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SFB-F44 - Cell signaling in chronic CNS disorders

Other relevant publications of Christian Humpel

2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2002 | 2001 | 1995


Ullrich C, Humpel C. (2011)
Mini-Ruby is Rapidly Taken up by Neurons and Astrocytes in Organotypic Brain Slices.
Neurochem Res. 2011 May 22.

Humpel C. (2011)
Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?
Exp Gerontol. 2011 Apr;46(4):225-32.

Humpel C. (2011)
Identifying and validating biomarkers for Alzheimer's disease.
Trends Biotechnol. 2011 Jan;29(1):26-32.


Pirchl M, Ullrich C, Humpel C. (2010)
Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats.
Eur J Neurosci. 2010 Nov;32(9):1516-27.

Ullrich C, Pirchl M, Humpel C. (2010)
Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits.
Mol Cell Neurosci. 2010 Dec;45(4):408-17.

Hohsfield  L, Humpel C (2010)
Homocysteine enhances transmigration of rat monocytes through a brain capillary endothelial cell monolayer via ICAM-1.
Current Neurovascular Research, in press.

Pirchl M, Kemmler G, Humpel C (2010)
Female Sprague Dawley rats show impaired spatial memory  in the 8-arm radial maze under dim blue and red light.
International Journal of Zoology, in press.

Ullrich C, Pirchl M, Humpel C (2010)
Effects of cholesterol and its 24S-OH- and 25-OH-oxysterols on choline acetyltransferase-positive neurons in brain slices.
Pharmacology, in press.

Willis M, Kaufmann WA, Wietzorrek G, Hutter-Paier B, Moosmang S,   Humpel C, Hofmann F, Windisch M, Knaus HG, Marksteiner J. (2010)
L-Type Calcium Channel Ca{V} 1.2 in Transgenic Mice Overexpressing Human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) Mutations. 
J Alzheimers Dis., in press.

Serbinek D,  Ullrich C, Pirchl M, Hochstrasser T, Schmidt-Kastner R, Humpel, C (2010)
S100b counteracts neurodegeneration of rat cholinergic neurons in brain slices after oxygen-glucose deprivation.
Cardiovascular Psychiatry and Neurology, in press.

Ullrich C, Mlekusch R, Kuschnig A, Marksteiner J, Humpel C (2010)
Ubiquitin enzymes, ubiquitin and proteasome activity in blood mononuclear cells of MCI, Alzheimer and Parkinson patients.
Curr Alzheimer Res. in press.

Teuchner B, Dimmer A, Humpel C, Amberger A, Fischer-Colbrie R, Nemeth J, Waschek JA, Kieselbach G, Kralinger M, Schmid E, Bechrakis N, Troger J. (2010)
VIP, PACAP-38, BDNF and ADNP in NMDA-induced excitotoxicity in the rat retina
Acta Ophthalmol. , in press.

Böttger D, Ullrich C, Humpel C (2010)
Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons.
Brain Research 1312: 108-119.

Olson L, Humpel C (2010)
Growth factors and cytokines/ chemokines  as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer´s disease and mild cognitive impairment.
Experimental Gerontology 45: 41-46

Hochstrasser T, Weiss E, Marksteiner J, Humpel C (2010)
Soluble cell adhesion molecules in monocytes of Alzheimer´s disease and mild cognitive impairment.
Experimental Gerontology  45: 70-74

Humpel C (2010)
Editorial to the Special Issue Biomarkers of Alzheimers Disease and Dementia and Cerebrospinal Fluid and Blood.
Experimental Gerontology 45: 1.


Marksteiner J, Kemmler G, Weiss E, Knaus G, Ullrich C, Mechteriakov S,Oberbauer H, Auffinger S, Hinterhölzl J, Hinterhuber H, Humpel C (2009)
Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer´s disease.
Neurobiology of Aging doi:10.1016/ j.neurobiolaging..03.011

Ullrich C, C Humpel C (2009)
Rotenone induces cell death of cholinergic neurons in an organotypic co-culture brain slice model.
Neurochemical Research, DOI: 10.1007/s11064-009-0014-9.

Pirchl M, Humpel. C (2009)
Spielt die Übersäuerung im Gehirn eine zentrale Rolle bei Alzheimer?.
Neuropsychiatrie 23:187-192.

C, Humpel C (2009)
The pro-apoptotic substance thapsigargin selectively stimulates re-growth of brain capillaries.
Curr. Neurovascular Research 6: 171-180.

Zenzmaier C, Marksteiner J, Kiefer A, Berger P, Humpel C (2009)
Dkk-3 is elevated in cerebrospinal fluid and plasma of Alzheimer’s disease patients.
Journal Neurochemistry 110: 653-661.

Klein-Weigel P, Gutsche-Petrak B, Humpel C, Riemekasten G, Ivanov S, Heidrich H. (2009)
Circulating nerve growth factor in primary and secondary Raynaud's syndrome - Results of a pilot study.
Vasa - Journal of vascular diseases 38: 39-45.

Marksteiner J, Humpel C (2009)
Glycogen-synthase kinase-3ß is decreased in peripheral blood mononuclear cells of patients with mild cognitive impairment.
Exp Gerontol 44:370-371.

Humpel C, Marksteiner J (2009)
Peripheral biomarkers in dementia and Alzheimers disease.
In: "The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes, Volume III: Metabolic and Peripheral Biomarkers", Michael S. Ritsner (Editor), Springer, ISBN: 978-1-4020-9837-6.

Blasko I, C. Humpel C, Grubeck-Loebenstein B (2009).
Glial Cells: Astrocytes and Oligodendrocytes during Normal Brain Aging.
In: "Encyclopedia of Neuroscience", Larry R. Squire (Editor), Elsevier,  pp. 743-747.

Schrott-Fischer A, Bitsche M, Humpel C, Maier H, Jellinger K, Rabl W, Glueckert R, Marksteiner J (2009)
Chromogranin peptides in amyotrophic lateral sclerosis.
Regulatory Peptides 152: 13-21


Humpel C (2008)
Alzheimer´s disease – is it caused by cerebrovascular dysfunction?"
Chapter 15, In: "Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging", Kenneth Maise (Editor), Oxford University Press, page 369-402, ISBN 978-0-19-532669-7.

Marksteiner J, Pirchl M, Ullrich C, Oberbauer H, Blasko I, Lederer W, Hinterhuber H, Humpel C (2008)
Analysis of cerebrospinal fluid of Alzheimer patients: biomarkers and toxic properties. Pharmacology 82: 214-220.

Humpel C (2008)
Basolateral aggregated rat amyloid-beta(1-42) potentiates transmigration of primary rat monocytes through a rat blood-brain barrier.
Current Neurovascular Research 5: 185-192

Doverhag C, Keller M, Karlsson A, Hedtjarn M, Nilsson U, Kapeller E, Sarkozy G, Klimaschewski L, Humpel C, Hagberg H, Simbruner G, Gressens P, K. Savman K (2008)
Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice.
Neurobiology of Disease 31: 133-144.

Willis M, Prokesch M, Hutter-Paier B, Windisch M, Stridsberg M, Mahata SK,  Kichmair R, Wietzorrek G, Knaus HG, Jellinger K, Humpel C, Marksteiner J  (2008)
Chromogranin B and Secretogranin II in Transgenic Mice Overexpressing Human APP751 with the London (V717I) and Swedish (K670M/N671L) Mutations and in Alzheimer Patients”. 
J Alzheimers Dis. 13: 123-135.

Marksteiner J, Humpel C (2008)
Beta-amyloid expression, release and extracellular deposition in aged rat brain slices.
Mol. Psychiatry 13: 939-952.


Humpel C (2007).
Cerebrovascular damage: a cause for Alzheimer´s disease.
Chapter I. In: "Ischemia-Reperfusion Pathways in Alzheimer´s disease", Ryszard Pluta (Editor), Nova Science Publishers, page 1-16, ISBN: 1-60021-744-3.

Moser KV, Humpel C (2007)
Primary rat monocytes migrate through a BCEC-monolayer and express microglia-markers at the basolateral side.
Brain Research Bulletin 74: 336-343.

Moser KV, Humpel C (2007)
Blood-derived serum albumin contributes to neurodegeneration via astroglial stress fiber formation.
Pharmacology 80: 286-292.

Marksteiner J, Hinterhuber, Humpel C (2007)
Cerebrospinal fluid biomarkers for diagnosis of Alzheimer´s disease: Beta-amyloid(1-42), tau, phospho-tau-181 and total protein.
Drugs of Today 43: 423-431.

Willis M, Hutter-Paier B, Wietzorrek G, Windisch M, Humpel C, Knaus HG,  Marksteiner J (2007)
Localization and expression of substance P in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations.
Brain Research 1143:199-207.


Pirchl M, Marksteiner J, Humpel C (2006)
Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance for vascular dementia and Alzheimer´s disease.
Neurological Research 28: 657-664.

Moser KV, Stöckl P, Humpel C (2006)
Cholinergic neurons degenerate when exposed to conditioned medium of primary rat brain capillary endothelial cells: Counteraction by NGF, MK-801 and inflammation.
Experimental Gerontology 41: 609-618.

Bitsche M, Schrott-Fischer A, Hinterhoelzl J, Fischer-Colbrie R, Sergi C, Glueckert R, Humpel C, Marksteiner J (2006)
First localization and biochemical identification of chromogranin B- and secretoneurin-like immunoreactivity in the fetal human vagal/nucleus solitary complex.
Regulatory peptides 134: 97-104.

Zassler B, Humpel C (2006)
Transplantation of NGF secreting primary monocytes counteracts NMDA-induced cell death of rat cholinergic neurons in vivo.
Experimental Neurology 198: 391-400.

Blasko I, Lederer W, Oberbauer H, Walch T, Kemmler G, Hinterhuber H, Marksteiner J, Humpel C (2006)
Measurement of thirteen biological markers in CSF of patients with Alzheimer’s disease and other dementias.
Dementia  and Geriatric Cognitive Disorders 21: 9-15.


Humpel C, Marksteiner J (2005)
Cerebrovascular damage as a cause for Alzheimer's disease?
Current Neurovascular Research  2: 341-347.

Humpel C, Blasko I, Marksteiner J, Lederer W, Oberbauer H, Walch T, Kemmler G, Hinterhuber H (2005)
Diagnostik der Alzheimer Demenz und anderere Demenzen in der Cerebrospinalflüssigkeit.
Neuropsychiatrie 19:97-101.

Moser KV, Humpel C (2005)
Vascular endothelial growth factor counteracts NMDA-induced cell death of adult cholinergic neurons in rat basal nucleus of Meynert.
Brain Research Bulletin 65:125-131.

Zassler B, Blasig, I, Humpel C (2005)
Protein Delivery of Caspase-3 induces Cell Death in Malignant C6 Glioma, Primary Astrocytes and Immortalized and Primary Brain Capillary Endothelial Cells.
J Neurooncol. 71: 127-34

Zassler B, Dechant G, Humpel C (2005)
Urea enhances the NGF-induced neuroprotective effect on cholinergic neurons in organotypic rat brain slices.
Neuroscience 130:  317-323.

Schmid E, Leierer J, Doblinger A, Laslop A, Fischer-Colbrie R, Humpel C, Theodorsson E, Teuchner B, Lalehabbasi D, Dragosits E, Kunze C, Philipp W, Gottinger W, Troger J (2005)
Neurokinin a is a main constituent of sensory neurons innervating the anterior segment of the eye.
Investigative Ophthalmology Vis Sci. 46: 268-74.


Marksteiner J, Kaufmann WA, Gurka P, Humpel C (2002)
Synaptic proteins in Alzheimer´s disease. 
Journal Molecular Neuroscience 18: 53-63.


Weis C, Marksteiner J, Humpel C (2001)
Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic phenotype in organotypic brain slices of the basal nucleus of Meynert.
Neuroscience 102: 129-138.


Humpel C, Lindqvist E, Söderström S, Kylberg A, Ebendal T, Olson L (1995)
Monitoring release of neurotrophic activity in the brains of awake rats.
Science 269: 552-554.