Veronika Temml, PhD
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Institut für Pharmazie, Abteilung Pharmakognosie
Publikationen 2017
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- PEDUTO, A.; SCUOTTO, M.; KRAUTH, V.; ROVIEZZO, F.; ROSSI, A.; TEMML, V.; ESPOSITO, V.; STUPPNER, H.; SCHUSTER, D.; D´AGOSTINO, B.; SCHIRALDI, C.; DE ROSA, M.; WERZ, O.; FILOSA, R. (2017): Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.
In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 127, S. 715 - 726. (DOI) (Weblink) - TEMML, V.; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D. (2017): Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.
In: Scientific Reports 7, No. 42751. (DOI) (Weblink) - VUORINEN, A.; ENGELI, RT.; LEUGGER, S.; BACHMANN, F.; AKRAM, M.; ATANASOV, AG.; WALTENBERGER, B.; TEMML, V.; STUPPNER, H.; KRENN, L.; ATEBA, SB.; NJAMEN, D.; DAVIS, RA.; ODERMATT, A.; SCHUSTER, D. (2017): Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.
In: Journal of Natural Products 80/4, S. 965 - 974. (DOI)
Beitrag in Proceedingsband (Abstract)
- TEMML, V.; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D. (2017): Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and solulble epoxide hydrolase using pharmacophore-based virtual screening.
In: Grasse, M.; Heinrichs, C. (Eds.): Abstract Book of the Life Science PhD Meeting, Innsbruck, 18.04. – 19.04.2017. Innsbruck: Eigenverlag - Universität Innsbruck / Innsbruck: Medizinische Universität Innsbruck, S. 79. (Weblink) - TEMML, V; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D (2017): Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and solulble epoxide hydrolase using pharmacophore-based virtual screening.
In: Stuppner, H.; Borchard, G.; Brenneisen, R.; Griesser, U.; Gstrein, E.: Book of Abstracts - Pharma2030 - Current and Future Challenges. A Joint Meeting of the Austrian Pharmaceutical Society (ÖPhG) and the Swiss Academy of Pharmaceutical Sciences (SAPhS), April 20-22, 2017. Innsbruck: Eigenverlag - Universität Innsbruck, S. 8.
Patente
Patent
- RICHOMME, P.; HELESBEUX, J-J.; GUILET, D.; SERAPHIN, D.; STUPPNER, H.; WALTENBERGER, B.; SCHUSTER, D.; TEMML, V.; KOEBERLE, A.; WERZ, O.: Preparation of tocotrienol derivatives, pharmaceutical composition and method of use in 5-lipoxygenase related diseases. World Intellectual Property Organization, WO/2017/032881 (2017).
Publikationen 2016
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- ALSABIL, K.; SUOR-CHERER, S.; KOEBERLE, A.; VIAULT, G.; LAVAUD, A.; TEMML, V.; WALTENBERGER, B.; SCHUSTER, D.; LITAUDON, M.; LORKOWSKI, S.; DE VAUMAS, R.; HELESBEUX, J-J.; GUILET, D.; STUPPNER, H.; WERZ, O.; SERAPHIN, D.; RICHOMME, P. (2016): Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.
In: Planta Medica 82/11/12, S. 1110 - 1116. (DOI) - SCHAIBLE, A.M.; FILOSA, R.; KRAUTH, V.; TEMML, V.; PACE, S.; GARSCHA, U.; LIENING, S.; WEINIGEL, C.; RUMMLER, S.; SCHIEFERDECKER, S.; NETT, M.; PEDUTO, A.; COLLARILE, S.; SCUOTTO, M.; ROVIEZZO, F.; SPAZIANO, G.; DE ROSA, M.; STUPPNER, H.; SCHUSTER, D.; D´AGOSTINO, B.; WERZ, O. (2016): The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.
In: Biochemical Pharmacology 112, S. 60 - 71. (DOI) - WALTENBERGER, B.; GARSCHA, U.; TEMML, V.; LIERS, J.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2016): Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening.
In: Journal of Chemical Information and Modeling 56/4, S. 747 - 762. (DOI) - Zatelli, G.A.; Temml, V.; Kutil, Z.; Landa, P.; Vanek, T.; Schuster, D.; Falkenberg, M. (2016): Miconidin Acetate and Primin as Potent 5-Lipoxygenase Inhibitors from Brazilian Eugenia hiemalis (Myrtaceae).
In: Planta Medica Letters 3/1, S. e17 - e19. (DOI)
Beitrag in Proceedingsband (Abstract)
- WALTENBERGER, B.; GARSCHA, U.; TEMML, V.; LIERS, J.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2016): Pharmacophore modeling and virtual screening for the discovery of potent soluble Epoxide hydrolase (sEH) inhibitors.
In: Hobmayer, Bert; Micura, Ronald; Striessnig, Jörg: Book of Abstracts - 6th CMBI Meeting. Gnadenwald, March 3-4, 2016. Innsbruck: Leopold-Franzens-Universität Innsbruck, S. 12. (Weblink)
Publikationen 2015
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- Kaserer, T.; Temml, V.; Kutil, Z.; Vanek, T.; Landa, P.; Schuster, D. (2015): Prospective performance evaluation of selected common virtual screening tools. Case study : Cyclooxygenase (COX) 1 and 2.
In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 96, S. 445 - 457. (DOI) (Weblink) - Kutil, Z.; Kvasnicova, M.; Temml, V.; Schuster, D.; Marsik, P.; Cusimamani, E.F.; Lou, J.D.; Vanek, T.; Landa, P. (2015): Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases Activities In Vitro.
In: INTERNATIONAL JOURNAL OF FOOD PROPERTIES 18/7, S. 1471 - 1477. (DOI) (Weblink) - Kutil, Z.; Kvasnicova, M.; Temml, V.; Schuster, D.; Vanek, T.; Fernandez, E.; Malik, J.; Landa, P. (2015): The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro.
In: FOOD AND AGRICULTURAL IMMUNOLOGY 26/4, S. 504 - 511. (DOI) (Weblink) - SEEBACHER, W.; FAIST, J.; PRESSER, A.; WEIS, R.; SAF, R.; KASERER, T.; TEMML, V.; SCHUSTER, D.; ORTMANN, S.; OTTO, N.; BAUER, R. (2015): Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2.
In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 101, S. 552 - 559. (DOI)
Zeitschriftenaufsatz (Review)
- ATANASOV, A.G.; WALTENBERGER, B.; PFERSCHY-WENZIG, E.M.; LINDER, T.; WAWROSCH, C.; UHRIN, P.; TEMML, V.; WANG, L.; SCHWAIGER, S.; HEISS, E.H.; ROLLINGER, J.M.; SCHUSTER, D.; BREUSS, J.M.; BOCHKOV, V.; MIHOVILOVIC, M.D.; KOPP, B.; BAUER, R.; DIRSCH, V.M.; STUPPNER, H. (2015): Discovery and resupply of pharmacologically active plant-derived natural products: A review.
In: BIOTECHNOLOGY ADVANCES 33/8, S. 1582 - 1614. (DOI) (Weblink)
Zeitschriftenbeitrag (Meeting-Abstract)
- ZATELLI, GA.; TEMML, V.; KUTIL, Z.; LANDA, P.; VANEK, T.; FALKENBERG, M.; SCHUSTER, D. (2015): Miconidin acetate, a natural 5-lipoxygenase (5-LOX) inhibitor from Eugenia hiemalis Camb. (Myrtaceae).
In: Planta Medica 81/16, S. 1441. (DOI)
Publikationen 2014
Beiträge in Büchern / Zeitschriften
Beitrag in Proceedingsband (Abstract)
- KASERER, T.; TEMML, V.; KUTIL, Z.; MÜLLER, K.; ELMER, S.; GANZERA, M.; LANDA, P.; SCHUSTER, D. (2014): Performance evaluation of common virtual screening tools on selected representatives of different target classes.
In: Book of Abstracts - 6th Life Science Meeting. Innsbruck: Eigenverlag - Universität Innsbruck, S. 19. - TEMML, V.; KASERER, T.; STEFANOVIC, I.; VON GRAFENSTEIN, S.; FUCHS, J.E.; LIEDL, K.R.; SCHUSTER, D. (2014): Natural products interacting with 5-lipoxygenase –but how and where?
In: Book of Abstracts - International Symposium "Natural Products and Drug Discovery - Future Perspectives". Innsbruck: Eigenverlag - Universität Innsbruck. - WALTENBERGER, B.; LIERS, J.; TEMML, V.; GARSCHA, U.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2014): Identification of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore modeling and virtual screening.
In: Book of Abstracts - 23rd Scientific Congress of the Austrian Pharmaceutical Society. Graz: Karl-Franzens Universität Graz, S. 33. - WALTENBERGER, B.; LIERS, J.; TEMML, V.; GARSCHA, U.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2014): Pharmacophore Modeling and Virtual Screening for Soluble Epoxide Hydrolase (sEH) Inhibitors.
In: Book of Abstracts - International Symposium "Natural Products and Drug Discovery - Future Perspectives". Innsbruck: Eigenverlag - Universität Innsbruck.
Publikationen 2013
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- Kuehnl, S.; Schroecksnadel, S.; Temml, V.; Gostner, J.M.; Schennach, H.; Schuster, D.; Schwaiger, S.; Rollinger, J.M.; Fuchs, D.; Stuppner, H. (2013): Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.
In: PHYTOMEDICINE 20/13, S. 1190 - 1195. (DOI) - Temml, Veronika; Kuehnl, S.; Schuster, Daniela; Schwaiger, Stefan; Stuppner, Herrmann; Fuchs, D. (2013): Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.
In: FEBS Open Bio 3, S. 450 - 452. (DOI) (Weblink)
Beitrag in Proceedingsband (Abstract)
- KASERER, T.; LAZIC, M.; TEMML, V.; SCHWAIGER, S.; STUPPNER, H.; SCHUSTER, D. (2013): Application of in silico profiling tools for the prediction and rationalization of natural product biological activities.
In: Trends in natural products research: a young scientists meeting of PSE and ÖPhG. Book of Abstracts. Leicester: Phytochemical Society of Europe, ISBN 978-0-9565472-3-1, S. 33. - TEMML, V.; WINEKENSTÄDDE, D.; VOSS, C.; ROLLINGER, J. M.; STUPPNER, H.; DIRSCH, V.; SCHUSTER, D (2013): Identification of new LXR-ß modulators by in silico screening and biological evaluation.
In: Trends in natural products research: a young scientists meeting of PSE and ÖPhG. Book of Abstracts. Leicester: Phytochemical Society of Europe, ISBN 978-0-9565472-3-1, S. 32.
Institut für Pharmazie, Abteilung Pharmazeutische Chemie
Publikationen 2017
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- Beck, K.R.; Bächler, M.; Vuorinen, A.; Wagner, S.; Akram, M.; Griesser, U.; Temml, V.; Klusonova, P.; Yamaguchi, H.; Schuster, D.; Odermatt, A. (2017): Inhibition of 11β-hydoxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole.
In: Biochemical Pharmacology 130, S. 93 - 103. (DOI) - Garscha, U.; Romp, E.; Pace, S.; Rossi, A.; Temml, V.; Schuster, D.; König, S.; Gerstmeier, J.; Liening, S.; Werner, M.; Atze, H.; Wittmann, S.; Weinigel, C.; Rummler, S.; Scriba, G.K.; Sautebin, L.; Werz, O. (2017): Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.
In: Scientific Reports 7, No. 9398. (DOI) (Weblink) - Hanáková, Z.; Hošek, J.; Kutil, Z.; Temml, V.; Landa, P.; Vanek, T.; Schuster, D.; Dall’Acqua, S.; Cvačka, J.; Polansky, O.; Šmejkal, K. (2017): Anti-inflammatory activity of natural geranylated flavonoids: cyclooxygenase and lipoxygenase inhibitory properties and proteomic analysis.
In: Journal of Natural Products 80/4, S. 999 - 1006. (DOI) (Weblink) - PEDUTO, A.; SCUOTTO, M.; KRAUTH, V.; ROVIEZZO, F.; ROSSI, A.; TEMML, V.; ESPOSITO, V.; STUPPNER, H.; SCHUSTER, D.; D´AGOSTINO, B.; SCHIRALDI, C.; DE ROSA, M.; WERZ, O.; FILOSA, R. (2017): Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.
In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 127, S. 715 - 726. (DOI) (Weblink) - TEMML, V.; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D. (2017): Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.
In: Scientific Reports 7, No. 42751. (DOI) (Weblink) - VUORINEN, A.; ENGELI, RT.; LEUGGER, S.; BACHMANN, F.; AKRAM, M.; ATANASOV, AG.; WALTENBERGER, B.; TEMML, V.; STUPPNER, H.; KRENN, L.; ATEBA, SB.; NJAMEN, D.; DAVIS, RA.; ODERMATT, A.; SCHUSTER, D. (2017): Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.
In: Journal of Natural Products 80/4, S. 965 - 974. (DOI)
Beitrag in Proceedingsband (Abstract)
- TEMML, V.; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D. (2017): Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and solulble epoxide hydrolase using pharmacophore-based virtual screening.
In: Grasse, M.; Heinrichs, C. (Eds.): Abstract Book of the Life Science PhD Meeting, Innsbruck, 18.04. – 19.04.2017. Innsbruck: Eigenverlag - Universität Innsbruck / Innsbruck: Medizinische Universität Innsbruck, S. 79. (Weblink) - TEMML, V; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D (2017): Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and solulble epoxide hydrolase using pharmacophore-based virtual screening.
In: Stuppner, H.; Borchard, G.; Brenneisen, R.; Griesser, U.; Gstrein, E.: Book of Abstracts - Pharma2030 - Current and Future Challenges. A Joint Meeting of the Austrian Pharmaceutical Society (ÖPhG) and the Swiss Academy of Pharmaceutical Sciences (SAPhS), April 20-22, 2017. Innsbruck: Eigenverlag - Universität Innsbruck, S. 8.
Patente
Patent
- RICHOMME, P.; HELESBEUX, J-J.; GUILET, D.; SERAPHIN, D.; STUPPNER, H.; WALTENBERGER, B.; SCHUSTER, D.; TEMML, V.; KOEBERLE, A.; WERZ, O.: Preparation of tocotrienol derivatives, pharmaceutical composition and method of use in 5-lipoxygenase related diseases. World Intellectual Property Organization, WO/2017/032881 (2017).
Publikationen 2016
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- ALSABIL, K.; SUOR-CHERER, S.; KOEBERLE, A.; VIAULT, G.; LAVAUD, A.; TEMML, V.; WALTENBERGER, B.; SCHUSTER, D.; LITAUDON, M.; LORKOWSKI, S.; DE VAUMAS, R.; HELESBEUX, J-J.; GUILET, D.; STUPPNER, H.; WERZ, O.; SERAPHIN, D.; RICHOMME, P. (2016): Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.
In: Planta Medica 82/11/12, S. 1110 - 1116. (DOI) - SCHAIBLE, A.M.; FILOSA, R.; KRAUTH, V.; TEMML, V.; PACE, S.; GARSCHA, U.; LIENING, S.; WEINIGEL, C.; RUMMLER, S.; SCHIEFERDECKER, S.; NETT, M.; PEDUTO, A.; COLLARILE, S.; SCUOTTO, M.; ROVIEZZO, F.; SPAZIANO, G.; DE ROSA, M.; STUPPNER, H.; SCHUSTER, D.; D´AGOSTINO, B.; WERZ, O. (2016): The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.
In: Biochemical Pharmacology 112, S. 60 - 71. (DOI) - WALTENBERGER, B.; GARSCHA, U.; TEMML, V.; LIERS, J.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2016): Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening.
In: Journal of Chemical Information and Modeling 56/4, S. 747 - 762. (DOI) - Zatelli, G.A.; Temml, V.; Kutil, Z.; Landa, P.; Vanek, T.; Schuster, D.; Falkenberg, M. (2016): Miconidin Acetate and Primin as Potent 5-Lipoxygenase Inhibitors from Brazilian Eugenia hiemalis (Myrtaceae).
In: Planta Medica Letters 3/1, S. e17 - e19. (DOI)
Beitrag in Proceedingsband (Abstract)
- WALTENBERGER, B.; GARSCHA, U.; TEMML, V.; LIERS, J.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2016): Pharmacophore modeling and virtual screening for the discovery of potent soluble Epoxide hydrolase (sEH) inhibitors.
In: Hobmayer, Bert; Micura, Ronald; Striessnig, Jörg: Book of Abstracts - 6th CMBI Meeting. Gnadenwald, March 3-4, 2016. Innsbruck: Leopold-Franzens-Universität Innsbruck, S. 12. (Weblink)
Publikationen 2015
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- Kaserer, T.; Temml, V.; Kutil, Z.; Vanek, T.; Landa, P.; Schuster, D. (2015): Prospective performance evaluation of selected common virtual screening tools. Case study : Cyclooxygenase (COX) 1 and 2.
In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 96, S. 445 - 457. (DOI) (Weblink) - Kutil, Z.; Kvasnicova, M.; Temml, V.; Schuster, D.; Marsik, P.; Cusimamani, E.F.; Lou, J.D.; Vanek, T.; Landa, P. (2015): Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases Activities In Vitro.
In: INTERNATIONAL JOURNAL OF FOOD PROPERTIES 18/7, S. 1471 - 1477. (DOI) (Weblink) - Kutil, Z.; Kvasnicova, M.; Temml, V.; Schuster, D.; Vanek, T.; Fernandez, E.; Malik, J.; Landa, P. (2015): The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro.
In: FOOD AND AGRICULTURAL IMMUNOLOGY 26/4, S. 504 - 511. (DOI) (Weblink) - SEEBACHER, W.; FAIST, J.; PRESSER, A.; WEIS, R.; SAF, R.; KASERER, T.; TEMML, V.; SCHUSTER, D.; ORTMANN, S.; OTTO, N.; BAUER, R. (2015): Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2.
In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 101, S. 552 - 559. (DOI)
Zeitschriftenaufsatz (Review)
- ATANASOV, A.G.; WALTENBERGER, B.; PFERSCHY-WENZIG, E.M.; LINDER, T.; WAWROSCH, C.; UHRIN, P.; TEMML, V.; WANG, L.; SCHWAIGER, S.; HEISS, E.H.; ROLLINGER, J.M.; SCHUSTER, D.; BREUSS, J.M.; BOCHKOV, V.; MIHOVILOVIC, M.D.; KOPP, B.; BAUER, R.; DIRSCH, V.M.; STUPPNER, H. (2015): Discovery and resupply of pharmacologically active plant-derived natural products: A review.
In: BIOTECHNOLOGY ADVANCES 33/8, S. 1582 - 1614. (DOI) (Weblink)
Zeitschriftenbeitrag (Meeting-Abstract)
- Koeberle, A.; Waltenberger, B.; Temml, V.; Schuster, D.; Sautebin, L.; Stuppner, H.; Richomme, P.; Werz, O. (2015): Vitamin E metabolites as potent inhibitors of 5-lipoxygenase.
In: Naunyn-Schmiedeberg's Archives of Pharmacology 338/Supp. 1, S. 26. (DOI) (Weblink) - ZATELLI, GA.; TEMML, V.; KUTIL, Z.; LANDA, P.; VANEK, T.; FALKENBERG, M.; SCHUSTER, D. (2015): Miconidin acetate, a natural 5-lipoxygenase (5-LOX) inhibitor from Eugenia hiemalis Camb. (Myrtaceae).
In: Planta Medica 81/16, S. 1441. (DOI)
Patente
Patent
- Richomme, P.; Helesbeux, J.J.; Guilet, D.; Seraphin, D.; Stuppner, H.; Waltenberger, B.; Schuster, D.; Temml, V.S.; Koeberle, A.; Werz, O.: Tocotrienol derivatives, pharmaceutical composition and method of use in chronic airway inflammatory disorders. European Patent Office, 15182827.4 – 1462, 20.11.2015 (2015).
Publikationen 2014
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- Kutil, Z.; Temml, V.; Maghradze, D.; Pribylova, M.; Dvorakova, M.; Schuster, D.; Vanek, T.; Landa, P. (2014): Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity.
In: MEDIATORS OF INFLAMMATION 2014, ID 178931. (Weblink) - Temml, Veronika; Kaserer, Teresa; Kutil, Zsofia; Landa, Premysl; Vanek, Tomas; Schuster, Daniela (2014): Pharmacophore modeling for COX-1 and -2 inhibitors with LigandScout in comparison to Discovery Studio.
In: Future Medicinal Chemistry 6/17, S. 1869 - 1881. (Weblink)
Beitrag in Proceedingsband (Abstract)
- KASERER, T.; TEMML, V.; KUTIL, Z.; MÜLLER, K.; ELMER, S.; GANZERA, M.; LANDA, P.; SCHUSTER, D. (2014): Performance evaluation of common virtual screening tools on selected representatives of different target classes.
In: Book of Abstracts - 6th Life Science Meeting. Innsbruck: Eigenverlag - Universität Innsbruck, S. 19. - TEMML, V.; KASERER, T.; STEFANOVIC, I.; VON GRAFENSTEIN, S.; FUCHS, J.E.; LIEDL, K.R.; SCHUSTER, D. (2014): Natural products interacting with 5-lipoxygenase –but how and where?
In: Book of Abstracts - International Symposium "Natural Products and Drug Discovery - Future Perspectives". Innsbruck: Eigenverlag - Universität Innsbruck. - WALTENBERGER, B.; LIERS, J.; TEMML, V.; GARSCHA, U.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2014): Identification of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore modeling and virtual screening.
In: Book of Abstracts - 23rd Scientific Congress of the Austrian Pharmaceutical Society. Graz: Karl-Franzens Universität Graz, S. 33. - WALTENBERGER, B.; LIERS, J.; TEMML, V.; GARSCHA, U.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2014): Pharmacophore Modeling and Virtual Screening for Soluble Epoxide Hydrolase (sEH) Inhibitors.
In: Book of Abstracts - International Symposium "Natural Products and Drug Discovery - Future Perspectives". Innsbruck: Eigenverlag - Universität Innsbruck.
Publikationen 2013
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- Kuehnl, S.; Schroecksnadel, S.; Temml, V.; Gostner, J.M.; Schennach, H.; Schuster, D.; Schwaiger, S.; Rollinger, J.M.; Fuchs, D.; Stuppner, H. (2013): Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.
In: PHYTOMEDICINE 20/13, S. 1190 - 1195. (DOI) - Landa, P.; Kutil, Z.; Temml, V.; Malik, J.; Kokoska, L.; Widowitz, U.; Pribylova, M.; Dvorakova, M.; Marsik, P.; Schuster, D.; Bauer, R.; Vanek, T. (2013): Inhibition of in vitro leukotriene B4 biosynthesis in human neutrophil granulocytes and docking studies of natural quinones.
In: Natural Product Communications 8/1, S. 105 - 108. (Weblink) - Schaible, A. M.; Traber, H.; Temml, V.; Noha, S. M.; Filosa, R.; Peduto, A.; Weinigel, C.; Barz, D.; Schuster, D.; Werz, O. (2013): Potent inhibition of 5-lipoxygenase and liposomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.
In: Biochemical Pharmacology 86/4, S. 476 - 486. (DOI) (Weblink) - Temml, Veronika; Kuehnl, S.; Schuster, Daniela; Schwaiger, Stefan; Stuppner, Herrmann; Fuchs, D. (2013): Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.
In: FEBS Open Bio 3, S. 450 - 452. (DOI) (Weblink)
Beitrag in Proceedingsband (Abstract)
- KASERER, T.; LAZIC, M.; TEMML, V.; SCHWAIGER, S.; STUPPNER, H.; SCHUSTER, D. (2013): Application of in silico profiling tools for the prediction and rationalization of natural product biological activities.
In: Trends in natural products research: a young scientists meeting of PSE and ÖPhG. Book of Abstracts. Leicester: Phytochemical Society of Europe, ISBN 978-0-9565472-3-1, S. 33. - TEMML, V.; WINEKENSTÄDDE, D.; VOSS, C.; ROLLINGER, J. M.; STUPPNER, H.; DIRSCH, V.; SCHUSTER, D (2013): Identification of new LXR-ß modulators by in silico screening and biological evaluation.
In: Trends in natural products research: a young scientists meeting of PSE and ÖPhG. Book of Abstracts. Leicester: Phytochemical Society of Europe, ISBN 978-0-9565472-3-1, S. 32.
Publikationen 2012
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- Landa, P.; Kutil, Z.; Temml, V.; Vuorinen, A.; Malik, J.; Dvorakova, M.; Marsik, P.; Kokoska, L.; Pribylova, M.; Schuster, D.; Vanek, T. (2012): Redox and Non-Redox Mechanism of In Vitro Cyclooxygenase Inhibition by Natural Quinones.
In: Planta Medica 78/4, S. 326 - 333. (DOI)
Institut für Pharmazie, Abteilung Pharmazeutische Technologie
Publikationen 2017
Beiträge in Büchern / Zeitschriften
Zeitschriftenaufsatz (Originalarbeit)
- Beck, K.R.; Bächler, M.; Vuorinen, A.; Wagner, S.; Akram, M.; Griesser, U.; Temml, V.; Klusonova, P.; Yamaguchi, H.; Schuster, D.; Odermatt, A. (2017): Inhibition of 11β-hydoxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole.
In: Biochemical Pharmacology 130, S. 93 - 103. (DOI)
Posters |
12) Computational binding mode prediction of natural and synthetic tocotrienols as inhibitors of 5-lipoxygenase. Temml, V.; Koeberle, A.; Garscha, U.; Helesbeux, J.-J.; Waltenberger, B.; Seraphin, D.; Richomme, P.; Stuppner, H.; Werz, O.; Schuster, D. First Austrian Summit on Natural Products. 14.-16.1.2018, Seefeld, Austria 11) Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Temml, V.; Garscha, U.; Romp, E.; Schubert, G.; Gerstmeier, J.; Kutil, Z.; Matuszczak, B.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D. Life Science PhD Meeting Innsbruck 2017, 18.-19.4.2017, Innsbruck, Austria 10) Design, synthesis and structure-activity relationship of N-phenylbenzenesulfonamides as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors. Cheung, S.Y.; Hanke, T.; Werner, M.; Pace, S.; Cantone, V.; Fischer, K.; Listing, M.; Temml, V.; Schuster, D.; Werz, O.; Schubert-Zsilavecz, M. Annual Meeting of the German Pharmaceutical Society (DPhG), Sep 23-25, 2015, Düsseldorf, Germany 9) Miconidin acetate, a natural 5-lipoxygenase (5-LOX) inhibitor from Eugenia hiemalis Camb. (Myrtaceae). Zatelli, G.; Temml, V.; Kutil, Z.; Landa, P.; Vanek, T.; Falkenberg, M.; Schuster, D. 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Aug 23-27, 2015, Budapest, Hungary 8) Pharmacophore modeling and virtual screening for soluble epoxide hydrolase (sEH) inhibitors. Waltenberger, B.; Liers, J.; Temml, V.; Garscha, U.; Werz, O.; Schuster, D.; Stuppner, H. International Symposium: Natural Products and Drug Discovery - Future Perspectives, Nov 13-14, 2014, Vienna, Austria 7) Search for new dual inhibitors of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase with pharmacophore modeling. Temml, V.; Kutil, Z.; Romp, E.; Garscha, U.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D. 20th EuroQSAR. Understanding Chemical-Biological Interactions. Aug 31-Sep 4, 2014, St. Petersburg, Russia 6) Identification and investigation of novel LXR modulators. Voss, C.; Winekenstädde, D.; Temml, V.; Schuster, D.; Rollinger, J.M.; Stuppner, H.; Dirsch, V. Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction, Apr 3-8, 2013, Alpbach, Austria 5) Prospective performance evaluation of different virtual screening tools for COX-activity prediction. Kaserer, T.; Temml, V.; Landa, P.; Schuster, D. 19th Euro QSAR, Aug 26-30, 2012, Vienna, Austria and 4th Life Science Meeting Innsbruck Universities, Sep 27-28, 2012, Igls, Austria 4) Inhibition modes of quinone compounds on 5-lipoxygenase. Temml, V.; Kutil, Z.; Landa, P.; Schuster, D. 19th Euro QSAR, Aug 26-30, 2012, Vienna, Austria and 4th Life Science Meeting Innsbruck Universities, Sep 27-28, 2012, Igls, Austria 3) Pharmacophore modeling of cyclooxygenase-2 in LigandScout and Discovery Studio - a comparison. Temml, V.; Kutil, Z.; Landa, P.; Schuster, D.; 26th Molecular Modelling Workshop, March 12-14, 2012, Erlangen, Germany 2) Finding and analyzing the binding mode of new cyclooxygenase inhibitors with pharmacophore modeling. Temml, V.S.; Kutil, Z.; Landa, P.; Malik, J.; Dvorakova, M.; Marsik, P.; Kokoska, L.; Pribylova, M.; Vanek, T.; Schuster, D. Joint Meeting of the Austrian and German Pharmaceutical Societies 2011, September 20-23, 2011, Innsbruck, Austria and 3rd Lifescience_Meeting Innsbruck Universities, September 23-24, 2011, Igls, Austria 1) In vitro cyclooxygenase inhibition by natural quinones and possible mechanism of their action. Kutil, Z.; Temml, V.; Landa, P.; Malik, J.; Kokoska, L.; Marsik, P.; Schuster, D.; Vanek, T.; Dvorakova, M. PharmSciFair, June 13-17, 2011, Prague, Czech Republic |
Short Lectures |
3) Discovery of the first dual inhibitor of 5-Lipogenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Temml, V.S.; Garscha, U.; Romp, E.; Schubert, G.; Gerstmeier, J.; Kutil, J.; Matuszczak, B.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D., Pharma 2030 - Current and Future Challenges (ÖPhG), University of Innsbruck, Austria, 20-22.4.2017 2) Identification of new LXR-β modulators by in-silico screening and biological evaluation. Temml, V.S.; Winekenstädde, D.; Voss, C.; Rollinger, J.M.; Stuppner, H.; Dirsch, V.; Schuster, D. Trends in Natural Products research (ÖPhG), Jul 24, 2014, Obergurgl, Austria 1) New perspectives on a classic inflammation target: Computational analysis of 5-lipoxygenase inhibition. Temml, V.S.; Kaserer, T.; Stefanovic, I.; von Grafenstein, S.; Fuchs, J.E.; Liedl, K.R.; Schuster, D. 23rd Scientific Congress of the Austrian Pharmaceutical Society (ÖPhG), Apr 24, 2014, Graz, Austria |
Invited Talks |
2) Interaction of Carthamus tinctorius lignin arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Schuster, D.; Temml, V.; Kühnl, S.; Schwaiger, S.; Stuppner, H.; Fuchs, D. 33rd International Winter-Workshop, Clinical, Chemical and Biochemical Aspects of Pteridines and Related Topics, Innsbruck, Austria, Feb 25, 2014 1) Molecular modeling of 5-lipoxygenase inhibitors. Temml, V.; Kutil, Z.; Landa, P.; Schuster, D. Institute Seminar at the University of Jena, Institute of Pharmaceutical Chemistry, Jena, Germany, February 20, 2012 |
PhD thesis | Molecular modeling and computational investigation of targets within the inflammatory cascade |
Master Thesis | Chemical synthesis of chromophore-DNA conjugates and their application as substrates for in-vitro selection of phosphodiesterase deoxyribozymes |