Innsbruck Doctoral College Ageing and Regeneration
(DC AGE_REG)

Publications 2022

Gerna D, Ballesteros D, Arc E, Stöggl W, Seal CE, Marami-Zonouz N, Na CS, Kranner I, Roach T. Does oxygen affect ageing mechanisms of Pinus densiflora seeds? A matter of cytoplasmic physical state. J Exp Bot. 2022 Jan 27:erac024. doi: 10.1093/jxb/erac024. Epub ahead of print. PMID: 35084458.

Publications 2021

Albertos P, Tatematsu K, Mateos I, Sánchez-Vicente I, Fernández-Arbaizar A, Nakabayashi K, Nambara E, Godoy M, Franco JM, Solano R, Gerna D, Roach T, Stöggl W, Kranner I, Perea-Resa C, Salinas J, Lorenzo O. Redox feedback regulation of ANAC089 signaling alters seed germination and stress response. Cell Rep. 2021 Jun 15;35(11):109263. doi: 10.1016/j.celrep.2021.109263. PMID: 34133931; PMCID: PMC8220255.

 


Cavinato M, Madreiter-Sokolowski CT, Büttner S, Schosserer M, Zwerschke W, Wedel S, Grillari J, Graier WF, Jansen-Dürr P. Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic
control. FEBS J. 2021 Jun;288(12):3834-3854. doi: 10.1111/febs.15631. Epub 2020 Dec 8. PMID: 33200494; PMCID: PMC7611050.

 


Fellner L, Gabassi E, Haybaeck J, Edenhofer F. Autophagy inα-Synucleinopathies-An Overstrained System. Cells. 2021 Nov 12;10(11):3143. doi:10.3390/cells10113143. PMID: 34831366; PMCID: PMC8618716.

 


Gerna D, Arc E, Holzknecht M, Roach T, Jansen-Dürr P, Weiss AKH, Kranner I. AtFAHD1a: A New Player Influencing Seed Longevity and Dormancy in Arabidopsis? Int J Mol Sci. 2021 Mar 15;22(6):2997. doi: 10.3390/ijms22062997. PMID: 33804275; PMCID: PMC8001395.Salti A, Etemad S, Cubero MS, Albertini E, Kovacs-Szalka B, Holzknecht M,Cappuccio E, Cavinato M, Edenhofer F, Jansen Dürr P. High Glycolytic ActivityEnhances Stem Cell Reprogramming of Fahd1-KO Mouse Embryonic Fibroblasts. Cells.2021 Aug 10;10(8):2040. doi: 10.3390/cells10082040. PMID: 34440809; PMCID: PMC8392800.

 


Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yanng L, Karbacher l, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A Goldstein LSB, Galasko D, Gage FH. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell. 2021 Sep 2;28(9):1533-1548.e6. doi: 10.1016/j.stem.2021.04.004. Epub 2021 Apr 27.

 


Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladevardi S, Mc Grath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH. Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH. Direktly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cells. 2015 Dec 3;17(6):705-718. doi: 10.1016/j.stem.2015.09.001. Epub 2015 Oct 8

 


Temocin O, Regele D, Sathianathan M, Überbacher C, Hartl M, Edenhofer F, Meyer D. Generation of an hiPSC-1 knock-in line expressing TY1-tagged MNX1-protein together with mScarlet. Stem Cell Res. 2021 Oct;56:102522. doi: 10.1016/j.scr.2021.102522. Epub 2021 Sep 2. PMID: 34509159

Publications 2020

Cavinato M., Wedel S., Jansen-Dürr P. Aging of Cells In Vitro. In: Rattan, S.I.S. (Ed.), Encyclopedia of Biomedical Gerontology. Elsevier 2020, vol. 1, Academic Press, pp. 138–148. https://dx.doi.org/10.1016/B978-0-12-801238-3.11409-6 ISBN: 9780128160756

 


Gerna D, Roach T, Mitter B, Stöggl W, Kranner I. Hydrogen Peroxide Metabolism in Interkingdom Interaction Between Bacteria and Wheat Seeds and Seedlings. Mol Plant Microbe Interact. 2020 Feb;33(2):336-348. doi: 10.1094/MPMI-09-19-0248-R. Epub 2019 Dec 18. PMID: 31631769.

 


Hagen M, Derudder E. Inflammation and the Alteration of B-Cell Physiology in Aging. Gerontology. 2020;66(2):105-113. doi: 10.1159/000501963. Epub 2019 Sep 25. PMID: 31553969

 


Martic I, Wedel S, Jansen-Dürr P, Cavinato M. A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes. Mech Ageing Dev.2020 Sep;190:111322. doi: 10.1016/j.mad.2020.111322. Epub 2020 Jul 29. PMID:32735894; PMCID: PMC7116475.

 


Wedel S, Martic I, Hrapovic N, Fabre S, Madreiter-Sokolowski CT, Haller T,Pierer G, Ploner C, Jansen-Dürr P, Cavinato M. tBHP treatment as a model forcellular senescence and pollution-induced skin aging. Mech Ageing Dev. 2020
Sep;190:111318. doi: 10.1016/j.mad.2020.111318. Epub 2020 Jul 22. PMID: 32710895; PMCID: PMC7610711.

 


Narzt MS, Pils V, Kremslehner C, Nagelreiter IM, Schosserer M, Bessonova E, Bayer A, Reifschneider R, Terlecki-Zaniewicz L, Waidhofer-Söllner P, Mildner M, Tschachler E, Cavinato M, Wedel S, Jansen-Dürr P, Nanic L, Rubelj I, El-
Ghalbzouri A, Zoratto S, Marchetti-Deschmann M, Grillari J, Gruber F, Lämmermann I. Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory
Phenotype (SASP) Factors. J Invest Dermatol. 2021 Apr;141(4S):993-1006.e15. doi: 10.1016/j.jid.2020.11.020. Epub 2020 Dec 15. PMID: 33333126.

 


Wedel S, Martic I, Hrapovic N, Fabre S, Madreiter-Sokolowski CT, Haller T,Pierer G, Ploner C, Jansen-Dürr P, Cavinato M. tBHP treatment as a model forcellular senescence and pollution-induced skin aging. Mech Ageing Dev. 2020 Sep;190:111318. doi: 10.1016/j.mad.2020.111318. Epub 2020 Jul 22. PMID:32710895; PMCID: PMC7610711.

 


Weiss A.K.H., Naschberger A., Cappuccio E., Metzger C., Mottes L., Holzknecht M., von Velsen J., Bowler M.W., Rupp B., Jansen-Dürr P. Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse. Biosci Rep. 2020 Mar 27;40(3). pii: BSR20194431. doi: 10.1042/BSR20194431

 


Weiss A.K.H., Albertini E., Holzknecht M., Cappuccio E., Dorigatti I., Krahbichler A., Damisch E., Gstach H., Jansen-Dürr P. Regulation of cellular senescence by eukaryotic members of the FAH superfamily - a role in calcium homeostasis? Mech Ageing Dev. 2020 Jun 20:111284. doi: 10.1016/j.mad.2020.111284

 


Weiss AKH, Holzknecht M, Cappuccio E, Dorigatti I, Kreidl K, Naschberger A,Rupp B, Gstach H, Jansen-Dürr P. Expression, Purification, Crystallization, andEnzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins. J Vis
Exp. 2019 Jun 20;(148):10.3791/59729. doi: 10.3791/59729. PMID: 31282888; PMCID:PMC7115867.

Publications 2019

Etemad S., Petit M., Weiss A.K.H., Schrattenholz A., Baraldo G., Jansen-Dürr P. Oxaloacetate decarboxylase FAHD1 - a new regulator of mitochondrial function and senescence. Mech Ageing Dev 2019;177:22-29. doi: 10.1016/j.mad.2018.07.007.

 


Böhnke L., Traxler L., Herdy J.R., Mertens J. Human neurons to model aging: A dish best served old. Drug Discovery Today: Disease Models (2019) https://doi.org/10.1016/j.ddmod.2019.01.001

 


Hartl M., Glasauer S., Gufler S., Raffeiner A., Puglisi K., Breuker K., Bister K., Hobmayer B. Differential regulation of myc homologs by Wnt/β-catenin signaling in the early metazoan Hydra. FEBS J. 2019;286(12): 2295-2310. doi: 10.1111/febs.14812

 


Meryk A, Pangrazzi L, Hagen M, Hatzmann F, Jenewein B, Jakic B, Hermann-Kleiter N, Baier G, Jylhävä J, Hurme M, Trieb K, Grubeck-Loebenstein B. Fcμreceptor as a Costimulatory Molecule for T Cells. Cell Rep. 2019 Mar5;26(10):2681-2691.e5. doi: 10.1016/j.celrep.2019.02.024. PMID: 30840890

 


Rocamora-Reverte L, Tuzlak S, von Raffay L, Tisch M, Fiegl H, Drach M,Reichardt HM, Villunger A, Tischner D, Wiegers GJ. Glucocorticoid Receptor-Deficient Foxp3+ Regulatory T Cells Fail to Control ExperimentalInflammatory Bowel Disease. Front Immunol. 2019 Mar 18;10:472. doi:10.3389/fimmu.2019.00472. PMID: 30936873; PMCID: PMC6431616.

 


Zeng F., Wunderer J., Salvenmoser W., Hess M.W., Ladurner P., Rothbächer U. Papillae revisited and the nature of the adhesive secreting collocytes. Dev Biol. 2019;448(2):183-198. doi: 10.1016/j.ydbio. 2018.11.012.

 


Weiss A.K.H., Holzknecht M., Cappuccio E., Dorigatti I., Kreidl K., Naschberger A., Rupp B., Gstach H., Jansen-Dürr P. Expression, purification, crystallization, and enzyme assays of fumarylacetoacetate hydrolase domain-containing proteins.J Vis Exp. 2019 Jun 20;(148). doi: 10.3791/59729.


Lourdes Rocamora-ReverteSelma TuzlakLaura von RaffayMarcel TischHeidi FieglMathias DrachHolger M ReichardtAndreas VillungerDenise TischnerG Jan Wiegers; Glucocorticoid Receptor-Deficient Foxp3 + Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease; Front Immunol. 2019 Mar 18;10:472. doi: 10.3389/fimmu.2019.00472. eCollection 2019

 


Meryk A., Pangrazzi L., Hagen M., Hatzmann F., Jenewein B., Jakic B., Hermann-Kleiter N., Baier G., Jylhävä J., Hurme M., Trieb K., Grubeck-Loebenstein B. Fcµ receptor as a costimulatory molecule for T cells. Cell Rep 2019;26(10):2681-2691.e5. doi: 10.1016/j.celrep.2019.02.024

 


Hagen M., Derudder E. Inflammation and the Alteration of B-Cell Physiology in Aging. Gerontology. 2019 Sep 25:1-9. doi: 10.1159/000501963


Anita ErharterSandra RizziJerome MertensFrank Edenhofer; Take the shortcut - direct conversion of somatic cells into induced neural stem cells and their biomedical applications; FEBS Lett 2019 Dec;593(23):3353-3369; doi: 10.1002/1873-3468.13656. Epub 2019 Dec 1.PMID: 31663609; PMCID: PMC6916337; DOI: 1002/1873-3468.13656

Publications 2018

Gerna D., Roach T., Arc E., Stöggl W., Limonta M., Vaccino P., Kranner I. Redox poise and metabolite changes in bread wheat seeds are advanced by priming with hot steam. Biochem J. 2018;475(23):3725-3743. doi: 10.1042/BCJ20180632.

 


Gufler S., Artes B., Bielen H., Krainer I., Eder M-K., Falschlunger J., Bollmann A., Ostermann T., Hartl M., Bister K., Technau U., Hobmayer B. β-Catenin acts in a position-independent regeneration response in the simple eumetazoan Hydra. Dev. Biol. 2018;433(2):310-323. doi: 10.1016/j.ydbio.2017.09.005.

 


Wedel S., Manola M., Cavinato M., Trougakos I.P., Jansen-Dürr P. Targeting protein quality control mechanisms by natural products to promote healthy ageing. Molecules 2018; 23(5). pii. E1219. doi: 10.3390/molecules23051219.

Revoltella S., Baraldo G., Waltenberger B., Schwaiger S., Kofler P., Moesslacher J., Huber-Seidel A., Pagitz K., Kohl R., Jansen-Duerr P., Stuppner H. Identification of the NADPH Oxidase 4 Inhibiting Principle of Lycopus europaeus. Molecules 2018;23(3). pii: E653. doi: 10.3390/molecules23030653.

 


Weiss A.K.H., Naschberger A., Loeffler J.R., Gstach H., Bowler M.W., Holzknecht M., Cappuccio E., Pittl A., Etemad S., Dunzendorfer-Matt T., Scheffzek K., Liedl K.R., Jansen-Dürr P. Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1. Biochem J 2018;475 (22):3561-3576. doi: 10.1042/BCJ20180750.

 


Zeng F., Wunderer J., Salvenmoser W., Hess M.W., Ladurner P., Rothbächer U. Papillae revisited and the nature of the adhesive secreting collocytes. Dev Biol. 2019;448(2):183198. doi: 10.1016/j.ydbio. 2018.11.012.

Publications 2017

Petit M., Koziel R., Etemad S., Pircher H., Jansen-Dürr P. Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells. Exp Gerontol. 2017;92:7-12. doi: 10.1016/j.exger.2017.03.004.

 


Gerna D., Roach T., Stöggl W., Wagner J., Vaccino P., Limonta M., Kranner I. Changes in low-molecular-weight thiol-disulphide redox couples are part of bread wheat seed germination and early seedling growth. Free Radic Res. 2017;51(6):568-581. doi:10.1080/10715762.2017.1338344

 


Bu H., Wedel S., Cavinato M., Jansen-Dürr P. MicroRNA regulation of oxidative stress-induced cellular senescence. Oxid Med Cell Longev, vol. 2017;2017:2398696.doi:10.1155/2017/2398696.

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