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SFB-F44 - Cell signaling in chronic CNS disorders

SFB Publications


2019

 

Porpora M, Sauchella S, Rinaldi L, Delle Donne R, Sepe M, Torres-Quesada O, Intartaglia D, Garbi C, Insabato L, Santoriello M, Bachmann V, Synofzik M, Lindner H, Ivan C, Stefan E, Feliciello A. Counterregulation of cAMP-directed kinase activities controls ciliogenesis. Nat. Commun. 2018 Mar 26;9(1):1224. doi: 10.1038/s41467-018-03643-9


Röck R, Mayrhofer JE, Torres-Quesada O, Enzler F, Raffeiner A, Raffeiner P, Feichtner A, Huber RG, Koide S, Taylor SS, Troppmair J, Stefan E*. (2019) BRAF inhibitors promote intermediate BRAF(V600E) conformations. Science Advances 2019 Aug 14;5(8):eaav8463. doi: 10.1126/sciadv.aav8463


Calorio C, Gavello D, Guarina L, Salio C, Sassoè-Pognetto M, Riganti C, Bianchi FT, Hofer NT, Tuluc P, Obermair GJ, Defilippi P, Balzac F, Turco E, Bett GC, Rasmusson RL, Carbone E (2019) Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2-neo mouse rescued by L-type calcium channel blockers. J Physiol. Jan 10. doi: 10.1113/JP277487. [Epub ahead of print] PubMed PMID: 30629744


Cera I, Whitton L, Donohoe G. Morris DW, Dechant G, Apostolova G (2019) Genes encoding SATB2-interacting proteins in adult cerebral cortex contribute to human cognitive ability. PLOS Genetics (in press, DOI: 10.1371/journal.pgen.1007890 


Geisler S, Schöpf CL  Stanika R, Kalb M, Campiglio M, Repetto D, Traxler L, Missler M, Obermair GJ (2019) Presynaptic α(2)δ-2 calcium channel subunits regulate postsynaptic GABA(A)-receptor abundance and axonal wiring. J Neurosci. Jan 25. pii: 2234-18. doi: 10.1523/JNEUROSCI.2234-18.2019. [Epub ahead of print] PubMed PMID: 30683685


Liss B, Striessnig J (2019) The Potential of L-Type Calcium Channels as a Drug Target for Neuroprotective Therapy in Parkinson’s Disease. Annu. Rev. Pharmacol. Toxicol. 59, 263–289. https://doi.org/10.1146/annurev-pharmtox-010818-021214


Jin J, Bhatti DL, Lee KW, Medrihan L, Cheng J, Wie J, Zhong P, Yan Z, Kooiker C, Song C, Ahn JH, Obermair GJ, Lee A, Gresack J, Greengard P, Kim Y  (2019) Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior. Mol Psychiatry. Feb 13. doi: 10.1038/s41380-019-0371-y. [Epub ahead of print] PubMed PMID: 30760886.

 

2018

 

Rinaldi L, Donne R, Catalanotti B, Torres-Quesada O, Moraca F, Nisticò R, Chiuso F, Piccinin S, Enzler F, Bachmann V, Garbi C, Scorziello A, Russo N, Synofzik M, Stelzl U, Annunziato L, Stefan E, Feliciello A. (2019) Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system. Nat. Commun. 2019 Jun 12;10(1):2572. doi: 10.1038/s41467-019-10037-y.


Bieler L, Grassner L, Zaunmair P, Kreutzer C, Lampe L, Trinka E, Marschallinger J, Aigner L, Couillard-Despres S (2018) Motor deficits following dorsal corticospinal tract transection in rats: voluntary versus skilled locomotion readouts. Heliyon. 2018 Mar 1;4(2):e00540. doi: 10.1016/j.heliyon.2018.e00540


Costé de Bagneaux P, Campiglio M, Benedetti B, Tuluc P, Flucher BE (2018) Role of putative voltage-sensor counter-charge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels. Channels. 12:249-261


Fellner L, Buchinger E, Brueck D, Irschick R, Wenning GK, Stefanova N (2018) Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis. BMC Neurosci. May 21;19(1):32. doi: 10.1186/s12868-018-0431-2. PubMed PMID:29783943; PubMed Central PMCID: PMC5963177


Folci A, Steinberger A, Lee B, Stanika R, Scheruebel S, Campiglio M, Ramprecht C, Pelzmann B, Hell JW, Obermair GJ, Heine M, Di Biase V (2018) Molecular mimicking of C-terminal phosphorylation tunes the surface dynamics of Ca(V)1.2 calcium channels in hippocampal neurons. J Biol Chem. Jan 19;293(3):1040-1053. doi: 10.1074/jbc.M117.799585. Epub 2017 Nov 27. PubMed PMID: 29180451; PubMed Central PMCID: PMC5777246

Heras-Garvin A, Weckbecker D, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK, Stefanova N (2018) Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy. Mov Disord. 2018 Nov 19. doi: 10.1002/mds.27562. [Epub ahead of print] PubMed PMID: 30452793


Hoernes TP, Faserl K, Juen MA, Kremser J, Gasser C, Fuchs E, et al (2018) Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions. Nature Communications. 2018 Nov 19;9(1):3497–12 


Kallab M, Herrera-Vaquero M, Johannesson M, Eriksson F, Sigvardson J, Poewe W, Wenning GK, Nordström E, Stefanova N (2018) Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of
Synucleinopathy. Front Neurosci. Jul 4;12:452. doi: 10.3389/fnins.2018.00452. eCollection 2018. PubMed PMID: 30022929; PubMed Central PMCID: PMC6039792


Kaindlstorfer C, Jellinger KA, Eschlböck S, Stefanova N, Weiss G, Wenning GK (2018) The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint. J Alzheimers Dis. 2018;61(4):1253-1273. doi: 10.3233/JAD-17060


Kandasamy M, Aigner L (2018) Reactive Neuroblastosis in Huntington's Disease: A Putative Therapeutic Target for Striatal Regeneration in the Adult Brain.Front Cell Neurosci. 2018 Mar 9;12:37. doi: 10.3389/fncel.2018.00037


Kaplan MM, Sultana N, Benedetti A, Obermair GJ, Linde NF, Papadopoulos S, Dayal A, Grabner M, Flucher BE (2019) Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation. Cell Rep. Jun 26;23(13):3891-3904. doi: 10.1016/j.celrep.2018.05.085. PubMed PMID: 29949772


Murphy CP, Singewald N (2018) Potential of microRNAs a novel targets in the alleviation of pathological fear. Genes Brain Behav. Mar;17(3):e12427. doi: 10.1111/gbb.12427. Epub 2017 Nov 24. Review. PMID: 29028150


O'Connor RM, McCafferty CP, Bravo JA, Singewald N, Holmes A, Cryan JF (2018) Increased amygdalar metabotropic glutamate receptro 7mRNA in a genetic mouse model of impaired fear extinction Psychopharmacology (Berl). Sep 13. doi: 10.1007/s00213-018-5031-4. [Epub ahead of print] PMID: 30215216


Pinggera A, Negro G, Tuluc P, Brown MJ, Lieb A, Striessnig J (2018) Motor Gating defects of disease-causing de novo mutations in Cav1.3 Ca2+ channels. Channels (Austin) 12, 388–402. https://doi.org/10.1080/19336950.2018.1546518


Refolo V, Bez F, Polissidis A, Kuzdas-Wood D, Sturm E, Kamaratou M, Poewe W, Stefanis L, Angela Cenci M, Romero-Ramos M, Wenning GK, Stefanova N (2018) Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies. Acta Neuropathol Commun. 2018 Jan 3;6(1):2. doi: 10.1186/s40478-017-0504-y


Rhomberg T, Rovira-Esteban L, Vikór A, Paradiso A., Kremser C, Nagy-Pál P, Papp O.I, Tasan R, Erdélyi F., Szabó G, Ferraguti F. and Hajos N (2018) VIP-immunoreactive interneurons within circuits of the mouse basolateral amygdala. J. Neurosci 38:6983-7003. doi: 10.1523/JNEUROSCI.2063-17.2018 


Rotheneichner P, Belles M, Benedetti B, König R, Dannehl D, Kreutzer C, Zaunmair P, Engelhardt M, Aigner L, Nacher J, Couillard-Despres S (2018) Cellular Plasticity in the Adult Murine Piriform Cortex: Continuous Maturation of Dormant Precursors Into Excitatory Neurons. Cereb Cortex. 2018 Apr 21. doi: 10.1093/cercor/


Salti A, Apostolova G, Kummer KK, Lemos C, Dechant G, El Rawas R (2018) Cocaine Paired Environment Increases SATB2 Levels in the Rat Paraventricular Thalamus. Front Behav Neurosci. 12:224. https://doi.org/10.3389/fnbeh.2018.00224


Singewald N, Holmes A (2018) Rodent models of impaired fear extinction. Psychopharmacology (Berl). 2018 Oct 31. doi: 10.1007/s00213-018-5054-x. [Epub ahead of print] Review. PMID: 30377749


Stefanova N (2018) Translational therapies for multiple system atrophy: Bottlenecks and future directions. Hauton Neurosci. 2018 May;211:7-14. doi: 10.1016/j.autneu.2017.09.016


Striessnig J (2018) Getting a handle on CaV2.2 (N-type) voltage-gated Ca2+ channels. Proc. Natl. Acad. Sci. U.S.A. https://doi.org/10.1073/pnas.1818608115


Trussel M, Lecca S, Nuno-Perez A, Harada H, Takemoto K, Takahashi T, Ferraguti F and Mameli M (2018) Punishment-predicitive cues guide avoidance through potentiation of hypothalamus-to-habenula synapses. Neuron in press


Tyutyaev P, Grissmer S (2018) Characterization of the σ-Pore in Mutant hKv1.3 Potassium Channels. Cell Physiol Biochem, 46:1112-1121. doi:10.1159/000488840


Unger MS, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar AA, Roßner S, Heneka MT, Couillard-Despres S, Rockenstein E, Masliah E, Attems J, Aigner L (2018) Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology? Alzheimers Dement. 2018 Apr 6. pii: S1552-5260(18)30071-2. doi: 10.1016/j.jalz.2018.02.017


Whitton L, Apostolova G, Rieder D, Dechant G, Rea S, Donohoe G, Morris DW (2018) Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment. PLOS Genetics 14(7): e1007515. https://doi.org/10.1371/journal.pgen.1007515


Zussy C, Gómez-Santacana X, Rovira X, De Bundel D, Ferrazzo S, Bosch D, Asede D, Malhaire F, Acher F, Giraldo J,Valjent E, Ehrlich i, Ferraguti F, Pin JP, Liebaria A, Goudet C (2018) Dynamic Modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic Glutamate receptor 4. Mol Psychiatry. 2018 Mar;23(3):509-520. doi: 10.1038/mp.2016.223. Epub 2016 Dec 20

 

 

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