Hypoxia Adaptation

hypoxia02 hypoxia01 Adaptation to changing environments includes immediate responses like changes in cardiac activity or ventilation, but also changes at the molecular level as revealed by changes in the expression level of various genes. Using the zebrafish as a model animal the effect oxygen deficiency caused by reduced oxygen availability or by an increase in local oxygen demand on the expression of genes of various functional groups is analyzed. Of particular interest is the role of the various isoforms of the hypoxia inducible transcription factor (Hif) in hypoxic signaling, but also during development. The analysis of the regulatory function of Hif proteins includes possible connections to the other major regulatory pathways of cell metabolism and the maintenance of cellular and organismic homeostasis in the face of changing environmental conditions.


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