Contact: Institute of Pharmacy/Pharmacognosy University of Innsbruck Center for Chemistry and Biomedicine Innrain 80 - 82/IV Room: L.04.050 6020 Innsbruck / Austria
Vandana Singh; Deepak K Tripathi; Vivek K Sharma; Devika Srivastava; Umesh Kumar; Krishna M Poluri; Brahma N Singh; Dinesh Kumar; Venkatesh Kumar. Silk fibroin hydrogel: A novel biopolymer for sustained release of vancomycin drug for diabetic wound healing. Journal of Molecular Structure (2023) 1286, 135548; https://doi.org/10.1016/j.molstruc.2023.135548.
Archana B Sonkar; Pranesh Kumar; Anand Kumar; Anurag K Gautam; Abhishek Verma; Amita Singh; Umesh Kumar; Dinesh Kumar; Tarun Mahata; Bolay Bhattacharya et al. Vinpocetine mitigates DMH-induce pre-neoplastic colon damage in rats through inhibition of pro-inflammatory cytokines. International Immunopharmacology (2023), 119, 110236; https://doi.org/10.1016/j.intimp.2023.110236.
Anusmita Shekher; Puneet; Nikee Awasthee; Umesh Kumar; Ritu Raj; Dinesh Kumar; Subash Chandra Gupta. Association of altered metabolic profiles and long non-coding RNAs expression with disease severity in breast cancer patients: analysis by 1H NMR spectroscopy and RT-q-PCR. Metabolomics (2023), 19 (2), 8; https://doi.org/10.1007/s11306-023-01972-5
Samagra Agarwal; Pooja Goswami; Shekhar Poudel; Deepak Gunjan; Namrata Singh; Rajni Yadav; Umesh Kumar; Gaurav Pande; Anoop Saraya. Acute pancreatitis is characterized by generalized intestinal barrier dysfunction in early stage. Pancreatology (2023) 23 (1), 9-17; https://doi.org/10.1016/j.pan.2022.11.011
2022
Gaurav Pande, Manjunath, Dinesh Kumar, Umesh Kumar... Vikas Agarwal*. Response guided slow infusion of albumin, vasoconstrictors and furosemide improves ascites mobilization and survival in acute on chronic liver failure: a proof-of-concept study. Journal of Inflammation Research (2022), 15 5027–5039; https://doi.org/10.2147/JIR.S377494.
Nisha Raquibun, Pranesh Kumar, Umesh Kumar, Anupam Guleria, and Shubhini A. Saraf. Assessment of hyaluronic acid-modified imatinib mesylate cubosomes through CD44 targeted drug delivery in NDEA-induced hepatic carcinoma. International Journal of Pharmaceutics (2022): 121848; https://doi.org/10.1016/j.ijpharm.2022.121848.
Pranesh Kumar; Mohit Kumar; Anurag Kumar Gautam; Archana Bharti Sonkar; Abhishek Verma; Amita Singh; Raquibun Nisha; Umesh Kumar; Dinesh Kumar; Tarun Mahata et al. Ameliorative effect of fluvoxamine against colon carcinogenesis via COX-2 blockade with oxidative and metabolic stress reduction at the cellular, molecular and metabolic levels. BBA advances, (2022) 2, 100046; https://doi.org/10.1016/j.bbadva.2022.100046.
Pranesh Kumar; Anurag Kumar Gautam; Umesh Kumar; Archana S. Bhadauria; Ashok K. Singh; Dinesh Kumar; Tarun Mahata; Biswanath Maity; Hriday Bera; Sudipta Saha. Mechanistic exploration of the activities of poly (lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid against hepatocellular carcinoma at cellular and molecular levels. Archives of Physiology and Biochemistry (2022),128 (3), 836-848; https://doi.org/10.1080/13813455.2020.1733024.
Devika Srivastava, Vandana Singh, Umesh Kumar. Alpha-Linolenic acid: A Pharmacologically Active Ingredient from Nature. The Indian Journal of Nutrition and Dietetics, (2022), 534-553; https://doi.org/10.21048/IJND.2021.58.4.28086.
2021
Anupam Guleria, Umesh Kumar, Dinesh Kumar, Vikas Agarwal, Ramnath Misra and Latika Gupta*. NMR based Serum and Muscle Metabolomics for Diagnosis and Activity Assessment in Idiopathic Inflammatory Myopathies. Analytical Science Advances (2021), 2 (11-12), 515-526; https://doi.org/10.1002/ansa.202000171.
Payal Arya, Umesh Kumar, Supriya Sharma, Gaurav Pande* and Dinesh Kumar*. Targeted NMR based serum metabolic profiling of serine, glycine and methionine in Acute-on- Chronic liver failure patients: Possible insights into mitochondrial dysfunction. Analytical Science Advances (2021), 2 (11-12), 536-545; https://doi.org/10.1002/ansa.202000167.
Sandeep Kumar Singh*, Umesh Kumar, Anupam Guleria and Dinesh Kumar. A brief overview about the use of different bioactive liposome-based drug delivery systems in Peritoneal Dialysis and some other diseases. Nano Express (2021), 2 (2), 022006; DOI 10.1088/2632-959X/abfdd1
Umesh Kumar, Venkatesh Kumar R, Ramnath Misra and Dinesh Kumar* et al. Circulatory Histidine levels as Predictive Indicators of Disease Activity in Takayasu Arteritis. Analytical Science Advances (2021), 2, 527-535; https://doi.org/10.1002/ansa.202000181
Umesh Kumar, Abhai Kumar*, R.N. Chaurasia, and Dinesh Kumar* et al. An elaborative NMR based plasma metabolomics study revealed metabolic derangements in patients with Mild Cognitive Impairment (MCI): A study on North Indian Population. Metabolic Brain Disease (2021) 36, 957–968; https://doi.org/10.1007/s11011-021-00700-z
Venkatesh Kumar; Devika Srivastava; Umesh Kumar; Mukesh Kumar; Prashant Singh. Bioprospecting of Omega 3 Fatty Acid from Silkworm Pupal Oil: From Molecular Mechanism to Biological Activities. Journal of Biologically Active Products from Nature. (2021)10 (6), 495-506; https://doi.org/10.1080/22311866.2020.1862704
2020
Umesh Kumar, Venkatesh Kumar R., Ramnath Misra* and Dinesh Kumar* et al. Circulatory Glutamine/Glucose ratio for evaluating disease activity in Takayasu arteritis: A NMR based serum metabolomics study. Journal of Pharmaceutical and Biomedical Analysis (2020), 180, 113080; https://doi.org/10.1016/j.jpba.2019.113080.
Umesh Kumar, Supriya Sharma, Venkatesh Kumar R, Gaurav Pande*, and Dinesh Kumar* et al. Serum Metabolic Disturbances Associated with Acute-on-chronic Liver Failure in Patients with Underlying Alcoholic Liver Diseases: An Elaborative NMR-based Metabolomics Study. Journal of Pharmacy and Bioallied Sciences (2020); DOI: 10.4103/JPBS.JPBS_333_20.
Nisha, Raquibun, Pranesh Kumar, Umesh Kumar, and Shubhini A. Saraf. Fabrication of imatinib mesylate-loaded lactoferrin-modified PEGylated liquid crystalline nanoparticles for mitochondrial-dependent apoptosis in hepatocellular carcinoma. Molecular pharmaceutics (2020),18, 3: 1102-1120; https://doi.org/10.1021/acs.molpharmaceut.0c01024.
Venkatesh Kumar R., Devika Srivastava, Vandana Singh, Umesh Kumar, Dinesh Kumar (2020). Characterization, biological evaluation and molecular docking of mulberry fruit pectin. Scientific Reports, (2020), 10 (1), 1-16; https://www.nature.com/articles/s41598-020-78086-8.
Sujata Ganguly, Umesh Kumar, Amita Aggarwal, Dinesh Kumar, Ramnath Misra*. NMR based Targeted profiling of urinary acetate and citrate following Cyclophosphamide therapy in patients with Lupus nephritis. Lupus, (2020),29(7), 1-5; https://journals.sagepub.com/doi/10.1177/0961203320918011.
Pranesh Kumar, A.K., Gautam, Umesh Kumar, Dinesh Kumar, Biswanath Maity and Sudipta Saha*. Mechanistic Exploration of the activities of PLGA-loaded betulinic acid nanoparticles against hepatocellular carcinoma at cellular and molecular levels. Archieves of Physiology and Biochemistry (2020),1-13; https://doi.org/10.1080/13813455.2020.1733024.
Venkatesh Kumar Ramappa; Devika Srivastava; Prashant Singh; Umesh Kumar; Dinesh Kumar; Sunil Babu Gosipatala; Sudipta Saha; Dhiraj Kumar; Ritu Raj. Mulberries: A Promising Fruit for Phytochemicals, Nutraceuticals, and Biological Activities. The Journal of Horticultural Science and Biotechnology (2020) 95 (6), 679-686; https://doi.org/10.1080/15538362.2020.1784075.
Venkatesh Kumar Ramappa; Devika Srivastava; Prashant Singh; Umesh Kumar; Vandana Singh. Mulberry 1-deoxynojirimycin (DNJ): an exemplary compound for therapeutics. The Journal of Horticultural Science and Biotechnology. (2020) 95 (6), 679-686; https://doi.org/10.1080/14620316.2020.1760738.
2019
Pranesh Kumar, Aakriti Agarwal, Ashok K.Singh, Umesh Kumar, Dinesh Kumar, Sudipta Sah,. Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis. Regulatory Toxicology and Pharmacology (2019), 109, 104489; https://doi.org/10.1016/j.yrtph.2019.104489.
Vinit Raj, Archana S. Bhadauria, Ashok K. Singh, Umesh Kumar, Dinesh Kumar and Sudipta Saha*. Novel 1, 3, 4-thiadiazoles inhibit colorectal cancer via blockade of IL-6/COX-2 mediated JAK2/STAT3 signals as evidenced through data-based mathematical modeling. Cytokine (2019). 118, 144-159; https://doi.org/10.1016/j.cyto.2018.03.026.
2018
Avinash Jain, Dinesh Kumar*, Anupam Guleria, Umesh Kumar, Debashish Danda, Ramnath Misra*. NMR-based Serum Metabolomics of patients with Takayasu arteritis (TA) – Relationship with disease activity. Journal of Proteome Research (2018), 17 (9), 3317-332; https://doi.org/10.1021/acs.jproteome.8b00456.
Anupam Guleria, Amit Kumar, Umesh Kumar, Ritu Raj, and Dinesh Kumar*. NMR based metabolomics: An exquisite and facile method for evaluating therapeutic efficacy and screening drug toxicity. Current Topics in Medicinal Chemistry (2018), 18(20), 1827-1849; DOI: 10.2174/1568026619666181120141603.
Anupam Guleria*, Sanat Phatak, Umesh Kumar, Ranjan Gupta, Amita Aggarwal, Dinesh Kumar*, and Ramnath Misra*. NMR based serum metabolomics reveals reprogramming of lipid dysregulation following Cyclophosphamide based induction therapy in lupus nephritis. Journal of Proteome Research (2018), 17 (7), 2440–2448; https://doi.org/10.1021/acs.jproteome.8b00192.
Amit Rai, Umesh Kumar, Vinit Raj, Ashok K Singh, Pranesh Kumar, Amit K Keshari, Dinesh Kumar, and Sudipta Saha*. Novel 1,4 benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. Pharmacological Research (2018),132,188-203; https://doi.org/10.1016/j.phrs.2017.12.010.
Ashok K Singh, Umesh Kumar, Vinit Raj, Vimal Maurya, Dinesh Kumar, and Sudipta Saha*. Novel fused oxazepino-indoles (FOIs) attenuate liver carcinogenesis through IL6/JAK2/STAT3 signaling blockade with strong metabolic regulations. Life Sciences (2018), 201, 161-172; https://doi.org/10.1016/j.lfs.2018.02.029.
Ashok Singh, Archana S Bhadauria, Umesh Kumar, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, and Sudipta Saha*. Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals. Scientific Reports (2018),8, 5932; https://www.nature.com/articles/s41598-018-24288-0.
Atul Rawat, Anupam Guleria, Durgesh Dubey, Umesh Kumar, Dinesh Kumar*,Sudipta Saha*. Metabolomics approach discriminates toxicity index of Pyrazinamide and its metabolic products; Pyrazinoic acid and 5-Hydroxy Pyrazinoic acid. Human and Experimental Toxicology (2018), 37(4),373-389; DOI: 10.4103/0975-7406.199339.
2017
Vinit Raj, Amit Rai, Ashok K Singh, Umesh Kumar, Dinesh Kumar, and Sudipta Saha*. Discovery of Novel 2- Amino-5-(Substituted)-1,3,4-Thiadiazole Derivatives: New Utilities for Colon Cancer Treatment. Anti-Cancer Agents in Medicinal Chemistry (2017); DOI: 10.2174/1871520617666170419122916.
Pranesh Kumar, Ashok K Singh, Amit K Keshari, Umesh Kumar, Dinesh Kumar, Anand Prakash, Anupam Guleria*, Sudipta Saha*. 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid attenuates hepatocellular carcinoma in rats with NMR based metabolic perturbations. Future Science (2017), 3(3); https://doi.org/10.4155/fsoa-2017-0008.
Anil Sahadev, Vinit Raj, Ashok Singh, Umesh Kumar, Atul Rawat, Dinesh Kumar, Anand Prakash, and Sudipta saha*. Ameliorative effects of Pyrazinoic acid against oxidative and metabolic stress manifested in rats with dimethylhydrazine induced colonic carcinoma. Cancer Biology and Therapy (2017) ,1-10; https://doi.org/10.1080/15384047.2017.1310341.
Dinesh Kumar*, Gaurav Pandey*, Deepak Bansal, Atul Rawat, Umesh Kumar, Durgesh Dubey, Anupam Guleria, and Vivek Anand Saraswat . NMR based urinary profiling of Lactulose/Mannitol ratio used to assess the altered intestinal permeability in acute on chronic liver failure (ACLF) patients. Magnetic Resonance in Chemistry, (2017), 55(4), 289-296; https://doi.org/10.1002/mrc.4525.
Vivek Saraswat, Gaurav Pandey*, Dinesh Kumar, Umesh Kumar, Krishna Vp, Anupam Guleria. Significant Increase in Intestinal Permeability in Acute-On-Chronic Liver Failure (ACLF) is Reversed after Slow Albumin furosemide Infusion with or without Terlipressin. Journal of Clinical and Experimental Hepatology (2017), 7, S70-S71; https://doi.org/10.1016/j.jceh.2017.01.093.
Amit Kesari, Ashok K Singh, Umesh Kumar, Dinesh Kumar, and Sudipta Saha*. 5H-benzo[h]thiazolo[2,3b] quinazolines ameliorate NDEA induced hepatocellular carcinogenesis in rats through IL-6 down-regulation along with oxidative and metabolicstress reduction. Drug Design, Development and Therapy (2017), 11: 2981–2995; https://doi.org/10.2147/DDDT.S143075.
Amit K Keshari, Singh AK, Vinit Raj, Umesh Kumar, Atul Rawat, Dinesh Kumar, and SudiptaSaha*. p-TSA– promoted syntheses of 5H-benzo[h]thiazolo[2,3-b] quinazoline and indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma. Drug Design, Development and Therapy (2017), 11, 1623-1642; https://doi.org/10.2147/DDDT.S136692.
Amit Rai, Umesh Kumar, Dinesh kumar and Sudipta Saha*. Design and synthesis of 1, 4-benzothiazine derivatives with promising effects against colorectal cancer cells. Cogent Chemistry (2017), 3, 1303909; https://doi.org/10.1080/23312009.2017.1303909.
2016
Anupam Guleria*, Avadhesh Pratap, Umesh Kumar, Durgesh Dubey, Atul Rawat, Paul Bacon, Ramnath Misra*, and Dinesh Kumar*. NMR based serum metabolomics reveals a distinctive signature in patients with Lupus Nephritis. Scientific Reports, (2016), 6, 35309; https://www.nature.com/articles/srep35309.
Atul Rawat, Durgesh Dubey, Anupam Guleria, Umesh Kumar, Amit Kesari, Swati Chaturvedi, Anand Prakash, Sudipta Saha, and Dinesh Kumar*. 1H NMR based Serum Metabolomics reveals Erythromycin induced Liver Toxicity in Albino Wistar Rats. Journal of Pharmacy and Bioallied Sciences (2016) , 8(4), 327-334; DOI: 10.4103/0975-7406.199339.
Anupam Guleria, Umesh Kumar and Dinesh Kumar*. NMR based metabolomics: An exquisite and facile method for evaluating therapeutic efficacy and screening drug toxicity. Current Topics in Medicinal Chemistry (CTMC)”; DOI: 10.2174/1568026619666181120141603.
Book chapters / Conference papers
Gupta L, Kumar D, Gulerai A, Kumar U, Misra R. “NMR-Based Serum, Urine and Muscle Metabolomics in Inflammatory Myositis for Diagnosis and Activity Assessment: Serum Metabolomics Can Differentiate Active from Inactive Myositis” Oral presentation at the ACR, Atlanta 2019. http://dx.doi.org/10.1136/annrheumdis-2020-eular.316.
Ganguly S, Kumar U, Gupta N, et al. AB1313 NMR Spectroscopy Reveals alterations of urinary Acetate and Citrate levels following Cyclophosphamide therapy in patients with Lupus Nephritis. Annals of the Rheumatic Diseases, (2019) ,78: 2119. http://dx.doi.org/10.1136/annrheumdis-2019-eular.6067.
Kumar D, Kumar U, Nair HG, Jain A, et al. SAT0225 targeted serum metabolic profile in patients with Takayasu Arteritis. Annals of the Rheumatic Diseases, (2019), 78:1188-1189. http://dx.doi.org/10.1136/annrheumdis-2019-eular.7672.
Latika Gupta, Dinesh Kumar,Umesh Kumar, Ritu Raj, Able Lawrence, and Ramnath Misra. NMR‐based serum metabolomics as surrogate for disease activity in inflammatory myositis. Conference paper accepted for Oral Presentation during 20th Asia Pacific League of Associations for Rheumatology Congress (APLAR), 6–9 September 2018, Kaohsiung, Taiwan. International Journal of Rheumatic Diseases (2018), 21 (Suppl. 1): Page 7.
Ramnath Misra, Avinash Jain, Dinesh Kumar....Umesh Kumar and Paul Bacon. NMRBased serum metabolomics of patients with Takayasu Arteritis (TA) and Relationship with Disease Activity. (Conference paper, 2017ACR/ARHP, Abstract Number: 1848) Arthritis and Rheumatology (2017).
P. Krishna, Gaurav Pandey, Dinesh Kumar, Umesh Kumar, Samir Mohindra, Manjunath Hatti and Vivek Saraswat. Significant Increase in Intestinal Permeability in Acute-On-Chronic Liver Failure (ACLF) is Reversed After Slow Albumin Furosemide Infusion with or Without Terlipressin. Journal of Clinical and Experimental Hepatology (2017), 7, S11.
Avinash Jain*, Dinesh Kumar, Umesh Kumar, Bacon PA, and Ramnath Misra. NMR-Based serum metabolomics of patients with Takayasu Arteritis (TA): Relationship with Disease Activity. (Conference paper, EULAR-2017, Identifier: THU0307). Annals of Rheumatic disease. http://dx.doi.org/10.1136/annrheumdis-2017-eular.6057.
Gaurav Pandey, Krishna V P, Umesh Kumar, Prabhat Sharma, Dinesh Kumar, Samir Mohindra, Deepak Bansal, and Vivek A. Saraswat. NMR based urinary profiling of Lactulose/Mannitol ratio to compare the intestinal permeability in cirrhosis, acute on chronic liver failure (ACLF) patients and normal controls. (Conference paper, The Liver Meeting AASLD 2016, Label: Infections and Acute on Chronic Liver Failure). Hepatology (2016), 64 (S1), 1025A.
Dinesh Kumar#, Atul Rawat, Durgesh Dubey, Umesh Kumar, Amit K Keshari, Sudipta Saha and Anupam Guleria. NMR based Metabolomics: An emerging tool for therapeutic evaluation of Traditional Herbal Medicines. (SMe Books: Nuclear Magnetic Resonance Spectroscopy (2016), 1-18.
