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SFB-F44 - Cell signaling in chronic CNS disorders

Project 12:
Functional role of L-type Ca2+- channels in dopaminergic midbrain neurons in health and disease states

Birgit Liss

We will define the cell-specific subunit composition and functional roles of L-type and other voltage gated Ca2+ channels in young, mature and aging dopamine neurons in health and disease states. In particular, we aim to define their age-dependent contributions in dopamine neurons to their electrical activity pattern, and their selective vulnerability to degeneration in Parkinson's Disease.