Circadian rhythm


The influence of training on the diurnal rhythmicity of period1 and clock1 mRNA expression in 15-day-old zebrafish larvae.

Circadian rhythms are concerned with the endogenous oscillations of physiological and molecular measurements in organisms with a period length of approximately 24 hours (Latin: circadian- "about a day"). These rhythms can be synchronized with the external day/night cycles by so-called timers. The most important timers include light, temperature, food availability, and physical activity. Our group is investigating the influence of oxygen deficiency on the circadian clock in zebrafish and, conversely, the circadian regulation of the hypoxia response. In this context, we mainly investigate gene expression patterns in their temporal sequence and the transcriptional regulation of the respective genes, but also use behavioral approaches and physiological measurements to verify our data on an organismal level. In addition to reduced oxygen availability, we are also investigating the influence of light, physical activity, and magnetism on the circadian clock and the hypoxia signaling pathway in zebrafish.






Members of this working group


Der Zebrafisch (Danio rerio)




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