PhD thesis topics at DP ARDRE

  • Adipose stem cells in obesity and caloric restriction (ASC)
  • Biology of voltage-gated calcium-channels (BVC)
  • Total synthesis of polycyclic anti-ageing natural products (TAP)
  • cWnt-Myc signaling in stem cell decision making and regeneration (WSR)
  • Metabolic signaling drives ageing: the interplay of the mTOR kinase network with energy metabolism and neuronal function (MSA) 
  • Mitochondria in ageing (MIA)
  • Molecular modelling in ageing and regeneration (MAR)
  • Natural compounds in ageing and regeneration (NAR)
  • Neural stem cells and neurodevelopmental disorders (NDD)
  • Plant ageing (PA)
  • Stem cells and regeneration (SCR)
  • Stemness and ageing in tunicates (SAT)

Biology of voltage-gated calcium-channels (BVC)

Scientific_background_image_2Requirements: M. Sc. in life sciences or related discipline. Background in cell signaling. Knowledge in electrophysiological techniques, ion channels and the pharmacological modulation of ion channels will be a plus. Strong communication skills in English (written and spoken) are a must.

Voltage-gated Ca2+-channels regulate the influx of Ca2+-ions into electrically excitable cells in response to changes in membrane potential. The resulting intracellular Ca2+-transients are essential for key physiological processes including muscle contraction, hormone secretion, sensory functions, neurotransmitter release, neuronal plasticity in neurons as well as learning and memory.

Our interdisciplinary team uses a wide spectrum of advanced biophysical, biochemical, molecular and cell biological, techniques to characterize the consequences of Ca2+-channel dysfunction in vitro and in vivo for several human disease. This includes neurological diseases (such as seizures) and neurodevelopmental disorders, including autism spectrum disorder.

The role of L-type Ca2+ channels for brain ageing and neuropsychiatric disorders (BVC-1)

The young researcher will use electrophysiological (brain slice recordings), immunohistochemical and biochemical techniques (e.g. qPCR, Western blotting) and perform behavioral studies in mice to study alterations in brain function induced by human Ca2+ channel mutations causing neuropsychiatric disorders and also determine effects on aging.

Supervisor: Striessnig; Co-supervisor: Edenhofer/Hobmayer

Subtype-selective inhibition of voltage-gated calcium channels (BVC-2)

The young researcher will use a combination of molecular modeling and electrophysiological techniques (Ca2+ channel recordings in wildtype and mutant Ca2+ channels) to characterize existing and discover new subtype-selective Ca2+ channel blockers.

Supervisor: Striessnig; Co-supervisor: Liedl/Edenhofer

 

 
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