Opioid Research Group

Schmidhammer


Helmut SCHMIDHAMMER
ao. Univ.-Prof. Mag. Dr.

Institute of Pharmacy/Pharmaceutical Chemistry
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/III
Room: L.03.132
6020 Innsbruck / Austria

e-mail: helmut.schmidhammer@uibk.ac.at
phone: +43-512-507-58248
fax: +43-512-507-58299

ORCID http://orcid.org/0000-0001-8752-5050

1965 - 1972
University of Innsbruck, Austria, Study of Pharmacy (M.Sc.)

1972 - 1975
Ph.D. Thesis, Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck (Ph.D. in Organic Chemistry)

1976 - 1985
Assistant Professor, Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck

1980 - 1982
Visting Scientist at the Section on Medicinal Chemistry, Laboratory of Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland, USA

1985
Associate Professor (Medicinal Chemistry), Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck

1994 - 1995
Visiting Professor, Astra Montreal Research Centre, Laval, Quebec, Canada

01/2000 bis 03/2010
Head of the Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Austria

1993 - 2011
Head of the “Opioid Research Group” at the Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Austria

Since 2001
Commitee member the "Georg und Christine Sosnovsky-Preis" of the Leopold-Franzens-Universität Innsbruck

Since 2004
Scientific Member of the Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Austria

Awards and honors

1974
Biochemie-Kundl Award

1986
Christian-Doppler Award of the Province of Salzburg

1986
Herba Award of the Herby Apotheker AG, Vienna

2001
Award for the best business plan for Tyrol (Austria) at the International Business Plan Competition “Best of Biotech (BOB)”, Vienna, Austria

2003
Winner (third place) in the Business Plan Competition “Adventure X”, Innsbruck, Austria

2003
Winner (first place) in the Business Plan Competition “Science4Life Venture Cup 2003”, Frankfurt a. M., Germany

Research topics

  • Development of potential drugs - Highly potent opioid analgesics - Drugs for the treatment of addiction (opioid, cocaine and alcohol) – Immunosuppressive drugs - Drugs for the treatment of ileus and inflammatory bowel diseases
  • Synthesis of 14-alkoxymorphinans – mu, delta and kappa opioid receptor selective opioid agonists and antagonists as pharmacological tools
  • Synthetical investigations on opium alkaloids (e.g. thebaine, codeine, noscapine)
  • Improvement of synthetical procedures in drug development
  • Structure-activity relationship studies on newly developed compounds

Methodologies

  • Organic chemical methods
  • Medicinal chemistry methods
  • Structure elucidation (NMR, IR, MS)
  • Determination of pka, logP, logD

Research projects and grants (Recent funding)

2000 - 2005 European Community EU-5FP (QLRT-1999-02234)
Opioid Treatment of Chronic Pain and Inflammation of the Locomotor System

2000 - 2005 Ministry of Education, Science and Culture
Opioid Treatment of Chronic Pain and Inflammation of the Locomotor System

2002 - 2006 Austrian Science Fund FWF P15481
Novel Therapies of Chronic Pain: Peripherally Acting 14-Alkoxymorphinen Derivatives

2003 - 2004 CAST
BioMare

2004- 2005 Universität Innsbruck
Peripherally Acting Analgesics

2004 - 2008 AlcaSynn Pharmaceuticals GmbH
AlcaSynn_1

2005 - 2006 Tyrolean Science Fund 0404/140
New Therapies for Chronic Pain

2009 - 2012 Austrian Science Fund FWF P21350
Peripheral Opioid Receptors, a Target for Gut Diseases

2010 - 2013 Austrian Science Fund FWF TRP16-B18
Novel Opioid Antagonists for Bowel Motility Disorders

2011 - 2012 Austrian Federal Ministry of Economy Prize 2010
Development of New Opioid Analgesics with Reduced Side Effects

Publications in Pubmed

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