Thomas GelbrichThomas Gelbrich, Dr.
Research associate

Phone: +43 512 507 58651
Mail: thomas.gelbrich@uibk.ac.at

University of Innsbruck, Institute of Pharmacy, Pharmaceutical Technology
Josef-Moeller-Haus, Innrain 52c, A-6020 Innsbruck, Austria

                  
Biography

                  
Publications

                  
Research

                  
Teaching


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Original research articles

2016

T. Gelbrich, D. E. Braun, U. J. Griesser. (2016) Specific energy contributions from competing hydrogen-bonded structures in six polymorphs of phenobarbital, Chem. Cent. J. 10, 8. (DOI

2015

D. E. Braun, T. Gelbrich, V. Kahlenberg, U. J. Griesser. (2015) Solid state forms of 4-aminoquinaldine - from void structures with and without solvent inclusion to close packing, CrystEngComm 17, 2504-2516. (DOI)

V. Kahlenberg, T. Gelbrich, R. Tessadri, F. Klauser. (2015) Crystal structure of cis-diamminebis(nitrito-[kappa]N)platinum(II), Acta Crystallogr., Sect. E.: Cryst. Commun. 71, 366-370. (DOI)

G. Laus, V. Kahlenberg, T. Gelbrich, S. Nerdinger, H. Schottenberger. (2015) Crystal structure of 3-bromo-2-hydroxybenzoic acid, Acta Crystallogr., Sect. E.: Struct Rep. Online 71, 531-535. (DOI

T. Gelbrich, U. J. Griesser. (2015) Crystal structure of 5-hydroxy-5-propylbarbituric acid, Acta Crystallogr., Sect. E.: Cryst. Commun. 71, 1311-1314. (DOI)

D. Hean, T. Gelbrich, U. J. Griesser, J. P. Michael, A. Lemmerer. (2015) Structural insights into the hexamorphic system of an isoniazid derivative, CrystEngComm 17, 5143-5153. (DOI)

T. Gelbrich, I. Meischberger, U. J. Griesser. (2015) Two polymorphs of 5-cyclohexyl-5-ethylbarbituric acid and their packing relationships with other barbiturates, Acta Crystallogr., Sect. C: Struct. Chem. 71, 204-210. doi:10.1107/S2053229615002880
http://journals.iucr.org/c/issues/2015/03/00/cu3074/

M. Hursthouse, D. Hughes, T. Gelbrich, T. Threlfall. (2015) Describing hydrogen-bonded structures; topology graphs, nodal symbols and connectivity tables, exemplified by five polymorphs of each of sulfathiazole and sulfapyridine, Chemistry Central Journal 9, 1. http://journal.chemistrycentral.com/content/9/1/1

T. Gelbrich, U. J. Griesser. (2015) Crystal structure of the [alpha]-racemate of methohexital, Acta Crystallogr., Sect. E.: Struct Rep. Online 71, 206-209. http://dx.doi.org/10.1107/S205698901500105X

G. Laus, T. Gelbrich, K. Wurst, H. Schottenberger. (2015) Crystal structure of 3-bromo-4-dimethylamino-1-methyl-1,2,4-triazol-5(4H)-one, Acta Crystallogr., Sect. E.: Struct Rep. Online 71, o23. http://dx.doi.org/10.1107/S205698901402636X

2014

D. E. Braun, T. Gelbrich, V. Kahlenberg, U. J. Griesser. (2014) Insights into Hydrate Formation and Stability of Morphinanes from a Combination of Experimental and Computational Approaches, Mol. Pharmaceutics 11, 3145-3163. http://dx.doi.org/10.1021/mp500334z

T. Gelbrich, T. L. Threlfall, M. B. Hursthouse. (2014) Interplay between hydrogen bonding and metal coordination in alkali metal tartrates and hydrogen tartrates, CrystEngComm 16, 6159-6169. http://dx.doi.org/10.1039/C4CE00291A

N. Zencirci, U. J. Griesser, T. Gelbrich, D. C. Apperley, R. K. Harris. (2014) Crystal Polymorphs of Barbital: News about a Classic Polymorphic System, Mol. Pharmaceutics 11, 338-350. http://pubs.acs.org/doi/abs/10.1021/mp400515f

N. Zencirci, U. J. Griesser, T. Gelbrich, V. Kahlenberg, R. K. R. Jetti, D. C. Apperley, R. K. Harris. (2014) New Solvates of an Old Drug Compound (Phenobarbital): Structure and Stability, J. Phys. Chem. B 118, 3267-3280. http://dx.doi.org/10.1021/jp409201v

R. Salchner, V. Kahlenberg, T. Gelbrich, K. Wurst, M. Rauch, G. Laus, H. Schottenberger. (2014) Hexaethylguanidinium Salts, Crystals 4, 404-416. http://www.mdpi.com/2073-4352/4/3/404

2013

T. Gelbrich, D. E. Braun, A. Ellern, U. J. Griesser. (2013) Four Polymorphs of Methyl Paraben: Structural Relationships and Relative Energy Differences, Cryst. Growth Des. 13, 1206-1217. http://dx.doi.org/10.1021/cg301639r

T. Gelbrich, V. Kahlenberg, U. J. Griesser. (2013) Alogliptin and its benzoate salt, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 69, 674-678. http://dx.doi.org/10.1107/S0108270113012560

T. Gelbrich, V. Kahlenberg, U. J. Griesser. (2013) Alogliptin and its benzoate salt, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 69, 674-678. http://dx.doi.org/10.1107/S0108270113012560

T. Gelbrich, V. Kahlenberg, U. J. Griesser. (2013) Alogliptin and its benzoate salt, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 69, 674-678. http://dx.doi.org/10.1107/S0108270113012560

T. Gelbrich, V. Kahlenberg, C. Langes, U. J. Griesser. (2013) Telaprevir: helical chains based on three-point hydrogen-bond connections, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 69, 179-182. (DOI)

T. Gelbrich, D. E. Braun, U. J. Griesser. (2013) Stable polymorph of morphine, Acta Crystallogr., Sect. E.: Struct Rep. Online 69, o2. (DOI

2012

T. Gelbrich, D. E. Braun, U. J. Griesser. (2012) Morphine hydrochloride anhydrate, Acta Crystallogr., Sect. E.: Struct Rep. Online 68, o3358-o3359. (DOI)

T. Gelbrich, T. L. Threlfall, M. B. Hursthouse. (2012) XPac dissimilarity parameters as quantitative descriptors of isostructurality: the case of fourteen 4,5'-substituted benzenesulfonamido-2-pyridines obtained by substituent interchange involving CF3/I/Br/Cl/F/Me/H CrystEngComm, 5454-5464. (DOI)

T. Gelbrich, T. L. Threlfall, M. B. Hursthouse. (2012) Eight isostructural 4,4'-disubstituted N-phenylbenzenesulfonamides, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 68, o421-o426. (DOI)

D. Rossi, T. Gelbrich, V. Kahlenberg, U. J. Griesser. (2012) Supramolecular constructs and thermodynamic stability of four polymorphs and a co-crystal of pentobarbital (nembutal), CrystEngComm 14, 2494-2506. (DOI)

T. Gelbrich, D. Rossi, U. J. Griesser. (2012) Two polymorphs and the diethylammonium salt of the barbiturate eldoral, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 68, o65-o70. (DOI)

T. Gelbrich, D. Rossi, U. J. Griesser. (2012) Tetragonal polymorph of 5,5-dichlorobarbituric acid, Acta Crystallogr., Sect. E.: Struct Rep. Online 68, o235-o236. (DOI)

S. J. Coles, S. H. Dale, M. R. J. Elsegood, K. G. Gaw, T. Gelbrich, M. B. Hursthouse, M. E. Light, T. A. Noble, M. B. Smith. (2012) Diverse Coordination Behaviour of Phosphorus(V)-Functionalised 6-Chloroaminobenzothiazole Anions at Various Metal Centres, Eur. J. Inorg. Chem., 859-865. (DOI)

2011

T. Gelbrich, D. Rossi, C. A. Häfele, U. J. Griesser. (2011) Barbiturates with hydrogen-bonded layer and framework structures, CrystEngComm 13, 5502-5509. (DOI)

B. Waltenberger, J. M. Rollinger, U. J. Griesser, H. Stuppner, T. Gelbrich. (2011) Plumeridoid C from the Amazonian traditional medicinal plant Himatanthus sucuuba, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 67, o409-o412. (DOI)

A. Abraham, D. C. Apperley, T. Gelbrich, R. K. Harris, U. J. Griesser. (2011) NMR crystallography — Three polymorphs of phenobarbital, Can. J. Chem. 89, 770-778. (DOI

T. Gelbrich, M. F. Haddow, U. J. Griesser. (2011) Benzylsulfamide, Acta Crystallogr., Sect. E.: Struct Rep. Online 67, o1551-o1552. (DOI

T. Gelbrich, M. F. Haddow, U. J. Griesser. (2011) Gliquidone, Acta Crystallogr., Sect. E.: Struct Rep. Online 67, o1343. (DOI)

D. S. Giera, L. Hennig, T. Gelbrich, C. Schneider. (2011) Synthesis and X-ray crystal structure analysis of 1,4-epoxy-4-methyl-1H,4H-2,3-benzodioxepin, Z. Naturforsch., B: J. Chem. Sci. 66, 419-424 (Weblink)

R. C. F. Jones, J. N. Iley, M. Sanchis-Amat, X. Zhang, V. McKee, S. J. Coles, T. Gelbrich. (2011) Imidazolium ylides from a conjugate addition-proton transfer route and their cycloaddition reactions, Chem. Commun. 47, 7965-7967. (DOI

G. Laus, M. Hummel, D. M. Többens, T. Gelbrich, V. Kahlenberg, K. Wurst, U. J. Griesser, H. Schottenberger. (2011) The 1 : 1 and 1 : 2 salts of 1,4-diazabicyclo[2.2.2]octane and bis(trifluoromethylsulfonyl)amine: thermal behaviour and polymorphism, CrystEngComm 13, 5439-5446. (DOI)

2010

N. Zencirci, T. Gelbrich, D. C. Apperley, R. K. Harris, V. Kahlenberg, U. J. Griesser. (2010) Structural Features, Phase Relationships and Transformation Behavior of the Polymorphs I-VI of Phenobarbital, Cryst. Growth Des. 10, 302-313. (DOI)

T. Gelbrich, N. Zencirci, U. J. Griesser. (2010) Hydrogen-bond motifs in N-monosubstituted derivatives of barbituric acid: 5-allyl-5-isopropyl-1-methylbarbituric acid (enallylpropymal) and 1,5-di(but-2-enyl)-5-ethylbarbituric acid, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 66, o55-o58. (DOI)

M. Hummel, G. Laus, A. Schwärzler, G. Bentivoglio, E. Rubatscher, H. Kopacka, K. Wurst, V. Kahlenberg, T. Gelbrich, U. J. Griesser, T. Röder, H. K. Weber, H. Schottenberger, H. Sixta. (2010) Non-Halide Ionic Liquids for Solvation, Extraction, and Processing of Cellulosic Materials, In Cellulose Solvents: For Analysis, Shaping and Chemical Modification, pp 229-259, American Chemical Society. (DOI)

T. Gelbrich, M. F. Haddow, U. J. Griesser. (2010) Polymorphic form II of 4,4 '-methylenebis(benzenesulfonamide), Acta Crystallogr., Sect. E.: Struct Rep. Online 66, O1619. (DOI)

T. Gelbrich, D. Rossi, U. J. Griesser. (2010) Butallylonal 1,4-dioxane hemisolvate, Acta Crystallogr., Sect. E.: Struct Rep. Online 66, o2688. (DOI)

T. Gelbrich, M. F. Haddow, U. J. Griesser. (2010) Polythiazide, Acta Crystallogr., Sect. E: Struct. Rep. Online 66, o1663-o1664. (DOI)

2009

N. Zencirci, T. Gelbrich, V. Kahlenberg, U. J. Griesser. (2009) Crystallization of Metastable Polymorphs of Phenobarbital by Isomorphic Seeding, Cryst. Growth Des. 9, 3444-3456. (DOI

F. P. A. Fabbiani, B. Dittrich, A. J. Florence, T. Gelbrich, M. B. Hursthouse, W. F. Kuhs, N. Shankland, H. Sowa. (2009) Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure, CrystEngComm 11, 1396-1406. (DOI)

S. J. Coles, T. Gelbrich, U. J. Griesser, M. B. Hursthouse, M. Pitak, T. Threlfall. (2009) The Elusive High Temperature Solid-State Structure of D,L-Norleucine, Cryst. Growth Des. 9, 4610-4612. (DOI)

D. E. Braun, T. Gelbrich, V. Kahlenberg, R. Tessadri, J. Wieser, U. J. Griesser. (2009) Stability of Solvates and Packing Systematics of Nine Crystal Forms of the Antipsychotic Drug Aripiprazole, Cryst. Growth Des. 9, 1054-1065. (DOI)

D. E. Braun, T. Gelbrich, V. Kahlenberg, R. Tessadri, J. Wieser, U. J. Griesser. (2009) Conformational Polymorphism in Aripiprazole: Preparation, Stability and Structure of Five Modifications, J. Pharm. Sci. 98, 2010-2026. (DOI)

A. Schwarzler, G. Laus, V. Kahlenberg, K. Wurst, T. Gelbrich, C. Kreutz, H. Kopacka, G. Bonn, H. Schottenberger. (2009) Quaternary 4-Amino-1,2,4-triazolium Salts: Crystal Structures of Ionic Liquids and N-Heterocyclic Carbene (NHC) Complexes, Z. Naturforsch., B: Chem. Sci. 64, 603-616. (Weblink

C. Langes, T. Gelbrich, U. J. Griesser, V. Kahlenberg. (2009) Codeine dihydrogen phosphate hemihydrate, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 65, o419-o422. (DOI)

M. J. Plater, P. Barnes, L. K. McDonald, S. Wallace, N. Archer, T. Gelbrich, P. N. Horton, M. B. Hursthouse. (2009) Hidden signatures: new reagents for developing latent fingerprints, Org. Biomol. Chem. 7, 1633-1641. (DOI)

2008

T. Gelbrich, D. S. Hughes, M. B. Hursthouse, T. L. Threlfall. (2008) Packing similarity in polymorphs of sulfathiazole, CrystEngComm 10, 1328-1334. (DOI)

A. J. Florence, C. T. Bedford, F. P. A. Fabbiani, K. Shankland, T. Gelbrich, M. B. Hursthouse, N. Shankland, A. Johnston, P. Fernandes. (2008) Two-dimensional similarity between forms I and II of cytenamide, a carbamazepine analogue, CrystEngComm 10, 811-813. (DOI)

D. E. Braun, T. Gelbrich, V. Kahlenberg, G. Laus, J. Wieser, U. J. Griesser. (2008) Packing polymorphism of a conformationally flexible molecule (aprepitant), New J. Chem. 32, 1677-1685. (DOI)

D. E. Braun, V. Kahlenberg, T. Gelbrich, J. Ludescher, U. J. Griesser. (2008) Solid state characterisation of four solvates of R-cinacalcet hydrochloride, CrystEngComm 10, 1617-1625. (DOI)

D. E. Braun, T. Gelbrich, R. K. R. Jetti, V. Kahlenberg, S. L. Price, U. J. Griesser. (2008) Colored polymorphs: Thermochemical and structural features of N-picryl-p-toluidine polymorphs and solvates, Cryst. Growth Des. 8, 1977-1989. (DOI)

M. F. Haddow, T. Gelbrich, U. J. Griesser. (2008) Similar sulfonamides with different crystal structures: sulfasymazine and sulfatriazine, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 64, o309-o312. (DOI)

A. J. Florence, K. Shankland, T. Gelbrich, M. B. Hursthouse, N. Shankland, A. Johnston, P. Fernandes, C. K. Leech. (2008) A catemer-to-dimer structural transformation in cyheptamide, CrystEngComm 10, 26-28. (DOI)

M. J. Plater, T. Gelbrich, M. B. Hursthouse, B. M. De Silva. (2008) Interpenetrating three-dimensional coordination networks with a rare 4-connected (6(5).8) topology and unusual geometrical features, CrystEngComm 10, 125-130. (DOI)

T. Gelbrich, A. L. Bingham, T. L. Threlfall, M. B. Hursthouse. (2008) delta-Sulfanilamide, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 64, o205-o207. (DOI

2007

T. Gelbrich, M. B. Hursthouse, T. L. Threlfall. (2007) Structural systematics of 4,4 '-disubstituted benzenesulfonamidobenzenes.
1. Overview and dimerbased isostructures, Acta Crystallogr., Sect. B: Struct. Sci. 63, 621-632. (DOI)

T. Gelbrich, T. L. Threlfall, A. L. Bingham, M. B. Hursthouse. (2007) Polymorph VI of sulfapyridine: interpenetrating two- and three-dimensional hydrogen-bonded nets formed from two tautomeric forms, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 63, o323-o326. (DOI

Gelbrich, N. Zencirci, U. J. Griesser. (2007) A polymorph of butobarbital with two distinct hydrogen-bonding motifs, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 63, o751-o753. (DOI)

T. L. Threlfall, T. Gelbrich. (2007) The crystal structure of methyl paraben at 118 K does not represent a new polymorph, Cryst. Growth Des. 7, 2297-2297. (DOI)

T. Gelbrich, M. F. Haddow, U. J. Griesser. (2007) Acemetacin monohydrate, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 63, o451-o453. (DOI

M. C. Aragoni, M. Arca, F. Demartin, F. A. Devillanova, T. Gelbrich, A. Garau, M. B. Hursthouse, F. Isaia, V. Lippolis. (2007) Charge-transfer adducts of N-methylthiazolidine-2-thione with IBr and I-2: An example of polymorphism featuring interpenetrating three-dimensional subcomponent assemblies and halogen center dot center dot center dot pi center dot center dot center dot halogen weak interactions, Cryst. Growth Des. 7, 1284-1290. (DOI

M. C. Aragoni, M. Arca, A. Bencini, A. J. Blake, C. Caltagirone, A. Danesi, F. A. Devillanova, A. Garau, T. Gelbrich, F. Isaia, V. Lippolis, M. B. Hursthouse, B. Valtancoli, C. Wilson. (2007) New fluorescent chemosensors for heavy metal ions based on functionalized pendant arm derivatives of 7-anthracenylmethyl-1,4,1 0-tri oxa-7,1 3-diazacyclopentadecane, Inorg.Chem. 46, 8088-8097. (DOI)

J. Wolf, W. Bohlmann, M. Findeisen, T. Gelbrich, H. J. Hofmann, B. Schulze. (2007) Synthesis of stable isothiazole carbenes, Angew. Chem. Int. Ed. 46, 3118-3121. (DOI

M. B. Smith, S. H. Dale, S. J. Coles, T. Gelbrich, M. B. Hursthouse, M. E. Light, P. N. Horton. (2007) Hydrogen bonded supramolecular assemblies based on neutral squareplanar palladium(II) complexes, CrystEngComm 9, 165-175. (DOI)

P. J. Skabara, A. Kanibolotsky, S. Render, R. Berridge, D. J. Crouch, N. Bricklebank, S. J. Coles, T. Gelbrich, M.B. Hursthouse. (2007) The role of functional nitro and cyano groups in the self-assembly of 1,3-dithiole-2-thione-halogen adducts, Heteroatom Chem. 18, 176-184. (DOI

R. B. Bedford, M. Betham, C. P. Butts, S. J. Coles, M. Cutajar, T. Gelbrich, M. B. Hursthouse, P. N. Scully, S. Wimperis. (2007) Five-coordinate Pd(II) orthometallated triarylphosphite complexes, Dalton Trans., 459-466. (DOI)

2006

T. Gelbrich, M. B. Hursthouse. (2006) Systematic investigation of the relationships between 25 crystal structures containing the carbamazepine molecule or a close analogue: a case study of the XPac method, CrystEngComm 8, 448-460. (DOI)

T. Gelbrich, T. L. Threlfall, S. Huth, E. Seeger. (2006) Structures of racemic lithium tartrate hydrates, Polyhedron 25, 937-944. (DOI) 10.1016/j.poly.2005.10.021

T. Gelbrich, T. L. Threlfall, M. B. Hursthouse. (2006) The anilinium chloride adduct of 4-bromo-N-phenylbenzenesulfonamide, Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 62, o470-o472. (DOI)

M. J. Plater, T. Gelbrich, M. B. Hursthouse, B. M. De Silva. (2006) Synthesis of co-ordination networks selecting from either (R, R), (S, S) and (R, S)-1,4- or -1,3-bis 2-(4-pyridyl)-2-methylethyl benzene and a discrete complex from 1,4-bis 2-(3-pyridyl)-2-methyl-cis-ethenyl) benzene, CrystEngComm 8, 895-903. (DOI)

M. J. Plater, B. De Silva, J. P. Sinclair, T. Gelbrich, M. B. Hursthouse. (2006) The first double helical coordination network with shared copper atoms, J. Mol. Struct. 784, 269-271. (DOI)

M. J. Plater, J. P. Sinclair, S. Kemp, T. Gelbrich, M. B. Hursthouse, C. J. Gomez-Garcia. (2006) New tetrahydro-1,2,4,5-tetrazinan-3-ones and oxoverdazyl free radicals, J. Chem. Res. (S), 515-520. http://docserver.ingentaconnect.com/deliver/connect/stl/03082342/v2006n8/s11.pdf

M. B. Smith, S. H. Dale, S. J. Coles, T. Gelbrich, M. B. Hursthouse, M. E. Light. (2006) Isomeric dinuclear gold(I) complexes with highly functionalised ditertiary phosphines: Self-assembly of dimers, rings and 1-D polymeric chains, CrystEngComm 8, 140-149. (DOI)

R. Venkateswarlu, C. Kamakshi, P. V. Subhash, S. G. A. Moinuddin, D. Rama Sekhara Reddy, R. S. Ward, A. Pelter, T. Gelbrich, M. B. Hursthouse, S. J. Coles, M. E. Light. (2006) Transformations of lignans. Part 11: Oxidation of diphyllin with hypervalent iodine reagents and reductive reactions of a resulting 1-methoxy-1-aryl-4-oxonaphthalene lactone, Tetrahedron 62, 4463-4473. (DOI)

2005

T. Gelbrich, M. B. Hursthouse. (2005) A versatile procedure for the identification, description and quantification of structural similarity in molecular crystals, CrystEngComm 7, 324-336. (DOI)

F. H. Fry, A. L. Holme, N. M. Giles, G. I. Giles, C. Collins, K. Holt, S. Pariagh, T. Gelbrich, M. B. Hursthouse, N. J. Gutowski, C. Jacob. (2005) Multifunctional redox catalysts as selective enhancers of oxidative stress, Org. Biomol. Chem. 3, 2579-2587. (DOI)

G. Kelly, F. Darviche, N. Robertson, T. Gelbrich, M. B. Hursthouse, D. A. Thomas, I. R. Butler. (2005) Directly-linked intramolecular donor-acceptor compounds of ferrocene and tetracyanoanthraquinodimethane, Inorg. Chem. Comm. 8, 874-877. (DOI