modulatory effects of minocycline. In: Brain, Behavior, and Immunity 119, S. 465 - 481. DOI: 10.1016/j.bbi.2024.03.035

2023

• Alexander, SPH; Kelly, E; Mathie, AA; ..., ...; Striessnig, J; et al (2023): The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. In: British Journal of Pharmacology 180/SI, S. 1 - 22. DOI: 10.1111/bph.16176
• Alexander, SPH; Mathie, AA; Peters, JA; ..., ....; Striessnig, J; et al (2023): The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. In: British Journal of Pharmacology 180/S2, S. S145 - S222. DOI: 10.1111/bph.16178
• Fritz, EM; De Bundel, D; Singewald, N (2023): Ghrelin receptor agonist MK0677 and overnight fasting do not rescue deficient fear extinction in 129S1/SvImJ mice. In: Frontiers in Psychiatry 14 -2023, No. 1094948. DOI 10.3389/fpsyt.2023.1094948
• Heigl, Thomas; Netzer, Michael A.; Zanetti, Lucia; Ganglberger, Matthias; Fernández-Quintero, Monica L.; Koschak, Alexandra (2023): Characterization of two pathological gating-charge substitutions in Cav1. 4 L-type calcium channels. In: Channels 17/1, Nr. 2192360. DOI 10.1080/19336950.2023.2192360
• Kalaba, P.; Pacher, K.; Neill, P.J.; ..., ...; Sartori, S.; Ebner, K.; Singewald, N.; ..., ...; Lubec, G. (2023): Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry. In: Biomolecules 13/9, Nr. 1415.DOI: 10.3390/biom13091415
• Ortner, Nadine J; Sah, Anupam; Paradiso, Enrica; Shin, Josef; Stojanovic, Strahinja; Hammer, Niklas; Haritonova, Maria; Hofer, Nadja T; Marcantoni, Andrea; Guarina, Laura; Tuluc, Petronel; Theiner, Tamara; Pitterl, Florian; Ebner, Karl; Oberacher, Herbert; Carbone, Emilio; Stefanova, Nadia; Ferraguti, Francesco; Singewald, Nicolas; Roeper, Jochen; Striessnig, Jörg (2023): The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice. In: JCI Insight 8/20, No. e162100. DOI: 10.1172/jci.insight.162100
• Seitter, Hartwig; Obkircher, Jana; Grabher, Patricia; Hartl, Julia; Zanetti, Lucia; Lux, Thorsten Uwe; Fotakis, Georgios; Fernández-Quintero, Monica L.; Kaserer, Teresa; Koschak, Alexandra (2023):A novel calcium channel Cavβ2 splice variant with unique properties predominates in the retina. In: Journal of Biological Chemistry 299/4, No. 102972. DOI: 10.1016/j.jbc.2023.102972
• Singewald, Nicolas; Sartori, Simone B.; Reif, Andreas; Holmes, Andrew (2023): Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder. In: Neuropharmacology 226, Nr. 109418. DOI: Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder. DOI: 10.1016/j.neuropharm.2023.109418

• Török, Ferenc; Tezcan, Kamer; Filippini, Ludovica; Fernández-Quintero, Monica L.; Zanetti, Lucia; Liedl, Klaus R.; Drexel, Raphaela S.; Striessnig, Jörg; Ortner, Nadine J (2023): Germline de novo variant F747S extends the phenotypic spectrum of CACNA1D Ca2+ channelopathies.In: Human Molecular Genetics 32/5, S. 847 - 859. DOI: 10.1093/hmg/ddac248