Veronika TemmlVeronika TEMML, Mag. rer.nat., PhD
Postdoctoral Researcher 

Contact:
Institute of Pharmacy/Pharmacognosy
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/IV
Room: L.04.062
6020 Innsbruck / Austria

Phone: +43 512 507 - 58419 | Fax: +43 512 507 - 58499
Email: veronika.temml@uibk.ac.at 

Research
Publications
Biography
Publication List

Publications  |  Book sections  |  Conferences and presentations


PhD-thesis

Molecular modeling and computational investigation of targets within the inflammatory cascade
July 2014, Institute of Pharmacy/Pharmaceutical Chemistry, University of Innsbruck


Diploma-thesis

Chemical synthesis of chromophore-DNA conjugates and their application as substrates for in vitro selection of phosphodiesterase deoxyribozymes
May 2011, Institute of Organic Chemistry, University of Innsbruck

 

Publications

Pharmacophore Modelling for Cyclooxygenase-1 and 2 inhibitors with LigandScout in comparison to Discovery Studio
Temml, V.; Kaserer, T.; Kutil, Z.; Landa, P.; Vanek, T.;Schuster D.; accepted by Future Medicinal Chemistry, 2014, 17 (6), 1869-1881, doi: 10.4155/FMC14.114

Impact of Wines and Wine Constituents on Cyclooxygenase-1, -2, and 5-Lipoxygenase Catalytic Activity
Kutil, Z.; Temml, V.; Maghradze, D.; Pribylova, M.; Dvorakova, M.; Schuster, D.; Vanek T.; Landa P.; Mediators of Inflammation 2014, Article ID 178931, 8 pages (online journal)

Effect of dietary stilbenes on 5-lipoxygenase and cyclooxygenases activities in vitro
Kutil, Z.; Pribylova M.;  Temml, V.; Schuster, D.; Marsik, P.; Fernandez, E.; Cusimamani, J.; Vanek, T.; Landa, P.; International Journal of Food Properties, 2014, (online journal), doi: 10.1080/10942912.2014.903416

Discovery of novel liver X receptor (LXR) agonists by pharmacophore- and shape-based virtual screening
Temml, V.; Voss, C.; Dirsch, V.M.; Schuster, D. Journal of Chemical Information and Modeling, 2014, 54(2), 367-371, doi: 10.1021/ci400682b

Elucidation of the molecular mechanism and the efficiency in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase
Schaible, A.; Filosa, R.;  Temml, V.; Matteis, M.; Peduto, A.; Luderer, S.; Roviezzo, F.; Di Mola, A.; De Rosa, M.; D'Agostino, B.; Weinigel, C.; Barz, D.; Koeberle, A.; Schuster, D.; Werz, O.; British Journal of Phamacology, 2014, 171(9), 2399-2412. doi: 10.1111/bph.12592

Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase
Temml, V.; Kuehnl, S.; Schuster, D.; Schwaiger, S.; Stuppner, H.; Fuchs, D.; FEBS Open Bio, 2013, 3, 450-452, doi: 10.1016/j.fob.2013.08.008 

Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase
Kuehnl, S.; Schroecksnadel, S.; Temml, V.; Gostner, J.M.; Schennach, H.; Schuster, D.; Schwaiger, S.; Rollinger, J.M.; Fuchs, D.; Stuppner, H.; Phytomedicine, 2013, 20(13), 1190-1195, doi: 10.1016/j.phymed.2013.06.006

Potent inhibition of 5-lipoxygenase and liposomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin
Schaible, A.M.; Traber, H.; Temml, V.; Noha, S.M.; Filosa, R.; Peduto, A.; Weinigel C.; Barz, D.; Schuster, D.; Werz, O.; Biochemical Pharmacology, 2013, 86(4), 476-486, doi: 10.1016/j.bcp.2013.04.015

Natural quinones as inhibitors of leukotriene B4 biosynthesis in human neutrophil granulocytes
Landa, P.; Kutil, Z.; Temml, V.; Malik, J.; Kokoska, L.; Widowitz, U.; Pribylova, M.; Dvorakova, M.; Marsik, P.; Schuster, D.; Bauer, R.; Vanek, T.; Natural Product Communications, 2013, 8(1), 105-108

Redox and non-redox mechanism of in vitro cyclooxygenase inhibition by natural quinones
Landa, P.; Kutil, Z.; Temml, V.; Vuorinen, A.; Malik, J.; Dvorakova, M.; Marsik, P.; Kokoska, L.; Pribylova, M.; Schuster, D.; Vanek, T.; Planta Medica 2012, 78(4), 326-333, doi: 10.1055/s-0031-1280430

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Book sections

Polypharmacology and adverse bioactivity profiles predict potential toxicity and drug-related ADRs
Kaserer, T.; Temml, V.; Schuster, D.; In Predictive ADMET: Integrated approaches in drug discovery and development (Eds. J. Wang, L. Urban), Wiley-VCH, Weinheim, Germany, 2014

Pharmacophore-based Methods for Predicting the Inhibition and Induction of Metabolic Enzymes
Kaserer, T.; Temml, V.; Schuster, D.; In Drug Metabolism Prediction, Methods and Principles in Medicinal Chemistry (Ed. J. Kirchmair), Wiley-VCH, Weinheim, German, 2014

Computational bioactivity profiling
Temml, V.; Kaserer, T.; Schuster D.; In Scientific Computing @ uibk (Ed. A. Ostermann, M. Barden), Innsbruck University Press, 2014

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Conferences and presentations

Oral presentations

Natural products interacting with 5-lipoxygenase – but how and where?
Temml, V.; Kaserer, T.; Stefanovic, I.; von Grafenstein, S.; Fuchs, J.E.; Liedl, K.R.; Schuster, D.; 14th of November, 2014, Natural Products and Drug Discovery – Future Perspectives, Vienna, Austria.

Identification of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore modeling and virtual screening
Waltenberger, B.; Liers, J.; Temml, V.; Garscha, U.; Werz, O.; Schuster, D.; Stuppner, H.; 24th of April, 2014, 23rd Scientific Congress of the Austrian Pharmaceutical Society (ÖPhG), Graz, Austria.

Pharmacophore-based discovery of novel inhibitors of the innovative therapeutic target soluble epoxide hydrolase (sEH)
Waltenberger, B.; Liers, J.; Temml, V.; Garscha, U.; Werz, O.; Schuster, D.; Stuppner, H.; March 17th-19th, 2014, 28th Molecular Modelling Workshop, Erlangen, Germany.

New perspectives on a classic inflammation target: Computational analysis of 5-lipoxygenase inhibition
Temml, V.;  Kaserer, T.; Stefanovic, I.; von Grafenstein, S.; Fuchs, J.E.; Liedl, K.R.; Schuster, D.; 24th of April, 2014, 23rd Scientific Congress of the Austrian Pharmaceutical Society (ÖPhG), Graz, Austria.

Indentification of new LXR-β modulators by in silico screening and biological evaluation
Temml, V.; Winekenstädde, D.; Voss, C.; Rollinger, J. M.; Stuppner, H.; Dirsch, V.; Schuster, D.; 24th of July, 2013, Trends in Natural Products research (ÖPHG), Obergurgl, Austria.


Poster presentations

Pharmacophore Modeling and Virtual Screening for Soluble Epoxide Hydrolase (sEH) Inhibitors
Waltenberger, B., Liers, J.; Temml, V.; Garscha, U.; Werz, O.; Schuster, D.; Stuppner, H.; Natural Products and Drug Discovery – Future Perspectives, 13th-14th of November, 2014, Vienna, Austria.

Search for New Dual Inhibitors of the 5-Lipoxygenase-Activating Protein and Soluble Epoxide Hydrolase with Pharmacophore Modeling
Temml, V.; Kutil, Z.; Romp, E.; Garscha, U.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D.; Russia, August 31st-September 4th, 2014, St. Petersburg, Russia. 

Identification of new LXR-β modulators by in silico screening and biological evaluation
Temml, V.; Voss, C.; Dirsch, V.; Schuster, D.; OEBMGT Meeting, September 25th-27th, 2013, Innsbruck, Austria.

In vitro cyclooxygenase inhibition by natural quinones and possible mechanism of their action
Kutil, Z.; Temml, V.; Landa, P.; Malik, J.; Kokoska, L.; Marsik, P.; Schuster, D.; Vanek, T.; Dvorakova, M.; PharmSciFair, June 13th-17th, 2011, Prague, Czech Republic.

Identification and investigation of novel LXR modulators
Voss, C.; Winekenstädde, D.; Temml, V.; Schuster, D.; Rollinger, J.M.; Stuppner, H.; Dirsch, V.; Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction, Apr 3rd-8th, 2013, Alpbach, Austria.

Inhibtion Modes of Quinone Compounds on 5-Lipoxygenase
Temml, V.; Kutil Z., Landa P., Schuster D.;

  • 19th Euro QSAR, Aug 26th-30th, 2012, Vienna, Austria 
  • 4th Life Science Meeting Innsbruck Universities, Sep 27th-28th, 2012, Igls, Austria.

Prospective performance evaluation of different virtual screening tools for COX-activity prediction
Kaserer, T; Temml, V.; Landa, P.; Schuster, D.;

  • 19th Euro QSAR, Aug 26th-30th, 2012, Vienna, Austria 
  • 4th Life Science Meeting Innsbruck Universities, Sep 27th-28th, 2012, Igls, Austria.

Pharmacophore Modeling of Cyclooxygenase-2 in LigandScout and Discovery Studio – A comparison
Temml, V.; Kutil, Z.; Landa, P.; Schuster, D.; Molecular Modeling Workshop, March 12th-14th, 2012, Erlangen, Germany

Finding and analyzing the binding mode of new cyclooxygenase inhibitors with pharmacophore modeling
Temml, V.; Kutil, Z.; Landa, P.; Malik, J.; Dvorakova, M.; Marsik. P.; Kokoska, L.; Pribylova, M.; Vanek, T.; Schuster, D.; Joint Meeting of the Austrian and German Pharmaceutical Societies, September 20th-23rd, 2011, Innsbruck, Austria

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