Veronika TemmlVeronika TEMML, Mag. rer.nat., PhD
Postdoctoral Researcher 

Contact:
Institute of Pharmacy/Pharmacognosy
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/IV
Room: L.04.062
6020 Innsbruck / Austria

Phone: +43 512 507 - 58419 | Fax: +43 512 507 - 58499
Email: veronika.temml@uibk.ac.at 

Research
Publications
Biography
Publication List

Publications  |  Book sections  |  Conferences and presentations  |  Patents


PhD-thesis

Molecular modeling and computational investigation of targets within the inflammatory cascade
July 2014, Institute of Pharmacy/Pharmaceutical Chemistry, University of Innsbruck


Diploma-thesis

Chemical synthesis of chromophore-DNA conjugates and their application as substrates for in vitro selection of phosphodiesterase deoxyribozymes
May 2011, Institute of Organic Chemistry, University of Innsbruck

 

Publications | Peer reviewed journals

2019

Novel N-aryl nicotinamide derivatives: taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors. Murineddu, G.; Gotti,C.; Aspronia, B.; Coronaa, P.; Martinello, K.;  Plutino, S.; Fucile, S.; Temml, V.; Moretti, M.; Viani, P.; Schuster, D.; Pirasa, S.; Deligia, F.; Pinna, G. European Journal of Medicinal Chemisty, 2019, accepted, https://doi.org/10.1016/j.ejmech.2019.06.079

Anti-inflammatory and antiproliferative compounds from Sphaeranthus africanus, Tran, H.T.; Gao, X.; Kretschmer, N.; Pferschy-Wenzig, E. M.; Raa, P.; Pirker, T.; Temml, V.; Schuster, D.; Kunert, O.; Huynh; L.; Bauer, R. Phytomedicine; 2019, 62, pp152951.,doi: 10.1016/j.phymed.2019.152951.

Discovery, Synthesis and in vitro Biological Evaluations of Carbazole Derivatives as Novel Allosteric MEK1 Inhibitors, Yan Niu, D.; Li, H.; Noha, S.; Temml, V.; Schuster, D.; Wang C.; Xu, F; Xu, P. European Journal of Medicinal Chemistry, 2019, 178, 15, p. 802-817, https://doi.org/10.1016/j.ejmech.2019.06.027.

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase Akram, M.; Patt, M.; Kaserer, T.; Temml, V.; Waratchareeyakul, W.; Kratschmar, D.; Haupenthal, J.;  Hartmann, R.; Odermatt, A.; Schuster, D. The Journal of Steroid Biochemistry and Molecular Biology, 2019, 192, 1053358, https://doi.org/10.1016/j.jsbmb.2019.04.007

Ginkgolic acid is a multi-target inhibitor of key enzymes in pro-inflammatory lipid mediator biosynthesis Werz, O.; Gerstmeier, J., Seegers, J.; Witt, F.; Waltenberger, B.; Temml, V.; Rollinger, JM;  Stuppner, H.; Koeberle, A.; Schuster, S. Frontiers in Pharmacology, 2019, 10, 797, doi: 10.3389/fphar.2019.00797

Pesticide contamination and associated risk factors at public playgrounds near intensively managed apple and wine orchards, Linhart, C.; Niedrist, G.; Nagler, M.; Nagrani, R.; Temml, V.; Bardelli, T.; Wilhalm, T.; Riedl, A.; Zaller, J.; Clausing, P.; Hertoge, K. Environmental Sciences Europe, 2019, published online, https://doi.org/10.1186/s12302-019-0206-0

Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids, Leláková, V.;  Šmejkal, K.;  Jakubczyk, K.;  Veselý, O.; Landa, P.; Václavík, J.; Bobá, P.; Pížová, H.; Temml, V.; Steinacher, T.; Schuster, D.; Granica, S.; Hanáko, Z.; Hošek, J. Food Chemistry, 2019, published online,  https://doi.org/10.1016/j.foodchem.2019.01.128

Synthesis, biological evaluation and structure-activity relationships of diflapolin analogs as dual sEH/FLAP inhibitors, Vieider; L. Romp, E; Temml, V.; Kretzer, C.; Schoenthaler, M.;Taha, A.; Fischer, J.; Hernández-Olmos, V.; Sturm, S.; Schuster, D.; Werz, O.; Garscha, U.; Matuszczak, B. Medicinal Chemistry Letters, 2019, 10, pp 62–66, doi: 10.1021/acsmedchemlett.8b00415

Early inhibition of endothelial retinoid uptake upon myocardial infarction restores cardiac function and prevents cell, tissue, and animal death, Danzla, K.; Messner, B.; Doppler, C.; Nebert, C.; Abfalterer, A; Sakica, A.; Temml, V.; Heinza, K.; Streitwieser, R.; Edelmann, T.; Mairhofer, M.; Grimm, M.; Laufer, G.; Zierer, A.; Stuppner, H.; Schuster, D.; Ploner , C.; Müller, T.; Berhard, D. Journal of Molecular and Cellular Cardiology, 2019, 126, pp105-117, doi: 10.1016/j.yjmcc.2018.11.012

2018

Magnolol dimer-derived fragments as PPARγ-selective probes, Dreier, D.; Resetar, M.; Temml, V.;  Rycek, L.; Kratena, N.; Schnürch, M.; Schuster, D.; Dirsch, V.M.; Mihovilovic, M. Organic & Biomolecular Chemistry, 2018, 16, pp7019 – 7028. doi: 10.1039/C8OB01745J

Endogenous metabolites of vitamin E limit inflammation by targeting, Pein, H.; Ville, A.; Pace, S.; Temml, V.; Garscha, U.; Raasch, M.; Alsabil, K.; Viault, G.; Dinh, C.-P.; Guilet, D.; Troisi, F.; Neukirch, K.; König, S.; Bilancia, R.; Waltenberger, B.; Stuppner, H.; Wallert, M.; Lorkowski, S.; Weinigl, C.; Rummler, S.; Birringer, M.; Roviezzo, F.; Sautebin, L.; Helesbeux, J.-J.; Seraphin, D.; Mosig, A.; Schuster, D.; Rossi, A.; Richomme, P.; Werz, O.; Koeberle, A. Nature Communications, 2018, 9:383,  doi: 10.1038/s41467-018-06158-5

Discovery of a benzenesulfonamide-based inhibitor of mPGES-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation. Cheunga1, S.Y.; Werner, M.; Esposito, L.;Troisib, F.; Cantone, V.; Liening, S.; König, S.; Gerstmeier, J.; Bilancia, R.; Rossi, A.; Roviezzo, F. ; Temml, V.; Schuster, D.; Stuppner, H.; Schubert-Zsilavecz, M. ; Werz, O.; Hanke, T.; Pace, S. European Journal of Medicinal Chemistry, 2018, 156, pp. 815-830. doi: 10.1016/j.ejmech.2018.07.031

2017

Inhibition of 11β-hydoxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole. Beck, K.R.; Bächler, M.; Vuorinen, A.; Wagner, S.; Akram, M.; Griesser, U.; Temml, V.; Klusonova, P.; Yamaguchi, H.; Schuster, D.; Odermatt, A.  Biochemical Pharmacology, 2017, 130, pp. 93 - 103. doi: 10.1016/j.bcp.2017.01.010

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Garscha, U.; Romp, E.; Pace, S.; Rossi, A.; Temml, V.; Schuster, D.; König, S.; Gerstmeier, J.; Liening, S.; Werner, M.; Atze, H.; Wittmann, S.; Weinigel, C.; Rummler, S.; Scriba, G.K.; Sautebin, L.; Werz, O. Scientific Reports, 2017, 7, No. 9398. doi:10.1038/s41598-017-09795-w

Anti-inflammatory activity of natural geranylated flavonoids: cyclooxygenase and lipoxygenase inhibitory properties and proteomic analysis. Hanáková, Z.; Hošek, J.; Kutil, Z.; Temml, V.; Landa, P.; Vanek, T.; Schuster, D.; Dall’Acqua, S.; Cvačka, J.; Polansky, O.; Šmejkal, K. Journal of Natural Products, 201780/4, p. 999 - 1006. Doi: 10.1021/acs.jnatprod.6b01011

Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2. Vuorinen, A.; Engeli, RT.; Leugger, S.; Bachmann, F.; Akram, M.; Atanasov, AG.; Waltenberger, B.; Temml, V.; Stuppner, H.; Krenn, L.; Ateba, SB.; Njamen, D.; Davis, RA.; Odermatt, A.; Schuster, D. Journal of Natural Products, 2017,  80/4, p. 965 - 974. doi: 10.1021/acs.jnatprod.6b00950

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Temml, V.; Garscha, U.; Romp, E.; Schubert, G.; Gerstmeier, J.; Kutil, Z.; Matuszczak, B.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D., Scientific Reports 2017, 7, No. 42751, doi:10.1038/srep42751

2016

Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors. Alsabil, K.; Suor-Cherer, S.; Koeberle, A.; Viault, G.; Lavaud, A.; Temml, V.; Waltenberger, B.; Scuster, D.; Litaudon, M.; Lorkowski, S.; De Vaumas, R.; Helesbeux, J-J.; Guilet, D.; Stuppner, H.; Werz, O.; Seraphin, D.; Richomme, P. Planta Medica, 2016, 82/11/12, p. 1110 - 1116. doi 10.1055/s-0042-108739

Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase. Scuotto, M.; Peduto, A.; Krauth, V.; Roviezzo, F.; Rossi, A.; Temml, V.; Esposito, V.; Stuppner, H.; Schuster, D.; D'Agostino, B.; Schiraldi, C.; Werz, O.; Filosa, R. European Journal of Medicinal Chemistry, 2016, e-pub ahead of print, doi: 10.1016/j.ejmech.2016.10.046

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. Schaible, A.; Filosa, R.; Krauth, V.; Temml, V.; Pace, S.; Garscha, U.; Liening, S.; Weinigel, C.; Rummler, S.; Schieferdecker, S.; Nett, M.; Peduto, A.; Collarile, S.; Scuotto, M.; Roviezzo, F.; Spaziano, G.; de Rosa, M.; Stuppner, H.; Schuster, D.; d'Agostino, B.; Werz, O. Biochemical Pharmacology, 2016, 112(Jul 15), 60-71, doi: 10.1016/j.bcp.2016.04.019

Semisynthetic and natural garcinoic acid isoforms as new mPGES-1 inhibitors. Alsabil, K.; Suor-Cherer, S.; Koeberle, A.; Viault, G.; Lavaud, A.; Temml, V.; Waltenberger, B.; Schuster, D.; Litaudon, M.; Lorkowski, S.; de Vaumas, R.; Helesbeux, J.J.; Guilet, D.; Stuppner, H.; Werz, O.; Seraphin, D.; Richomme, P. Planta Medica, 2016, 82(11-12), 1110-1116, doi: 10.1055/s-0042-108739

Miconidin acetate and primin as potent 5-lipoxygenase inhibitors from Brazilian Eugenia hiemalis (Myrtaceae). Zatelli, G.A.; Temml, V.; Kutil, Z.; Landa, P.; Vanek, T.; Schuster, D.; Falkenberg, M. Planta Medica Letters, 2016, 1(3), e17-e19, doi: 10.1055/s-0042-102460

Discovery of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore-based virtual screening. Waltenberger, B.; Garscha, U.; Temml, V.; Liers, J.; Werz, O.; Schuster, D.; Stuppner, H. Journal of Chemical Information and Modeling, 2016, 56(4), 747-762, doi: 10.1021/acs.jcim.5b00592

2015

Discovery and resupply of pharmacologically active plant-derived natural products: A review. Atanasov, A.G.; Waltenberger, B.; Pferschy-Wenzig, E.M.; Linder, T.; Wawrosch, C.; Uhrin, P.; Temml, V.; Wang, L.; Schwaiger, S.; Heiss, E.H.; Rollinger, J.M.; Schuster, D.; Breuss, J.M.; Bochkov, V.; Mihovilovic, M.D.; Kopp, B.; Bauer, R.; Dirsch, V.M.; Stuppner, H. Biotechnology Advances, 2015, 33(8), 1582-1614, doi: 10.1016/j.biotechadv.2015.08.001

Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2. Seebacher, W.; Faist, J.; Presser, A.; Weis, R.; Saf, R.; Kaserer, T.; Temml, V.; Schuster, D.; Ortmann, S.; Otto, N.; Bauer, R. European Journal of Medicinal Chemistry, 2015, 101, 552-559, doi: 10.1016/j.ejmech.2015.07.003

Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2. Kaserer T.; Temml, V.; Kutil, Z.; Vanek, T.; Landa, P.; Schuster, D. European Journal of Medicinal Chemistry, 2015,  doi: 10.1016/j.Ejmech.2015.04.017

The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro. Kutil, Z.; Kvasnicova, M.; Temml, V.; Schuster, D.; Vanek, T.; Fernandez, E.; Malik, J.; Landa, P. Food and Agricultural Immunology, 2015, 26(4), 504-511, doi: 10.1080/09540105.2014.988126

Effect of dietary stilbenes on 5-lipoxygenase and cyclooxygenase activities in vitro. Kutil, Z.; Pribylova, M.; Temml, V.; Schuster, D.; Marsik, P.; Susimamani, E.; Lou, J.D.; Vanek, T.; Landa, P. International Journal of Food Properties, 2015, 18(7), 1471-1477, doi: 10.1080/10942912.2014.903416

2014

Pharmacophore Modelling for Cyclooxygenase-1 and 2 inhibitors with LigandScout in comparison to Discovery Studio, by Temml, V.; Kaserer, T.; Kutil, Z.; Landa, P.; Vanek, T.; Schuster D., accepted by Future Medicinal Chemistry, 2014, 17 (6), 1869-1881, doi: 10.4155/FMC14.114,

Impact of Wines and Wine Constituents on Cyclooxygenase-1, -2, and 5-Lipoxygenase Catalytic Activity, by Kutil, Z.; Temml, V.; Maghradze, D.; Pribylova, M.; Dvorakova, M.; Schuster, D.; Vanek T.; Landa P., Mediators of Inflammation 2014, Article ID 178931, 8 pages (online journal)

Effect of dietary stilbenes on 5-lipoxygenase and cyclooxygenases activities in vitro. Kutil, Z.; Pribylova M.;  Temml, V.; Schuster, D.; Marsik, P.; Fernandez, E.; Cusimamani, J. ; Vanek, T.; Landa, P., International Journal of Food Properties, 2014, (online journal), doi: 10.1080/10942912.2014.903416

Discovery of novel liver X receptor (LXR) agonists by pharmacophore- and shape-based virtual screening. Temml, V.; Voss, C.; Dirsch, V.M.; Schuster, D. Journal of Chemical Information and Modeling, 2014, 54(2), 367-371, doi: 10.1021/ci400682b

Elucidation of the molecular mechanism and the efficiency in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase. Schaible, A.; Filosa, R.;  Temml, V.; Matteis, M.; Peduto, A.; Luderer, S.; Roviezzo, F.; Di Mola, A.; De Rosa, M.; D'Agostino, B.; Weinigel, C.; Barz, D.; Koeberle, A.; Schuster, D.; Werz, O. British Journal of Phamacology, 2014, 171(9), 2399-2412. doi: 10.1111/bph.12592.

2013

Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. Temml, V.; Kuehnl, S.; Schuster, D.; Schwaiger, S.; Stuppner, H.; Fuchs, D. FEBS Open Bio, 2013, 3, 450-452, doi: 10.1016/j.fob.2013.08.008 

Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase. Kuehnl, S.; Schroecksnadel, S.; Temml, V.; Gostner, J.M.; Schennach, H.; Schuster, D.; Schwaiger, S.; Rollinger, J.M.; Fuchs, D.; Stuppner, H. Phytomedicine, 2013, 20(13), 1190-1195, doi: 10.1016/j.phymed.2013.06.006

Potent inhibition of 5-lipoxygenase and liposomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. Schaible, A.M.; Traber, H.; Temml, V.; Noha, S.M.; Filosa, R.; Peduto, A.; Weinigel C.; Barz, D.; Schuster, D.; Werz, O. Biochemical Pharmacology, 2013, 86(4), 476-486, doi: 10.1016/j.bcp.2013.04.015

Natural quinones as inhibitors of leukotriene B4 biosynthesis in human neutrophil granulocytes. Landa, P.; Kutil, Z.; Temml, V.; Malik, J.; Kokoska, L.; Widowitz, U.; Pribylova, M.; Dvorakova, M.; Marsik, P.; Schuster, D.; Bauer, R.; Vanek, T. Natural Product Communications, 2013, 8(1), 105-108

2012

Redox and non-redox mechanism of in vitro cyclooxygenase inhibition by natural quinones. Landa, P.; Kutil, Z.; Temml, V.; Vuorinen, A.; Malik, J.; Dvorakova, M.; Marsik, P.; Kokoska, L.; Pribylova, M.; Schuster, D.; Vanek, T. Planta Medica 2012, 78(4), 326-333, doi: 10.1055/s-0031-1280430

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Book sections

Mayr F.; Temml V; Vieider C.; Stuppner, H.; Schuster, D.  Open access activity prediction tools for natural products. Case study: hERG blockers  in Progress in the Chemistry of Organic Natural Products, Volume: Chemoinformatics in Natural Product Research (Ed. Kinghorn), Springer, Berlin, Germany, in press

Computational studies on natural products for the development of multi-target drugs Temml, V.; Schuster, D. in Multi-Target Drug Design Using Chem-Bioinformatic Approaches (Ed. Kunal Roy), Methods in Pharmacology and Toxicology, Springer, Berlin, Germany, 2018  

Polypharmacology and adverse bioactivity profiles predict potential toxicity and drug-related ADRs
Kaserer, T.; Temml, V.; Schuster, D.; In Predictive ADMET: Integrated approaches in drug discovery and development (Eds. J. Wang, L. Urban), Wiley-VCH, Weinheim, Germany, 2014

Pharmacophore-based Methods for Predicting the Inhibition and Induction of Metabolic Enzymes
Kaserer, T.; Temml, V.; Schuster, D.; In Drug Metabolism Prediction, Methods and Principles in Medicinal Chemistry (Ed. J. Kirchmair), Wiley-VCH, Weinheim, German, 2014

Computational bioactivity profiling
Temml, V.; Kaserer, T.; Schuster D.; In Scientific Computing @ uibk (Ed. A. Ostermann, M. Barden), Innsbruck University Press,

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Conferences and presentations

Oral presentations

Computational profiling as an early warning system for potentially harmful substances in cosmetics Temm, V.; First Austrian Summit on Phytocosmetics, 1. Juli 2019, Lienz, Austria

Discovery of the first dual inhibitor of 5-lipoxygenase-activating protein and solulble epoxide hydrolase using pharmacophore-based virtual screening. Temml, V; Garscha, U.; Romp, E.; Schubert, G.; Gerstmair, J.; Kutil, Z.; Matuszack, B.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D Pharma2030 - Current and Future Challenges. A Joint Meeting of the Austrian Pharmaceutical Society (ÖPhG) and the Swiss Academy of Pharmaceutical Sciences (SAPhS), April 20-22, 2017, Innsbruck.

Natural products interacting with 5-lipoxygenase – but how and where?
Temml, V.; Kaserer, T.; Stefanovic, I.; von Grafenstein, S.; Fuchs, J.E.; Liedl, K.R.; Schuster, D.; 14th of November, 2014, Natural Products and Drug Discovery – Future Perspectives, Vienna, Austria.

Identification of potent soluble epoxide hydrolase (sEH) inhibitors by pharmacophore modeling and virtual screening
Waltenberger, B.; Liers, J.; Temml, V.; Garscha, U.; Werz, O.; Schuster, D.; Stuppner, H.; 24th of April, 2014, 23rd Scientific Congress of the Austrian Pharmaceutical Society (ÖPhG), Graz, Austria.

Pharmacophore-based discovery of novel inhibitors of the innovative therapeutic target soluble epoxide hydrolase (sEH)
Waltenberger, B.; Liers, J.; Temml, V.; Garscha, U.; Werz, O.; Schuster, D.; Stuppner, H.; March 17th-19th, 2014, 28th Molecular Modelling Workshop, Erlangen, Germany.

New perspectives on a classic inflammation target: Computational analysis of 5-lipoxygenase inhibition
Temml, V.;  Kaserer, T.; Stefanovic, I.; von Grafenstein, S.; Fuchs, J.E.; Liedl, K.R.; Schuster, D.; 24th of April, 2014, 23rd Scientific Congress of the Austrian Pharmaceutical Society (ÖPhG), Graz, Austria.

Indentification of new LXR-β modulators by in silico screening and biological evaluation
Temml, V.; Winekenstädde, D.; Voss, C.; Rollinger, J. M.; Stuppner, H.; Dirsch, V.; Schuster, D.; 24th of July, 2013, Trends in Natural Products research (ÖPHG), Obergurgl, Austria.


Poster presentations

Computational Investigation of multi-target effects in the arachidonic acid cascade on the example of potent natural 5-LO inhibitor garcinoic acid Temml, V.; Pein, H.; Koeberle, A.; Garscha, U.; Helesbeux, J-J; Waltenberger, B., Seraphin, D.; Richomme, P. , Stuppner, H.; Werz, O.; Schuster, D., 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), September 1-5, 2019, Innsbruck, Austria

Computational binding mode prediction of ω-oxidized tocotrienols as inhibitors of 5-lipoxygenase. Temml, V.; Koeberle, A.; Garscha, U.; Helesbeux, J-J; Waltenberger, B., Seraphin, D.; Richomme, P. , Stuppner, H.; Werz, O.; Schuster, D. First Austrian Summit on Natural Products, Science and Technology behind Phytopharmacy, Phytocosmetics and Phytonutrition, January 14 - 16, 2018, Seefeld, Austria

Pharmacophore Modeling and Virtual Screening for Soluble Epoxide Hydrolase (sEH) Inhibitors
Waltenberger, B., Liers, J.; Temml, V.; Garscha, U.; Werz, O.; Schuster, D.; Stuppner, H.; Natural Products and Drug Discovery – Future Perspectives, 13th-14th of November, 2014, Vienna, Austria.

Search for New Dual Inhibitors of the 5-Lipoxygenase-Activating Protein and Soluble Epoxide Hydrolase with Pharmacophore Modeling
Temml, V.; Kutil, Z.; Romp, E.; Garscha, U.; Waltenberger, B.; Stuppner, H.; Werz, O.; Schuster, D.; Russia, August 31st-September 4th, 2014, St. Petersburg, Russia. 

Identification of new LXR-β modulators by in silico screening and biological evaluation
Temml, V.; Voss, C.; Dirsch, V.; Schuster, D.; OEBMGT Meeting, September 25th-27th, 2013, Innsbruck, Austria.

In vitro cyclooxygenase inhibition by natural quinones and possible mechanism of their action
Kutil, Z.; Temml, V.; Landa, P.; Malik, J.; Kokoska, L.; Marsik, P.; Schuster, D.; Vanek, T.; Dvorakova, M.; PharmSciFair, June 13th-17th, 2011, Prague, Czech Republic.

Identification and investigation of novel LXR modulators
Voss, C.; Winekenstädde, D.; Temml, V.; Schuster, D.; Rollinger, J.M.; Stuppner, H.; Dirsch, V.; Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction, Apr 3rd-8th, 2013, Alpbach, Austria.

Inhibtion Modes of Quinone Compounds on 5-Lipoxygenase
Temml, V.; Kutil Z., Landa P., Schuster D.;

  • 19th Euro QSAR, Aug 26th-30th, 2012, Vienna, Austria 
  • 4th Life Science Meeting Innsbruck Universities, Sep 27th-28th, 2012, Igls, Austria.

Prospective performance evaluation of different virtual screening tools for COX-activity prediction
Kaserer, T; Temml, V.; Landa, P.; Schuster, D.;

  • 19th Euro QSAR, Aug 26th-30th, 2012, Vienna, Austria 
  • 4th Life Science Meeting Innsbruck Universities, Sep 27th-28th, 2012, Igls, Austria.

Pharmacophore Modeling of Cyclooxygenase-2 in LigandScout and Discovery Studio – A comparison
Temml, V.; Kutil, Z.; Landa, P.; Schuster, D.; Molecular Modeling Workshop, March 12th-14th, 2012, Erlangen, Germany

Finding and analyzing the binding mode of new cyclooxygenase inhibitors with pharmacophore modeling
Temml, V.; Kutil, Z.; Landa, P.; Malik, J.; Dvorakova, M.; Marsik. P.; Kokoska, L.; Pribylova, M.; Vanek, T.; Schuster, D.; Joint Meeting of the Austrian and German Pharmaceutical Societies, September 20th-23rd, 2011, Innsbruck, Austria

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Patents

N,N’-Diarylurea and N,N’-diarylthiourea compounds for use in treatment and prevention of inflammatory disease. Schuster, D.; Temml, V.; Kutil, Z.; Matuszczak, B.; Werz, O.; Garscha, U.; Waltenberger, B.; Stuppner, H. EP16195622.2, 27.10.2016

Tocotrienol derivatives, pharmaceutical composition and method of use in chronic airway inflammatory disorders. Richomme, P.; Helesbeux, J.J.; Guilet, D.; Seraphin, D.; Stuppner, H.; Waltenberger, B.; Schuster, D.; Temml, V.; Koeberle, A.; Werz, O. EP15182827.4-1462, 27.08.2015.

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