Hermann StuppnerHermann STUPPNER, Univ.-Prof. Dr.
Head of Department, Dean of Studies

Institute of Pharmacy/Pharmacognosy
University of Innsbruck
Center for Chemistry and Biomedicine
Innrain 80 - 82/IV
Room: L.04.012
6020 Innsbruck / Austria

Phone: +43 512 507 - 58400 | Fax: +43 512 507 - 58499
Email: hermann.stuppner@uibk.ac.at


Publication List 

Original papers


Becker K, Schwaiger S, Waltenberger B, Fuchs D, Pezzei CK, Schennach H, Stuppner H, Gostner JM. Immunomodulatory Effects of Diterpene Quinone Derivatives from the Roots of Horminum pyrenaicum in Human PBMC. Oxidative Medicine and Cellular Longevity, 2018, Article ID 2980295. Doi: 10.1155/2018/2980295

Ferraz Gomes A, Almeida MP, Leite MF, Schwaiger S, Stuppenr H, Halabalaki M, Amaral JG, David JM. Seasonal variation in the chemical composition of two chemotypes of Lippia alba. Food Chemistry, 2018, in press. Doi: 10.1016/j.foodchem.2017.11.089

Ferraz Gomes A, Ganzera M, Schwaiger S, Stuppner H, Halabalaki M, Almeide MP,  Leite MF, Amaral JG, David JM. Simultaneous determination of iridoids, phenylpropanoids and flavonoids in Lippia alba extracts by micellar electrokinetic capillary chromatography. Microchemical Journal, 2018, 138, 494-500. Doi: 10.1016/j.microc.2018.02.003

Gibitz Eisath N, Sturm S, Stuppner H. Supercritical Fluid Chromatography in Natural Product Analysis – An Update. Planta Medica, 2018, 84(6/7), 361-371. Doi:  10.1055/s-0037-1599461

Gufler V, Nguyen Ngoc H, Stuppner H, Ganzera M.  Capillary electrophoresis as a fast and efficient alternative for the analysis of Urceola rosea leaf extracts. Fitoterapia, 2018, 125, 1-5. Doi: 10.1016/j.fitote.2017.12.007

Liu R, Heiss EH, Waltenberger B, Blazevic T, Schachner D, Jiang B, Krystof V, Liu W, Schwaiger S, Pena-Rodriguez LM, Breuss JM, Stuppner H, Dirsch V, Atanasov AG. Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor. Molecular Nutrition & Food Research, 2018, 62, e1700860. Doi: 10.1002/mnfr.201700860

Moosmang S, Pitscheider M, Sturm S, Seger C, Tilg H, Halabalaki M, Stuppner H. Metabolomic analysis—Addressing NMR and LC-MS related problems in human feces sample preparation. Clinica Chimica Acta, 2018, in press. Doi: 10.1016/j.cca.2017.10.029

Mutschlechner B, Schwaiger S, Tran TVA, Stuppner H. Development of a selective HPLC-DAD/ELSD method for the qualitative and quantitative assessment of commercially available Eurycoma longifolia products and plant extracts. Fitoterapia, 2018, 124, 188-192. Doi: 10.1016/j.fitote.2017.11.015

Mutschlechner B, Rainer B, Schwaiger S, Stuppner H. Tyrosinase Inhibitors from the Aerial Parts of Wulfenia carinthiaca Jacq. Chemistry & Biodiversity, 2018, 15, e1800014. Doi: 10.1002/cbdv.201800014

Nguyen Ngoc H, Nghiem, DT, Pham TLG, Stuppner H, Ganzera M. Phytochemical and analytical characterization of constituents in Urceola rosea (Hook. & Arn.) D.J. Middleton leaves. Journal of Pharmaceutical and Biomedical Analysis, 2018, 149, 66-69. Doi: 10.1016/j.jpba.2017.10.031

Piwowarskia J, Waltenberger B, Stuppner H, Kiss AK, Granica S. The analysis of phenolic compounds from the aerial parts of Eupatorium cannabinum L. subsp. cannabinum.
Biochemical Systematics and Ecology, 2018, 79, 37-43. Doi: 10.1016/j.bse.2018.05.001

Pompermaier L, Marzocco S, Adesso S, Monizi M, Schwaiger S, Neinhuis C, Stuppner H, Lauternschläger T. Medicinal plants of northern Angola and their anti-inflammatory properties. Journal of Ethnopharmacology, 2018, 216, 26-36. Doi: 10.1016/j.jep.2018.01.019

Revoltella S, Baraldo G, Waltenberger B, Schwaiger S, Kolfer P, Moesslacher J, Huber-Seidel A, Pagitz K, Kohl R, Jansen-Duerr P, Stuppner H. Identification of the NADPH Oxidase 4 Inhibiting Principle of Lycopus europaeus. Molecules, 2018, 23(3), 653. Doi: 10.3390/molecules23030653

Waltenberger B, Halabalaki M, Schwaiger S,  Adamopoulos N, Allouche N, Fiebich BL, Hermans N, Jansen-Dürr P, Kesternich V, Pieters L, Schönbichler S, Skaltsounis A-L, Tran H, Trougakos IP, Viljoen A, Wolfender J-L, Wolfrum C, Xynos N,  Stuppner H. Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources—The MediHealth Project. Molecules, 2018, 23(5), 1097. Doi: 10.3390/molecules23051097


Cavinato M, Waltenberger B, Baraldo G, Grade CVC, Stuppner H, Jansen-Dürr P. Plant extracts and natural compounds used against UVB-induced photoaging. Biogerontology, 2017, 18(4), 499-516. Doi: 10.1007/s10522-017-9715-7

Dreier D, Latkolik  S, Rycek L, Schnürch M, Dymáková A,  Atanasov AG, Ladurner A, Heiss EH, Stuppner H, Schuster D, Mihovilovic MD, Dirsch VM. Linked magnolol dimer as a selective PPARγ agonist – Structure-based rational design, synthesis, and bioactivity evaluation. Scientific Reports, 2017, 7, 13002. Doi: 10.1038/s41598-017-12628-5

Haller J, Schwaiger S, Stuppner H, Gafner F, Ganzera M. Isolation of three triterpene saponins, including two new oleanane derivatives, from Soldanella alpina and Hydrophilic Interaction Liquid Chromatography-​Evaporative Light Scattering Detection of these three saponins in four Soldenella species. Phytochemical Analysis, 2017, 28(6), 567-574. Doi: 10.1002/pca.2706

Hochleitner J, Akram M, Ueberall M, Davis RA, Waltenberger B, Stuppner  H, Sturm S, Ueberall F, Gostner  JM, Schuster D. A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature. Scientific Reports, 2017, 7, 8071. Doi: 10.1038/s41598-017-08404-0

Khan SY, Awad EM, Oszwald A, Mayr M, Yin X, Waltenberger B, Stuppner H, Lipovac M, Pavel U, Breuss JM. Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin. Scientific Reports, 2017, 7, 39501. Doi: 10.1038/srep39501

Mailainer C, Schachner D, Sangiovanni E, Atanasov AG, Schwaiger S, Stuppner H, Heiss EH, Dirsch VM. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level. Journal of Natural Products, 2017, 80(12), 3186-3193. Doi: 10.1021/acs.jnatprod.7b00503

Marzocco S, Adesso S, Alilou M, Stuppner H., Schwaiger S. Anti-Inflammatory and Anti-Oxidant Potential of the Root Extract and Constituents of Doronicum austriacum. Molecules, 2017, 22(6), 1003. Doi: 10.3390/molecules22061003

Pataczek L, Cheilari A, Zikeli S, Sturm S, Stuppner H, Gruber S. Centaurium erythraea Cultivation Method for Optimal Yield and Product Quality. Journal of Herbs, Spices & Medicinal Plants, 2017, 23(3), 193-215. Doi: 10.1080/10496475.2017.1295414

Peduto A, Scuotto M, Krauth V, Roviezzo F, Rossi A, Temml V, Esposito V, Stuppner H, Schuster D, D´Agostino B., Schiraldi C, De Rosa M, Werz O, Filosa R. Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase. European Journal of Medicinal Chemistry, 2017, 127, 715-726. Doi: 10.1016/j.ejmech.2016.10.046

Schäfer S, Schwaiger S, Stuppner H. Aristolic Acid Derivates from the Bark of Antidesma ghaesembilla. Planta Medica, 2017, 83(12/13), 1097-1102. Doi: 10.1055/s-0043-110141

Taibon J, Sturm S, Strasser H, Stuppner H. Combination of a Quechers-Based extraction protocol with a fast and selective UHPLC-QTOF-MS assay for the detection and quantification of Metarhizium brunneum metabolites from honey samples. SOJ  Pharmacy & Pharmaceutical Sciences, 2017, 4(1), 1-5. Doi: 10.15226/2374-6866/4/1/00147

Temml V, Garscha U, Romp E, Schubert G, Gerstmeier J, Kutil Z, Matuszczak B, Waltenberger B, Stuppner H, Werz O, Schuster D. Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. Scientific Reports, 2017, 7, 42751. Doi: 10.1038/srep42751

Vuorinen A, Engeli RT, Leugger S, Bachmann F, Akram M, Atanasov AG, Waltenberger B, Temml V, Stuppner H,  Krenn L, Ateba SB, Njamen D, Davis RA, Odermatt A, Schuster D. Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2. Journal of Natural Products, 2017, 80(4), 965-974. Doi: 10.1021/acs.jnatprod.6b00950


Alsabil K, Suor-Cherer S, Koeberle A, Viault G, Lavaud A, Temml V, Waltenberger B, Schuster D, Litaudon M, Lorkowski S, de Vaumas R, Helesbeux  JJ, Guilet D, Stuppner H, Werz O, Seraphin D, Richomme P. Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors. Planta Medica, 2016, 82 (11/12), 1110-1116. Doi: 10.1055/s-0042-108739

Antal DS, Pinzaru I, Borcan F, Marti TD, Ledeti I, Coricovac D, Schwaiger S, Stuppner H, Dehelean CA, Ollivier E, Soica C.  Inclusion Complexes of the Aurone Sulfuretin and the Chalcone Butein from Cotinus coggygria Wood in Two Cyclodextrin Types: First data on physico-chemical properties. Revista De Chimie, 2016 67(6), 1104-1109.

Cheilari A, Sturm S, Intelmann D, Seger C, Stuppner H. Head-to-Head Comparison of Ultra-High-Performance Liquid Chromatography with Diode Array Detection versus Quantitative Nuclear Magnetic Resonance for the Quantitative Analysis of the Silymarin Complex in Silybum marianum Fruit Extracts. Journal of Agricultural and Food Chemistry, 2016, 64(7), 1618-1626. Doi: 10.1021/acs.jafc.5b05494

Heiss EH, Liu R, Waltenberger B, Khan S, Schachner D, Kollmann P, Zimmermann K, Cabaravdic M, Uhrin P, Stuppner H, Breuss JM, Atanasov AG, Dirsch VM. Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation. Scientific reports, 2016, 6, 20771. Doi: 10.1038/srep20771

Papadakis ES, Robson N, Yeomans A, Bailey S, Laversin S, Beer S, Sayan A, Ashton-Key M, Schwaiger S, Stuppner H, Troppmair J, Packham G, Cutress R. A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells. Oncotarget, 2016, 7(14), 18851-18864. Doi: 10.18632/oncotarget.7944

Papadakis ES, Barker CR, Syed H, Reeves T, Schwaiger S, Stuppner H, Troppmair J, Blaydes JP, Cutress RI. The Bag-1 inhibitor, Thio-2, reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal carcinoma in situ. Oncogenesis, 2016, 5, e215. Doi: 10.1038/oncsis.2016.10

Schäfer S, Salcher S, Seiter M, Ranninger C, Moest M, Obexer P, Huber CG, Ausserlechner MJ, Schwaiger S, Stuppner H. Characterization of the XIAP-Inhibiting Proanthocyanidin Fraction of the Aerial Parts of Ephedra sinica. Planta Medica, 2016, 82(11/12), 973-985. Doi: 10.1055/s-0042-107253

Schaible AM, Filosa R, Krauth V, Temml V, Pace S, Garscha U, Liening S, Weinigel C, Rummler S, Schieferdecker S, Nett M, Peduto A, Collarile S, Scuott M, Roviezzo F, Spaziano G, De Rosa M, Stuppner H, Schuster D, D´Agostino, B, Werz O. The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. Biochemical Pharmacology, 2016, 112, 60-71. Doi: 10.1016/j.bcp.2016.04.019

Scharinger B, Messner B, Türkcan A, Schuster D, Vuorinen A, Pitterl F, Heinz K, Arnhard K, Laufer G, Grimm M, Stuppner H, Oberacher H, Eller P, Ritsch A, Bernhard D. Leoligin, the major lignan from edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE −/− mice. Journal of Molecular and Cellular Cardiology, 2016, 99, 35-46. Doi: 10.1016/j.yjmcc.2016.08.003

Waltenberger B, Garscha U, Temml V, Liers J, Werz O, Schuster D, Stuppner H. Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening. Journal of Chemical Information and Modeling, 2016, 56(4), 747-762.  Doi: 10.1021/acs.jcim.5b00592

Waltenberger B, Atanasov AG, Heiss EH, Bernhard D, Rollinger JM, Breuss JM, Schuster D, Bauer R, Kopp B, Franz C, Bochkov V, Mihovilovic MD, Dirsch VM, Stuppner H. Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project. Monatshefte für Chemie, 2016, 147(3), 479-491. Doi: 10.1007/s00706-015-1653-y

Wang L, Ladurner A, Latkolik S, Schwaiger S, Linder T, Hosek J, Palme V, Schilcher N, Polanský O, Heiss EH, Stangl H, Mihovilovic MD, Stuppner H, Dirsch VM, Atanasov AG. Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages. Journal of Natural Products, 2016, 79(6), 1651-1657.
Doi:  10.1021/acs.jnatprod.6b00227



Aguiriano-Moser V, Svejda B, Li ZX, Sturm S, Stuppner H, Ingolic E, Höger H, Siegl V, Meier-Allard N, Sadjak A, Pfragner R. Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells. Molecular medicine reports, 2015, 12(4), 5003-5011. Doi: 10.3892/mmr.2015.4053

Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger J, Schuster D, Breuss JM, Bochov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology Advances, 2015, 33(8), 1582-1614.
Doi: 10.1016/j.biotechadv.2015.08.001

Taibon J, Sturm S, Seger C, Strasser OH, Stuppner H. Quantitative Assessment of Destruxins from Strawberry and Maize in the Lower ppb Range: Combination of a QuEChERS-based Extraction Protocol with a Fast and Selective UHPLC-QTOF-MS Assay. Journal of Agricultural and Food Chemistry, 2015, 63(23), 5707-5713. Doi: 10.1021/acs.jafc.5b01562

Taibon J, Ankli A, Schwaiger S, Magnenat C, Boka VI, Simoes-Pires C, Aligiannis N, Cuendet M, Skaltsounis AL, Reich E, Stuppner H. Prevention of false positive results: development of an HPTLC autographic assay for the detection of natural tyrosinase inhibitors. Planta Medica, 2015, 81(12/13), 1198-1204. Doi: 10.1055/s-0035-1546250

Taibon J,  Sturm S, Seger C, Werth M, Strasser H, Stuppner H. Supercritical Fluid Chromatography as an Alternative Tool for the Qualitative and Quantitative Analysis of Metarhizium brunneum Metabolites from Culture Broth. Planta Medica, 2015, 81(18), 1736-1743. Doi: 10.1055/s-0035-1557823

Tran TVA, Mailaner C, Schwaiger S, Hung T, Atanasov AG, Heiss EH, DIRSCH V, Stuppner H. Screening of Vietnamese medicinal plants for NF-κB signaling inhibitors: Assessing the activity of flavonoids from the stem bark of Oroxylum indicum. Journal of Ethnopharmacology, 2015, 159, 36-42. Doi: 10.1016/j.jep.2014.10.012

Waltenberger B, Liu R., Atanasov AG, Schwaiger S, Heiss EH, Dirsch VM, Stuppner H. Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation. Molecules, 2015, 20(11), 20381-20390. Doi: 10.3390/molecules201119703

Winekenstädde D, Angelis A, Waltenberger B, Schwaiger S, Tchoumtchoua J, König S, Werz O, Aligiannis N, Skaltsounis AL, Stuppner H. Phytochemical profile of the aerial parts of Sedum sediforme and anti-inflammatory activity of myricitrin. Natural Product Communications, 2015, 10(1), 83-88.



Fakhrudin N, Waltenberger B, Cabaravdic M,  Atanasov AG, Malainer C, Schachner D, Heiss EH, Liu R, Noha SM, Grzywacz AM, Mihaly-Bison J, Awad EM, Schuster D, Breuss JM, Rollinger JM, Bochkov V, Stuppner H, Dirsch VM. Identification of plumericin as a potent new scaffold inhibitor of the NF-kB pathway with anti-inflammatory activity in vitro and in vivo. British Journal of Pharmacology, 2014, 171(7), 1676-1686. Doi: 10.1111/bph.12558

Heiss EH, Tran TVH, Zimmermann K, Schwaiger S, Vouk C, Mayerhofer B, Malainer C, Atanasov AG, Stuppner H, Dirsch VM. Identification of Chromomoric Acid C‑I as an Nrf2 Activator in Chromolaena odorata. Journal of Natural Products, 2014, 77(3), 503-508. Doi: 10.1021/np400778m

Krautscheid Y, Senning CJA, Sartori SB, Singewald N, Schuster D, Stuppner H. Pharmacophore Modeling, Virtual Screening, and in Vitro Testing Reveal Haloperidol, Eprazinone, and Fenbutrazate as Neurokinin Receptors Ligands. Journal of Chemical Information and Modeling, 2014, 54(6), 1747-1757. Doi: 10.1021/ci500106z

Öttl S, Hubert J, Nuzzilard J-M, Stuppner H, Renault J-H, Rollinger JM. Dereplication of depsides from the lichen Pseudevernia furfuracea by centrifugal partition chromatography combined to 13C nuclear magnetic resonance pattern recognition. Analytica Chimica Acta, 2014, 846, 60-67. Doi: 10.1016/j.aca.2014.07.009

Picker P, Vogl S, McKinnon R, Mihaly-Bison J, Binder M, Atanasov AG, Fakhrudin N, Grzywacz AM, Heiss EH, Zehl M, Saukel J, Wawrosch C, Schinkovitz A, Waltenberger B, Bauer R, Rollinger JM, Stuppner H, Dirsch VM, Bochkov V, Reznicek G, Kopp B. Plant extracts in cell-based anti-inflammatory assays—Pitfalls and considerations related to removal of activity masking bulk components. Phytochemistry Letters, 2014, 10, xli–xlvii,
Doi: 10.1016/j.phytol.2014.04.001

Stille JS, Jäger M, Dickore WB, Ehlers K, Holzhauer SIJ, Mayland-Quellhorst E, Safer S, Schwaiger S, Stuessy TF, Stuppner H, Wissemann V. Chromosome numbers of the Edelweiss, Leontopodium (Asteraceae, Compositae - Gnaphalieae). Edinburgh Journal of Botany, 2014, 71(1), 23-33. Doi: 10.1017/S0960428613000243

Strommer B, Khom S, Kastenberger I, Cicek SS, Stuppner H, Schwarzer C, Hering S.  A Cycloartane Glycoside Derived from Actaea racemosa L. Modulates GABAA Receptors and Induces Pronounced Sedation in Mice. The Journal of Pharmacology and Experimental Therapeutics, 2014, 351(2), 234-242. Doi: 10.1124/jpet.114.218024

Taibon J, Sturm S, Seger C, Parth M, Strasser H, Stuppner H. Development of a fast and selective UHPLC-DAD-QTOF-MS/MS method for the qualitative and quantitative assessment of destruxin profiles. Analytical and Bioanalytical Chemistry, 2014, 406(29), 7623-7632. Doi: 10.1007/s00216-014-8203-z

Tappeiner J, Vasiliou A, Ganzera M, Fessas D, Stuppner H, Papageorgiou VP, Assimopoulou A. Quantitative determination of alkannins and shikonins in endemic Mediterranean Alkanna species. Biomedical Chromatography, 2014, 28(7), 923-933. Doi: 10.1002/bmc.3096

Tran TVH, Malainer C, Schwaiger S, Atanasov AG, Heiss EH, Dirsch VM, Stuppner H. NF-κB Inhibitors from Eurycoma longifolia. Journal of Natural Products, 2014, 77(3), 483-488. Doi: 10.1021/np400701k

Wang L, Waltenberger B, Pferschy-Wenzig E-M, Blunder M, Liu X, Malainer C, Blazevic T, Schwaiger S, Rollinger JM, Heiss EH, Schuster D, Kopp B, Bauer R, Stuppner H, Dirsch VM, Atanasov AG. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochemical Pharmacology, 2014, 92(1), 89-92, Doi: 10.1016/j.bcp.2014.07.018

Wawrosch C, Schwaiger S, Stuppner H, Kopp B. Lignan formation in hairy root cultures of Edelweiss (Leontopodium nivale ssp. alpinum (Cass.) Greuter). Fitoterapia, 2014, 97, 219-223. Doi: 10.1016/j.fitote.2014.06.008 



Atanasov AG, Wang JN, Gu SP, Bu J, Kramer MP, Baumgartner L, Fakhrudin N, Ladurner A, Malainer C, Vuorinen A, Noha SM, Schwaiger S, Rollinger JM, Schuster D, Stuppner H, Dirsch VM, Heiss EH. Honokiol: A non-adipogenic PPARγ agonist from nature. Biochimica et biophysica acta,2013, 1830(10), 4813-4819. Doi: 10.1016/j.bbagen.2013.06.021

Do TCMV, Nguyen TD, Tran H, Stuppner H, Ganzera M. Analysis of alkaloids in Lotus (Nelumbo nucifera Gaertn.) leaves by non-aqueous capillary electrophoresis using ultraviolet and mass spectrometric detection. Journal of Chromatography A, 2013, 1302, 174-180. Doi: 10.1016/j.chroma.2013.06.002

Enthammer M, Papadakis ES, Gachet MS, Deutsch M, Schwaiger S, Koziel K, Ashraf MI, Khalid S, Wolber G, Packham G, Cutress RI, Stuppner H, Troppmair J. Isolation of a Novel Thioflavin S-Derived Compound that Inhibits BAG-1-Mediated Protein Interactions and Targets BRAF Inhibitor-Resistant Cell Lines. Molecualar cancer therapeutics, 2013, in print, Doi: 10.1158/1535-7163.MCT-13-0142

Hofer D, Schwach G, Tabrizi-Wizsy NG, Sadjak A, Sturm S, Stuppner H, Pfragner R. Christia vespertilionis plant extracts as novel antiproliferative agent against human neuroendocrine tumor cells. Oncology Reports, 2013, 29(6), 2219-2226. Doi: 10.3892/or.2013.2367

Högner C, Sturm S, Seger C, Stuppner H. Development and validation of a rapid ultra-high performance liquid chromatography diode array detector method for Vitex agnus-castus. Journal of Chromatography B, 2013, 927, 181-190. Doi: 10.1016/j.jchromb.2013.02.037

Kühnl S, Schröcksnadel S, Temml V, Gostner JM, Schennach H, Schuster D, Schwaiger S, Rollinger JM, Fuchs D, Stuppner H. Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase. Phytomedicine,2013, 20(13), 1190-1195. Doi: 10.1016/j.phymed.2013.06.006

Messner B, Kern J, Wiedemann D, Schwaiger S, Türkcan A, Ploner C, Trockenbacher A, Aumayr K, Bonaros N, Laufer G, Stuppner H, Untergasser G, Bernhard D. 5-Methoxyleoligin, a Lignan from Edelweiss, Stimulates CYP26B1-Dependent Angiogenesis In Vitro and Induces Arteriogenesis in Infarcted Rat Hearts In Vivo. PLoS One, 2013, 8(3), e58342. Doi: 10.1371/journal.pone.0058342

Neu V, Bielow C, Gostomski I, Wintringer R, Braun R, Reinert K, Schneider P, Stuppner H, Huber CG. Rapid and Comprehensive Impurity Profiling of Synthetic Thyroxine by Ultrahigh-Performance Liquid Chromatography–High-Resolution Mass Spectrometry. Analytical Chemistry, 2013, 85(6), 3309-3317. Doi: 10.1021/ac303722j

Neu V, Bielow C, Schneider P, Braun R, Stuppner H, Reinert K, Huber C.G. UHPLC-HRMS-Experimente planen und auswerten Beispiel Thyroxin. Nachrichten aus der Chemie, 2013, 61(4), 455-458.

Neu V, Bielow C, Schneider P, Reinert K, Stuppner H, Huber CG. Investigation of Reaction Mechanisms of Drug Degradation in the Solid State: A Kinetic Study Implementing Ultrahigh-Performance Liquid Chromatography and High-Resolution Mass Spectrometry for Thermally Stressed Thyroxine. Analytical Chemistry 2013, 85(4), 2385-2390. Doi: 10.1021/ac303404e

Öttl S, Gerstmeier J, Khan SY, Wiechmann K, Bauer J, Atanasov AG, Malainer C, Awad EM, Uhrin P, Heiss EH, Waltenberger B, Remias D, Breuss JM, Boustie J, Dirsch VM, Stuppner H, Werz O, Rollinger JM. Imbricaric Acid and Perlatolic Acid: Multi-Targeting Anti-Inflammatory Depsides from Cetrelia monachorum. PLOS One, 2013, 8(19), e76929. Doi: 10.1371/journal.pone.0076929

Pezzei C, Kopp B, Stuppner H, Huck C.W. Advances on an Infrared Hyperspectral Spectroscopy Platform for Medicianl Plant Materials Analysis and its Impact on In vivo Studies. Current Bioactive Compounds 2013, (9(3), 235-246. Doi: 10.2174/15734072113099990015

Russel A, Safer S, Weiss-Schneeweiss H, Temsch E, Stuppner H, Stuessy TF, Samuel R. Chromosome counts and genome size of Leontopodium species (Asteraceae: Gnaphalieae) from south-western China. Botanical Journal of the Linnean Society, 2013, 171(3), 627-636. Doi: 10.1111/boj.12011

Seger C, Sturm S, Stuppner H. Mass spectrometry and NMR spectroscopy: modern high-end detectors for high resolution separation techniques – state of the art in natural product HPLC-MS, HPLC-NMR, and CE-MS hyphenations. Natural Product Reports, 2013, 30(7), 970-987. Doi: 10.1039/C3NP70015A

Temml V, Kühnl S, Schuster D, Schwaiger S, Stuppner H, Fuchs D. Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. FEBS Open Bio, 2013, 450-452(3). Doi: 10.1016/j.fob.2013.08.008



Bauer J, Kühnl S, Rollinger JM, Scherer O, Northoff H, Stuppner H, Werz O, Köberle A. Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E2 Synthase-1. Journal of Pharmacology and Experimental Therapeutics, 2012, 342(1), 169-176. Doi: 10.1124/jpet.112.193847

Bauer J, Waltenberger B, Noha SM, Schuster D, Rollinger JM, Boustie J, Chollet M, Stuppner H, Werz O. Discovery of Depsides and Depsidones from Lichen as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase-1 Using Pharmacophore Models. ChemMedChem, 2012, 7(12), 2077-2081. Doi: 10.1002/cmdc.201200345

Do TCMV, Nguyen TD, Tran H, Stuppner H, Ganzera M. Quantitative Determination of Phenolic Compounds in Lotus (Nelumbo nucifera) Leaves by Capillary Zone Electrophoresis. Planta Medica, 2012, 78(16), 1796-1799. Doi: 10.1055/s-0032-1315258

Ganzera M, Greifeneder V, Schwaiger S, Stuppner H. Chemical profiling of Edelweiss (Leontopodium alpinum Cass.) extracts by micellar electrokinetic capillary chromatography. Fitoterapia, 2012, 83(8), 1680-1686. Doi: 10.1016/j.fitote.2012.09.023

Heiss EH, Baumgartner L, Schwaiger S, Heredia RJ, Atanasov AG, Rollinger JM, Stuppner H, Dirsch V. Ratanhiaphenol III from Ratanhiae Radix is a PTP1B Inhibitor. Planta Medica, 2012, 78(7), 678-681. Doi: 10.1055/s-0031-1298242

Ladurner A, Atanasov AG, Heiss EH, Baugartner L, Schwaiger S, Rollinger JM, Stuppner H, Dirsch M. 2-(2,4-dihydroxyphenyl)-5-(E)-propenylbenzofuran promotes endothelial nitric oxide synthase activity in human endothelial cells. Biochemical Pharmacology, 2012, 84(6), 804-812. Doi: 10.1016/j.bcp.2012.06.029

Noha SM, Jazzar B, Kühnl S, Rollinger JM, Stuppner H, Schaible AM, Werz O, Wolber G, Schuster D. Pharmacophore-based discovery of a novel cytosolic phospholipase A2α inhibitor. Bioorganic & Medicinal Chemistry Letters, 2012, 22(2), 1202-1207. Doi: 10.1016/j.bmcl.2011.11.093

Pieri V, Sturm S, Seger C, Franz C, Stuppner H. 1H NMR-based metabolic profiling and target analysis: a combined approach for the quality control of Thymus vulgaris. Metabolomics, 2012, 8(2), 335-346. Doi: 10.1007/s11306-011-0317-0

Remias D, Schwaiger S, Aigner S, Leya T, Stuppner H, Lütz C. Characterization of an UV- and VIS-absorbing, purpurogallin-derived secondary pigment new to algae and highly abundant in Mesotaenium berggrenii (Zygnematophyceae, Chlorophyta), an extremophyte living on glaciers. FEMS Microbiology Ecology, 2012, 79(3), 638-648. Doi: 10.1111/j.1574-6941.2011.01245.x

Steinmann D, Baumgartner RR, Heiss EH, Bartenstein S, Atanasov AG, Dirsch VM, Ganzera M, Stuppner H. Bioguided Isolation of (9Z)-Octadec-9-enoic Acid from Phellodendron amurense Rupr. and Identification of Fatty Acids as PTP1B Inhibitors. Planta Medica, 2012, 78(3), 219-224. Doi: 10.1055/s-0031-1280377

Zeller I, Wiedemann D, Schwaiger S, Stelzmüller M, Kreutmayer S, Leberfing O, Stuppner H, Bernhard D. Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats. European Journal Of Cardio-Thoracic Surgery, 2012;,  2(5), 878-884. Doi: 10.1093/ejcts/ezs128



Aberham A, Pieri V, Croom Jr EM, Ellmerer E, Stuppner H. Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC–MS and RP-HPLC. Journal of Pharmaceutical and Biomedical Analysis, 2011, 54(3), 517-525. Doi: 10.1016/j.jpba.2010.09.030

Baumgartner L, Schwaiger S, Stuppner H. Quantitative analysis of anti-inflammatory lignan derivatives in Ratanhiae radix and its tincture by HPLC–PDA and HPLC–MS. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56(3), 546-552. Doi: 10.1016/j.jpba.2011.06.016

Baumgartner L, Sosa S, Atanasov AG, Bodensieck A, Fakhrudin N, Bauer J, Del Favero G, Ponti C, Heiss EH, Schwaiger S, Ladurner A, Widowitz U, Della Loggia R, Rollinger JM, Werz O, Bauer R, Dirsch VM, Tubaro A, Stuppner H. Lignan Derivatives from Krameria lappacea Roots Inhibit Acute Inflammation in Vivo and Pro-inflammatory Mediators in Vitro. Journal of Natural Products, 2011, 74(8), 1779-1786. Doi: 10.1021/np200343t

Cicek SS, Aberham A, Ganzera M, Stuppner H. Quantitative analysis of cycolartane glycosides in black cohosh rhizomes and dietary supplements by RRLC-ELSD and RRLC-qTOF-MS. Analytical and Bioanalytical Chemistry, 2011, 400(8), 2597-2605. Doi: 10.1007/s00216-010-4068-y

Duwensee K, Schwaiger S, Tancevksi I, Eller K, Van Eck M, Makrt P, Linder T, Stanzl U, Ritsch A, Patsch JR, Schuster D, Stuppner H, Bernhard D, Eller P. Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein. Atherosclerosis, 2011, 219/1, 109-115. Doi: 10.1016/j.atherosclerosis.2011.07.023

Grienke U, Mihaly-Bison J, Schuster D, Afonyushkin T, Binder M, Guan S-H, Cheng C-R, Wolber G, Stuppner H, Guo D-A, Bochkov VN, Rollinger JM. Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum. Bioorganic & Medicinal Chemistry, 2011, 19/22, 6779-6791. Doi: 10.1016/j.bmc.2011.09.039

Hornick A, Lieb A, Vo NP, Rollinger JM, Stuppner H, Prast H. The coumarin scopoletin potentiates acetylcholine release from synatposomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory. Neuroscience, 2011, 197, 280-292. Doi: 10.1016/j.neuroscience.2011.09.006

Noha SM, Atanasov AG, Schuster D, Markt P, Fakhrudin N, Heiss EH, Schrammel O, Rollinger JM, Stuppner H, Dirsch VM, Wolber G. Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques. Bioorganic & Medicinal Chemistry Letters, 2011, 21(1), 577-583. Doi: 10.1016/j.bmcl.2010.10.051

Pfisterer PH, Shen C, Nikolovska-Coleska Z, Schyschka L, Schuster D, Rudy A, Wolber G, Vollmar AM, Rollinger JM, Stuppner H. In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3. Bioorganic & Medicinal Chemistry, 2011, 19(2), 1002-1009. Doi: 10.1016/j.bmc.2010.10.046

Pieri V, Belancic A, Morales S, Stuppner H. Identification and Quantification of Major Steviol Glycosides in Stevia rebaudiana Purified Extracts by 1H NMR Spectroscopy. Journal of Agricultural and Food Chemistry, 2011, 59(9), 4378-4384. Doi: 10.1021/jf104922q

Pieri V, Stuppner H. Quantification of Cynaropicrin in Artichoke Leaf Extracts by 1H NMR Spectroscopy. Planta Medica, 2011, 77(15), 1756-1758. Doi: 10.1055/s-0030-1271083

Safer S, Tremetsberger K, Guo Y-P, Kohl G, Samuel MR, Stuessy TF, Stuppner H. Phylogenetic relationships in the genus Leontopodium (Asteraceae: Gnaphalieae) based on AFLP data. Botanical Journal of the Linnean Society, 2011, 165(4), 364-377. Doi: 10.1111/j.1095-8339.2011.01117.x

Safer S, Cicek SS, Pieri V, Schwaiger S, Schneider P, Wissemann V, Stuppner H. Metabolic fingerprinting of Leontopodium species (Asteraceae) by means of 1H NMR and HPLC-ESI-MS. Phytochemistry, 2011, 72(11-12), 1379-1389. Doi: 10.1016/j.phytochem.2011.04.006

Schuster D, Markt P, Grienke U, Mihaly-Bison J, Binder M, Noha SM, Rollinger JM, Stuppner H, Bochkov VN, Wolber G. Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation. Bioorganic & Medicinal Chemistry, 2011, 19/23, 7168-7180. Doi: 10.1016/j.bmc.2011.09.056

Schwaiger S, Zeller I, Poelzelbauer P, Frotschnig S, Laufer G, Messner B, Pieri V, Stuppner H, Bernhard D. Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.). Journal of Ethnopharmacology, 2011, 133(2), 704-709. Doi: 10.1016/j.jep.2010.10.049

Waltenberger B, Rollinger JM, Griesser U, Stuppner H, Gelbrich T. Plumeridoid C from the Amazonian traditional medicinal plant Himatanthus sucuuba. Acta Crystallographic Section C, Crystal Structure Communications, 2011, 67/10, 409-412. Doi: 10.1107/S0108270111035761 

Waltenberger B, Schuster D, Paramapjon S, Gritsanapan W, Wolber G, Rollinger JM, Stuppner H. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine. Phytomedicine, 2011, 18(2-3), 119-133. Doi: 10.1016/j.phymed.2010.08.002

Waltenberger B, Wiechmann K, Bauer J, Markt P, Noha SM, Wolber G, Rollinger JM, Werz O, Schuster D, Stuppner H. Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1). Journal of Medicinal Chemistry, 2011, 54(9), 3163-3174. Doi: 10.1021/jm101309g



Aberham A, Cicek SS, Schneider P, Stuppner H. Analysis of Sesquiterpene Lactones, Lignans, and Flavonoids in Wormwood (Artemisia absinthium L.) Using High-Performance Liquid Chromatography (HPLC)-Mass Spectrometry, Reversed Phase HPLC, and HPLC-Solid Phase Extraction-Nuclear Magnetic Resonance. Journal of Agricultural and Food Chemistry, 2010, 58(20), 10817-10823. Doi: 10.1021/jf1022059

Antal DS, Schwaiger S, Ellmerer-Müller EP, Stuppner H. Cotinus coggygria wood: novel flavanone dimer and development of an HPLC/UV/MS method for the simultaneous determination of fourteen phenolic constituents. Planta Medica, 2010, 76(15), 1765-1772. Doi: 10.1055/s-0030-1249878

Baumgartner RR, Steinmann D, Heiss EH, Atanasov AG, Ganzera M, Stuppner H, Dirsch VM. Bioactivity-Guided Isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora Roots As a PTP1B Inhibitor. Journal of Natural Products, 2010, 73(9), 1578-1581. Doi: 10.1021/np100258e

Cicek SS, Khom S, Taferner B, Hering S, Stuppner H. Bioactivity-Guided Isolation of GABAA Receptor Modulating Constituents from the Rhizomes of Actaea racemosa. Journal of Natural Products, 2010, 73(12), 2024-2028. Doi: 10.1021/np100479w

Cicek SS, Schwaiger S, Ellmerer EP, Stuppner H. Development of a fast and convenient method for the isolation of triterpene saponins from Actaea racemosa by high-speed countercurrent chromatography coupled with evaporative light scattering detection. Planta Medica, 2010, 76(5), 467-473. Doi: 10.1055/s-0029-1186236

Fakhrudin N, Ladurner A, Atanasov AG, Heiss EH, Baumgartner L, Markt P, Schuster D, Ellmerer EP, Wolber G, Rollinger JM, Stuppner H, Dirsch VM. Computer-Aided Discovery, Validation, and Mechanistic Characterization of Novel Neolignan Activators of Peroxisome Proliferator-Activated Receptor γ. Molecular Pharmacology, 2010, 77(4), 559-566. Doi: 10.1124/mol.109.062141

Gao H, Zehl M, Kählig HP, Schneider P, Stuppner H, Banuls LMY, Kiss R, Kopp B. Rapid Structural Identification of Cytotoxic Bufadienolide Sulfates in Toad Venom from Bufo melanostictus by LC-DAD-MSn and LC-SPE-NMR. Journal of Natural Products, 2010, 73(4), 603-608. Doi: 10.1021/np900746k

Grienke U, Schmidtke M, Kirchmair J, Pfarr K, Wutzler P, Dürrwald R, Wolber G, Liedl KR, Stuppner H, Rollinger JM. Antiviral Potential and Molecular Insight into Neuraminidase Inhibiting Diarylheptanoids from Alpinia katsumadai. Journal of Medicinal Chemistry, 2010, 53(2), 778-786. Doi: 10.1021/jm901440f

Pfisterer PH, Wolber G, Efferth T, Rollinger JM, Stuppner H. Natural products in structure-assisted design of molecular cancer therapeutics. Current Pharmaceutical Design, 2010, 16(15), 1718-1741.

Pfisterer, P.H., Rollinger, J.M., Schyscka, L., Rudy, A., Vollmar, A.M., Stuppner H Neoandrographolide from Andrographis paniculata as a potential natural chemosensitizer. Planta Medica, 2010, 76(15), 1698-1700. Doi: 10.1055/s-0030-1249876

Rollinger JM, Kratschmar DV, Schuster D, Pfisterer PH, Gumy C, Aubry EM, Brandstötter S., Stuppner H, Wolber G, Odermatt A. 11β-hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorganic & Medicinal Chemistry, 2010, 18(4), 1507-1515. Doi: 10.1016/j.bmc.2010.01.010 

Schuster D, Kern L, Hristozov DP, Terfloth L, Bienfait B, Laggner C, Kirchmair J, Grienke U, Wolber G, Langer T, Stuppner H, Gasteiger J, Rollinger JM. Applications of integrated data mining methods to exploring natural product space for acetylcholinesterase inhibitors. Combinatorial Chemistry & High Throughput Screening, 2010, 13(1), 54-66. Doi: 10.2174/138620710790218212

Schuster D, Spetea M, Music M, Rief S, Fink M, Kirchmair J, Schütz J, Wolber G, Langer T, Stuppner H, Schmidhammer H, Rollinger JM. Morphinans and isoquinolines: Acetylcholinersterase inhibition, pharmacophore modeling, and interaction with opioid receptors. Bioorganic & Medicinal Chemistry, 2010, 18(14), 5071-5080. Doi: 10.1016/j.bmc.2010.05.071

Schuster D, Waltenberger B, Kirchmair J, Distinto S, Markt P, Stuppner H, Rollinger JM, Wolber G. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part I: model generation, validation and applicability in ethnopharmacology. Molecular Informatics, 2010, 29(1-2), 75-86. Doi: 10.1002/minf.200900071 

Schwaiger S, Hehenberger S, Ellmerer EP, Stuppner H. A new Bisabolane Derivative of Leontopodium andersonii. Natural Product Communications, 2010, 5(5), 667-668.

Svejda B, Aguiriano-Moser V, Sturm S, Hoger H, Ingolic E, Siegl V, Stuppner H, Pfragner R. Anticancer activity of novel plant extracts from Trailliaedoxa gracilis (W. W. Smith & Forrest) in human carcinoid KRJ-I Cells. Anticancer Research, 2010, 30(1), 55-64.



Assimopoulou AN, Sturm S, Stuppner H, Papageorgiou VP. Preparative isolation and purification of alkannin/shikonin derivatives from natural products by high-speed counter-current chromatography. Biomedical Chromatography, 2009, 23(2), 182-198. Doi: 10.1002/bmc.1101

Costa S, Schwaiger S, Cervellati R, Stuppner H, Speroni E, Guerra CM. In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage. Journal of Applied Toxicology, 2009, 29(1), 7-14. Doi: 10.1002/jat.1372

Ganzera M, Nischang I, Siegl C, Senzenberger B, Svec F, Stuppner H. Application of MEKC and monolithic CEC for the analysis of bioactive naphthoquinones in Eleutherine americana. Electrophoresis, 2009, 30(21), 3757-3763. Doi: 10.1002/elps.200900247

Ganzera M, Sturm S, Stuppner H. Plant analysis – state of the art and future developments. Planta Medica, 2009, 75(7), 671-671. Doi: 10.1055/s-0029-1185603

Gumy C, Thurnbichler C, Aubry EM, Balasz Z, Pfisterer P, Baumgartner L, Stuppner H, Odermatt A, Rollinger JM. Inhibition of 11β-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines. Fitoterapia, 2009, 80(3), 200-205. Doi: 10.1016/j.fitote.2009.01.009

Horak SB, Koschak A, Stuppner H, Striessnig J. Use-dependent block of voltage-gated Cav2.1 Ca2+ channels by petasins and eudesmol isomers. The Journal of Pharmacology and Experimental Therapeutics, 2009, 330(1), 220-226. Doi: 10.1124/jpet.109.151183

Pieri V, Schwaiger S, Ellmerer EP, Stuppner H. Iridoid Glycosides from the Leaves of Sambucus ebulus. Journal of Natural Products, 2009, 72(10), 1798-1803. Doi: 10.1021/np900373u 

Reisinger U, Schwaiger S, Zeller I, Messner B, Stigler R, Wiedemann D, Mayr T, Seger C, Schachner T, Dirsch VM, Vollmar AM, Bonatti JO, Stuppner H, Laufer G, Bernhard D. Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts. Cardiovascular Research, 2009, 82(3), 542-549. Doi: 10.1093/cvr/cvp059

Rinner B, Li Zeng X, Haas H, Siegl V, Sturm S, Stuppner H, Pfragner R. Antiproliferative and Pro-apoptotic Effects of Uncaria tomentosa in Human Medullary Thyroid Carcinoma Cells. Anticancer Research, 2009, 29(11), 4519-4528.

Rollinger JM, Schuster D, Danzl B, Schwaiger S, Markt P, Schmidtke M, Gertsch J, Raduner S, Wolber G, Langer T, Stuppner H. In silico Target Fishing for Rationalized Ligand Discovery Exemplified on Constituents of Ruta graveolens. Planta Medica, 2009, 75(3), 195-204. Doi: 10.1055/s-0029-1202470