Age-related diseases, which include neurodegenerative disorders, cardiovascular disease, diabetes but also cancer, establish a challenge to our society. Aging and cancer are highly correlated biological phenomena, and increasing evidence suggests a central role for metabolic regulation in control of ageing and lifespan. By searching for new mitochondrial regulators of cellular senescence, FAH domain containing protein 1 (FAHD1) was identified as a protein differentially expressed in mitochondria from young vs. senescent human umbilical endothelial vein cells (HUVEC). Ensuing studies revealed that depletion of FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in HUVEC. Our current research focus addresses the question whether FAHD proteins play a role in proliferation of human cancer cells, thus having potential as pharmacological targets in selected human malignancies. For a more detailed description of our research focus, please visit http://akhw.at/research.php