Circadian Rhythms

circadian

The influence of exercise on the diurnal transcription of period1 and clock1 mRNA in zebrafish larvae at the age of 15 dpf.

Circadian rhythms define endogenous oscillations of physiological and molecular parameters in organisms with a period length of about 24 hours (latin: circadian- “about a day”). These rhythms can be entrained and synchronized to the external day/night cycles by so called Zeitgebers. Among the most important timing cues are light, temperature, food availability and physical activity. Our group focusses on the impact of low oxygen availability on the circadian timing system of zebrafish and, in turn, on the circadian regulation of the hypoxic response. In this context we concentrate especially on temporal gene expression patterns and the transcriptional control of the involved genes, but we also use behavioural and physiological measurements to prove our data at the organismic level. In addition to low oxygen availability we also study light, activity and magnetism as external stress factors for the hypoxic pathway and the circadian clock in zebrafish.

 

Members of this workgroup:

zebrafish

The Zebrafish (Danio rerio)

Center for Molecular Biosciences Innsbruck