Publications

Selected papers from CMBI labs

• Weber LI, Timpen LE, Egger-Hörschinger AS, Schöpf P, Ayhan ND, Demmel D, Hotze M, Zhang Y, Mehrabi M, Puglisi K, Stefan E, Ghaffari-Tabrizi-Wizsy N, Ramos-Pittol JM, Kwiatkowski M, Hartl M. (2026) Reactivation of the silenced BASP1 gene suppresses oncogenic WNT signaling in human colorectal cancer cells. Proc Natl Acad Sci USA. 123, e2524159123.
• Tang X, Hermenean HC, Yakimchyk A, Tuluc P, Ortner NJ, Liedl KR. (2026) Identification of novel functional sites in the Cav1.3 calcium channel α1-subunit using evolutionary modeling. Proc Natl Acad Sci USA. 123, e2602636123.
• Tisch M, Geisler SM, Gabassi E, Schlemmer Q, Lechner M, Ulz JA, Suarez-Cubero M, De Gaetano L, Spathopoulou A, Striessnig J, Ortner NJ, Günther K, Tuluc P, Edenhofer F. (2026) Aberrant calcium signaling and neuronal activity in the L271H CACNA1D (Cav1.3) iPSC model of neurodevelopmental disease. Mol Psychiatry. 31, 2927-2940.
• Company-Garrido I, Zurita Carpio A, Colomer-Rosell M, Ciraulo B, Molkenbur R, Lanzerstorfer P, Pezzano F, Agazzi C, Hauschild R, Jain S, Jacques JM, Venturini V, Knapp C, Xie Y, Merrin J, Weghuber J, Schaaf M, Quidant R, Kiermaier E, Ortega Arroyo J, Ruprecht V, Wieser S. (2026) Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses. Dev Cell. 61, 356-371.e12.
• Mitteregger C, Bereiter R, Schramm A, Ennifar E, Kreutz C, Micura R. (2026) 1-Deazainosine—impact on RNA structure and role in exploring ribozyme catalysis. Chem Sci. 17, 13874-13883.
• Karg CA, Rüdiger D, Hammerle F, Zahler S, Moser S. (2026) Phylloroseobilin impairs tumor cell migration and vascular network stability via cytoskeletal destabilization. Eur J Pharm Sci. 225, 107607.
• Marami-Zonouz N, Arc E, Roach T, Jansen-Dürr P, Bader W, Hobmayer B, Kranner I. (2026) Metabolic signatures of aging and gametogenesis in Hydra oligactis. Aging Cell. 25, e70643.
• Ruetz L, Leiner S, Marotto A, Plangger R, Kreutz C. (2026) An electrophilic uridine building block for post-synthetic RNA modification as exemplified for spin labeling. Chemistry. [Epub ahead of print], e71319.
• Ploner A, Heel SV, Breuker K. (2026) Exploring RNA G-quadruplex stability in the gas phase: insights from native mass spectrometry. ChemPlusChem. 91, e202500679.
• Waltl L, Holubek D, Speck K, Wildermuth R, Haut FL, Permann S, Plangger I, Steinborn C, Rao Z, D’Avino D, Cerqua I, Stadler J, Roviezzo F, Schlenke P, Siller A, Schennach H, Koeberle SC, Pferschy-Wenzig EM, Rossi A, Magauer T, Koeberle A. (2026) Reorganization of innate immune cell lipid profiles by bioinspired meroterpenoids to limit inflammation. Adv Sci (Weinh). [Epub ahead of print], e76861.
• Geisler SM, Jacobo-Piqueras N, Theiner T, Taguchi RS, Häfele LE, Campiglio M, Tuluc P. (2026) Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis. J Physiol. [Epub ahead of print].
• Striessnig J. (2026) Brain voltage-gated Ca2+ channels and calmodulin: teaming up in calmodulinopathies? J Gen Physiol. 158, e202613981.
• Świt P, Hammerle F, Ganzera M. (2026) AI-driven data extraction and AGREE-based greenness evaluation of analytical methods for natural products: insights from selected studies. Anal Chem. 98, 22595-22608.
• Izadi F, Pelc A, Ameixa J, Kossoski F, Denifl S. (2026) Formation of the long-lived parent anion upon electron attachment to menadione. J Phys Chem A. 130, 2041-2050.
• Küssner K, Wolf M, Cucchiaro A, Hartinger CG, Meier-Menches S, Cziferszky M. (2026) Competitive LC-MS/MS assay to investigate protein metalation dynamics. Inorg Chem Front. 13, 3574-3586.
• Belleza OJV, Zhang H, Schmidhammer H, Gonzalez TI, Ciotu CI, Tomašević N, Ocampo CMM, Fernando JC, Koehbach J, Schwarz P, Al Makhlouf M, Tajti G, Hasinger S, Kastner N, Avsar O, Retzl B, Jäntsch K, Jiang Y, Hellinger R, Fischer MJM, Rosengren KJ, Gruber CW, Villaraza AJL, Stockner T, Spetea M, Xu HE, Sitte HH. (2026) Structural and functional basis of antinociceptive action of χ-conotoxin AoIA at the noradrenaline transporter. Nat Struct Mol Biol. [Epub ahead of print].
• Happacher I, Pichler G, Abt B, Tagirdzhanova G, Oberegger S, Kraihammer M, Faserl K, Sarg B, Decristoforo C, Türk R, Winkelmann G, Talbot NJ, Brock M, Kranner I, Haselwandter K, Haas H. (2026) Siderophore production by the lichen fungus Xanthoria parietina supports its algal symbiont. Nat Commun. 17, 8234.
• Demir H, Unterhauser J, Strobl MR, Vollmann U, Repiská K, Wozniak-Knopp G, Tollinger M, Bohle B. (2026) Identification of an immunodominant IgE epitope on Mal d 1 and its role for treatment of birch pollen-related apple allergy. Allergol Int. 75, 168-170.
• Revilla I, Vivar-Quintana AM, Martínez-Martín I, Hernández-Ramos P, Hernández-Jiménez M, Grabska J, Beć KB, Huck CW. (2026) The influence of the site of recording and benchtop and portable NIRS equipment on predicting the sensory properties of Iberian ham. Foods. 15, 436.
• Bohn JP, Scheiber A, Sturm G, Maurer T, Mair A, Kugler V, Feichtner A, Fritz A, Torres-Quesada O, Jaeger U, Huber R, Daum S, Martowicz A, Redlinger N, Pircher A, Sopper S, Trajanoski Z, Stefan E, Salcher S, Wolf D. (2026) DUSP1 is a key driver of disease persistence and potential therapeutic target in hairy cell leukemia. Blood Adv. 10, 5238-5249.
• Plangger I, Schmidhammer E, Schaar S, Wurst K, Podewitz M, Magauer T. (2025) Non-enzymatic methylcyclization of alkenes. Nat Chem. 17, 904-910.
• Bereiter R, Flemmich L, Nykiel K, Heel S, Geley S, Hanisch M, Eichler C, Breuker K, Lusser A, Micura R. (2025) Engineering covalent small molecule–RNA complexes in living cells. Nat Chem Biol. 21, 843-854.
• Ghose R, Pezzano F, Badia R, Kourtis S, Sheraj I, Das S, Gañez Zapater A, Ghose U, Musa-Afaneh S, Espinar L, Coll-Manzano A, Parapatics K, Ivanova S, Sànchez-Fernàndez-de-Landa P, Radivojevikj D, Venturini V, Wieser S, Zorzano A, Müller AC, Ruprecht V, Sdelci S. (2025) Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects. Nat Commun. 16, 6613.
• Gollowitzer A, Pein H, Rao Z, Waltl L, Bereuter L, Loeser K, Meyer T, Jafari V, Witt F, Winkler R, Su F, Große S, Thürmer M, Grander J, Hotze M, Harder S, Espada L, Magnutzki A, Gstir R, Weinigel C, Rummler S, Bonn G, Pachmayr J, Ermolaeva M, Harayama T, Schlüter H, Kosan C, Heller R, Thedieck K, Schmitt M, Shimizu T, Popp J, Shindou H, Kwiatkowski M, Koeberle A. (2025) Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation. Nat Commun. 16, 1774.
• Hilber S, Marotto A, Mitteregger C, Tollinger M, Kreutz C. (2025) Methylation of cytidine 1407 increases the lifetimes of the A-site ground and excited states of E. coli 16S ribosomal RNA. J Am Chem Soc. 147, 26097-26101.
• Ploner A, Mitteregger C, Glasner H, Bereiter R, Micura R, Breuker K. (2025) The intrinsic preference of guanosine bases for cleavage-facilitating interactions with phosphodiester moieties in RNA anions revealed by base modifications and mass spectrometry. Nucleic Acids Res. 53, gkaf494.
• Bertel C, Arc E, Bohutínská M, Kaplenig D, Maindok J, La Regina E, Wos G, Kolář F, Hülber K, Kofler W, Neuner G, Kranner I. (2025) Repeated colonisation of alpine habitats by Arabidopsis arenosa involved parallel adjustments of leaf cuticle traits. New Phytol. 246, 1597-1608.
• Ganglberger M, Zanetti L, Egger AS, Günter A, Wagner B, Belhadj S, Mühlfriedel R, Knoflach D, Casanova E, Rülicke T, Seeliger MW, Kwiatkowski M, Seitter H, Koschak A. (2025) Quantitative proteomics identifies potential molecular adaptations in mouse models of congenital stationary night blindness type 2. Mol Cell Proteomics. 24, 101462.
• Nguyen VTT, Chen J, Ončák M, Denifl S. (2025) Free electron interaction with genistein: positive and negative ion formation. RSC Adv. 15, 46717-46726.
• Pedrini-Martha V, Egger B, Niederwanger M, Dallinger R, Höckner M. (2025) Structural and functional plasticity of metal-responsive transcription factor 1 (MTF-1) within Lophotrochozoa. Comp Biochem Physiol B Biochem Mol Biol. 279, 111116.
• Peruzzotti-Jametti L, Vicario N, Volpe G, Rizzi S, Kwok C, Lombardi I, Bergholt MS, Barea-Moya L, D’Angelo A, Nicaise AM, D’Amico G, Krzak G, Willis CM, Gil-Perotin S, Hruba O, Braga A, Stevens MM, Garcia-Verdugo JM, Saeb-Parsy K, Zhao C, Franklin RJM, Edenhofer F, Pluchino S. (2025) Remyelination of chronic demyelinated lesions with directly induced neural stem cells. Brain. 148, 3505-3513.
• Pelizzari S, Campiglio M, Fernández-Quintero ML, Heiss MC, Tuluc P, Flucher BE. (2025) Divergent actions of CaV1.1 voltage-sensing domain III in activating EC coupling and channel gating. Biophys J. 124, 4228-4242.
• Zanetti L, Török F, Leitzbach L, Stark H, Striessnig J. (2025) Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ channels. Channels (Austin). 19, 2556101.
• Scheiblecker L, Klampfl T, Doma E, Nebenfuehr S, Torres-Quesada O, Strich S, Heller G, Werdenich D, Tschulenk W, Zojer M, Bellutti F, Schirripa A, Zöchbauer-Müller S, Valent P, Walter I, Stefan E, Sexl V, Kollmann K. (2025) CDK6 kinase inhibition unmasks metabolic dependencies in BCR::ABL1+ leukemia. Cell Death Dis. 16, 107.
• Stringer RN, Tang X, Jurkovicova-Tarabova B, Murphy M, Liedl KR, Weiss N. (2025) Functional characterization of a novel de novo CACNA1C pathogenic variant in a patient with neurodevelopmental disorder. Mol Brain. 18, 26.
• Price KL, Tharakan DM, Salvenmoser W, Ayers K, Mah J, Dunn C, Hobmayer B, Cooley L. (2025) Examination of germline and somatic intercellular bridges in Hydra vulgaris reveals insights into the evolutionarily conserved mechanism of intercellular bridge formation. Mol Biol Evol. 42, msaf248.
• Kieninger C, Wurst K, Leitner D, Peters LP, Dinu DF, Wiedemair M, Zaretzke MK, Bröring M, Hohloch S, Liedl KR, Kräutler B. (2025) Encasing the paramagnetic copper(II) ion by the ring-contracted corrin ligand of vitamin B12. Chem Commun (Camb). 61, 10606-10609.
• Gearing HB, Cziferszky M, Söhnel T, Wright LJ, Crowley JD, Hartinger CG. (2025) Pd(μ‑L)4Pt vs. Pd(μ‑L)4RuCl2: chlorido ancillary ligands as defining factors in the host–guest interactions of M(μ‑L)4M′ heterodimetallic supramolecular architectures. Chem Sci. 16, 7294-7301.

• Heel SV, Juen F, Bartosik K, Micura R, Kreutz C, Breuker K. (2024) Resolving the intricate binding of neomycin B to multiple binding motifs of a neomycin-sensing riboswitch aptamer by native top-down mass spectrometry and NMR spectroscopy. Nucleic Acids Res. 52, 4691-4701.

• Izadi F, Luxford TFM, Sedmidubská B, Arthur-Baidoo E, Kočišek J, Ončák M, Denifl S. (2024) Dissociative Electron Attachment Dynamics of a Promising Cancer Drug Indicates Its Radiosensitizing Potential. Angew. Chem. Int. Ed. 63, e202407469.

• Spathopoulou A, Podlesnic M, De Gaetano L, Kirsch EM, Tisch M, Finotello F, Aigner L, Günther K, Edenhofer F. (2024) Single-cell Profiling of Reprogrammed Human Neural Stem Cells Unveils High Similarity to Neural Progenitors in the Developing Central Nervous System. Stem Cell Rev. Rep. 20, 1325-1339.

• Müller N, Kováč O, Rode A, Atzl D, Magauer T. (2024) Total Synthesis of Ganoapplanin Enabled by a Radical Addition/Aldol Reaction Cascade. J. Am. Chem. Soc. 146, 22937-22942.

• Puls K, Olivé-Marti AL, Hongnak S, Lamp D, Spetea M, Wolber G. (2024) Discovery of Novel, Selective, and Nonbasic Agonists for the Kappa-Opioid Receptor Determined by Salvinorin A-Based Virtual Screening. J. Med. Chem. 67, 13788-13801.

• Flemmich L, Bereiter R, Micura R. (2024) Chemical Synthesis of Modified RNA. Angew. Chem. Int. Ed. 63, e202403063.

• Juen F, Glänzer D, Plangger R, Kugler V, Fleischmann J, Stefan E, Case DA, Kovacs H, Kwaku Dayie T, Kreutz C. (2024) Enhanced TROSY Effect in [2-19F, 2-13C] Adenosine and ATP Analogs Facilitates NMR Spectroscopy of Very Large Biological RNAs in Solution. Angew. Chem. Int. Ed. 63, e202316273.

• Zwerger M, Boeck L, Manzl J, Schwaiger S, Ganzera M. (2024) Novel Approaches for the Analysis and Isolation of Benzylisoquinoline Alkaloids in Chelidonium majus. Planta Med. 90, 523-533.

• Keramidioti A, Schneid S, Busse C, Cramer von Laue C, Bertulat B, Salvenmoser W, Hess M, Alexandrova O, Glauber KM, Steele RE, Hobmayer B, Holstein TW, David CN. (2024) A new look at the architecture and dynamics of the Hydra nerve net. Elife 12, RP87330.

• Hernández-Jiménez M, Revilla I, Vivar-Quintana AM, Grabska J, Beć KB, Huck CW. (2024) Performance of benchtop and portable spectroscopy equipment for discriminating Iberian ham according to breed. Curr. Res. Food Sci. 8, 100675.

• Cavinato M, Martic I, Wedel S, Pittl A, Koziel R, Weinmmüllner R, Schosserer M, Jenewein B, Bobbili MR, Arcalis E, Haybaeck J, Pierer G, Ploner C, Hermann M, Romani N, Schmuth M, Grillari J, Jansen-Dürr P. (2024) Elimination of damaged mitochondria during UVB-induced senescence is orchestrated by NIX-dependent mitophagy. Aging Cell 23, e14186.

• Kugler V, Schwaighofer S, Feichtner A, Enzler F, Fleischmann J, Strich S, Schwarz S, Wilson R, Tschaikner P, Troppmair J, Sexl V, Meier P, Kaserer T, Stefan E. (2024) Impact of protein and small molecule interactions on kinase conformations. Elife 13, RP94755.

• Röck M, Heel SV, Juen FS, Eidelpes R, Kreutz C, Breuker K, Tollinger M. (2024) The PR-10 Protein Pru p 1 is an Endonuclease that Preferentially Cleaves Single-Stranded RNA. Chembiochem 25, e202400204.

• Su F, Koeberle A. (2024) Regulation and targeting of SREBP-1 in hepatocellular carcinoma. Cancer Metastasis Rev. 43, 673-708.

• Fiala J, Roach T, Holzinger A, Husiev Y, Delueg L, Hammerle F, Armengol ES, Schöbel H, Bonnet S, Laffleur F, Kranner I, Lackner M, Siewert B. (2024) The Light-activated Effect of Natural Anthraquinone Parietin against Candida auris and Other Fungal Priority Pathogens. Planta Med. 90, 588-594.

• Egger AS, Rauch E, Sharma S, Kipura T, Hotze M, Mair T, Hohenegg A, Kobler P, Heiland I, Kwiatkowski M. (2024) Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites. Mol. Metab. 90, 102032.

• Dinu DF, Oenen K, Schlagin J, Podewitz M, Grothe H, Loerting T, Liedl KR. (2024) How Vibrational Notations Can Spoil Infrared Spectroscopy: A Case Study on Isolated Methanol. ACS Phys. Chem. Au 4, 679-695.

• Frei P, Nadegger C, Vollmar AM, Müller T, Moser S. (2024) Structural Characterization, and Antioxidative and Anti-inflammatory Activities of Phylloxanthobilins in Tropaeolum majus, a Plant with Relevance in Phytomedicine. Planta Med. 90, 641-650.

• Theiner T, Ortner NJ, Oberacher H, Stojanovic G, Tuluc P, Striessnig J. (2024) Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study. Channels 18, 2335469.

• Sartori SB, Keil TMV, Kummer KK, Murphy CP, Gunduz-Cinar O, Kress M, Ebner K, Holmes A, Singewald N. (2024) Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex. Transl. Psychiatry 14, 11.

• Geisler SM, Ottaviani MM, Jacobo-Piqueras N, Theiner T, Mastrolia V, Guarina L, Ebner K, Obermair GJ, Carbone E, Tuluc P. (2024) Deletion of the α2δ-1 calcium channel subunit increases excitability of mouse chromaffin cells. J. Physiol. 602, 3793-3814.

• Erhart T, Nadegger C, Vergeiner S, Kreutz C, Müller T, Kräutler B. (2024) Novel Types of Phyllobilins in a Fern - Molecular Reporters of the Evolution of Chlorophyll Breakdown in the Paleozoic Era. Chem. Eur. J. 30, e202401288.

• Dallinger R. (2024) Metals and metallothionein evolution in snails: a contribution to the concept of metal-specific functionality from an animal model group. Biometals 37, 671-696.

• Kugler V, Lieb A, Guerin N, Donald BR, Stefan E, Kaserer T. (2023) Disruptor: Computational identification of oncogenic mutants disrupting protein-protein and protein-DNA interactions. Commun. Biol. 6, 720.
• Ortner NJ, Sah A, Paradiso E, Shin J, Stojanovic S, Hammer N, Haritonova M, Hofer NT, Marcantoni A, Guarina L, Tuluc P, Theiner T, Pitterl F, Ebner K, Oberacher H, Carbone E, Stefanova N, Ferraguti F, Singewald N, Roeper J, Striessnig J. (2023) The human channel gating-modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome-like phenotype in mice. JCI Insight 8, e162100.
• Plangger I, Pinkert T, Wurst K, Magauer T. (2023) A Divergent Polyene Cyclization for the Total Synthesis of Greenwayodendrines, Greenwaylactams, Polysin and Polyveoline. Angew. Chem. Int. Ed. 62, e202307719.
• Cazet JF, Siebert S, Little HM, Bertemes P, Primack AS, Ladurner P, Achrainer M, Fredriksen MT, Moreland RT, Singh S, Zhang S, Wolfsberg TG, Schnitzler CE, Baxevanis AD, Simakov O, Hobmayer B, Juliano CE. (2023) A chromosome-scale epigenetic map of the Hydra genome reveals conserved regulators of cell state. Genome Res. 33, 283-298.
• Grabska J, Beć KB, Ueno N, Huck CW. (2023) Analyzing the Quality Parameters of Apples by Spectroscopy from Vis/NIR to NIR Region: A Comprehensive Review. Foods. 12, 1946.
• García-Risco M, Calatayud S, Pedrini-Martha V, Albalat R, Palacios Ò, Capdevila M, Dallinger R. (2023) A de novo evolved domain improves the cadmium detoxification capacity of limpet metallothioneins. Sci. Rep. 13, 8895.
• Heel SV, Bartosik K, Juen F, Kreutz C, Micura R, Breuker K. (2023) Native Top-Down Mass Spectrometry Uncovers Two Distinct Binding Motifs of a Functional Neomycin-Sensing Riboswitch Aptamer. J. Am. Chem. Soc. 145, 15284-15294.
• Orfanoudaki M, Alilou M, Hartmann A, Mayr J, Karsten U, Nguyen-Ngoc H, Ganzera M. (2023) Isolation and Structure Elucidation of Novel Mycosporine-like Amino Acids from the Two Intertidal Red Macroalgae Bostrychia scorpioides and Catenella caespitosa. Mar. Drugs. 21, 543.
• Polikanov YS, Etheve-Quelquejeu M, Micura R. (2023) Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications. Acc. Chem. Res. 56, 2713-2725.
• Seitter H, Obkircher J, Grabher P, Hartl J, Zanetti L, Lux UT, Fotakis G, Fernández-Quintero ML, Kaserer T, Koschak A. (2023) A novel calcium channel Cavβ2 splice variant with unique properties predominates in the retina. J. Biol. Chem. 299, 102972.

• Muratspahić E., Deibler K., Han J., Tomašević N., Jadhav K.B., Olivé-Marti A.-L., Hochrainer N.,Hellinger R.,Koehbach J., Fay J.F., Rahman M.H., Hegazy L., Craven T., Varga B.R., Bhardwaj G., Appourchaux K., Majumdar S., Muttenthaler M., Hosseinzadeh P., Craik D.J., Spetea M., Che T., Baker D., Gruber C.W. (2023)  De novo design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor. Nat. Commun. 14:8064 .

• Aigner GP, Peer V, Fiechtner B, Piechnik CA, Höckner M. (2023) Wound healing and Cadmium detoxification in the earthworm Lumbricus terrestris - a potential case for coelomocytes? Front. Immunol. 14, 1272191.
• Koeberle SC, Kipp AP, Stuppner H, Koeberle A. (2023) Ferroptosis-modulating small molecules for targeting drug-resistant cancer: Challenges and opportunities in manipulating redox signaling. Med. Res. Rev. 43, 614-682.
• Rainer T, Egger AS, Zeindl R, Tollinger M, Kwiatkowski M, Müller T. (2022) 3D-Printed High-Pressure-Resistant Immobilized Enzyme Microreactor (μIMER) for Protein Analysis. Anal. Chem. 94, 8580-8587.
• Mack HID, Kremer J, Albertini E, Mack EKM, Jansen-Dürr P. (2022) Regulation of fatty acid desaturase- and immunity gene-expression by mbk-1/DYRK1A in Caenorhabditis elegans. BMC Genomics 23, 25.
• Gruber K, Csitkovits V, Łyskowski A, Kratky C, Kräutler B. (2022) Structure-Based Demystification of Radical Catalysis by a Coenzyme B12 Dependent Enzyme-Crystallographic Study of Glutamate Mutase with Cofactor Homologues. Angew. Chem. Int. Ed. 61, e202208295.
• Thürmer M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, Löser K, Grander J, Hotze M, Harder S, Döding A, Meßner M, Troisi F, Ardelt M, Schlüter H, Pachmayr J, Gutiérrez-Gutiérrez Ó, Rudolph KL, Thedieck K, Schulze-Späte U, González-Estévez C, Kosan C, Svatoš A, Kwiatkowski M, Koeberle A. (2022) PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling. Nat. Commun. 13, 2982.
• Siller A, Hofer NT, Tomagra G, Burkert N, Hess S, Benkert J, Gaifullina A, Spaich D, Duda J, Poetschke C, Vilusic K, Fritz EM, Schneider T, Kloppenburg P, Liss B, Carabelli V, Carbone E, Ortner NJ, Striessnig J. (2022) β2-subunit alternative splicing stabilizes Cav2.3 Ca2+ channel activity during continuous midbrain dopamine neuron-like activity. Elife 11, e67464.

• Rinkevich B, Ballarin L, Martinez P, Somorjai I, Ben-Hamo ., Borisenko I, Berezikov E, Ereskovsky AV, Gazave E, Khnykin D, Manni L, Petukhova O, Rosner A, Röttinger E, Spagnuolo A, Sugni M, Tiozzo S, Hobmayer B. (2022). A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape. Biological Reviews 97, 299.

• Brooun M, Salvenmoser W, Dana C, Sudol M, Steele R, Hobmayer B, McNeill H. (2022). The Hippo pathway regulates axis formation and morphogenesis in Hydra. PNAS 119, e2203257119.

• Bereiter R, Renard E, Breuker K, Kreutz C, Ennifar E, Micura R. (2022) 1-Deazaguanosine-Modified RNA: The Missing Piece for Functional RNA Atomic Mutagenesis. J. Am. Chem. Soc. 144, 10344. 

• Paciorek J, Höfler D, Sokol KR, Wurst K, Magauer T. (2022) Total Synthesis of the Dihydrooxepine-Spiroisoxazoline Natural Product Psammaplysin A.  J. Am. Chem. Soc. 144, 19704.

• Fernández-Quintero ML, Vangone A, Loeffler JR, Seidler CA, Georges G, Liedl KR. (2022) Paratope states in solution improve structure prediction and docking.  Structure, 30, 430.

• Tisch M, Carmen De Mingo Alemany M, Suarez-Cubero M, Fauth C, Defrancesco M, Zschocke J, Günther K, Edenhofer F. (2022) Generation of the human induced pluripotent stem cell line (IBKMOLi002-A) from PBMCs of a patient carrying the heterozygous L271H mutation of the voltage-gated calcium channel subunit Cav1.3-encoding CACNA1D gene. Stem Cell Res. 61, 102784.

• Puls K, Olivé-Marti AL, Pach S, Pinter B, Erli F, Wolber G, Spetea M. (2022). In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist. Pharmaceuticals 15, 680.
• Ozaki Y, Beć KB, Morisawa Y, Yamamoto S, Tanabe I, Huck CW, Hofer TS (2021). Advances, challenges and perspectives of quantum chemical approaches in molecular spectroscopy of the condensed phase. Chem. Soc. Rev. 50, 10917.

• Führer S, Kamenik AS, Zeindl R, Nothegger B, Hofer F, Reider N, Liedl KR, Tollinger M (2021). Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens.  Scientific Reports 11, 4173.

• Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K (2021). G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell 184, 655-674.
• Striessnig J. (2021). Voltage-Gated Ca2+-Channel α1-Subunit de novo Missense Mutations: Gain or Loss of Function - Implications for Potential Therapies. Front Synaptic Neurosci. 13, 634760.
• Haut FL, Habiger C, Wein LA, Wurst K, Podewitz M, Magauer T. (2021). Rapid Assembly of Tetrasubstituted Furans via Pummerer-Type Rearrangement. J. Am. Chem. Soc. 143, 1216-1223.
• Krasheninina OA, Thaler J, Erlacher MD, Micura R. (2021). Amine-to-Azide Conversion on Native RNA via Metal-Free Diazotransfer Opens New Avenues for RNA Manipulations. Angew. Chem. Int. Ed. 60, 6970-6974.
• Fernández-Quintero ML, El Ghaleb Y, Tuluc P, Campiglio M, Liedl KR, Flucher BE. (2021). Structural determinants of voltage-gating properties in calcium channels. Elife 10, e64087.
• Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A, Goldstein LSB, Galasko D, Gage FH. (2021). Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell 28, 1-16, S1934-5909(21)00161-2.
• Zanetti L, Kilicarslan I, Netzer M, Babai N, Seitter H, Koschak A. (2021) Function of cone and cone-related pathways in CaV1.4 IT mice. Sci Rep. 11, 2732.
• Gerna D, Arc E, Holzknecht M, Roach T, Jansen-Dürr P, Weiss AKH, Kranner I. (2021). AtFAHD1a: A New Player Influencing Seed Longevity and Dormancy in Arabidopsis? Int. J. Mol. Sci. 22, 2997.
• Calatayud S, Garcia-Risco M, Pedrini-Martha V, Eernisse DJ, Dallinger R, Palacios Ò, Capdevila M, Albalat R (2021). Modularity in Protein Evolution: Modular Organization and De Novo Domain Evolution in Mollusk Metallothioneins. Mol. Biol. Evol. 38, 424-436.
• Arthur-Baidoo E, Ameixa J, Ziegler P, Ferreira da Silva F, Ončák M, Denifl S. (2020). Reactions in Tirapazamine Induced by the Attachment of Low-Energy Electrons: Dissociation Versus Roaming of OH. Angew. Chem. Int. Ed. 59, 17177-17181.
• Mayrhofer JE, Enzler F, Feichtner A, Röck R, Fleischmann J, Raffeiner A, Tschaikner P, Ogris E, Huber RG, Hartl M, Schneider R, Troppmair J, Torres-Quesada O, Stefan E (2020). Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies. PNAS 117, 31105-31113.
• Mitter M, Gasser C, Takacs Z, Langer CCH, Tang W, Jessberger G, Beales CT, Neuner E, Ameres SL, Peters JM, Goloborodko A, Micura R, Gerlich DW. (2020). Conformation of sister chromatids in the replicated human genome. Nature 586, 139-144.
• Schneeberger E-M, Halper M, Palasser M, Heel SV, Vušurović J, Plangger R, Juen M, Kreutz C, Breuker K (2020). Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA. Nat. Commun. 11, 5750.
• Steinborn C, Wildermuth RE, Barber DM, Magauer T (2020). Total Synthesis of (+)-Cornexistin. Angew. Chem. Int. Ed. 59, 17282-17285.
• Nußbaumer F, Plangger R, Roeck M, Kreutz C (2020). Aromatic ¹⁹F-¹³C TROSY - [¹⁹F,¹³C] pyrimidine labeling for NMR spectroscopy of RNA. Angew. Chem. Int. Ed. 59, 17062-17069.
• Calderisi G, Glasner H, Breuker K (2020). Radical transfer dissociation for de novo characterization of modified ribonucleic acids by mass spectrometry. Angew. Chem. Int. Ed. 59, 4309-4313.
• Gonzalez S, Dumitrascuta M, Eiselt E, Louis S, Kunze L, Blasiol A, Vivancos M, Previti S, Dewolf E, Martin C, Tourwé D, Cavelier F, Gendron L, Sarret P, Spetea M, Ballet S. (2020). Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies. J. Med. Chem. 63, 12929-12941.
• Kieninger C, Wurst K, Podewitz M, Stanley M, Deery E, Lawrence AD, Liedl KR, Warren MJ, Kräutler B. (2020). Replacement of the Cobalt Center of Vitamin B12 by Nickel: Nibalamin and Nibyric Acid Prepared from Metal-Free B12  Ligands Hydrogenobalamin and Hydrogenobyric Acid. Angew. Chem. Int. Ed. 59, 20129-20136.
• Fuchs E, Falschlunger C, Micura R, Breuker K (2019). The effect of adenine protonation on RNA phosphodiester backbone bond cleavage elucidated by deaza-nucleobase modifications and mass spectrometry. Nucleic Acids Res. 47, 7223-7234.
• Sun A, Gasser C, Li F, Chen H, Mair S, Krasheninina O, Micura R, Ren A (2019). SAM-VI riboswitch structure and signature for ligand discrimination. Nat. Commun. 10, 5728.
• Haut FL, Habiger C, Speck K, Wurst K, Mayer P, Korber JN, Müller T, Magauer T (2019). Synthetic Entry to Polyfunctionalized Molecules through the [3+2]-Cycloaddition of Thiocarbonyl Ylides. J. Am. Chem. Soc. 141, 13352-13357.
• Plangger R, Juen AR, Hoernes TP, Nußbaumer F, Kremser J, Strebitzer S, Klingler D, Erharter K, Tollinger M, Erlacher MD, Kreutz C (2019). Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing. Nucleic Acids Res. 2019 47, 11430-11440.
• Dikova V, Vorhauser J, Geng A, Pelster B, Sandbichler AM (2019). Metabolic interaction of hydrogen peroxide and hypoxia in zebrafish fibroblasts. Free Rad. Biol. Med. 152, 469-481.
• Mandl M, Wagner SA, Hatzmann FM, Mitterberger-Vogt MC, Zwierzina ME, Mattesich M, Zwerschke W (2019). Sprouty1 is a weight-loss target gene in human adipose stem/progenitor cells that is mandatory for the initiation of adipogenesis. Cell Death Dis. 10, 411.
• Spetea M, Rief SB, Ben Haddou T, Fink M, Kristeva E, Mittendorfer H, Haas S, Hummer N, Follia V, Guerrieri E, Asim MF, Sturm S, Schmidhammer H (2019). Synthesis, Biological and Structural Explorations of New Zwitterionic Derivatives of 14-O-Methyloxymorphone, as Potent Mu/Delta Opioid Agonists and Peripherally Selective Antinociceptives.   J. Med. Chem. 62, 641–653.
• Porpora M, Sauchella S, Rinaldi L, Delle Donne R, Sepe M, Torres-Quesada O, Intartaglia D, Garbi C, Insabato L, Santoriello M, Bachmann V, Synofzik M, Lindner H, Conte I, Stefan E, Feliciello A (2018). Counterregulation of cAMP-directed kinase activities controls ciliogenesis. Nat. Commun. 9, e1224.
• Haushalter K, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS (2018). Phosphorylation of Protein Kinase A (PKA) regulatory subunit RIa by Protein Kinase G (PKG) primes PKA for catalytic activity in cells. J. Biol. Chem. 293, 4411-4421.
• Martin C, Dumitrascuta M, Mannes M, Lantero A, Bucher D, Walker K, Van Wanseele Y, Oyen E, Hernot S, Van Eeckhaut A, Madder A, Hoogenboom R, Spetea M, Ballet S (2018). Biodegradable Amphipathic Peptide Hydrogels as Extended-Release System for Opioid Peptides. J. Med. Chem. 61, 9784-9789.
• Schweiger S, Matthes F, Posey K, Kickstein E, Weber S, Hettich MM, Pfurtscheller S, Ehninger D, Schneider R, Krauß S (2017). Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex. Scientific Reports 7, 13753.
• Baumann C, Beil A, Jurt S, Niederwanger M, Palacios O, Capdevila M, Atrian S, Dallinger R, Zerbe O (2017). Structural Adaptation of a Protein to Increased Metal Stress: NMR Structure of a Marine Snail Metallothionein with an Additional Domain. Angew. Chem. Int. Ed. 56, 4617–4622.
• Liu JJ, Sharma K, Zangrandi L, Chen C, Humphrey SJ, Chiu YT, Spetea M, Liu-Chen LY, Schwarzer C, Mann M (2018). In vivo brain GPCR signaling elucidated by phosphoproteomics. Science 360, pii: eaao4927.
• Kremser J, Strebitzer E, Plangger R, Juen MA, Nußbaumer F, Glasner H, Breuker K, Kreutz C (2017). Chemical synthesis and NMR spectroscopy of long stable isotope labelled RNA. Chem. Comm. 53, 12938-12941.
• Zheng L, Mairhofer E, Teplova M, Zhang Y, Ma J, Patel D J, Micura R, Ren A (2017). Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme. Nat. Commun. 8, 1180.
• Erli F, Guerrieri E, Ben Haddou T, Lantero A, Mairegger M, Schmidhammer H, Spetea M (2017). Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships. J Med Chem. 60, 7579-7590.
• Riml C, Amort T, Rieder D, Gasser C, Lusser A, Micura R (2017). Osmium-Mediated Transformation of 4-Thiouridine to Cytidine as Key To Study RNA Dynamics by Sequencing. Angew Chem Int Ed Engl. 56, 13479-13483.
• Aufschnaiter R, Wedlich-Söldner R, Zhang X, Hobmayer B (2017). Apical and basal epitheliomuscular F-actin dynamics during Hydra bud evagination. Biology Open 6, 1137-1148.
• Spetea M, Eans S O, Ganno M L, Lantero Aquilino, Mairegger M, Toll L, Schmidhammer H. McLaughlin J P (2017). Selective κ opioid receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. Br. J. Pharmacol. 174, 2444-2456.
• Stefan E, Bister K (2017). MYC and RAF: Key effectors in cellular signaling and major drivers in human cancer. Curr. Top. Microbiol. Immunol. 407, 117-151.
• Raffeiner P, Schraffl A, Schwarz T, Röck R, Ledolter K, Hartl M, Konrat R, Stefan E, Bister K (2017). Calcium-dependent binding of Myc to calmodulin. Oncotarget 8, 3327-3343.
• Lagard C, Chevillard L, Guillemyn K, Risède P, Laplanche J.-L., Spetea M, Ballet S, Mégarbane B (2017). Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain. Pain 158, 505-515.

Comprehensive lists of publications are available on the individual web sites of the CMBI labs.