Veronika Temml, PhD


CONTACT:

address:

 

email:

phone:

fax:

Innrain 80/82,

A-6020 Innsbruck

Veronika.Temml@uibk.ac.at

+43-512-507-58419

+43-512-507-58299

 

Temml
Research Interests
  • Virtual screening of natural products with pharmacophore models and molecular docking
  • Computational analysis and modeling of inflammation related targets with a special focus on asthma
  • Application and optimized use of computational methods for drug discovery and lead optimization
Current pROJECT New ways to counter inflammation - Computer aided discovery of multi-target anti-inflammatory natural products
 

 

PUBLICATIONS:


Institut für Pharmazie, Abteilung Pharmakognosie

Publikationen 2018

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Cheung, SY.; Werner, M.; Esposito, L.; Troisi, F.; Cantone, V.; Liening, S.; König, S.; Gerstmeier, J.; Koeberle, A.; Bilancia, R.; Rizza, R.; Rossi, A.; Roviezzo, F.; Temml, V.; Schuster, D.; Stuppner, H.; Schubert-Zsilavecz, M.; Werz, O.; Hanke, T.; Pace, S. (2018): Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.
    In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 156, S. 815 - 830. (DOI)

  • PEIN, H.; VILLE, A.; PACE, S.; TEMML, V.; GARSCHA, U.; RAASCH, M.; ALSABIL, K.; VIAULT, G.; DINH, C.-P.; GUILET, D.; TROISI, F.; NEUKIRCH, K.; KÖNIG, S.; BILANCIA, R.; WALTENBERGER, B.; STUPPNER, H.; WALLERT, M.; LORKOWSKI, S.; WEINIGEL, C.; RUMMLER, S.; BIRRINGER, M.; ROVIEZZO, F.; SAUTEBIN, L.; HELESBEUX, J.-J.; SERAPHIN, D.; MOSIG, A.S.; SCHUSTER, D.; ROSSI, A.; RICHOMME, P.; WERZ, O.; KOEBERLE, A. (2018): Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.
    In: Nature Communications, S. 1 - 17. (DOI)

Patente

Patent
  • SCHUSTER, D.; TEMML, V.; KUTIL, Z.; MATUSZCZAK, B.; WERZ, O.; GARSCHA, U.; WALTENBERGER, B.; STUPPNER, H.: N,n' -diarylurea, n,n' -diarylthiourea and n,n' -diarylguanidino compounds for use in treatment and prevention of inflammatory disease. European Patent Office, EP 3315495 A1 20180502 (2018). (Weblink)

Publikationen 2017

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • PEDUTO, A.; SCUOTTO, M.; KRAUTH, V.; ROVIEZZO, F.; ROSSI, A.; TEMML, V.; ESPOSITO, V.; STUPPNER, H.; SCHUSTER, D.; D´AGOSTINO, B.; SCHIRALDI, C.; DE ROSA, M.; WERZ, O.; FILOSA, R. (2017): Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.
    In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 127, S. 715 - 726. (DOI) (Weblink)

  • TEMML, V.; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D. (2017): Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.
    In: Scientific Reports 7, No. 42751. (DOI) (Weblink)

  • VUORINEN, A.; ENGELI, RT.; LEUGGER, S.; BACHMANN, F.; AKRAM, M.; ATANASOV, AG.; WALTENBERGER, B.; TEMML, V.; STUPPNER, H.; KRENN, L.; ATEBA, SB.; NJAMEN, D.; DAVIS, RA.; ODERMATT, A.; SCHUSTER, D. (2017): Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.
    In: Journal of Natural Products 80/4, S. 965 - 974. (DOI)

Beitrag in Proceedingsband (Abstract)
  • TEMML, V.; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D. (2017): Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and solulble epoxide hydrolase using pharmacophore-based virtual screening.
    In: Grasse, M.; Heinrichs, C. (Eds.): Abstract Book of the Life Science PhD Meeting, Innsbruck, 18.04. – 19.04.2017. Innsbruck: Eigenverlag - Universität Innsbruck / Innsbruck: Medizinische Universität Innsbruck, S. 79. (Weblink)

  • TEMML, V; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D (2017): Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and solulble epoxide hydrolase using pharmacophore-based virtual screening.
    In: Stuppner, H.; Borchard, G.; Brenneisen, R.; Griesser, U.; Gstrein, E.: Book of Abstracts - Pharma2030 - Current and Future Challenges. A Joint Meeting of the Austrian Pharmaceutical Society (ÖPhG) and the Swiss Academy of Pharmaceutical Sciences (SAPhS), April 20-22, 2017. Innsbruck: Eigenverlag - Universität Innsbruck, S. 8.

Patente

Patent
  • RICHOMME, P.; HELESBEUX, J-J.; GUILET, D.; SERAPHIN, D.; STUPPNER, H.; WALTENBERGER, B.; SCHUSTER, D.; TEMML, V.; KOEBERLE, A.; WERZ, O.: Preparation of tocotrienol derivatives, pharmaceutical composition and method of use in 5-​lipoxygenase related diseases. World Intellectual Property Organization, WO/2017/032881 (2017).

Publikationen 2016

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • ALSABIL, K.; SUOR-CHERER, S.; KOEBERLE, A.; VIAULT, G.; LAVAUD, A.; TEMML, V.; WALTENBERGER, B.; SCHUSTER, D.; LITAUDON, M.; LORKOWSKI, S.; DE VAUMAS, R.; HELESBEUX, J-J.; GUILET, D.; STUPPNER, H.; WERZ, O.; SERAPHIN, D.; RICHOMME, P. (2016): Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.
    In: Planta Medica 82/11/12, S. 1110 - 1116. (DOI)

  • SCHAIBLE, A.M.; FILOSA, R.; KRAUTH, V.; TEMML, V.; PACE, S.; GARSCHA, U.; LIENING, S.; WEINIGEL, C.; RUMMLER, S.; SCHIEFERDECKER, S.; NETT, M.; PEDUTO, A.; COLLARILE, S.; SCUOTTO, M.; ROVIEZZO, F.; SPAZIANO, G.; DE ROSA, M.; STUPPNER, H.; SCHUSTER, D.; D´AGOSTINO, B.; WERZ, O. (2016): The 5-​lipoxygenase inhibitor RF-​22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.
    In: Biochemical Pharmacology 112, S. 60 - 71. (DOI)

  • WALTENBERGER, B.; GARSCHA, U.; TEMML, V.; LIERS, J.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2016): Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening.
    In: Journal of Chemical Information and Modeling 56/4, S. 747 - 762. (DOI)

  • Zatelli, G.A.; Temml, V.; Kutil, Z.; Landa, P.; Vanek, T.; Schuster, D.; Falkenberg, M. (2016): Miconidin Acetate and Primin as Potent 5-Lipoxygenase Inhibitors from Brazilian Eugenia hiemalis (Myrtaceae).
    In: Planta Medica Letters 3/1, S. e17 - e19. (DOI)

Beitrag in Proceedingsband (Abstract)
  • WALTENBERGER, B.; GARSCHA, U.; TEMML, V.; LIERS, J.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2016): Pharmacophore modeling and virtual screening for the discovery of potent soluble Epoxide hydrolase (sEH) inhibitors.
    In: Hobmayer, Bert; Micura, Ronald; Striessnig, Jörg: Book of Abstracts - 6th CMBI Meeting. Gnadenwald, March 3-4, 2016. Innsbruck: Leopold-Franzens-Universität Innsbruck, S. 12. (Weblink)

Publikationen 2015

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Kaserer, T.; Temml, V.; Kutil, Z.; Vanek, T.; Landa, P.; Schuster, D. (2015): Prospective performance evaluation of selected common virtual screening tools. Case study : Cyclooxygenase (COX) 1 and 2.
    In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 96, S. 445 - 457. (DOI) (Weblink)

  • Kutil, Z.; Kvasnicova, M.; Temml, V.; Schuster, D.; Marsik, P.; Cusimamani, E.F.; Lou, J.D.; Vanek, T.; Landa, P. (2015): Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases Activities In Vitro.
    In: INTERNATIONAL JOURNAL OF FOOD PROPERTIES 18/7, S. 1471 - 1477. (DOI) (Weblink)

  • Kutil, Z.; Kvasnicova, M.; Temml, V.; Schuster, D.; Vanek, T.; Fernandez, E.; Malik, J.; Landa, P. (2015): The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro.
    In: FOOD AND AGRICULTURAL IMMUNOLOGY 26/4, S. 504 - 511. (DOI) (Weblink)

  • SEEBACHER, W.; FAIST, J.; PRESSER, A.; WEIS, R.; SAF, R.; KASERER, T.; TEMML, V.; SCHUSTER, D.; ORTMANN, S.; OTTO, N.; BAUER, R. (2015): Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2.
    In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 101, S. 552 - 559. (DOI)

Zeitschriftenaufsatz (Review)
  • ATANASOV, A.G.; WALTENBERGER, B.; PFERSCHY-WENZIG, E.M.; LINDER, T.; WAWROSCH, C.; UHRIN, P.; TEMML, V.; WANG, L.; SCHWAIGER, S.; HEISS, E.H.; ROLLINGER, J.M.; SCHUSTER, D.; BREUSS, J.M.; BOCHKOV, V.; MIHOVILOVIC, M.D.; KOPP, B.; BAUER, R.; DIRSCH, V.M.; STUPPNER, H. (2015): Discovery and resupply of pharmacologically active plant-derived natural products: A review.
    In: BIOTECHNOLOGY ADVANCES 33/8, S. 1582 - 1614. (DOI) (Weblink)

Zeitschriftenbeitrag (Meeting-Abstract)
  • ZATELLI, GA.; TEMML, V.; KUTIL, Z.; LANDA, P.; VANEK, T.; FALKENBERG, M.; SCHUSTER, D. (2015): Miconidin acetate, a natural 5-lipoxygenase (5-LOX) inhibitor from Eugenia hiemalis Camb. (Myrtaceae).
    In: Planta Medica 81/16, S. 1441. (DOI)

Publikationen 2014

Beiträge in Büchern / Zeitschriften

Beitrag in Proceedingsband (Abstract)
  • KASERER, T.; TEMML, V.; KUTIL, Z.; MÜLLER, K.; ELMER, S.; GANZERA, M.; LANDA, P.; SCHUSTER, D. (2014): Performance evaluation of common virtual screening tools on selected representatives of different target classes.
    In: Book of Abstracts - 6th Life Science Meeting. Innsbruck: Eigenverlag - Universität Innsbruck, S. 19.

  • TEMML, V.; KASERER, T.; STEFANOVIC, I.; VON GRAFENSTEIN, S.; FUCHS, J.E.; LIEDL, K.R.; SCHUSTER, D. (2014): Natural products interacting with 5-lipoxygenase –but how and where?
    In: Book of Abstracts - International Symposium "Natural Products and Drug Discovery - Future Perspectives". Innsbruck: Eigenverlag - Universität Innsbruck.

  • WALTENBERGER, B.; LIERS, J.; TEMML, V.; GARSCHA, U.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2014): Identification of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore modeling and virtual screening.
    In: Book of Abstracts - 23rd Scientific Congress of the Austrian Pharmaceutical Society. Graz: Karl-Franzens Universität Graz, S. 33.

  • WALTENBERGER, B.; LIERS, J.; TEMML, V.; GARSCHA, U.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2014): Pharmacophore Modeling and Virtual Screening for Soluble Epoxide Hydrolase (sEH) Inhibitors.
    In: Book of Abstracts - International Symposium "Natural Products and Drug Discovery - Future Perspectives". Innsbruck: Eigenverlag - Universität Innsbruck.

Publikationen 2013

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Kuehnl, S.; Schroecksnadel, S.; Temml, V.; Gostner, J.M.; Schennach, H.; Schuster, D.; Schwaiger, S.; Rollinger, J.M.; Fuchs, D.; Stuppner, H. (2013): Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.
    In: PHYTOMEDICINE 20/13, S. 1190 - 1195. (DOI)

  • Temml, Veronika; Kuehnl, S.; Schuster, Daniela; Schwaiger, Stefan; Stuppner, Herrmann; Fuchs, D. (2013): Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.
    In: FEBS Open Bio 3, S. 450 - 452. (DOI) (Weblink)

Beitrag in Proceedingsband (Abstract)
  • KASERER, T.; LAZIC, M.; TEMML, V.; SCHWAIGER, S.; STUPPNER, H.; SCHUSTER, D. (2013): Application of in silico profiling tools for the prediction and rationalization of natural product biological activities.
    In: Trends in natural products research: a young scientists meeting of PSE and ÖPhG. Book of Abstracts. Leicester: Phytochemical Society of Europe, ISBN 978-0-9565472-3-1, S. 33.

  • TEMML, V.; WINEKENSTÄDDE, D.; VOSS, C.; ROLLINGER, J. M.; STUPPNER, H.; DIRSCH, V.; SCHUSTER, D (2013): Identification of new LXR-ß modulators by in silico screening and biological evaluation.
    In: Trends in natural products research: a young scientists meeting of PSE and ÖPhG. Book of Abstracts. Leicester: Phytochemical Society of Europe, ISBN 978-0-9565472-3-1, S. 32.




Institut für Pharmazie, Abteilung Pharmazeutische Chemie

Publikationen 2018

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • PEIN, H.; VILLE, A.; PACE, S.; TEMML, V.; GARSCHA, U.; RAASCH, M.; ALSABIL, K.; VIAULT, G.; DINH, C.-P.; GUILET, D.; TROISI, F.; NEUKIRCH, K.; KÖNIG, S.; BILANCIA, R.; WALTENBERGER, B.; STUPPNER, H.; WALLERT, M.; LORKOWSKI, S.; WEINIGEL, C.; RUMMLER, S.; BIRRINGER, M.; ROVIEZZO, F.; SAUTEBIN, L.; HELESBEUX, J.-J.; SERAPHIN, D.; MOSIG, A.S.; SCHUSTER, D.; ROSSI, A.; RICHOMME, P.; WERZ, O.; KOEBERLE, A. (2018): Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.
    In: Nature Communications, S. 1 - 17. (DOI)

Patente

Patent
  • SCHUSTER, D.; TEMML, V.; KUTIL, Z.; MATUSZCZAK, B.; WERZ, O.; GARSCHA, U.; WALTENBERGER, B.; STUPPNER, H.: N,n' -diarylurea, n,n' -diarylthiourea and n,n' -diarylguanidino compounds for use in treatment and prevention of inflammatory disease. European Patent Office, EP 3315495 A1 20180502 (2018). (Weblink)

Publikationen 2017

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Beck, K.R.; Bächler, M.; Vuorinen, A.; Wagner, S.; Akram, M.; Griesser, U.; Temml, V.; Klusonova, P.; Yamaguchi, H.; Schuster, D.; Odermatt, A. (2017): Inhibition of 11β-hydoxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole.
    In: Biochemical Pharmacology 130, S. 93 - 103. (DOI)

  • Garscha, U.; Romp, E.; Pace, S.; Rossi, A.; Temml, V.; Schuster, D.; König, S.; Gerstmeier, J.; Liening, S.; Werner, M.; Atze, H.; Wittmann, S.; Weinigel, C.; Rummler, S.; Scriba, G.K.; Sautebin, L.; Werz, O. (2017): Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.
    In: Scientific Reports 7, No. 9398. (DOI) (Weblink)

  • Hanáková, Z.; Hošek, J.; Kutil, Z.; Temml, V.; Landa, P.; Vanek, T.; Schuster, D.; Dall’Acqua, S.; Cvačka, J.; Polansky, O.; Šmejkal, K. (2017): Anti-inflammatory activity of natural geranylated flavonoids: cyclooxygenase and lipoxygenase inhibitory properties and proteomic analysis.
    In: Journal of Natural Products 80/4, S. 999 - 1006. (DOI) (Weblink)

  • PEDUTO, A.; SCUOTTO, M.; KRAUTH, V.; ROVIEZZO, F.; ROSSI, A.; TEMML, V.; ESPOSITO, V.; STUPPNER, H.; SCHUSTER, D.; D´AGOSTINO, B.; SCHIRALDI, C.; DE ROSA, M.; WERZ, O.; FILOSA, R. (2017): Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.
    In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 127, S. 715 - 726. (DOI) (Weblink)

  • TEMML, V.; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D. (2017): Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.
    In: Scientific Reports 7, No. 42751. (DOI) (Weblink)

  • VUORINEN, A.; ENGELI, RT.; LEUGGER, S.; BACHMANN, F.; AKRAM, M.; ATANASOV, AG.; WALTENBERGER, B.; TEMML, V.; STUPPNER, H.; KRENN, L.; ATEBA, SB.; NJAMEN, D.; DAVIS, RA.; ODERMATT, A.; SCHUSTER, D. (2017): Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.
    In: Journal of Natural Products 80/4, S. 965 - 974. (DOI)

Beitrag in Proceedingsband (Abstract)
  • TEMML, V.; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D. (2017): Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and solulble epoxide hydrolase using pharmacophore-based virtual screening.
    In: Grasse, M.; Heinrichs, C. (Eds.): Abstract Book of the Life Science PhD Meeting, Innsbruck, 18.04. – 19.04.2017. Innsbruck: Eigenverlag - Universität Innsbruck / Innsbruck: Medizinische Universität Innsbruck, S. 79. (Weblink)

  • TEMML, V; GARSCHA, U.; ROMP, E.; SCHUBERT, G.; GERSTMEIER, J.; KUTIL, Z.; MATUSZCZAK, B.; WALTENBERGER, B.; STUPPNER, H.; WERZ, O.; SCHUSTER, D (2017): Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and solulble epoxide hydrolase using pharmacophore-based virtual screening.
    In: Stuppner, H.; Borchard, G.; Brenneisen, R.; Griesser, U.; Gstrein, E.: Book of Abstracts - Pharma2030 - Current and Future Challenges. A Joint Meeting of the Austrian Pharmaceutical Society (ÖPhG) and the Swiss Academy of Pharmaceutical Sciences (SAPhS), April 20-22, 2017. Innsbruck: Eigenverlag - Universität Innsbruck, S. 8.

Patente

Patent
  • RICHOMME, P.; HELESBEUX, J-J.; GUILET, D.; SERAPHIN, D.; STUPPNER, H.; WALTENBERGER, B.; SCHUSTER, D.; TEMML, V.; KOEBERLE, A.; WERZ, O.: Preparation of tocotrienol derivatives, pharmaceutical composition and method of use in 5-​lipoxygenase related diseases. World Intellectual Property Organization, WO/2017/032881 (2017).

Publikationen 2016

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • ALSABIL, K.; SUOR-CHERER, S.; KOEBERLE, A.; VIAULT, G.; LAVAUD, A.; TEMML, V.; WALTENBERGER, B.; SCHUSTER, D.; LITAUDON, M.; LORKOWSKI, S.; DE VAUMAS, R.; HELESBEUX, J-J.; GUILET, D.; STUPPNER, H.; WERZ, O.; SERAPHIN, D.; RICHOMME, P. (2016): Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.
    In: Planta Medica 82/11/12, S. 1110 - 1116. (DOI)

  • SCHAIBLE, A.M.; FILOSA, R.; KRAUTH, V.; TEMML, V.; PACE, S.; GARSCHA, U.; LIENING, S.; WEINIGEL, C.; RUMMLER, S.; SCHIEFERDECKER, S.; NETT, M.; PEDUTO, A.; COLLARILE, S.; SCUOTTO, M.; ROVIEZZO, F.; SPAZIANO, G.; DE ROSA, M.; STUPPNER, H.; SCHUSTER, D.; D´AGOSTINO, B.; WERZ, O. (2016): The 5-​lipoxygenase inhibitor RF-​22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.
    In: Biochemical Pharmacology 112, S. 60 - 71. (DOI)

  • WALTENBERGER, B.; GARSCHA, U.; TEMML, V.; LIERS, J.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2016): Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening.
    In: Journal of Chemical Information and Modeling 56/4, S. 747 - 762. (DOI)

  • Zatelli, G.A.; Temml, V.; Kutil, Z.; Landa, P.; Vanek, T.; Schuster, D.; Falkenberg, M. (2016): Miconidin Acetate and Primin as Potent 5-Lipoxygenase Inhibitors from Brazilian Eugenia hiemalis (Myrtaceae).
    In: Planta Medica Letters 3/1, S. e17 - e19. (DOI)

Beitrag in Proceedingsband (Abstract)
  • WALTENBERGER, B.; GARSCHA, U.; TEMML, V.; LIERS, J.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2016): Pharmacophore modeling and virtual screening for the discovery of potent soluble Epoxide hydrolase (sEH) inhibitors.
    In: Hobmayer, Bert; Micura, Ronald; Striessnig, Jörg: Book of Abstracts - 6th CMBI Meeting. Gnadenwald, March 3-4, 2016. Innsbruck: Leopold-Franzens-Universität Innsbruck, S. 12. (Weblink)

Publikationen 2015

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Kaserer, T.; Temml, V.; Kutil, Z.; Vanek, T.; Landa, P.; Schuster, D. (2015): Prospective performance evaluation of selected common virtual screening tools. Case study : Cyclooxygenase (COX) 1 and 2.
    In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 96, S. 445 - 457. (DOI) (Weblink)

  • Kutil, Z.; Kvasnicova, M.; Temml, V.; Schuster, D.; Marsik, P.; Cusimamani, E.F.; Lou, J.D.; Vanek, T.; Landa, P. (2015): Effect of Dietary Stilbenes on 5-Lipoxygenase and Cyclooxygenases Activities In Vitro.
    In: INTERNATIONAL JOURNAL OF FOOD PROPERTIES 18/7, S. 1471 - 1477. (DOI) (Weblink)

  • Kutil, Z.; Kvasnicova, M.; Temml, V.; Schuster, D.; Vanek, T.; Fernandez, E.; Malik, J.; Landa, P. (2015): The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro.
    In: FOOD AND AGRICULTURAL IMMUNOLOGY 26/4, S. 504 - 511. (DOI) (Weblink)

  • SEEBACHER, W.; FAIST, J.; PRESSER, A.; WEIS, R.; SAF, R.; KASERER, T.; TEMML, V.; SCHUSTER, D.; ORTMANN, S.; OTTO, N.; BAUER, R. (2015): Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2.
    In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 101, S. 552 - 559. (DOI)

Zeitschriftenaufsatz (Review)
  • ATANASOV, A.G.; WALTENBERGER, B.; PFERSCHY-WENZIG, E.M.; LINDER, T.; WAWROSCH, C.; UHRIN, P.; TEMML, V.; WANG, L.; SCHWAIGER, S.; HEISS, E.H.; ROLLINGER, J.M.; SCHUSTER, D.; BREUSS, J.M.; BOCHKOV, V.; MIHOVILOVIC, M.D.; KOPP, B.; BAUER, R.; DIRSCH, V.M.; STUPPNER, H. (2015): Discovery and resupply of pharmacologically active plant-derived natural products: A review.
    In: BIOTECHNOLOGY ADVANCES 33/8, S. 1582 - 1614. (DOI) (Weblink)

Zeitschriftenbeitrag (Meeting-Abstract)
  • Koeberle, A.; Waltenberger, B.; Temml, V.; Schuster, D.; Sautebin, L.; Stuppner, H.; Richomme, P.; Werz, O. (2015): Vitamin E metabolites as potent inhibitors of 5-lipoxygenase.
    In: Naunyn-Schmiedeberg's Archives of Pharmacology 338/Supp. 1, S. 26. (DOI) (Weblink)

  • ZATELLI, GA.; TEMML, V.; KUTIL, Z.; LANDA, P.; VANEK, T.; FALKENBERG, M.; SCHUSTER, D. (2015): Miconidin acetate, a natural 5-lipoxygenase (5-LOX) inhibitor from Eugenia hiemalis Camb. (Myrtaceae).
    In: Planta Medica 81/16, S. 1441. (DOI)

Patente

Patent
  • Richomme, P.; Helesbeux, J.J.; Guilet, D.; Seraphin, D.; Stuppner, H.; Waltenberger, B.; Schuster, D.; Temml, V.S.; Koeberle, A.; Werz, O.: Tocotrienol derivatives, pharmaceutical composition and method of use in chronic airway inflammatory disorders. European Patent Office, 15182827.4 – 1462, 20.11.2015 (2015).

Publikationen 2014

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Kutil, Z.; Temml, V.; Maghradze, D.; Pribylova, M.; Dvorakova, M.; Schuster, D.; Vanek, T.; Landa, P. (2014): Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity.
    In: MEDIATORS OF INFLAMMATION 2014, ID 178931. (Weblink)

  • Temml, Veronika; Kaserer, Teresa; Kutil, Zsofia; Landa, Premysl; Vanek, Tomas; Schuster, Daniela (2014): Pharmacophore modeling for COX-1 and -2 inhibitors with LigandScout in comparison to Discovery Studio.
    In: Future Medicinal Chemistry 6/17, S. 1869 - 1881. (Weblink)

Beitrag in Proceedingsband (Abstract)
  • KASERER, T.; TEMML, V.; KUTIL, Z.; MÜLLER, K.; ELMER, S.; GANZERA, M.; LANDA, P.; SCHUSTER, D. (2014): Performance evaluation of common virtual screening tools on selected representatives of different target classes.
    In: Book of Abstracts - 6th Life Science Meeting. Innsbruck: Eigenverlag - Universität Innsbruck, S. 19.

  • TEMML, V.; KASERER, T.; STEFANOVIC, I.; VON GRAFENSTEIN, S.; FUCHS, J.E.; LIEDL, K.R.; SCHUSTER, D. (2014): Natural products interacting with 5-lipoxygenase –but how and where?
    In: Book of Abstracts - International Symposium "Natural Products and Drug Discovery - Future Perspectives". Innsbruck: Eigenverlag - Universität Innsbruck.

  • WALTENBERGER, B.; LIERS, J.; TEMML, V.; GARSCHA, U.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2014): Identification of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore modeling and virtual screening.
    In: Book of Abstracts - 23rd Scientific Congress of the Austrian Pharmaceutical Society. Graz: Karl-Franzens Universität Graz, S. 33.

  • WALTENBERGER, B.; LIERS, J.; TEMML, V.; GARSCHA, U.; WERZ, O.; SCHUSTER, D.; STUPPNER, H. (2014): Pharmacophore Modeling and Virtual Screening for Soluble Epoxide Hydrolase (sEH) Inhibitors.
    In: Book of Abstracts - International Symposium "Natural Products and Drug Discovery - Future Perspectives". Innsbruck: Eigenverlag - Universität Innsbruck.

Publikationen 2013

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Kuehnl, S.; Schroecksnadel, S.; Temml, V.; Gostner, J.M.; Schennach, H.; Schuster, D.; Schwaiger, S.; Rollinger, J.M.; Fuchs, D.; Stuppner, H. (2013): Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase.
    In: PHYTOMEDICINE 20/13, S. 1190 - 1195. (DOI)

  • Landa, P.; Kutil, Z.; Temml, V.; Malik, J.; Kokoska, L.; Widowitz, U.; Pribylova, M.; Dvorakova, M.; Marsik, P.; Schuster, D.; Bauer, R.; Vanek, T. (2013): Inhibition of in vitro leukotriene B4 biosynthesis in human neutrophil granulocytes and docking studies of natural quinones.
    In: Natural Product Communications 8/1, S. 105 - 108. (Weblink)

  • Schaible, A. M.; Traber, H.; Temml, V.; Noha, S. M.; Filosa, R.; Peduto, A.; Weinigel, C.; Barz, D.; Schuster, D.; Werz, O. (2013): Potent inhibition of 5-lipoxygenase and liposomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.
    In: Biochemical Pharmacology 86/4, S. 476 - 486. (DOI) (Weblink)

  • Temml, Veronika; Kuehnl, S.; Schuster, Daniela; Schwaiger, Stefan; Stuppner, Herrmann; Fuchs, D. (2013): Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase.
    In: FEBS Open Bio 3, S. 450 - 452. (DOI) (Weblink)

Beitrag in Proceedingsband (Abstract)
  • KASERER, T.; LAZIC, M.; TEMML, V.; SCHWAIGER, S.; STUPPNER, H.; SCHUSTER, D. (2013): Application of in silico profiling tools for the prediction and rationalization of natural product biological activities.
    In: Trends in natural products research: a young scientists meeting of PSE and ÖPhG. Book of Abstracts. Leicester: Phytochemical Society of Europe, ISBN 978-0-9565472-3-1, S. 33.

  • TEMML, V.; WINEKENSTÄDDE, D.; VOSS, C.; ROLLINGER, J. M.; STUPPNER, H.; DIRSCH, V.; SCHUSTER, D (2013): Identification of new LXR-ß modulators by in silico screening and biological evaluation.
    In: Trends in natural products research: a young scientists meeting of PSE and ÖPhG. Book of Abstracts. Leicester: Phytochemical Society of Europe, ISBN 978-0-9565472-3-1, S. 32.

Publikationen 2012

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Landa, P.; Kutil, Z.; Temml, V.; Vuorinen, A.; Malik, J.; Dvorakova, M.; Marsik, P.; Kokoska, L.; Pribylova, M.; Schuster, D.; Vanek, T. (2012): Redox and Non-Redox Mechanism of In Vitro Cyclooxygenase Inhibition by Natural Quinones.
    In: Planta Medica 78/4, S. 326 - 333. (DOI)




Institut für Pharmazie, Abteilung Pharmazeutische Technologie

Publikationen 2017

Beiträge in Büchern / Zeitschriften

Zeitschriftenaufsatz (Originalarbeit)
  • Beck, K.R.; Bächler, M.; Vuorinen, A.; Wagner, S.; Akram, M.; Griesser, U.; Temml, V.; Klusonova, P.; Yamaguchi, H.; Schuster, D.; Odermatt, A. (2017): Inhibition of 11β-hydoxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole.
    In: Biochemical Pharmacology 130, S. 93 - 103. (DOI)

Posters

13) Computational analysis of the interaction between vitamin E derivatives and 5-lipoxygenase.  Temml, V.; Pein, H.; Pace, S.; Garscha, U.; Waltenberger, B.; Stuppner, H.; Roviezzo, F.; Helesbeux, J.-J.; Seraphin, D.; Rossi, A.; Richomme, P.; Werz, O.; Koeberle, A.; Schuster, D. Paracelsus Science Get Together 2018, Salzburg, 29.06.2018

12) Computational binding mode prediction of natural and synthetic tocotrienols as inhibitors of 5-lipoxygenase. Temml, V.; Koeberle, A.; Garscha, U.; Helesbeux, J.-J.; Waltenberger, B.; Seraphin, D.; Richomme, P.; Stuppner, H.; Werz, O.; Schuster, D. First Austrian Summit on Natural Products. 14.-16.1.2018, Seefeld, Austria

11) Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Temml, V.; Garscha, U.; Romp, E.; Schubert, G.; Gerstmeier, J.; Kutil, Z.; Matuszczak, B.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D. Life Science PhD Meeting Innsbruck 2017, 18.-19.4.2017, Innsbruck, Austria

10) Design, synthesis and structure-activity relationship of N-phenylbenzenesulfonamides as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors. Cheung, S.Y.; Hanke, T.; Werner, M.; Pace, S.; Cantone, V.; Fischer, K.; Listing, M.; Temml, V.; Schuster, D.; Werz, O.; Schubert-Zsilavecz, M. Annual Meeting of the German Pharmaceutical Society (DPhG), Sep 23-25, 2015, Düsseldorf, Germany

9) Miconidin acetate, a natural 5-lipoxygenase (5-LOX) inhibitor from Eugenia hiemalis Camb. (Myrtaceae). Zatelli, G.; Temml, V.; Kutil, Z.; Landa, P.; Vanek, T.; Falkenberg, M.; Schuster, D. 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Aug 23-27, 2015, Budapest, Hungary

8) Pharmacophore modeling and virtual screening for soluble epoxide hydrolase (sEH) inhibitors. Waltenberger, B.; Liers, J.; Temml, V.; Garscha, U.; Werz, O.; Schuster, D.; Stuppner, H. International Symposium: Natural Products and Drug Discovery - Future Perspectives, Nov 13-14, 2014, Vienna, Austria

7) Search for new dual inhibitors of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase with pharmacophore modeling. Temml, V.; Kutil, Z.; Romp, E.; Garscha, U.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D. 20th EuroQSAR. Understanding Chemical-Biological Interactions. Aug 31-Sep 4, 2014, St. Petersburg, Russia

6) Identification and investigation of novel LXR modulators. Voss, C.; Winekenstädde, D.; Temml, V.; Schuster, D.; Rollinger, J.M.; Stuppner, H.; Dirsch, V. Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction, Apr 3-8, 2013, Alpbach, Austria

5) Prospective performance evaluation of different virtual screening tools for COX-activity prediction. Kaserer, T.; Temml, V.; Landa, P.; Schuster, D. 19th Euro QSAR, Aug 26-30, 2012, Vienna, Austria and 4th Life Science Meeting Innsbruck Universities, Sep 27-28, 2012, Igls, Austria

4) Inhibition modes of quinone compounds on 5-lipoxygenase. Temml, V.; Kutil, Z.; Landa, P.; Schuster, D. 19th Euro QSAR, Aug 26-30, 2012, Vienna, Austria and 4th Life Science Meeting Innsbruck Universities, Sep 27-28, 2012, Igls, Austria

3) Pharmacophore modeling of cyclooxygenase-2 in LigandScout and Discovery Studio - a comparison. Temml, V.; Kutil, Z.; Landa, P.; Schuster, D.; 26th Molecular Modelling Workshop, March 12-14, 2012, Erlangen, Germany

2) Finding and analyzing the binding mode of new cyclooxygenase inhibitors with pharmacophore modeling. Temml, V.S.; Kutil, Z.; Landa, P.; Malik, J.; Dvorakova, M.; Marsik, P.; Kokoska, L.; Pribylova, M.; Vanek, T.; Schuster, D. Joint Meeting of the Austrian and German Pharmaceutical Societies 2011, September 20-23, 2011, Innsbruck, Austria and 3rd Lifescience_Meeting Innsbruck Universities, September 23-24, 2011, Igls, Austria

1) In vitro cyclooxygenase inhibition by natural quinones and possible mechanism of their action. Kutil, Z.; Temml, V.; Landa, P.; Malik, J.; Kokoska, L.; Marsik, P.; Schuster, D.; Vanek, T.; Dvorakova, M. PharmSciFair, June 13-17, 2011, Prague, Czech Republic

Short Lectures 

3) Discovery of the first dual inhibitor of 5-Lipogenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Temml, V.S.; Garscha, U.; Romp, E.; Schubert, G.; Gerstmeier, J.; Kutil, J.; Matuszczak, B.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D., Pharma 2030 - Current and Future Challenges (ÖPhG), University of Innsbruck, Austria, 20-22.4.2017

2) Identification of new LXR-β modulators by in-silico screening and biological evaluation. Temml, V.S.; Winekenstädde, D.; Voss, C.; Rollinger, J.M.; Stuppner, H.; Dirsch, V.; Schuster, D. Trends in Natural Products research (ÖPhG), Jul 24, 2014, Obergurgl, Austria

1) New perspectives on a classic inflammation target: Computational analysis of 5-lipoxygenase inhibition. Temml, V.S.; Kaserer, T.; Stefanovic, I.; von Grafenstein, S.; Fuchs, J.E.; Liedl, K.R.; Schuster, D. 23rd Scientific Congress of the Austrian Pharmaceutical Society (ÖPhG), Apr 24, 2014, Graz, Austria

Invited Talks

2) Interaction of Carthamus tinctorius lignin arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Schuster, D.; Temml, V.; Kühnl, S.; Schwaiger, S.; Stuppner, H.; Fuchs, D. 33rd International Winter-Workshop, Clinical, Chemical and Biochemical Aspects of Pteridines and Related Topics, Innsbruck, Austria, Feb 25, 2014

1) Molecular modeling of 5-lipoxygenase inhibitors. Temml, V.; Kutil, Z.; Landa, P.; Schuster, D. Institute Seminar at the University of Jena, Institute of Pharmaceutical Chemistry, Jena, Germany, February 20, 2012

 PhD thesis  Molecular modeling and computational investigation of targets within the inflammatory cascade
Master Thesis Chemical synthesis of chromophore-DNA conjugates and their application as substrates for in-vitro selection of phosphodiesterase deoxyribozymes